GPCRdb

PF-04995274

SMILES	OC1(CCOCC1)CN1CCC(CC1)COc1noc2c1c(ccc2)O[C@H]1COCC1
InChIKey	WLLOFQROROXOMO-GOSISDBHSA-N

Chemical properties

Hydrogen bond acceptors	8
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	432.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb

Bioactivities

Affinity
Potency

Receptor					Activity				Source
GTP	Uniprot	Species	Family	Class	Type	Min	Avg	Max	Database
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	9.82	9.82	9.82	Guide to Pharmacology
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pKi	9.52	9.52	9.52	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	9.34	9.52	9.82	ChEMBL

Receptor					Activity				Source
GTP	Uniprot	Species	Family	Class	Type	Min	Avg	Max	Database
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pEC50	9.19	9.21	9.23	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pEC50	8.82	9.28	9.7	ChEMBL