GPCRdb

chloroquine

Agent/drug
Bioactivity

chloroquine

SMILES	CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChIKey	WHTVZRBIWZFKQO-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	8
Molecular weight (Da)	319.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.27	8.27	8.27	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.36	5.36	5.36	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.35	8.35	8.35	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	4.50	4.50	4.50	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.22	5.22	5.22	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	4.40	4.78	5.20	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.21	5.21	5.21	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	5.04	5.04	5.04	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.30	8.30	8.30	Drug Central
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.33	5.33	5.33	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	8.27	8.27	8.27	Drug Central
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.48	5.48	5.48	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	8.26	8.26	8.26	Drug Central
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	5.24	5.24	5.24	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	8.28	8.28	8.28	Drug Central
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	4.66	4.66	4.66	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	9.40	9.40	9.40	PDSP Ki database
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	8.33	8.33	8.33	Drug Central

Showing 1 to 20 of 20 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CXCR4	CXCR4	Human	Chemokine	A	pEC50	5.19	5.19	5.19	ChEMBL
MRGPRX1	MRGX1	Human	A orphans	A	pEC50	3.53	3.53	3.53	Guide to Pharmacology

Showing 1 to 2 of 2 entries

chloroquine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.