endomorphin-2
SMILES | None |
InChIKey | XIJHWXXXIMEHKW-LJWNLINESA-N |
Sequence | YPFF |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Physiological/Surrogate | Endogenous |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
μ | OPRM | Rat | Opioid | A | pKi | 8.5 | 8.5 | 8.5 | Guide to Pharmacology |
κ | OPRK | Rat | Opioid | A | pKi | 7.97 | 7.97 | 7.97 | ChEMBL |
κ | OPRK | Guinea pig | Opioid | A | pKi | 5.11 | 5.34 | 5.57 | ChEMBL |
μ | OPRM | Rat | Opioid | A | pKi | 7.72 | 8.53 | 9.31 | ChEMBL |
δ | OPRD | Human | Opioid | A | pKi | 5.1 | 5.24 | 5.47 | ChEMBL |
κ | OPRK | Human | Opioid | A | pKi | 5.28 | 5.62 | 5.95 | ChEMBL |
μ | OPRM | Human | Opioid | A | pKi | 8.09 | 8.57 | 9.16 | ChEMBL |
μ | OPRM | Rat | Opioid | A | pKi | 7.71 | 8.51 | 9.24 | PDSP Ki database |
μ | OPRM | Mouse | Opioid | A | pKi | 8.8 | 8.83 | 8.86 | PDSP Ki database |
μ | OPRM | Bovine | Opioid | A | pKi | 9.37 | 9.37 | 9.37 | PDSP Ki database |
κ | OPRK | Guinea pig | Opioid | A | pKi | 6.3 | 6.3 | 6.3 | PDSP Ki database |
δ | F1N083 | Bovine | Opioid | A | pKi | 6.3 | 6.3 | 6.3 | PDSP Ki database |
NK1 | NK1R | Rat | Tachykinin | A | pKi | 7.52 | 7.88 | 8.06 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
μ | OPRM | Mouse | Opioid | A | pIC50 | 7.62 | 7.7 | 7.78 | ChEMBL |
δ | OPRD | Mouse | Opioid | A | pIC50 | 6.29 | 6.93 | 7.82 | ChEMBL |
μ | OPRM | Rat | Opioid | A | pIC50 | 8.46 | 9.0 | 9.16 | ChEMBL |
μ | OPRM | Rat | Opioid | A | pEC50 | 6.42 | 6.73 | 7.11 | ChEMBL |
μ | OPRM | Human | Opioid | A | pEC50 | 7.2 | 8.25 | 10.4 | ChEMBL |