AQ-RA 741


SMILES CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC
InChIKey BCUGCHZRMKTPMU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 463.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.2 7.35 7.5 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.4 8.4 8.4 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.2 7.25 7.3 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.8 8.0 8.2 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.1 6.95 7.8 Guide to Pharmacology
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 6.6 6.7 6.8 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.3 8.39 8.49 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 6.98 7.29 7.6 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.9 5.99 6.08 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.1 8.14 8.19 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.3 8.34 8.37 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 8.03 8.27 8.5 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.3 7.42 7.54 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.54 7.54 7.54 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.37 8.37 8.37 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.2 7.2 7.2 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.08 6.08 6.08 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.0 7.1 7.2 ChEMBL
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 8.0 8.0 8.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database