GPCRdb

DROPERIDOL

Agent/drug
Bioactivity

DROPERIDOL

SMILES	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1
InChIKey	RMEDXOLNCUSCGS-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	379.2

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	9.18	9.18	9.18	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.01	8.01	8.01	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.39	7.39	7.39	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.95	5.95	5.95	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.00	7.00	7.00	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.59	6.59	6.59	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.86	6.86	6.86	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	9.13	9.13	9.13	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.04	8.04	8.04	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.07	6.07	6.07	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.62	6.62	6.62	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central

Showing 1 to 20 of 37 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.78	8.78	8.78	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.06	8.06	8.06	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	7.75	7.75	7.75	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.08	7.08	7.08	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.53	5.53	5.53	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.66	6.66	6.66	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.75	5.75	5.75	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.62	6.62	6.62	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.18	8.18	8.18	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.59	8.59	8.59	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.87	5.87	5.87	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.34	6.34	6.34	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.96	5.96	5.96	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.62	8.62	8.62	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	8.56	8.56	8.56	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	5.34	5.34	5.34	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	5.42	5.42	5.42	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	5.64	5.64	5.64	ChEMBL

Showing 1 to 18 of 18 entries

DROPERIDOL

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 5

Approved Yes

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

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Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90		0.543	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z		0.545	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z		0.609	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z		0.601	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z		0.370	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90		0.573	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z		0.527	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z		0.615	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90		0.540	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z		0.502	3	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z		0.591	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90		0.520	4	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Pain, unspecified	MG3Z		0.498	3	Yes
DRD4	D₄ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z		0.583	4	Yes

Showing 1 to 14 of 14 entries

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DROPERIDOL

DROPERIDOL

Chemical Properties

Database connections

Bioactivities

DROPERIDOL

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information