CHEMBL2376800


SMILES CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1
InChIKey PREVTMRNRJIUDH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 258.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pKi 7.3 7.3 7.3 ChEMBL
H4 HRH4 Rat Histamine A pKi 7.15 7.15 7.15 ChEMBL
H4 HRH4 Human Histamine A pKi 7.97 7.97 7.97 ChEMBL
H4 HRH4 Human Histamine A pKd 8.07 8.07 8.07 ChEMBL
H2 HRH2 Human Histamine A pKi 4.85 4.85 4.85 ChEMBL
H1 HRH1 Human Histamine A pKi 4.47 4.47 4.47 ChEMBL
H3 HRH3 Human Histamine A pKi 6.11 6.11 6.11 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 6.95 6.95 6.95 ChEMBL