LY2119620


SMILES CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1
InChIKey TYTGOXSAAQWLPJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 437.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 4MQT 6U1N 6OIK 7T94 7T96 7V68

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 5.5 5.6 5.7 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKd 5.5 5.5 5.5 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.03 5.19 5.45 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 5.45 5.45 5.45 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database