eglumegad


SMILES OC(=O)[C@H]1[C@H]2[C@@H]1[C@](CC2)(N)C(=O)O
InChIKey VTAARTQTOOYTES-RGDLXGNYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 185.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 7E9G 7EPB

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.9 6.9 6.9 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.9 8.9 8.9 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 7.3 7.3 7.3 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 7.8 7.85 7.9 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKd 7.7 7.7 7.7 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pKi 4.92 4.92 4.92 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pKi 5.52 5.52 5.52 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 6.9 7.05 7.42 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 7.27 7.27 7.27 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 7.63 7.63 7.63 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.07 7.32 7.96 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu6 GRM6 Human Metabotropic glutamate C pIC50 5.5 5.5 5.5 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 5.1 5.1 5.1 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 4.94 4.94 4.94 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 5.47 5.49 5.52 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 6.85 7.42 7.61 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 7.55 7.55 7.55 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 7.2 7.31 7.42 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 7.46 7.72 7.96 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.46 8.03 8.29 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 8.15 8.2 8.25 ChEMBL