tolazoline


SMILES c1ccc(cc1)CC1=NCCN1
InChIKey JIVZKJJQOZQXQB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 160.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 6.7 6.7 6.7 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 5.5 5.5 5.5 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 5.43 5.43 5.43 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 5.43 6.04 6.65 PDSP Ki database
α2B ADA2B Rat Adrenoceptors A pKi 6.95 6.95 6.95 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.64 7.13 7.62 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 5.5 5.5 5.5 PDSP Ki database
α1A ADA1A Human Adrenoceptors A pKi 8.26 8.26 8.26 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.26 8.26 8.26 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.27 8.27 8.27 Drug Central
TA1 TAAR1 Human Trace amine A pKi 8.24 8.24 8.24 Drug Central
TA1 TAAR1 Human Trace amine A pKi 5.79 5.79 5.79 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.8 4.8 ChEMBL
TA1 TAAR1 Human Trace amine A pEC50 6.0 6.0 6.0 ChEMBL
TA1 TAAR1 Human Trace amine A pIC50 5.32 5.32 5.32 ChEMBL