angiotensin II
SMILES | None |
InChIKey | CZGUSIXMZVURDU-JZXHSEFVSA-N |
Sequence | DRVYIHPF |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Physiological/Surrogate | Endogenous |
Approved drug | Yes |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
AT2 | AGTR2 | Human | Angiotensin | A | pKd | 10.2 | 10.2 | 10.2 | Guide to Pharmacology |
AT1 | AGTRA | Rat | Angiotensin | A | pKi | 9.02 | 9.02 | 9.02 | PDSP Ki database |
AT2 | AGTR2 | Human | Angiotensin | A | pKd | 7.99 | 7.99 | 7.99 | Drug Central |
AT1 | AGTRB | Rat | Angiotensin | A | pKi | 8.02 | 8.02 | 8.02 | Drug Central |
AT1 | AGTR1 | Human | Angiotensin | A | pKi | 9.05 | 9.44 | 9.8 | ChEMBL |
AT1 | AGTR1 | Human | Angiotensin | A | pKd | 8.7 | 8.7 | 8.7 | ChEMBL |
AT2 | AGTR2 | Human | Angiotensin | A | pKi | 8.92 | 9.48 | 9.7 | ChEMBL |
AT1 | AGTR1 | Bovine | Angiotensin | A | pKd | 8.08 | 8.08 | 8.08 | Drug Central |
AT1 | AGTR1 | Bovine | Angiotensin | A | pKd | 8.24 | 8.24 | 8.24 | ChEMBL |
AT1 | AGTRB | Rat | Angiotensin | A | pKi | 9.02 | 9.27 | 9.51 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
AT1 | AGTR1 | Human | Angiotensin | A | pIC50 | 9.0 | 9.15 | 9.3 | Guide to Pharmacology |
AT1 | AGTRA | Rat | Angiotensin | A | pIC50 | 8.03 | 8.03 | 8.03 | Drug Central |
AT1 | AGTR1 | Human | Angiotensin | A | pIC50 | 8.03 | 8.03 | 8.03 | Drug Central |
AT1 | AGTR1 | Human | Angiotensin | A | pIC50 | 7.99 | 8.57 | 9.14 | ChEMBL |
AT1 | AGTR1 | Human | Angiotensin | A | pEC50 | 8.01 | 8.8 | 9.31 | ChEMBL |
AT2 | AGTR2 | Human | Angiotensin | A | pIC50 | 8.6 | 9.3 | 10.1 | ChEMBL |
AT1 | AGTRB | Rat | Angiotensin | A | pIC50 | 9.4 | 9.4 | 9.4 | ChEMBL |
AT1 | AGTRA | Rat | Angiotensin | A | pEC50 | 8.17 | 8.53 | 8.89 | ChEMBL |
AT1 | AGTRA | Rat | Angiotensin | A | pIC50 | 9.4 | 9.4 | 9.4 | ChEMBL |