loratadine


SMILES CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
InChIKey JCCNYMKQOSZNPW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 382.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations H1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 7.43 7.43 7.43 Guide to Pharmacology
H1 HRH1 Rat Histamine A pKi 6.46 6.46 6.46 ChEMBL
H1 HRH1 Guinea pig Histamine A pKd 7.14 7.14 7.14 ChEMBL
H1 HRH1 Human Histamine A pKi 6.38 7.0 7.7 ChEMBL
H1 HRH1 Human Histamine A pKd 6.72 6.72 6.72 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.81 6.81 6.81 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
H1 HRH1 Human Histamine A pKi 8.16 8.16 8.16 Drug Central
H1 HRH1 Guinea pig Histamine A pKd 8.15 8.15 8.15 Drug Central
H1 HRH1 Rat Histamine A pKi 8.19 8.19 8.19 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.7 5.3 5.9 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.54 6.65 6.77 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.61 6.61 6.61 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 5.13 5.4 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.55 4.7 ChEMBL