L-glutamic acid


SMILES OC(=O)CC[C@@H](C(=O)O)N
InChIKey WHUUTDBJXJRKMK-VKHMYHEASA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 4
Molecular weight (Da) 147.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 7MTS 7MTR 8JD0 8JD3 8JD1 8JD5 8JD2 8JD4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 4.9 4.9 4.9 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 7.4 7.4 7.4 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKi 3.1 3.1 3.1 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 6.4 6.4 6.4 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 5.4 5.65 5.9 Guide to Pharmacology
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 6.4 6.45 6.5 Guide to Pharmacology
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 4.9 5.2 5.5 Guide to Pharmacology
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 5.47 5.47 5.47 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pKi 5.02 5.02 5.02 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pKi 4.42 4.42 4.42 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 5.47 5.47 5.47 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 5.05 6.14 7.24 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 6.47 6.47 6.47 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 5.0 5.91 6.6 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pKi 4.77 5.51 5.85 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 4.92 5.35 5.92 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 4.94 5.65 6.41 ChEMBL
D1 DRD1 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 5.0 5.54 6.95 PDSP Ki database
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 5.0 5.48 5.96 PDSP Ki database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 5.4 5.4 5.4 PDSP Ki database
mGlu3 GRM3 Human Metabotropic glutamate C pKi 5.4 5.4 5.4 PDSP Ki database
mGlu7 GRM7 Human Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu8 GRM8 Human Metabotropic glutamate C pKi 7.7 7.7 7.7 PDSP Ki database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 5.0 5.86 7.57 PDSP Ki database
CB1 CNR1 Human Cannabinoid A pKi 6.0 6.0 6.0 PDSP Ki database
mGlu6 GRM6 Rat Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
mGlu1 GRM1 Human Metabotropic glutamate C pKi 8.18 8.18 8.18 Drug Central
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.13 8.13 8.13 Drug Central
mGlu4 GRM4 Human Metabotropic glutamate C pKi 8.23 8.23 8.23 Drug Central
mGlu5 GRM5 Human Metabotropic glutamate C pKi 8.19 8.19 8.19 Drug Central
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 8.26 8.26 8.26 Drug Central
mGlu6 GRM6 Human Metabotropic glutamate C pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pEC50 4.8 4.9 5.0 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 4.7 5.05 5.4 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 5.3 5.35 5.4 Guide to Pharmacology
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 4.7 5.1 5.5 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 5.0 5.25 5.5 Guide to Pharmacology
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 5.0 5.0 5.0 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 3.0 3.0 3.0 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 4.9 5.25 5.6 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 5.0 5.35 5.7 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 6.1 6.1 6.1 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 4.4 4.4 4.4 Guide to Pharmacology
mGlu8 GRM8 Mouse Metabotropic glutamate C pEC50 7.66 7.66 7.66 ChEMBL
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 4.08 4.66 5.12 ChEMBL
mGlu8 GRM8 Rat Metabotropic glutamate C pEC50 4.67 4.87 5.1 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 8.24 8.24 8.24 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 4.7 5.0 5.31 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 5.93 5.93 5.93 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pEC50 4.9 5.26 5.54 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 5.29 5.89 7.22 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 5.47 6.36 7.24 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pEC50 4.25 5.08 5.8 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 4.74 5.26 6.21 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pEC50 4.72 5.45 5.98 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 4.7 5.01 5.5 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 4.58 5.38 6.54 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 4.87 5.3 5.92 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 4.8 5.26 5.51 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.21 8.21 8.21 Drug Central
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 8.18 8.18 8.18 Drug Central
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 8.27 8.27 8.27 Drug Central
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 8.23 8.23 8.23 Drug Central
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 8.24 8.24 8.24 Drug Central
mGlu3 GRM3 Rat Metabotropic glutamate C pEC50 8.26 8.26 8.26 Drug Central
mGlu5 GRM5 Rat Metabotropic glutamate C pEC50 8.27 8.27 8.27 Drug Central
mGlu8 GRM8 Mouse Metabotropic glutamate C pEC50 8.12 8.12 8.12 Drug Central
mGlu2 GRM2 Rat Metabotropic glutamate C pEC50 8.27 8.27 8.27 Drug Central
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 8.32 8.32 8.32 Drug Central
mGlu1 GRM1 Rat Metabotropic glutamate C pEC50 8.3 8.3 8.3 Drug Central
mGlu4 GRM4 Rat Metabotropic glutamate C pEC50 8.31 8.31 8.31 Drug Central