CHEMBL2376803
SMILES | CNC1CN(c2nc(N)nc3cc(C4CCCC4)cnc23)C1 |
InChIKey | HTLDHQKBLGJBRF-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 6 |
Hydrogen bond donors | 2 |
Rotatable bonds | 3 |
Molecular weight (Da) | 298.2 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
H4 | HRH4 | Mouse | Histamine | A | pKi | 7.71 | 7.71 | 7.71 | ChEMBL |
H4 | HRH4 | Rat | Histamine | A | pKi | 7.56 | 7.56 | 7.56 | ChEMBL |
H4 | HRH4 | Human | Histamine | A | pKi | 8.19 | 8.19 | 8.19 | ChEMBL |
H4 | HRH4 | Human | Histamine | A | pKd | 7.99 | 7.99 | 7.99 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pKi | 5.55 | 5.55 | 5.55 | ChEMBL |
H1 | HRH1 | Human | Histamine | A | pKi | 4.78 | 4.78 | 4.78 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKi | 6.82 | 6.82 | 6.82 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
H4 | HRH4 | Human | Histamine | A | pIC50 | 7.01 | 7.01 | 7.01 | ChEMBL |