GPCRdb

cinnarizine

Agent/drug
Bioactivity

cinnarizine

SMILES	C(=C/c1ccccc1)\CN1CCN(C(c2ccccc2)c2ccccc2)CC1
InChIKey	DERZBLKQOCDDDZ-JLHYYAGUSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	368.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.11	6.11	6.11	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.30	6.30	6.30	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.24	6.24	6.24	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.78	6.78	6.78	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.99	5.99	5.99	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.02	7.02	7.02	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
μ	OPRM	Human	Opioid	A	pKi	6.04	6.04	6.04	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.21	6.21	6.21	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.99	6.99	6.99	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.33	6.33	6.33	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	7.88	7.88	7.88	Guide to Pharmacology

Showing 1 to 20 of 36 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	5.72	5.72	5.72	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.24	8.24	8.24	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.04	6.04	6.04	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.93	5.93	5.93	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.35	6.35	6.35	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.65	5.65	5.65	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.19	6.19	6.19	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	5.64	5.64	5.64	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.96	5.96	5.96	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.22	8.22	8.22	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.44	6.44	6.44	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.14	6.14	6.14	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.11	6.11	6.11	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.60	6.60	6.60	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	7.13	7.13	7.13	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.60	5.60	5.60	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.30	5.53	5.75	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	6.12	6.12	6.12	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	5.44	5.44	5.44	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	6.12	6.12	6.12	ChEMBL

Showing 1 to 20 of 21 entries

cinnarizine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	N07C	0.526	4	Yes

Showing 1 to 1 of 1 entry