mirtazapine
| SMILES | CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 |
| InChIKey | RONZAEMNMFQXRA-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 3 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 0 |
| Molecular weight (Da) | 265.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
GTP
| Uniprot
| Species
| Family
| Class
| Type
| Min | Avg | Max | Database
|
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 7.75 | 7.75 | 7.75 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKd | 5.3 | 5.3 | 5.3 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKd | 8.28 | 8.28 | 8.28 | Drug Central |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 7.74 | 7.74 | 7.74 | PDSP Ki database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.16 | 7.16 | 7.16 | PDSP Ki database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.16 | 7.62 | 8.09 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.16 | 7.16 | 7.16 | Guide to Pharmacology |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.7 | 8.7 | 8.7 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.41 | 7.41 | 7.41 | ChEMBL |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.26 | 8.26 | 8.26 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.41 | 7.73 | 8.05 | PDSP Ki database |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 7.41 | 7.41 | 7.41 | Guide to Pharmacology |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.26 | 8.26 | 8.26 | ChEMBL |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.58 | 6.58 | 6.58 | PDSP Ki database |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.58 | 6.58 | 6.58 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pKi | 5.38 | 5.38 | 5.38 | PDSP Ki database |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
| D1 | DRD1 | Rat | Dopamine | A | pKi | 5.38 | 5.38 | 5.38 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 5.84 | 5.84 | 5.84 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.26 | 5.26 | 5.26 | PDSP Ki database |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 5.3 | 5.48 | 5.84 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pKi | 5.24 | 6.47 | 7.7 | PDSP Ki database |
| D3 | DRD3 | Human | Dopamine | A | pKi | 5.24 | 5.24 | 5.24 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.8 | 9.05 | 9.3 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.8 | 8.8 | 8.8 | ChEMBL |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 8.29 | 8.29 | 8.29 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 9.2 | 9.33 | 9.5 | PDSP Ki database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 6.43 | 6.43 | 6.43 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.7 | 7.7 | 7.7 | PDSP Ki database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.7 | 7.7 | 7.7 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.8 | 6.95 | 7.1 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.1 | 6.4 | 6.7 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.74 | 7.74 | 7.74 | PDSP Ki database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.75 | 7.75 | 7.75 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.0 | 7.35 | 7.7 | Guide to Pharmacology |
Showing 1 to 47 of 47 entries
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
GTP
| Uniprot
| Species
| Family
| Class
| Type
| Min | Avg | Max | Database
|
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.5 | 4.5 | 4.5 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pIC50 | 8.26 | 8.26 | 8.26 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pIC50 | 5.5 | 5.5 | 5.5 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 7.07 | 7.07 | 7.07 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 7.1 | 7.1 | 7.1 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 6.65 | 6.65 | 6.65 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 8.18 | 8.18 | 8.18 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.7 | 6.7 | 6.7 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.7 | 6.7 | 6.7 | Guide to Pharmacology |
Showing 1 to 9 of 9 entries