2-methyl-5-HT


SMILES Cc1c(CCN)c2c([nH]1)ccc(c2)O
InChIKey WYWNEDARFVJQSG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 190.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT2A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.7 5.95 6.2 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.1 6.1 6.1 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.2 6.75 7.3 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.91 5.91 5.91 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.4 7.03 7.34 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.77 5.92 6.07 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.04 6.13 6.29 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.71 6.71 6.71 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 6.5 6.53 6.55 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.09 6.09 6.09 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.38 6.38 6.38 PDSP Ki database
5-HT2B 5HT2B Mouse 5-Hydroxytryptamine A pKi 5.18 5.18 5.18 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.51 5.51 5.51 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.34 7.34 7.34 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.25 6.77 7.28 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.86 5.86 5.86 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.19 6.19 6.19 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.6 5.76 5.92 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.84 5.86 5.9 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL