Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
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Activity
Value
Unit Assay Type Assay Description Mol
weight
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H don H acc LogP Smiles
CHEMBL4765074 5ht2c_human Human No 10.2 EC50 = 0.1 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
231 2 1 3 1.8 CCCc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL39 5ht2c_human Human Yes 10.1 EC50 = 0.1 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 10.1 EC50 = 0.1 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL595195 5ht2c_human Human No 10.0 EC50 = 0.1 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
329 3 1 4 3.2 Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21
CHEMBL609306 5ht2c_human Human No 10.0 EC50 = 0.1 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
329 3 1 4 3.2 Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21
CHEMBL4213447 5ht2c_human Human No 10.0 EC50 = 0.1 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
257 2 1 3 2.1 c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2
CHEMBL4213447 5ht2c_human Human No 10.0 EC50 = 0.1 nM Funct
Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
257 2 1 3 2.1 c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2
CHEMBL494947 5ht2c_human Human Yes 10.0 EC50 = 0.1 nM Bind
Agonist activity at 5HT2C receptor (unknown origin) relative to controlAgonist activity at 5HT2C receptor (unknown origin) relative to control
304 4 1 5 2.1 Clc1cccc(COc2cncc(N3CCNCC3)n2)c1
CHEMBL4213379 5ht2c_human Human No 9.9 EC50 = 0.1 nM Funct
Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
279 2 1 3 2.4 c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1
CHEMBL4213379 5ht2c_human Human No 9.9 EC50 = 0.1 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
279 2 1 3 2.4 c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1
CHEMBL39 5ht2c_human Human Yes 9.9 EC50 = 0.1 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 9.9 EC50 = 0.1 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 9.8 EC50 = 0.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 9.8 EC50 = 0.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 9.8 EC50 = 0.2 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL350221 5ht2c_human Human Yes 9.7 EC50 = 0.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O
CHEMBL39 5ht2c_human Human Yes 9.7 EC50 = 0.2 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4208452 5ht2c_human Human No 9.7 EC50 = 0.2 nM Funct
Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
297 2 1 3 2.5 Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1
CHEMBL39 5ht2c_human Human Yes 9.7 EC50 = 0.2 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 9.7 EC50 = 0.2 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4776557 5ht2c_human Human No 9.7 EC50 = 0.2 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
230 2 1 2 2.4 CCCc1cccc2c1CC[C@@H]1CNCCN21
CHEMBL3947276 5ht2c_human Human No 9.7 EC50 = 0.2 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
230 2 1 2 2.4 CCCc1cccc2c1CCC1CNCCN21
CHEMBL171774 5ht2c_human Human Yes 9.7 EC50 = 0.2 nM Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
200 2 1 2 2.1 NCCc1cn2c3c(cccc13)CCC2
CHEMBL39 5ht2c_human Human Yes 9.7 EC50 = 0.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL350221 5ht2c_human Human Yes 9.7 EC50 = 0.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O
CHEMBL172159 5ht2c_human Human No 9.6 EC50 = 0.2 nM Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
252 2 1 3 2.9 NCCc1cn2c3c(cc(Cl)cc13)SCC2
CHEMBL3979806 5ht2c_human Human No 9.5 EC50 = 0.3 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
248 2 1 3 2.5 CCSc1cccc2c1CCC1CNCCN21
CHEMBL39 5ht2c_human Human Yes 9.5 EC50 = 0.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL93240 5ht2c_human Human Yes 9.4 EC50 = 0.4 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL4777852 5ht2c_human Human No 9.4 EC50 = 0.4 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
245 2 1 3 2.0 CC(C)Cc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL2260569 5ht2c_human Human No 9.4 EC50 = 0.4 nM Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assay
248 0 1 2 3.6 Cc1c2n(c3c(C)c(Cl)ccc13)C(C)NCC2
CHEMBL39 5ht2c_human Human Yes 9.4 EC50 = 0.4 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 9.4 EC50 = 0.4 nM Funct
Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4803306 5ht2c_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL4803306 5ht2c_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL4778570 5ht2c_human Human No 9.2 EC50 = 0.6 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
279 2 1 3 2.4 c1ccc(Cc2cncc3c2CC[C@@H]2CNCCN32)cc1
CHEMBL1224034 5ht2c_human Human No 9.1 EC50 = 0.7 nM Funct
Agonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assay
336 1 1 3 3.9 O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21
CHEMBL1186509 5ht2c_human Human No 9.1 EC50 = 0.8 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccccc1Br
CHEMBL467736 5ht2c_human Human No 9.1 EC50 = 0.8 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccccc1Br
CHEMBL3959570 5ht2c_human Human No 9.1 EC50 = 0.8 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
284 2 1 3 3.1 c1csc(Cc2cccc3c2CCC2CNCCN32)c1
CHEMBL3967107 5ht2c_human Human No 9.1 EC50 = 0.8 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
206 0 1 2 1.6 Fc1ccc2c(c1)N1CCNCC1CC2
CHEMBL4646618 5ht2c_human Human No 9.1 EC50 = 0.8 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
202 0 1 2 2.0 Cc1ccc2c3c1C(C)CN3CCNC2
CHEMBL39 5ht2c_human Human Yes 9.1 EC50 = 0.9 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 9.1 EC50 = 0.9 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL3769454 5ht2c_human Human No 9.0 EC50 = 1.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2c_human Human No 9.0 EC50 = 1.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL595645 5ht2c_human Human No 9.0 EC50 = 1 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
359 4 1 4 3.4 C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2
CHEMBL2337490 5ht2c_human Human No 9.0 EC50 = 1 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.5 O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21
CHEMBL2365083 5ht2c_human Human No 9.0 EC50 = 1 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.5 O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21
CHEMBL1091106 5ht2c_human Human No 9.0 EC50 = 1 nM Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
366 5 2 3 3.7 CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1
CHEMBL407909 5ht2c_human Human Yes 9.0 EC50 = 1 nM Bind
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced phosphoinositide hydrolysis by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced phosphoinositide hydrolysis by cell based assay
243 3 1 4 2.7 CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C
CHEMBL407909 5ht2c_human Human Yes 9.0 EC50 = 1 nM Funct
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
243 3 1 4 2.7 CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C
CHEMBL3956394 5ht2c_human Human No 9.0 EC50 = 1 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
296 2 1 2 3.1 Fc1ccc2c(c1Cc1ccccc1)CCC1CNCCN21
CHEMBL3769454 5ht2c_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2c_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL2337494 5ht2c_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
202 0 2 2 0.8 Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21
CHEMBL2365470 5ht2c_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
202 0 2 2 0.8 Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21
CHEMBL4204710 5ht2c_human Human No 8.9 EC50 = 1.1 nM Funct
Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
243 1 1 3 2.1 c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2
CHEMBL4218374 5ht2c_human Human No 8.9 EC50 = 1.2 nM Funct
Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
231 2 1 3 1.8 CCCc1cncc2c1CC[C@@H]1CNCCN21
CHEMBL4803306 5ht2c_human Human No 8.9 EC50 = 1.2 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL4803306 5ht2c_human Human No 8.9 EC50 = 1.2 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL4206126 5ht2c_human Human No 8.9 EC50 = 1.3 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
285 2 1 3 2.3 FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL4218374 5ht2c_human Human No 8.9 EC50 = 1.3 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
231 2 1 3 1.8 CCCc1cncc2c1CC[C@@H]1CNCCN21
CHEMBL1187185 5ht2c_human Human Yes 8.9 EC50 = 1.3 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NCC1CC1c1ccccc1Br
CHEMBL492916 5ht2c_human Human Yes 8.9 EC50 = 1.3 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NCC1CC1c1ccccc1Br
CHEMBL4206126 5ht2c_human Human No 8.9 EC50 = 1.3 nM Funct
Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
285 2 1 3 2.3 FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL223468 5ht2c_human Human No 8.9 EC50 = 1.4 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.4 CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21
CHEMBL594469 5ht2c_human Human No 8.9 EC50 = 1.4 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
345 4 1 4 3.0 Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1
CHEMBL4639090 5ht2c_human Human No 8.9 EC50 = 1.4 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
266 0 1 2 2.5 CC1CN2CCNCc3ccc(Br)c1c32
CHEMBL3919795 5ht2c_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
278 2 1 2 3.0 c1ccc(Cc2cccc3c2CCC2CNCCN32)cc1
