GPCRdb

cariprazine

Agent/drug
Bioactivity

cariprazine

SMILES	CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1
InChIKey	KPWSJANDNDDRMB-QAQDUYKDSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	426.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7VOD
Ligand site mutations	5-HT_2A D₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.62	6.62	6.62	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.71	5.71	5.71	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.49	6.49	6.49	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.76	5.76	5.76	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.96	5.96	5.96	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.63	6.63	6.63	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.65	6.65	6.65	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.27	8.38	8.74	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.07	8.07	8.07	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.89	6.89	6.89	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.11	7.11	7.11	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.25	7.24	7.73	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	9.82	9.82	9.82	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.90	6.49	6.70	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.48	5.48	5.48	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.89	5.89	5.89	ChEMBL

Showing 1 to 20 of 38 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pEC50	6.95	8.64	9.74	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.77	8.77	8.78	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	8.11	8.11	8.11	Drug Central
D₂	DRD2	Rat	Dopamine	A	pIC50	7.80	7.80	7.80	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.24	8.48	8.72	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	8.70	8.70	8.70	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	8.06	8.06	8.06	Drug Central
D₃	DRD3	Rat	Dopamine	A	pIC50	8.80	8.80	8.80	ChEMBL

Showing 1 to 8 of 8 entries

cariprazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 5

Phase III 8

Phase IV 22

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7VOD
Ligand site mutations	5-HT_2A D₂

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	3	6A02.Z	N05A	0.451
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.591
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	4	6A7Z	N05A	0.596
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Generalised anxiety disorder	2	6B00	N05A	0.543
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.622
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	4	6A70.3	N05A	0.634
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	3	6A02.Z	N05A	0.462
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	4	6A7Z	N05A	0.607
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Generalised anxiety disorder	2	6B00	N05A	0.392
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.620
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	4	6A70.3	N05A	0.632
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.074
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	4	6A7Z	N05A	0.448
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	4	6A20.Z	N05A	0.591
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	4	6A70.3	N05A	0.050
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	3	6A02.Z	N05A	0.499
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.660
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	4	6A7Z	N05A	0.655
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Generalised anxiety disorder	2	6B00	N05A	0.391

Showing 1 to 20 of 28 entries

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cariprazine

cariprazine

Chemical Properties

Database connections

Bioactivities

cariprazine

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information