nebivolol


SMILES OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O
InChIKey KOHIRBRYDXPAMZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 6
Molecular weight (Da) 405.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β1 ADRB1 Human Adrenoceptors A pKi 9.1 9.1 9.1 Guide to Pharmacology
β2 ADRB2 Human Adrenoceptors A pKi 7.9 7.95 8.0 Guide to Pharmacology
β3 ADRB3 Human Adrenoceptors A pKi 5.66 6.33 7.0 Guide to Pharmacology
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.59 7.59 7.59 PDSP Ki database
β3 ADRB3 Human Adrenoceptors A pKi 8.25 8.25 8.25 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database