CHEMBL4751981 5ht2c_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802812 5ht2c_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4751981 5ht2c_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802812 5ht2c_human Human No 8.8 EC50 = 1.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL39 5ht2c_human Human Yes 8.8 EC50 = 1.6 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 8.8 EC50 = 1.7 nM Bind
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2c_human Human Yes 8.8 EC50 = 1.7 nM Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL275854 5ht2c_rat Rat Yes 8.7 EC50 = 1.8 nM Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N
CHEMBL590483 5ht2c_human Human No 8.7 EC50 = 1.8 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
251 0 2 3 1.2 O=C1NC2CCNCCN2c2cccc(Cl)c21
CHEMBL360328 5ht2c_human Human Yes 8.7 EC50 = 1.8 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL494947 5ht2c_human Human Yes 8.7 EC50 = 1.9 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
304 4 1 5 2.1 Clc1cccc(COc2cncc(N3CCNCC3)n2)c1
CHEMBL494947 5ht2c_human Human Yes 8.7 EC50 = 1.9 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
304 4 1 5 2.1 Clc1cccc(COc2cncc(N3CCNCC3)n2)c1
CHEMBL4747291 5ht2c_human Human No 8.7 EC50 = 2.0 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
203 0 1 3 1.1 Cc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL3930174 5ht2c_human Human Yes 8.7 EC50 = 2.0 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
202 0 1 2 1.7 Cc1cccc2c1CCC1CNCCN21
CHEMBL2113264 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 2 2.8 CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12
CHEMBL595194 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
343 3 1 4 3.6 Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21
CHEMBL76781 5ht2c_human Human Yes 8.0 EC50 = 10 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL2397877 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
236 0 1 2 1.3 O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12
CHEMBL4782824 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 3.3 CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803449 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 3.3 CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL1187194 5ht2c_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1cccc(Cl)c1
CHEMBL493128 5ht2c_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1cccc(Cl)c1
CHEMBL254215 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.0 C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21
CHEMBL440752 5ht2c_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
239 0 1 1 2.7 CC1CNCCc2ccc(Br)cc21
CHEMBL572228 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
318 5 1 5 2.2 Clc1ccccc1CCOc1cncc(N2CCNCC2)n1
CHEMBL3286556 5ht2c_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.4 CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C
CHEMBL3943620 5ht2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
300 1 1 3 3.1 COc1cc2c(c(Cl)c1Cl)N1CCCNC[C@H]1CC2
CHEMBL4782824 5ht2c_human Human No 8.0 EC50 = 10.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 3.3 CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803449 5ht2c_human Human No 8.0 EC50 = 10.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 3.3 CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL76781 5ht2c_human Human Yes 8.0 EC50 = 10.7 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL1770373 5ht2c_canlf Dog Yes 8.0 EC50 = 10.8 nM Funct
Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor
239 2 1 3 1.8 c1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL4802486 5ht2c_human Human No 8.0 EC50 = 11.0 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL4803134 5ht2c_human Human No 8.0 EC50 = 11.0 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
277 6 1 3 3.4 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCCF
CHEMBL4117120 5ht2c_human Human No 8.0 EC50 = 11.0 nM Bind
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
347 9 1 3 4.1 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCCF
CHEMBL4209572 5ht2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
189 0 1 3 0.8 c1cnc2c(c1)CC[C@@H]1CNCCN21
CHEMBL4799299 5ht2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4804137 5ht2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL1770380 5ht2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.1 Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL2331794 5ht2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
244 3 1 4 1.9 c1ccc(COc2noc3c2CCNCC3)cc1
CHEMBL3956136 5ht2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
280 2 1 3 3.2 c1ccc(Oc2cccc3c2CCC2CNCCN32)cc1
CHEMBL318639 5ht2c_rat Rat No 7.0 EC50 = 100 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
270 3 1 3 3.2 COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C
CHEMBL3947432 5ht2c_human Human No 6.0 EC50 = 1000 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
232 1 1 3 1.8 COc1cccc2c1CC[C@@H]1CNCCCN21
CHEMBL316527 5ht2c_rat Rat Yes 6.0 EC50 = 1000 nM Funct
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor
235 3 1 4 1.1 COc1c2c(c(CCN)c3c1OCC3)CCO2
CHEMBL317564 5ht2c_rat Rat No 5.0 EC50 = 10000 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
204 3 1 3 2.0 COc1ccc2c(ccn2CC(C)N)c1
CHEMBL4789175 5ht2c_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1
CHEMBL4803726 5ht2c_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1
CHEMBL568897 5ht2c_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
378 5 1 6 1.5 O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Br
CHEMBL4789175 5ht2c_human Human No 7.0 EC50 = 102.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1
CHEMBL4803726 5ht2c_human Human No 7.0 EC50 = 102.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1
CHEMBL4117313 5ht2c_human Human No 7.0 EC50 = 102.3 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COC1=C(C=C(C=C1)F)[C@@H]2C[C@H]2CNCC3=CC=CC=C3OC
CHEMBL2331794 5ht2c_human Human No 7.0 EC50 = 102.3 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
244 3 1 4 1.9 c1ccc(COc2noc3c2CCNCC3)cc1
CHEMBL571733 5ht2c_human Human No 6.0 EC50 = 1020 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
328 6 1 6 1.4 Cc1cc(=O)n(CCCOc2ccccc2)c(N2CCNCC2)n1
CHEMBL3416035 5ht2c_human Human No 7.0 EC50 = 103 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546870 5ht2c_human Human No 7.0 EC50 = 103 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL4117313 5ht2c_human Human No 7.0 EC50 = 103 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COC1=C(C=C(C=C1)F)[C@@H]2C[C@H]2CNCC3=CC=CC=C3OC
CHEMBL568437 5ht2c_human Human No 7.0 EC50 = 103 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
366 5 1 6 2.0 CCn1c(COc2cc(F)ccc2Cl)nc(N2CCNCC2)cc1=O
CHEMBL209714 5ht2c_human Human No 7.0 EC50 = 103 nM Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
256 1 1 2 2.5 FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1
CHEMBL4093102 5ht2c_human Human No 6.0 EC50 = 1032 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
349 3 1 3 4.3 Cc1cc(-c2cccc3ccccc23)oc1C(=O)N1CCC(CO)CC1
CHEMBL3769704 5ht2c_human Human No 7.0 EC50 = 104 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3771398 5ht2c_human Human No 7.0 EC50 = 104 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3769704 5ht2c_human Human No 7.0 EC50 = 104.7 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3771398 5ht2c_human Human No 7.0 EC50 = 104.7 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL4059943 5ht2c_human Human No 6.0 EC50 = 1040 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
337 2 1 4 3.3 Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCNCC1
CHEMBL4544700 5ht2c_human Human No 6.0 EC50 = 1064 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1
CHEMBL4597226 5ht2c_human Human No 6.0 EC50 = 1064 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1
CHEMBL223628 5ht2c_human Human No 7.0 EC50 = 107 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.6 CC(C)Oc1cccc2c1C(=O)N1CCNCC21
CHEMBL577410 5ht2c_human Human No 7.0 EC50 = 107 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
339 3 1 5 1.9 O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2
CHEMBL30713 5ht2c_human Human Yes 7.0 EC50 = 107.1 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12
CHEMBL30713 5ht2c_human Human Yes 7.0 EC50 = 107.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12
CHEMBL3769581 5ht2c_human Human No 7.0 EC50 = 107.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771395 5ht2c_human Human No 7.0 EC50 = 107.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL4544700 5ht2c_human Human No 6.0 EC50 = 1071.5 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1
CHEMBL4597226 5ht2c_human Human No 6.0 EC50 = 1071.5 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1
CHEMBL2397899 5ht2c_human Human No 7.0 EC50 = 108 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
244 2 1 2 1.6 CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O
CHEMBL3769581 5ht2c_human Human No 7.0 EC50 = 108 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771395 5ht2c_human Human No 7.0 EC50 = 108 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3416040 5ht2c_human Human No 6.0 EC50 = 1082 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL3546903 5ht2c_human Human No 6.0 EC50 = 1082 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL220211 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
286 1 1 3 1.8 COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21
CHEMBL2337499 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
250 1 2 2 1.7 CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365399 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
250 1 2 2 1.7 CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O
CHEMBL3416061 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
223 5 1 2 2.7 CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN
CHEMBL3546956 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
223 5 1 2 2.7 CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN
CHEMBL4802486 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL4803134 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
277 6 1 3 3.4 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCCF
CHEMBL1186458 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl
CHEMBL464475 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl
CHEMBL570274 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
382 5 1 6 2.1 C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1
CHEMBL4117120 5ht2c_human Human No 8.0 EC50 = 11 nM Bind
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
347 9 1 3 4.1 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCCF
CHEMBL360328 5ht2c_human Human Yes 8.0 EC50 = 11 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL181172 5ht2c_human Human Yes 8.0 EC50 = 11 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
195 0 1 1 2.6 CC1CNCCc2ccc(Cl)cc21
CHEMBL181787 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
225 1 1 2 2.6 COc1cc2c(cc1Cl)C(C)CNCC2
CHEMBL426235 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
283 2 1 2 3.1 CCC1CNCCc2cc(OC)c(Br)cc21
CHEMBL211153 5ht2c_human Human No 8.0 EC50 = 11 nM Funct
Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration
193 0 1 1 2.2 Clc1ccc2c(c1)C[C@@H]1CNC[C@H]21
CHEMBL1770374 5ht2c_human Human No 7.0 EC50 = 110 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 3 1 3 2.0 c1ccc(CCc2ncc3c(n2)CCNCC3)cc1
CHEMBL590482 5ht2c_human Human No 7.0 EC50 = 110 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
237 0 2 3 0.8 O=C1NC2CNCCN2c2ccc(Cl)cc21
CHEMBL4437696 5ht2c_human Human No 7.0 EC50 = 110 nM Funct
Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
253 2 1 3 2.3 CC(c1ccccc1)c1cc2c(nn1)CCNCC2
CHEMBL576253 5ht2c_human Human No 7.0 EC50 = 112 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
339 5 1 7 1.1 CCn1c(COc2cccc(C#N)c2)nc(N2CCNCC2)cc1=O
CHEMBL3286565 5ht2c_human Human No 7.0 EC50 = 112 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.4 CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2
CHEMBL4752604 5ht2c_human Human No 7.0 EC50 = 112.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4802785 5ht2c_human Human No 7.0 EC50 = 112.2 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL3416054 5ht2c_human Human No 6.0 EC50 = 1127 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 1 2 2.8 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF
CHEMBL3546906 5ht2c_human Human No 6.0 EC50 = 1127 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 1 2 2.8 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF
CHEMBL4752604 5ht2c_human Human No 7.0 EC50 = 113 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4802785 5ht2c_human Human No 7.0 EC50 = 113 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL572253 5ht2c_human Human No 6.9 EC50 = 114 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
325 5 1 7 0.6 N#Cc1ccccc1OCCn1nc(N2CCNCC2)ccc1=O
CHEMBL4762960 5ht2c_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN
CHEMBL4803163 5ht2c_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN
CHEMBL3769968 5ht2c_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771384 5ht2c_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3769633 5ht2c_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771389 5ht2c_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL4762960 5ht2c_human Human No 6.9 EC50 = 115 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN
CHEMBL4803163 5ht2c_human Human No 6.9 EC50 = 115 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN
CHEMBL523169 5ht2c_human Human No 6.9 EC50 = 115 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
404 4 1 4 2.7 O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2F)CC1
CHEMBL3769968 5ht2c_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771384 5ht2c_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3769633 5ht2c_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771389 5ht2c_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL1186720 5ht2c_human Human No 5.9 EC50 = 1179 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
252 5 2 2 3.4 NC[C@H]1C[C@@H]1c1cccc(NCc2ccccc2)c1
CHEMBL475384 5ht2c_human Human No 5.9 EC50 = 1179 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
252 5 2 2 3.4 NC[C@H]1C[C@@H]1c1cccc(NCc2ccccc2)c1
CHEMBL4065444 5ht2c_human Human No 6.9 EC50 = 119 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
342 2 0 4 3.6 O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCOCC1
CHEMBL1186669 5ht2c_human Human No 5.9 EC50 = 1196 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 3.0 NC[C@H]1C[C@@H]1c1ccc(-c2ccco2)cc1
CHEMBL474206 5ht2c_human Human No 5.9 EC50 = 1196 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 3.0 NC[C@H]1C[C@@H]1c1ccc(-c2ccco2)cc1
CHEMBL385577 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
252 1 1 3 1.4 COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21
CHEMBL2337504 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
230 1 2 2 1.4 CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365200 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
230 1 2 2 1.4 CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL4638807 5ht2c_human Human No 7.9 EC50 = 12 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
222 0 1 2 2.2 Clc1ccc2c3c1CCCN3CCNC2
CHEMBL2397894 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.7 COc1cccc2c1C(=O)N1CCNC[C@H]1C2
CHEMBL2397907 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.7 COc1cccc2c1C[C@@H]1CNCCN1C2=O
CHEMBL4757214 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4803017 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL493757 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
392 4 1 4 2.5 O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC(Oc2cccc(Cl)c2)C1
CHEMBL4085497 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
348 3 2 2 4.0 Cc1[nH]c(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1
CHEMBL4090637 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
373 4 0 4 4.9 Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)Cc1cccnc1
CHEMBL4516935 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL4596490 5ht2c_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL301466 5ht2c_human Human Yes 7.9 EC50 = 12 nM Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
271 0 2 3 1.7 O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12
CHEMBL197664 5ht2c_human Human Yes 7.9 EC50 = 12 nM Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay
218 3 1 3 2.0 CN(C)CCc1cn(C)c2cccc(O)c12
CHEMBL180668 5ht2c_human Human Yes 7.9 EC50 = 12 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
181 0 1 1 2.0 Clc1ccc2c(c1)CCNCC2
CHEMBL440752 5ht2c_human Human Yes 7.9 EC50 = 12 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
239 0 1 1 2.7 CC1CNCCc2ccc(Br)cc21
CHEMBL4757214 5ht2c_human Human No 7.9 EC50 = 12.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4803017 5ht2c_human Human No 7.9 EC50 = 12.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4209052 5ht2c_human Human No 7.9 EC50 = 12.3 nM Funct
Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
257 2 1 3 2.1 c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2
CHEMBL4516935 5ht2c_human Human No 7.9 EC50 = 12.3 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL4596490 5ht2c_human Human No 7.9 EC50 = 12.3 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL180668 5ht2c_human Human Yes 7.9 EC50 = 12.6 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
181 0 1 1 2.0 Clc1ccc2c(c1)CCNCC2
CHEMBL181172 5ht2c_human Human Yes 7.9 EC50 = 12.6 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
195 0 1 1 2.6 CC1CNCCc2ccc(Cl)cc21
CHEMBL478 5ht2c_human Human Yes 7.9 EC50 = 12.6 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL234464 5ht2c_rat Rat No 7.9 EC50 = 12.6 nM Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
263 4 1 4 1.6 COCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2
CHEMBL4098721 5ht2c_human Human No 7.9 EC50 = 12.9 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 6 1 2 2.7 C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC
CHEMBL4116380 5ht2c_human Human No 7.9 EC50 = 12.9 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 6 1 2 2.7 C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC
CHEMBL593545 5ht2c_human Human No 6.9 EC50 = 120 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
343 3 1 4 3.6 Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21
CHEMBL4117915 5ht2c_human Human No 6.9 EC50 = 120 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
291 6 1 3 3.8 COC1=C(C=C(C=C1)F)[C@H]2C[C@@H]2CNCC3=CC=CS3
CHEMBL6557 5ht2c_human Human Yes 6.9 EC50 = 120 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
200 0 1 2 1.9 Cn1c2c(c3ccccc31)CCNCC2
CHEMBL2022189 5ht2c_human Human No 6.9 EC50 = 120 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
217 5 1 2 2.5 NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1
CHEMBL2027896 5ht2c_human Human No 6.9 EC50 = 120 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
217 5 1 2 2.5 NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1
CHEMBL272942 5ht2c_human Human Yes 6.9 EC50 = 120 nM Funct
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O
CHEMBL4117915 5ht2c_human Human No 6.9 EC50 = 120.2 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
291 6 1 3 3.8 COC1=C(C=C(C=C1)F)[C@H]2C[C@@H]2CNCC3=CC=CS3
CHEMBL4103313 5ht2c_human Human No 6.9 EC50 = 120.2 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1ccc(F)cc1C1CC1CNCc1sccc1OC
CHEMBL4116143 5ht2c_human Human No 6.9 EC50 = 120.2 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1ccc(F)cc1C1CC1CNCc1sccc1OC
CHEMBL595646 5ht2c_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
360 4 1 6 3.3 Clc1cccc(COc2nc(N3CCNCC3)nc3sccc23)c1
CHEMBL4078425 5ht2c_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1
CHEMBL4115999 5ht2c_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1
CHEMBL2393233 5ht2c_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
290 2 1 6 -0.0 CN1CCN(c2nc3c(c(N(C)C)n2)CCNCC3)CC1
CHEMBL3040291 5ht2c_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
290 2 1 6 -0.0 CN1CCN(c2nc3c(c(N(C)C)n2)CCNCC3)CC1
CHEMBL4640047 5ht2c_human Human No 4.9 EC50 = 12000 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
222 0 1 2 2.4 CC1CN2CCNCc3cc(Cl)cc1c32
CHEMBL2331792 5ht2c_human Human Yes 4.9 EC50 = 12000 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
168 1 1 4 0.4 COc1noc2c1CCNCC2
CHEMBL4078425 5ht2c_human Human No 5.9 EC50 = 1202.3 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1
CHEMBL4115999 5ht2c_human Human No 5.9 EC50 = 1202.3 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1
CHEMBL2331792 5ht2c_human Human Yes 4.9 EC50 = 12022.6 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
168 1 1 4 0.4 COc1noc2c1CCNCC2
CHEMBL4103313 5ht2c_human Human No 6.9 EC50 = 121 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1ccc(F)cc1C1CC1CNCc1sccc1OC
CHEMBL4116143 5ht2c_human Human No 6.9 EC50 = 121 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1ccc(F)cc1C1CC1CNCc1sccc1OC
CHEMBL2022190 5ht2c_human Human No 5.9 EC50 = 1210 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
231 5 1 2 2.9 NC[C@H]1C[C@@H]1c1ccccc1OCC1CCC1
CHEMBL2027922 5ht2c_human Human No 5.9 EC50 = 1210 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
231 5 1 2 2.9 NC[C@H]1C[C@@H]1c1ccccc1OCC1CCC1
CHEMBL3416034 5ht2c_human Human No 5.9 EC50 = 1228 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546890 5ht2c_human Human No 5.9 EC50 = 1228 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL6557 5ht2c_human Human Yes 6.9 EC50 = 123.0 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
200 0 1 2 1.9 Cn1c2c(c3ccccc31)CCNCC2
CHEMBL1770376 5ht2c_human Human No 6.9 EC50 = 125 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 3 1.9 Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1
CHEMBL576651 5ht2c_human Human No 6.9 EC50 = 125 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
323 2 1 4 2.0 O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2
CHEMBL3891704 5ht2c_human Human No 6.9 EC50 = 125.9 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
270 2 1 2 3.1 c1cc(CC2CCC2)c2c(c1)N1CCCNCC1CC2
CHEMBL3891802 5ht2c_human Human No 6.9 EC50 = 125.9 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
216 0 1 2 2.2 c1ccc2c(c1)CCC1CCNCCCN21
CHEMBL3899449 5ht2c_human Human No 6.9 EC50 = 125.9 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
264 1 1 2 3.1 c1ccc(-c2cccc3c2CCC2CNCCN32)cc1
CHEMBL2115252 5ht2c_rat Rat No 6.9 EC50 = 125.9 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
210 2 1 2 2.3 C[C@@H](N)Cn1ccc2cc(F)c(F)cc21
CHEMBL594489 5ht2c_human Human No 5.9 EC50 = 1250 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
246 3 1 6 0.6 CCCn1cnc2c(N3CCNCC3)ncnc21
CHEMBL3416058 5ht2c_human Human No 5.9 EC50 = 1258 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF
CHEMBL3546873 5ht2c_human Human No 5.9 EC50 = 1258 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF
CHEMBL181324 5ht2c_human Human Yes 5.9 EC50 = 1258.9 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 1.9 COc1ccc2c(c1)CCNCC2C
CHEMBL3973690 5ht2c_human Human No 5.9 EC50 = 1258.9 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
216 0 1 2 2.1 CC1(C)CC2CNCCN2c2ccccc21
CHEMBL92565 5ht2c_rat Rat No 5.9 EC50 = 1258.9 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
192 2 1 2 2.1 CC(N)Cn1ccc2c(F)cccc21
CHEMBL96095 5ht2c_rat Rat No 4.9 EC50 = 12589.3 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
204 3 1 3 2.0 COc1cccc2c1ccn2CC(C)N
CHEMBL2011553 5ht2c_human Human Yes 5.9 EC50 = 1260 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
229 1 1 1 3.2 FC(F)(F)c1cccc(C2CCNCC2)c1
CHEMBL2021656 5ht2c_human Human Yes 5.9 EC50 = 1260 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
229 1 1 1 3.2 FC(F)(F)c1cccc(C2CCNCC2)c1
CHEMBL4645583 5ht2c_human Human No 4.9 EC50 = 12600 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
174 0 1 2 1.2 c1cc2c3c(c1)CNCCN3CC2
CHEMBL4062613 5ht2c_human Human No 5.9 EC50 = 1272 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
326 2 0 4 3.1 O=C(c1csc(-c2cccc(Cl)c2F)n1)N1CCOCC1
CHEMBL15988 5ht2c_human Human Yes 6.9 EC50 = 128 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
200 1 2 1 2.6 c1ccc2c(C3CCNCC3)c[nH]c2c1
CHEMBL2011564 5ht2c_human Human Yes 6.9 EC50 = 128 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
200 1 2 1 2.6 c1ccc2c(C3CCNCC3)c[nH]c2c1
CHEMBL1187390 5ht2c_human Human No 6.9 EC50 = 128 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F
CHEMBL501526 5ht2c_human Human No 6.9 EC50 = 128 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F
CHEMBL4083432 5ht2c_human Human No 6.9 EC50 = 129 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
354 2 0 4 3.7 O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CC2CC1CO2
CHEMBL3416033 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 4 1 2 2.8 CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546889 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 4 1 2 2.8 CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL4098721 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 6 1 2 2.7 C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC
CHEMBL4116380 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 6 1 2 2.7 C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC
CHEMBL1187354 5ht2c_human Human Yes 7.9 EC50 = 13 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NCC1CC1c1ccccc1
CHEMBL500093 5ht2c_human Human Yes 7.9 EC50 = 13 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NCC1CC1c1ccccc1
CHEMBL1187556 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
213 2 1 1 2.9 Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F
CHEMBL508680 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
213 2 1 1 2.9 Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F
CHEMBL4071321 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
376 4 0 5 4.3 Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)Cc1ccn(C)n1
CHEMBL4083752 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
301 3 0 5 3.6 CCn1nc(-c2cccc3ccncc23)cc1-c1cccnn1
CHEMBL3769987 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771387 5ht2c_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3769987 5ht2c_human Human No 7.9 EC50 = 13.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771387 5ht2c_human Human No 7.9 EC50 = 13.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3769543 5ht2c_human Human No 7.9 EC50 = 13.5 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL3771390 5ht2c_human Human No 7.9 EC50 = 13.5 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL4460600 5ht2c_human Human No 6.9 EC50 = 130 nM Funct
Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
239 2 1 3 1.8 c1ccc(Cc2cc3c(nn2)CCNCC3)cc1
CHEMBL3891802 5ht2c_human Human No 6.9 EC50 = 130 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
216 0 1 2 2.2 c1ccc2c(c1)CCC1CCNCCCN21
CHEMBL80246 5ht2c_human Human No 6.9 EC50 = 130 nM Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
262 2 1 2 2.6 C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21
CHEMBL4646559 5ht2c_human Human No 5.9 EC50 = 1320 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
272 0 1 4 1.0 O=S1(=O)CCN2CCNCc3ccc(Cl)c1c32
CHEMBL3416051 5ht2c_human Human No 6.9 EC50 = 133 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.3 C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546894 5ht2c_human Human No 6.9 EC50 = 133 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.3 C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL590089 5ht2c_human Human No 6.9 EC50 = 133 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 0.5 Cc1ccc2c(c1)C(=O)NC1CNCCN21
CHEMBL3770862 5ht2c_human Human No 6.9 EC50 = 134.9 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1c(OCCF)ccc(F)c1Cl
CHEMBL3771397 5ht2c_human Human No 6.9 EC50 = 134.9 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1c(OCCF)ccc(F)c1Cl
CHEMBL1186590 5ht2c_human Human No 6.9 EC50 = 135 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccc([C@H]2C[C@@H]2CN)cc1
CHEMBL471202 5ht2c_human Human No 6.9 EC50 = 135 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccc([C@H]2C[C@@H]2CN)cc1
CHEMBL3770862 5ht2c_human Human No 6.9 EC50 = 135 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1c(OCCF)ccc(F)c1Cl
CHEMBL3771397 5ht2c_human Human No 6.9 EC50 = 135 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1c(OCCF)ccc(F)c1Cl
CHEMBL2397883 5ht2c_human Human No 5.9 EC50 = 1358 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.0 C[C@@]12CNCCN1C(=O)c1ccccc1C2
CHEMBL376456 5ht2c_human Human No 6.9 EC50 = 136 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
218 1 1 3 0.8 COc1cccc2c1C(=O)N1CCNCC21
CHEMBL1186108 5ht2c_human Human No 6.9 EC50 = 136 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
171 2 1 1 1.7 C#Cc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL450178 5ht2c_human Human No 6.9 EC50 = 136 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
171 2 1 1 1.7 C#Cc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL304013 5ht2c_human Human No 6.9 EC50 = 136 nM Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
305 0 2 3 2.1 O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNCC12
CHEMBL609595 5ht2c_human Human Yes 5.9 EC50 = 1360 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
281 1 1 5 0.9 Brc1cn2ccnc2c(N2CCNCC2)n1
CHEMBL590077 5ht2c_human Human No 6.9 EC50 = 137 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
203 0 2 3 0.2 O=C1NC2CNCCN2c2ccccc21
CHEMBL4750271 5ht2c_human Human No 6.9 EC50 = 138 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
285 6 1 3 3.8 CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1
CHEMBL4802701 5ht2c_human Human No 6.9 EC50 = 138 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
285 6 1 3 3.8 CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1
CHEMBL1187408 5ht2c_human Human No 6.9 EC50 = 138 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Br)cc1
CHEMBL501854 5ht2c_human Human No 6.9 EC50 = 138 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Br)cc1
CHEMBL4750271 5ht2c_human Human No 6.9 EC50 = 138.0 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
285 6 1 3 3.8 CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1
CHEMBL4802701 5ht2c_human Human No 6.9 EC50 = 138.0 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
285 6 1 3 3.8 CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1
CHEMBL375170 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
296 1 1 2 2.7 O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12
CHEMBL2397890 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 1 1 2 1.2 CCc1cccc2c1C(=O)N1CCNC[C@H]1C2
CHEMBL2397910 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 0 1 2 1.3 Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O
CHEMBL1187522 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1cccc(Br)c1
CHEMBL506727 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1cccc(Br)c1
CHEMBL448971 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
406 4 1 4 2.9 O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC[C@@H](Oc2ccccc2Cl)C1
CHEMBL4091448 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
340 5 0 4 4.0 COCCN(C)C(=O)c1sc(-c2cccc3ccccc23)nc1C
CHEMBL3769543 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL3771390 5ht2c_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL4740346 5ht2c_human Human No 7.8 EC50 = 14.5 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL4802388 5ht2c_human Human No 7.8 EC50 = 14.5 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL4644315 5ht2c_human Human No 5.9 EC50 = 1400 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
202 0 1 2 1.9 c1cc2c3c(c1)CNCCN3CCCC2
CHEMBL3286558 5ht2c_human Human Yes 5.8 EC50 = 1460 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
255 2 2 4 1.5 Oc1nc(Cc2ccccc2)nc2c1CCNCC2
CHEMBL478 5ht2c_human Human Yes 7.8 EC50 = 15 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL4740346 5ht2c_human Human No 7.8 EC50 = 15 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL4802388 5ht2c_human Human No 7.8 EC50 = 15 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL478 5ht2c_human Human Yes 7.8 EC50 = 15 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL478 5ht2c_human Human Yes 7.8 EC50 = 15 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL4082753 5ht2c_human Human No 7.8 EC50 = 15 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
300 3 0 4 4.2 CCn1nc(-c2cccc3ccccc23)cc1-c1cccnn1
CHEMBL39 5ht2c_human Human Yes 7.8 EC50 = 15 nM Bind
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL203013 5ht2c_human Human No 7.8 EC50 = 15 nM Funct
Efficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPR
273 4 1 4 1.7 C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12
CHEMBL39 5ht2c_human Human Yes 7.8 EC50 = 15.1 nM Bind
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL3770963 5ht2c_human Human No 7.8 EC50 = 15.5 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771381 5ht2c_human Human No 7.8 EC50 = 15.5 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL178365 5ht2c_human Human Yes 7.8 EC50 = 15.9 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
195 0 1 1 2.6 C[C@@H]1CNCCc2ccc(Cl)cc21
CHEMBL376455 5ht2c_human Human Yes 5.8 EC50 = 1500 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
188 0 1 2 0.8 O=C1c2ccccc2C2CNCCN12
CHEMBL2393240 5ht2c_human Human No 5.8 EC50 = 1500 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
356 3 2 6 1.8 CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1
CHEMBL3039632 5ht2c_human Human No 5.8 EC50 = 1500 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
356 3 2 6 1.8 CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1
CHEMBL3769499 5ht2c_human Human No 6.8 EC50 = 151 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771379 5ht2c_human Human No 6.8 EC50 = 151 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3769499 5ht2c_human Human No 6.8 EC50 = 151.4 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771379 5ht2c_human Human No 6.8 EC50 = 151.4 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL4088662 5ht2c_human Human No 5.8 EC50 = 1520 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
356 2 0 4 3.9 Cc1sc(-c2cccc(Cl)c2Cl)nc1C(=O)N1CCOCC1
CHEMBL4084236 5ht2c_human Human No 5.8 EC50 = 1522 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
324 2 0 4 3.4 O=C(c1cnc(-c2cccc3ccccc23)s1)N1CCOCC1
CHEMBL3286563 5ht2c_human Human No 6.8 EC50 = 154 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 1 4 1.8 CN(C)c1nc(Cc2ccccc2)nc2c1CCNCC2
CHEMBL3589596 5ht2c_human Human No 4.8 EC50 = 15488.2 nM Bind
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
395 8 2 5 3.5 COc1cc(CCNCc2cccc(OC)c2O)c(OC)cc1Br
CHEMBL3416062 5ht2c_human Human No 6.8 EC50 = 157 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
221 5 1 2 2.5 C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN
CHEMBL3546957 5ht2c_human Human No 6.8 EC50 = 157 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
221 5 1 2 2.5 C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN
CHEMBL1187449 5ht2c_human Human No 5.8 EC50 = 1577 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 3 1 1 4.1 NC[C@H]1C[C@@H]1c1cccc(-c2ccc(Cl)cc2)c1
CHEMBL502979 5ht2c_human Human No 5.8 EC50 = 1577 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 3 1 1 4.1 NC[C@H]1C[C@@H]1c1cccc(-c2ccc(Cl)cc2)c1
CHEMBL2011565 5ht2c_human Human Yes 6.8 EC50 = 158 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
227 1 1 1 3.1 FC(F)(F)c1cccc(C2=CCNCC2)c1
CHEMBL2021626 5ht2c_human Human Yes 6.8 EC50 = 158 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
227 1 1 1 3.1 FC(F)(F)c1cccc(C2=CCNCC2)c1
CHEMBL3934644 5ht2c_human Human No 6.8 EC50 = 158.5 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
266 1 1 3 2.5 COc1ccc2c(c1Cl)N1CCCNC[C@H]1CC2
CHEMBL96816 5ht2c_rat Rat Yes 6.8 EC50 = 158.5 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
192 2 2 1 2.2 CC(N)Cc1c[nH]c2ccc(F)cc12
CHEMBL220789 5ht2c_human Human No 5.8 EC50 = 1580 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 0 1 2 2.6 CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1
CHEMBL493 5ht2c_human Human Yes 5.8 EC50 = 1584.9 nM Bind
Agonist activity at 5HT2C receptor VGV isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assayAgonist activity at 5HT2C receptor VGV isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assay
653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C
CHEMBL96883 5ht2c_rat Rat Yes 5.8 EC50 = 1584.9 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
192 2 1 2 2.1 CC(N)Cn1ccc2cc(F)ccc21
CHEMBL221113 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 2 2.4 CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21
CHEMBL2397892 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
270 0 1 2 1.7 O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12
CHEMBL2397914 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
258 0 1 3 1.0 O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3
CHEMBL1187195 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL493129 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL590816 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 0.6 O=C1NC2CCNCCN2c2ccccc21
CHEMBL3286557 5ht2c_human Human Yes 7.8 EC50 = 16 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
304 3 2 4 2.3 CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2
CHEMBL4095663 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
349 3 1 4 3.2 Cc1nn(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1
CHEMBL3770689 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771380 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3770963 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771381 5ht2c_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL178365 5ht2c_human Human Yes 7.8 EC50 = 16 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
195 0 1 1 2.6 C[C@@H]1CNCCc2ccc(Cl)cc21
CHEMBL4095079 5ht2c_human Human Yes 7.8 EC50 = 16 nM Funct
Positive allosteric modulation of human 5-HT2C receptor expressed in human HeLa-K1 cells assessed as potentiation of 5-HT-induced inositol monophosphate release after 20 mins by HTRF assayPositive allosteric modulation of human 5-HT2C receptor expressed in human HeLa-K1 cells assessed as potentiation of 5-HT-induced inositol monophosphate release after 20 mins by HTRF assay
313 5 1 3 4.7 c1ccc(Cn2cc(CNc3cccnc3)c3ccccc32)cc1
CHEMBL360328 5ht2c_canlf Dog Yes 7.8 EC50 = 16.2 nM Funct
Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL3770689 5ht2c_human Human No 7.8 EC50 = 16.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771380 5ht2c_human Human No 7.8 EC50 = 16.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3769454 5ht2c_human Human No 7.8 EC50 = 16.6 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2c_human Human No 7.8 EC50 = 16.6 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL269521 5ht2c_human Human Yes 6.8 EC50 = 160 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
198 1 1 4 0.5 Clc1cncc(n1)N1CCNCC1
CHEMBL578365 5ht2c_human Human No 6.8 EC50 = 160 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
348 4 1 6 1.7 Cc1ccc(Cl)cc1OCc1nc(N2CCNCC2)cc(=O)n1C
CHEMBL179329 5ht2c_human Human No 6.8 EC50 = 160 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
297 2 1 2 3.3 COc1cc2c(cc1Br)C(C(C)C)CNCC2
CHEMBL4062011 5ht2c_human Human No 5.8 EC50 = 1600 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
301 3 0 5 3.6 CCn1nc(-c2cccc3cnccc23)cc1-c1cccnn1
CHEMBL1187377 5ht2c_human Human No 6.8 EC50 = 161 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
163 2 2 2 1.5 NC[C@H]1C[C@@H]1c1ccccc1O
CHEMBL501117 5ht2c_human Human No 6.8 EC50 = 161 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
163 2 2 2 1.5 NC[C@H]1C[C@@H]1c1ccccc1O
CHEMBL269521 5ht2c_human Human Yes 6.8 EC50 = 162.2 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
198 1 1 4 0.5 Clc1cncc(n1)N1CCNCC1
CHEMBL4073406 5ht2c_human Human No 5.8 EC50 = 1621.8 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
303 6 1 2 3.9 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F
CHEMBL4117722 5ht2c_human Human No 5.8 EC50 = 1621.8 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
303 6 1 2 3.9 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F
CHEMBL2011570 5ht2c_human Human Yes 6.8 EC50 = 163 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
198 1 2 1 2.5 C1=C(c2c[nH]c3ccccc23)CCNC1
CHEMBL27811 5ht2c_human Human Yes 6.8 EC50 = 163 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
198 1 2 1 2.5 C1=C(c2c[nH]c3ccccc23)CCNC1
CHEMBL583192 5ht2c_human Human No 6.8 EC50 = 163 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
342 6 1 6 1.8 Cc1cc(=O)n(CCCOc2ccccc2)c(N2CCNC[C@H]2C)n1
CHEMBL595555 5ht2c_human Human Yes 6.8 EC50 = 164 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
203 1 1 4 1.2 c1cc2occc2c(N2CCNCC2)n1
CHEMBL570937 5ht2c_human Human No 6.8 EC50 = 164 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
334 5 1 6 1.4 O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Cl
CHEMBL4073406 5ht2c_human Human No 5.8 EC50 = 1640 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
303 6 1 2 3.9 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F
CHEMBL4117722 5ht2c_human Human No 5.8 EC50 = 1640 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
303 6 1 2 3.9 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F
CHEMBL3769633 5ht2c_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771389 5ht2c_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3769581 5ht2c_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771395 5ht2c_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3769633 5ht2c_human Human No 6.8 EC50 = 166.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771389 5ht2c_human Human No 6.8 EC50 = 166.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3769581 5ht2c_human Human No 6.8 EC50 = 166.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771395 5ht2c_human Human No 6.8 EC50 = 166.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL2337102 5ht2c_human Human No 6.8 EC50 = 168 nM Bind
Agonist activity at 5-HT2C receptor (unknown origin)Agonist activity at 5-HT2C receptor (unknown origin)
388 2 1 3 4.6 COc1ccc(-c2cc3c4c(c2)[C@@H]2CNCC[C@@H]2N4CCC3)c(C(F)(F)F)c1
CHEMBL4086216 5ht2c_human Human No 5.8 EC50 = 1697 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
300 3 0 4 4.2 CCn1nc(-c2cccc3ccccc23)cc1-c1ncccn1
CHEMBL374436 5ht2c_human Human No 7.8 EC50 = 17 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.4 CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21
CHEMBL2337496 5ht2c_human Human No 7.8 EC50 = 17 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
236 0 2 2 1.4 Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365472 5ht2c_human Human No 7.8 EC50 = 17 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
236 0 2 2 1.4 Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL4636196 5ht2c_human Human No 7.8 EC50 = 17 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
214 0 1 2 2.0 c1cc2c3c(c1)C1(CCC1)CN3CCNC2
CHEMBL4068476 5ht2c_human Human No 7.8 EC50 = 17 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
366 2 1 4 4.3 Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCCC(O)CC1
CHEMBL478 5ht2c_human Human Yes 6.8 EC50 = 170 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL492362 5ht2c_human Human No 6.8 EC50 = 170 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
390 6 1 5 2.2 COc1cc(S(=O)(=O)N(C)Cc2ccccc2)c(OC)c2c1CCNCC2
CHEMBL478 5ht2c_human Human Yes 6.8 EC50 = 170 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL2331807 5ht2c_human Human No 5.8 EC50 = 1700 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
244 2 1 4 1.2 O=c1c2c(on1Cc1ccccc1)CCNCC2
CHEMBL2397901 5ht2c_human Human No 6.8 EC50 = 171 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
236 0 1 2 1.3 O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12
CHEMBL223469 5ht2c_human Human No 5.8 EC50 = 1730 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
206 0 1 2 0.9 O=C1c2c(F)cccc2C2CNCCN12
CHEMBL2331807 5ht2c_human Human No 5.8 EC50 = 1737.8 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
244 2 1 4 1.2 O=c1c2c(on1Cc1ccccc1)CCNCC2
CHEMBL2396668 5ht2c_human Human No 5.8 EC50 = 1744 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.0 C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1
CHEMBL4645774 5ht2c_human Human No 6.8 EC50 = 175 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
202 0 1 2 1.9 CC1(C)CN2CCNCc3cccc1c32
CHEMBL577903 5ht2c_human Human No 6.8 EC50 = 176 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
243 3 2 3 1.7 c1ccc(COc2n[nH]c3c2CCNCC3)cc1
CHEMBL101664 5ht2c_human Human Yes 5.8 EC50 = 1760 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
193 1 1 1 2.7 Clc1ccc(C2=CCNCC2)cc1
CHEMBL2011566 5ht2c_human Human Yes 5.8 EC50 = 1760 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
193 1 1 1 2.7 Clc1ccc(C2=CCNCC2)cc1
CHEMBL3416044 5ht2c_human Human No 5.8 EC50 = 1762 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
271 6 1 3 3.1 CSCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546953 5ht2c_human Human No 5.8 EC50 = 1762 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
271 6 1 3 3.1 CSCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL6616 5ht2c_rat Rat Yes 6.8 EC50 = 178 nM Bind
Agonist activity at rat 5-HT2C receptor expressed in African clawed frog oocytes assessed as increase in current amplitudeAgonist activity at rat 5-HT2C receptor expressed in African clawed frog oocytes assessed as increase in current amplitude
321 4 1 3 2.2 COc1cc(I)c(cc1CC(N)C)OC
CHEMBL223272 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 2 2.2 C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12
CHEMBL2397915 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
270 0 1 2 1.7 O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12
CHEMBL1186164 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl
CHEMBL452458 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl
CHEMBL2022185 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
191 4 1 2 2.1 CCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL2027895 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
191 4 1 2 2.1 CCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL1643675 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
335 3 1 6 1.7 c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1
CHEMBL4067417 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
342 2 0 4 3.6 O=C(c1nc(-c2cccc(Cl)c2Cl)cs1)N1CCOCC1
CHEMBL3770950 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1cc(Cl)c(Cl)cc1OCCF
CHEMBL3771391 5ht2c_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1cc(Cl)c(Cl)cc1OCCF
CHEMBL76781 5ht2c_human Human Yes 7.8 EC50 = 18 nM Bind
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL76781 5ht2c_human Human Yes 7.8 EC50 = 18 nM Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL3770950 5ht2c_human Human No 7.7 EC50 = 18.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1cc(Cl)c(Cl)cc1OCCF
CHEMBL3771391 5ht2c_human Human No 7.7 EC50 = 18.2 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1cc(Cl)c(Cl)cc1OCCF
CHEMBL1770382 5ht2c_human Human No 6.8 EC50 = 180 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
273 2 1 3 2.4 Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1
CHEMBL170319 5ht2c_human Human No 6.8 EC50 = 180 nM Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
246 3 1 2 3.1 CNCCc1cn2c3c(cc(F)cc13)CCC2C
CHEMBL208936 5ht2c_human Human No 6.8 EC50 = 180 nM Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 4 1.3 FC(F)(F)c1ccnc(N2CCC3CNCC32)n1
CHEMBL4066653 5ht2c_human Human No 5.7 EC50 = 1804 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
349 3 1 4 3.1 Cn1cc(-c2cccc3ccccc23)nc1C(=O)N1CCC(CO)CC1
CHEMBL1092167 5ht2c_human Human No 6.7 EC50 = 183 nM Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
348 4 2 2 4.0 O=C(NCc1ccc(-c2cc(Cl)cc(Cl)c2)cc1)[C@@H]1CCCN1
CHEMBL3416043 5ht2c_human Human No 6.7 EC50 = 183 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 6 1 3 2.4 COCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546952 5ht2c_human Human No 6.7 EC50 = 183 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 6 1 3 2.4 COCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL223584 5ht2c_human Human No 5.7 EC50 = 1840 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 2 1.8 O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12
CHEMBL492357 5ht2c_human Human No 6.7 EC50 = 186 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
296 2 1 4 0.4 O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCOCC1
CHEMBL4083787 5ht2c_human Human No 5.7 EC50 = 1860 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
319 6 1 2 4.4 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl
CHEMBL4117262 5ht2c_human Human No 5.7 EC50 = 1860 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
319 6 1 2 4.4 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl
CHEMBL4083787 5ht2c_human Human No 5.7 EC50 = 1862.1 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
319 6 1 2 4.4 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl
CHEMBL4117262 5ht2c_human Human No 5.7 EC50 = 1862.1 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
319 6 1 2 4.4 COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl
CHEMBL608135 5ht2c_human Human Yes 6.7 EC50 = 187 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
219 1 1 4 1.7 c1cc2sccc2c(N2CCNCC2)n1
CHEMBL4087951 5ht2c_human Human No 5.7 EC50 = 1870 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
363 3 1 4 3.4 Cc1nc(-c2cccc3ccccc23)n(C)c1C(=O)N1CCC(CO)CC1
CHEMBL1643858 5ht2c_human Human No 6.7 EC50 = 188 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
406 4 1 7 1.7 CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1
CHEMBL4777303 5ht2c_human Human No 7.7 EC50 = 19 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4802306 5ht2c_human Human No 7.7 EC50 = 19 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL305123 5ht2c_human Human No 7.7 EC50 = 19 nM Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
291 0 2 3 2.6 FC(F)(F)c1cc2c(cc1Cl)N1CCNC[C@@H]1CN2
CHEMBL60280 5ht2c_human Human No 7.7 EC50 = 19 nM Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
305 0 2 3 2.1 O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNC[C@H]12
CHEMBL4803813 5ht2c_human Human No 7.7 EC50 = 19.5 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
243 5 1 3 3.1 C=CCOC1=C(C2=C(C=C1)OC=C2)[C@H]3C[C@@H]3CN
CHEMBL4777303 5ht2c_human Human No 7.7 EC50 = 19.5 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4802306 5ht2c_human Human No 7.7 EC50 = 19.5 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL179337 5ht2c_human Human Yes 7.7 EC50 = 20.0 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.2 CC1CNCCc2c(Cl)cc(Cl)cc21
CHEMBL253810 5ht2c_human Human No 7.7 EC50 = 20.0 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
209 1 1 1 3.0 CC[C@@H]1CNCCc2ccc(Cl)cc21
CHEMBL368016 5ht2c_human Human Yes 7.7 EC50 = 20.0 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
213 0 1 1 2.7 CC1CNCCc2ccc(Cl)c(F)c21
CHEMBL3907399 5ht2c_human Human No 7.7 EC50 = 20.0 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
258 2 1 3 2.3 c1cc(OC2CCC2)c2c(c1)N1CCNCC1CC2
CHEMBL3950846 5ht2c_human Human No 7.7 EC50 = 20.0 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
230 2 1 2 2.4 CCCc1ccc2c(c1)CCC1CNCCN21
CHEMBL3961589 5ht2c_human Human No 7.7 EC50 = 20.0 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
310 2 1 2 3.5 Fc1ccc2c(c1Cc1ccccc1)CC[C@@H]1CNCCCN21
CHEMBL3978882 5ht2c_human Human No 7.7 EC50 = 20.0 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
232 2 1 3 1.6 COCc1cccc2c1CCC1CNCCN21
CHEMBL4643574 5ht2c_human Human No 6.7 EC50 = 190 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
202 1 1 2 1.7 CCc1ccc2c3c1CCN3CCNC2
CHEMBL1770373 5ht2c_human Human Yes 6.7 EC50 = 190 nM Funct
Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay
239 2 1 3 1.8 c1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL1770373 5ht2c_human Human Yes 6.7 EC50 = 190 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
239 2 1 3 1.8 c1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL4096385 5ht2c_human Human No 6.7 EC50 = 190 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
303 3 0 5 3.5 CCn1nc(-c2cccc3ccccc23)cc1-c1ncnn1C
CHEMBL4437696 5ht2c_human Human No 6.7 EC50 = 190 nM Funct
Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
253 2 1 3 2.3 CC(c1ccccc1)c1cc2c(nn1)CCNCC2
CHEMBL39 5ht2c_human Human Yes 6.7 EC50 = 190.6 nM Bind
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL1770367 5ht2c_human Human No 5.7 EC50 = 1900 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 4 1 3 2.3 c1ccc(CCCc2ncc3c(n2)CCNC3)cc1
CHEMBL4633193 5ht2c_human Human No 4.7 EC50 = 19000 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
188 0 1 2 1.5 CC1Cc2cccc3c2N1CCNC3
CHEMBL1770383 5ht2c_human Human No 6.7 EC50 = 192 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
273 2 1 3 2.4 Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL2397884 5ht2c_human Human No 6.7 EC50 = 193 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 0 2 1.0 CN1CCN2C(=O)c3ccccc3C[C@@H]2C1
CHEMBL1770375 5ht2c_human Human No 6.7 EC50 = 194 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 3 1.9 Fc1ccccc1Cc1ncc2c(n1)CCNCC2
CHEMBL1186710 5ht2c_human Human No 5.7 EC50 = 1965 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
263 3 1 2 4.2 NC[C@H]1C[C@@H]1c1ccccc1-c1cc2ccccc2o1
CHEMBL475021 5ht2c_human Human No 5.7 EC50 = 1965 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
263 3 1 2 4.2 NC[C@H]1C[C@@H]1c1ccccc1-c1cc2ccccc2o1
CHEMBL522349 5ht2c_human Human No 6.7 EC50 = 197 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
320 3 2 3 2.3 O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2
CHEMBL361742 5ht2c_human Human Yes 6.7 EC50 = 199.5 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 1.9 COc1ccc2c(c1)C(C)CNCC2
CHEMBL398926 5ht2c_human Human Yes 6.7 EC50 = 199.5 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
209 0 1 1 2.8 CC1(C)CNCCc2ccc(Cl)cc21
CHEMBL3928762 5ht2c_human Human No 6.7 EC50 = 199.5 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
250 0 1 2 2.8 Clc1ccc2c(c1)CCC1CCNCCCN21
CHEMBL76781 5ht2c_rat Rat Yes 6.7 EC50 = 199.5 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL328761 5ht2c_rat Rat No 6.7 EC50 = 199.5 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
254 2 1 2 3.5 Cc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C
CHEMBL40726 5ht2c_rat Rat No 6.7 EC50 = 199.5 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
210 2 1 2 2.3 C[C@H](N)Cn1ccc2cc(F)c(F)cc21
CHEMBL94272 5ht2c_rat Rat No 6.7 EC50 = 199.5 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
258 2 1 2 3.3 CC(N)Cn1ccc2c1-c1cc(F)ccc1C2(C)C
CHEMBL2011548 5ht2c_human Human Yes 5.7 EC50 = 1995 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
175 1 1 1 2.5 Cc1cccc(C2CCNCC2)c1
CHEMBL2021617 5ht2c_human Human Yes 5.7 EC50 = 1995 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
175 1 1 1 2.5 Cc1cccc(C2CCNCC2)c1
CHEMBL273304 5ht2c_rat Rat No 5.7 EC50 = 1995.3 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
242 3 1 3 2.4 COc1ccc2c(c1)Cc1ccn(CC(C)N)c1-2
CHEMBL276673 5ht2c_rat Rat Yes 5.7 EC50 = 1995.3 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
252 2 1 2 2.8 CC(N)Cn1ccc2cc(Br)ccc21
CHEMBL328844 5ht2c_rat Rat Yes 5.7 EC50 = 1995.3 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
208 2 1 2 2.6 CC(N)Cn1ccc2cc(Cl)ccc21
CHEMBL2337490 5ht2c_human Human No 8.7 EC50 = 2 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.5 O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21
CHEMBL2365083 5ht2c_human Human No 8.7 EC50 = 2 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.5 O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21
CHEMBL4646572 5ht2c_human Human No 8.7 EC50 = 2 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
334 1 1 2 3.4 FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32
CHEMBL590580 5ht2c_human Human No 8.7 EC50 = 2 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 0.9 Cc1cccc2c1C(=O)NC1CCNCCN21
CHEMBL4100216 5ht2c_human Human No 8.7 EC50 = 2 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
301 3 0 5 3.6 CCn1nc(-c2cccc3cccnc23)cc1-c1cccnn1
CHEMBL179378 5ht2c_human Human Yes 8.7 EC50 = 2 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
317 1 1 2 2.5 COc1cc2c(cc1I)C(C)CNCC2
CHEMBL360328 5ht2c_human Human Yes 8.7 EC50 = 2.1 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL2337501 5ht2c_human Human No 8.7 EC50 = 2.2 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
236 0 2 2 1.4 Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21
CHEMBL2365359 5ht2c_human Human No 8.7 EC50 = 2.2 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
236 0 2 2 1.4 Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21
CHEMBL76781 5ht2c_human Human Yes 8.7 EC50 = 2.2 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL76781 5ht2c_human Human Yes 8.7 EC50 = 2.2 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL1091105 5ht2c_human Human Yes 8.6 EC50 = 2.3 nM Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
378 6 2 4 3.6 COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1
