GPCRdb

clazosentan

Agent/drug
Bioactivity

clazosentan

SMILES	COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO
InChIKey	LFWCJABOXHSRGC-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	13
Hydrogen bond donors	3
Rotatable bonds	11
Molecular weight (Da)	577.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

ET_A	EDNRA	Human	Endothelin	A	pKi	9.89	9.89	9.89	Guide to Pharmacology
ET_A	EDNRA	Human	Endothelin	A	pKi	9.89	9.89	9.89	ChEMBL
ET_B	EDNRB	Human	Endothelin	A	pKi	6.76	6.76	6.76	Guide to Pharmacology
ET_B	EDNRB	Human	Endothelin	A	pKi	6.76	6.76	6.76	ChEMBL

Showing 1 to 4 of 4 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

ET_A	EDNRA	Human	Endothelin	A	pA2	9.50	9.50	9.50	Guide to Pharmacology
ET_A	EDNRA	Human	Endothelin	A	pIC50	8.77	8.77	8.77	ChEMBL
ET_B	EDNRB	Human	Endothelin	A	pIC50	6.76	6.76	6.76	ChEMBL

Showing 1 to 3 of 3 entries

clazosentan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

EDNRA	ET_A receptor	Endothelin receptors	Peptide receptors	Class A	Subarachnoid haemorrhage	8B01	C04A	0.351	4	Yes

Showing 1 to 1 of 1 entry