gallamine


SMILES CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC
InChIKey OZLPUNFFCJDMJD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 21
Molecular weight (Da) 510.5

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations M1 M2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.8 6.7 7.6 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 5.9 6.1 6.3 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 5.6 5.6 5.6 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.43 5.97 6.33 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.07 5.07 5.07 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.76 5.76 5.76 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 5.58 5.58 5.58 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.29 8.29 8.29 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.25 8.25 8.25 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.6 4.67 4.75 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.7 5.91 6.11 ChEMBL
M2 ACM2 Pig Acetylcholine (muscarinic) A pEC50 8.16 8.16 8.16 Drug Central
TSH TSHR Human Glycoprotein hormone A Potency 5.2 5.2 5.2 ChEMBL
M2 ACM2 Pig Acetylcholine (muscarinic) A pEC50 6.88 6.88 6.89 ChEMBL