compound 30 [PMID: 21757343]


SMILES Clc1cccc(c1)c1ncc(c(c1)C)[C@H]1CCCN1C(=O)c1nccs1
InChIKey GCSDBTCZHROCLZ-GOSISDBHSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 383.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.92 7.92 7.92 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.92 7.92 7.92 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.77 7.77 7.77 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 7.92 7.92 7.92 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.77 7.77 7.77 ChEMBL