compound 25e [PMID: 25875054]


SMILES CN(Cc1ccc2c(c1)C(C)CN(C2)C(=O)c1cc2c(n1C)cnc(c2)Br)C
InChIKey BSGIKRCNMBTGEB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 440.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.8 7.8 7.8 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 6.33 6.41 6.48 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.11 8.24 8.37 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.36 8.46 8.57 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 7.95 8.02 8.09 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database