CHEMBL244989


SMILES COc1ccccc1N1CCN(C/C=C/CNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1
InChIKey UUYDEYACQFNFMI-VOTSOKGWSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 453.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.75 6.75 6.75 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.14 7.14 7.14 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.18 7.18 7.18 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.92 8.42 8.92 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.32 7.32 7.32 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 7.72 7.72 7.72 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.75 6.75 6.75 ChEMBL