neuropeptide Y


SMILES None
InChIKey XKWCTHKJQNUFOQ-HRPSIEBRSA-N
Sequence YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Structure pdb 7VGX 7YOO 7X9A 7X9B

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y2 NPY2R Human Neuropeptide Y A pKi 9.3 9.4 9.5 Guide to Pharmacology
Y2 NPY2R Human Neuropeptide Y A pKd 9.2 9.2 9.2 Guide to Pharmacology
Y4 NPY4R Human Neuropeptide Y A pKi 8.0 8.0 8.0 Guide to Pharmacology
Y5 NPY5R Human Neuropeptide Y A pKi 9.1 9.1 9.1 Guide to Pharmacology
PrRP PRLHR Human Prolactin-releasing peptide A pKi 5.4 5.4 5.4 Guide to Pharmacology
Y1 NPY1R Rat Neuropeptide Y A pKd 9.2 9.2 9.2 Guide to Pharmacology
Y1 NPY1R Rat Neuropeptide Y A pKi 10.5 10.5 10.5 Guide to Pharmacology
Y4 NPY4R Rat Neuropeptide Y A pKi 6.4 7.0 8.8 Guide to Pharmacology
Y5 NPY5R Rat Neuropeptide Y A pKi 9.3 9.3 9.3 Guide to Pharmacology
Y2 Q9ERC0 Rat Neuropeptide Y A pKi 9.4 9.4 9.4 Guide to Pharmacology
Y1 NPY1R Human Neuropeptide Y A pKi 9.3 9.67 10.02 ChEMBL
Y2 NPY2R Human Neuropeptide Y A pKi 9.1 9.61 10.12 ChEMBL
Y4 NPY4R Human Neuropeptide Y A pKi 6.55 6.55 6.55 ChEMBL
Y5 NPY5R Human Neuropeptide Y A pKi 8.66 8.66 8.66 ChEMBL
Y1 NPY1R Mouse Neuropeptide Y A pKd 8.8 8.8 8.8 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y1 NPY1R Rat Neuropeptide Y A pIC50 8.6 8.7 8.8 Guide to Pharmacology
Y1 NPY1R Human Neuropeptide Y A pIC50 8.59 9.48 10.15 ChEMBL
Y2 NPY2R Human Neuropeptide Y A pIC50 9.3 9.91 10.55 ChEMBL
Y4 NPY4R Human Neuropeptide Y A pEC50 6.38 6.38 6.38 ChEMBL
Y5 NPY5R Human Neuropeptide Y A pIC50 8.52 8.52 8.52 ChEMBL