basimglurant


SMILES Fc1ccc(cc1)n1c(C)nc(c1C)C#Cc1ccnc(c1)Cl
InChIKey UPZWINBEAHDTLA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 325.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.44 7.44 7.44 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.44 7.44 7.44 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 8.15 8.15 8.15 ChEMBL