GSK 172981


SMILES Fc1cccc(c1)c1nc2ccccc2c(c1N)C(=O)N[C@H](c1ccccc1)C1CC1
InChIKey ZKGNLARKIMWKFE-XMMPIXPASA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 411.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK3 NK3R Human Tachykinin A pKi 8.0 8.0 8.0 Guide to Pharmacology
NK3 NK3R Guinea pig Tachykinin A pKi 8.11 8.11 8.11 Guide to Pharmacology
NK3 NK3R Human Tachykinin A pKi 8.0 8.0 8.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database