dynorphin A-(1-13)
SMILES | None |
InChIKey | OVVIBUHLQIYUEU-IWIISZHXSA-N |
Sequence | YGGFLRRIRPKLK |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Physiological/Surrogate | Endogenous |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
κ | OPRK | Human | Opioid | A | pKi | 9.3 | 10.0 | 10.7 | Guide to Pharmacology |
μ | OPRM | Human | Opioid | A | pKi | 8.3 | 8.3 | 8.3 | Guide to Pharmacology |
κ | OPRK | Rat | Opioid | A | pKi | 9.9 | 9.9 | 9.9 | Guide to Pharmacology |
κ | OPRK | Rat | Opioid | A | pKi | 8.47 | 8.94 | 9.22 | ChEMBL |
κ | OPRK | Guinea pig | Opioid | A | pKi | 8.44 | 8.97 | 9.51 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 7.55 | 7.99 | 8.42 | ChEMBL |
κ | OPRK | Human | Opioid | A | pKi | 9.64 | 9.85 | 10.05 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 8.1 | 8.1 | 8.1 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 7.8 | 7.8 | 7.8 | Guide to Pharmacology |
μ | OPRM | Rat | Opioid | A | pKi | 8.4 | 8.4 | 8.4 | ChEMBL |
κ | OPRK | Mouse | Opioid | A | pKi | 9.52 | 9.52 | 9.52 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
κ | OPRK | Rat | Opioid | A | pEC50 | 7.75 | 8.02 | 8.22 | ChEMBL |
δ | OPRD | Mouse | Opioid | A | pIC50 | 8.04 | 8.12 | 8.2 | ChEMBL |
κ | OPRK | Guinea pig | Opioid | A | pIC50 | 9.94 | 9.94 | 9.94 | ChEMBL |
κ | OPRK | Guinea pig | Opioid | A | pEC50 | 7.75 | 7.75 | 7.75 | ChEMBL |
δ | OPRD | Human | Opioid | A | pIC50 | 8.39 | 8.39 | 8.39 | ChEMBL |
δ | OPRD | Human | Opioid | A | pEC50 | 7.73 | 7.73 | 7.73 | ChEMBL |
κ | OPRK | Human | Opioid | A | pIC50 | 9.83 | 9.83 | 9.83 | ChEMBL |
κ | OPRK | Human | Opioid | A | pEC50 | 7.4 | 8.19 | 8.82 | ChEMBL |
μ | OPRM | Human | Opioid | A | pEC50 | 6.67 | 6.67 | 6.67 | ChEMBL |
κ | OPRK | Mouse | Opioid | A | pEC50 | 6.8 | 7.48 | 8.17 | ChEMBL |