neurotensin
SMILES | None |
InChIKey | PCJGZPGTCUMMOT-ISULXFBGSA-N |
Sequence | XLYENKPRRPYIL |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Peptide |
Physiological/Surrogate | Endogenous |
Approved drug | No |
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
NTS1 | NTR1 | Human | Neurotensin | A | pKi | 8.3 | 9.0 | 9.7 | Guide to Pharmacology |
NTS2 | NTR2 | Human | Neurotensin | A | pKi | 8.8 | 8.8 | 8.8 | Guide to Pharmacology |
NTS2 | NTR2 | Mouse | Neurotensin | A | pKd | 8.6 | 8.6 | 8.6 | Guide to Pharmacology |
NTS1 | NTR1 | Rat | Neurotensin | A | pKi | 8.2 | 9.1 | 10.0 | Guide to Pharmacology |
NTS1 | NTR1 | Rat | Neurotensin | A | pKd | 9.6 | 9.75 | 9.9 | Guide to Pharmacology |
NTS1 | NTR1 | Mouse | Neurotensin | A | pKi | 9.77 | 9.77 | 9.77 | ChEMBL |
NTS2 | NTR2 | Rat | Neurotensin | A | pKi | 7.55 | 7.65 | 7.72 | ChEMBL |
NTS1 | NTR1 | Rat | Neurotensin | A | pKi | 8.77 | 8.87 | 8.96 | ChEMBL |
NTS2 | NTR2 | Human | Neurotensin | A | pKi | 8.31 | 8.34 | 8.39 | ChEMBL |
NTS1 | NTR1 | Human | Neurotensin | A | pKi | 8.48 | 8.88 | 9.57 | ChEMBL |
NTS1 | NTR1 | Human | Neurotensin | A | pKd | 9.23 | 9.26 | 9.29 | ChEMBL |
NTS2 | NTR2 | Mouse | Neurotensin | A | pKi | 8.15 | 8.15 | 8.15 | PDSP Ki database |
NTS1 | NTR1 | Mouse | Neurotensin | A | pKi | 9.6 | 9.6 | 9.6 | PDSP Ki database |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
NTS2 | NTR2 | Mouse | Neurotensin | A | pIC50 | 8.5 | 8.6 | 8.7 | Guide to Pharmacology |
NTS2 | NTR2 | Rat | Neurotensin | A | pIC50 | 8.649999999999999 | 8.65 | 8.65 | Guide to Pharmacology |
NTS1 | NTR1 | Mouse | Neurotensin | A | pEC50 | 8.7 | 8.7 | 8.7 | ChEMBL |
NTS2 | NTR2 | Rat | Neurotensin | A | pIC50 | 6.94 | 7.35 | 7.73 | ChEMBL |
NTS1 | NTR1 | Rat | Neurotensin | A | pEC50 | 10.4 | 10.4 | 10.4 | ChEMBL |
NTS2 | NTR2 | Human | Neurotensin | A | pIC50 | 8.96 | 8.96 | 8.96 | ChEMBL |
NTS2 | NTR2 | Human | Neurotensin | A | pEC50 | 6.96 | 6.96 | 6.96 | ChEMBL |
NTS1 | NTR1 | Human | Neurotensin | A | pIC50 | 8.22 | 9.19 | 9.8 | ChEMBL |
NTS1 | NTR1 | Human | Neurotensin | A | pEC50 | 6.51 | 8.47 | 9.64 | ChEMBL |