ATC0175


SMILES O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C
InChIKey FAIMGWSOSCFGRU-IYBDPMFKSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 425.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MCH1 MCHR1 Human Melanin-concentrating hormone A pIC50 7.9 8.0 8.1 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pIC50 6.52 6.52 6.52 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.58 6.78 6.98 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 7.77 7.77 7.77 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.82 7.42 8.02 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.82 6.82 6.82 ChEMBL
MCH1 MCHR1 Human Melanin-concentrating hormone A pIC50 8.08 8.23 8.47 ChEMBL
Y5 NPY5R Human Neuropeptide Y A pIC50 5.57 5.57 5.57 ChEMBL