GPCRdb

(+)-chlorpheniramine

Agent/drug
Bioactivity

(+)-chlorpheniramine

SMILES	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1
InChIKey	SOYKEARSMXGVTM-HNNXBMFYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	5
Molecular weight (Da)	274.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central DrugBank PubChem Guide To Pharmacology ChEMBL_compound_ids PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central PubChem GPCRdb
Ligand site mutations	H₁ TAS2R40

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.07	5.07	5.07	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	4.78	4.78	4.78	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.32	8.32	8.32	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.12	5.12	5.12	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.29	8.29	8.29	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.68	5.68	5.68	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.25	8.25	8.25	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.98	5.98	5.98	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.29	8.29	8.29	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.92	5.92	5.92	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.51	5.51	5.51	PDSP Ki database
5-HT_2C	5HT2C	Mouse	5-Hydroxytryptamine	A	pKi	5.30	5.30	5.30	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	6.40	7.72	8.60	Guide to Pharmacology
H₁	HRH1	Rat	Histamine	A	pKi	8.26	8.41	8.70	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	8.15	8.67	9.14	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKi	9.30	9.33	9.36	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	5.00	7.68	8.60	PDSP Ki database

Showing 1 to 20 of 37 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	4.81	4.81	4.81	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	4.47	4.47	4.47	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	4.69	4.69	4.69	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.34	5.34	5.34	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.43	5.43	5.43	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.63	5.63	5.63	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	7.18	7.69	8.20	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pIC50	8.09	8.09	8.09	Drug Central
H₁	HRH1	Guinea pig	Histamine	A	pIC50	7.92	7.99	8.06	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	5.08	5.08	5.08	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.86	5.86	5.86	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.90	5.31	5.90	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.16	5.16	5.16	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	5.59	5.59	5.59	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	5.70	5.70	5.70	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	5.98	5.98	5.98	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.60	5.05	5.50	ChEMBL

Showing 1 to 18 of 18 entries

(+)-chlorpheniramine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 1

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central DrugBank PubChem Guide To Pharmacology ChEMBL_compound_ids PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central PubChem GPCRdb
Ligand site mutations	H₁ TAS2R40

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02		0.589	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z		0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01		0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z		0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Idiopathic angioedema	EB04		0.537	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Other allergic rhinitis	CA08.03		0.602	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Sunburn, unspecified	EJ40.Z		0.567	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05		0.606	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Vasomotor rhinitis	CA08.3		0.590	4	Yes

Showing 1 to 9 of 9 entries