Ro 10-4548


SMILES COc1cc(ccc1O)N1CCN(CC1)CC(COc1ccccc1NC(=O)C)O
InChIKey MXZGRDMOUWOERR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Molecular weight (Da) 415.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.42 7.42 7.42 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.42 7.42 7.42 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.52 7.52 7.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.49 7.49 7.49 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 7.44 7.47 7.5 ChEMBL