GLPG1205


SMILES O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1
InChIKey IRBAWVGZNJIROV-SFHVURJKSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 378.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR84 GPR84 Human A orphans A pKi 7.52 7.52 7.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR84 GPR84 Human A orphans A pIC50 7.0 9.0 11.0 Guide to Pharmacology
GPR84 GPR84 Human A orphans A pEC50 4.03 5.16 6.21 ChEMBL
GPR84 GPR84 Human A orphans A pIC50 6.95 8.69 11.0 ChEMBL