CHEMBL471839 5ht2c_human Human Yes 8.6 EC50 = 2.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assay
185 2 1 1 2.7 CC(N)Cc1ccc2ccccc2c1
CHEMBL4117120 5ht2c_human Human No 8.6 EC50 = 2.4 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCCF
CHEMBL4117120 5ht2c_human Human No 8.6 EC50 = 2.4 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCCF
CHEMBL4634942 5ht2c_human Human No 8.6 EC50 = 2.5 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
222 0 1 2 2.4 CC1CN2CCNCc3ccc(Cl)c1c32
CHEMBL3946277 5ht2c_human Human No 8.6 EC50 = 2.5 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
188 0 1 2 1.4 c1ccc2c(c1)CC[C@@H]1CNCCN21
CHEMBL4756903 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803034 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL2337493 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
222 0 2 2 1.1 O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21
CHEMBL2365469 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
222 0 2 2 1.1 O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21
CHEMBL4756903 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803034 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL2393247 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
348 4 2 4 3.6 Fc1ccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)cc1
CHEMBL3040281 5ht2c_human Human No 8.6 EC50 = 2.6 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
348 4 2 4 3.6 Fc1ccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)cc1
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.6 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.6 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL4748110 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL4802669 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL4790652 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4803766 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4748110 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL4802669 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL4790652 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4803766 5ht2c_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.7 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.7 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL4466591 5ht2c_human Human No 8.6 EC50 = 2.8 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@]1(F)c1cccc(F)c1
CHEMBL4597360 5ht2c_human Human No 8.6 EC50 = 2.8 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@]1(F)c1cccc(F)c1
CHEMBL39 5ht2c_rat Rat Yes 8.6 EC50 = 2.8 nM Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL201930 5ht2c_human Human No 8.5 EC50 = 2.9 nM Bind
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
225 2 1 3 2.5 C[C@H](N)Cn1ccc2ccc3ncccc3c21
CHEMBL220900 5ht2c_human Human No 7.7 EC50 = 20 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 2 2.1 O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12
CHEMBL2337503 5ht2c_human Human No 7.7 EC50 = 20 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
216 0 2 2 1.1 Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365465 5ht2c_human Human No 7.7 EC50 = 20 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
216 0 2 2 1.1 Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL4803813 5ht2c_human Human No 7.7 EC50 = 20 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
243 5 1 3 3.1 C=CCOC1=C(C2=C(C=C1)OC=C2)[C@H]3C[C@@H]3CN
CHEMBL4752412 5ht2c_human Human No 7.7 EC50 = 20 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4802814 5ht2c_human Human No 7.7 EC50 = 20 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4100812 5ht2c_human Human No 7.7 EC50 = 20 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
365 3 1 3 4.7 Cc1cc(-c2cccc3ccccc23)sc1C(=O)N1CCC(CO)CC1
CHEMBL179337 5ht2c_human Human Yes 7.7 EC50 = 20 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 1 3.2 CC1CNCCc2c(Cl)cc(Cl)cc21
CHEMBL2393243 5ht2c_human Human No 7.7 EC50 = 20.1 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
330 4 2 4 3.5 c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1
CHEMBL3040324 5ht2c_human Human No 7.7 EC50 = 20.1 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
330 4 2 4 3.5 c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1
CHEMBL4752412 5ht2c_human Human No 7.7 EC50 = 20.4 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4802814 5ht2c_human Human No 7.7 EC50 = 20.4 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL380763 5ht2c_human Human No 6.7 EC50 = 200 nM Bind
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
315 5 1 3 4.4 C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1
CHEMBL102347 5ht2c_rat Rat Yes 5.7 EC50 = 2000 nM Funct
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor
223 4 1 4 1.1 COc1cc(CCN)c2c(c1OC)OCC2
CHEMBL319415 5ht2c_rat Rat Yes 5.7 EC50 = 2000 nM Funct
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor
225 6 1 4 1.6 CCOc1c(OC)cc(CCN)cc1OC
CHEMBL181324 5ht2c_human Human Yes 5.7 EC50 = 2000 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
191 1 1 2 1.9 COc1ccc2c(c1)CCNCC2C
CHEMBL3416059 5ht2c_human Human No 6.7 EC50 = 206 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF
CHEMBL3546910 5ht2c_human Human No 6.7 EC50 = 206 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF
CHEMBL39 5ht2c_human Human Yes 7.7 EC50 = 21 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4786831 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803642 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL2023357 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
235 5 1 2 2.7 NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1
CHEMBL2023357 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilization
235 5 1 2 2.7 NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1
CHEMBL576453 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
346 5 1 5 2.1 CCn1c(CCc2ccccc2Cl)nc(N2CCNCC2)cc1=O
CHEMBL577250 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
346 4 1 5 2.0 C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2Cl)n1
CHEMBL3769454 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL80731 5ht2c_human Human No 7.7 EC50 = 21 nM Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
254 4 1 3 2.6 CCSc1cc2c(cc1F)CCN2C[C@H](C)N
CHEMBL4786831 5ht2c_human Human No 7.7 EC50 = 21.4 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803642 5ht2c_human Human No 7.7 EC50 = 21.4 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL39 5ht2c_human Human Yes 7.7 EC50 = 21.9 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL360328 5ht2c_human Human Yes 6.7 EC50 = 210 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL1770379 5ht2c_human Human No 6.7 EC50 = 210 nM Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.1 Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1
CHEMBL1643856 5ht2c_human Human No 6.7 EC50 = 211 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 7 1.1 c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1
CHEMBL3416053 5ht2c_human Human No 6.7 EC50 = 212 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.4 C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546905 5ht2c_human Human No 6.7 EC50 = 212 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.4 C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL2337498 5ht2c_human Human No 6.7 EC50 = 218 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
264 2 2 2 2.1 CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365254 5ht2c_human Human No 6.7 EC50 = 218 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
264 2 2 2 2.1 CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL531 5ht2c_human Human Yes 6.7 EC50 = 218.8 nM Bind
Agonist activity at 5HT2C receptor VGV isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assayAgonist activity at 5HT2C receptor VGV isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assay
314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3
CHEMBL3589578 5ht2c_human Human No 6.7 EC50 = 218.8 nM Funct
Partial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay
393 7 1 5 3.5 COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br
CHEMBL379223 5ht2c_human Human No 6.7 EC50 = 219 nM Bind
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
329 5 1 3 4.7 Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21
CHEMBL2022181 5ht2c_human Human No 5.7 EC50 = 2190 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
271 4 1 2 3.6 COc1ccc(-c2ccc(F)cc2)cc1[C@H]1C[C@@H]1CN
CHEMBL2027920 5ht2c_human Human No 5.7 EC50 = 2190 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
271 4 1 2 3.6 COc1ccc(-c2ccc(F)cc2)cc1[C@H]1C[C@@H]1CN
CHEMBL595553 5ht2c_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
329 3 1 4 3.2 Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21
CHEMBL1091452 5ht2c_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assay
409 5 1 6 3.5 Cc1noc(C)c1COc1cc(F)c(COC(=O)N2[C@@H](C)CNC[C@H]2C)c(F)c1
CHEMBL4803134 5ht2c_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
277 6 1 3 3.4 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCCF
CHEMBL3416065 5ht2c_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.8 C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN
CHEMBL3546960 5ht2c_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.8 C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN
CHEMBL2397893 5ht2c_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
236 0 1 2 1.3 O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12
CHEMBL368016 5ht2c_human Human Yes 7.7 EC50 = 22 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
213 0 1 1 2.7 CC1CNCCc2ccc(Cl)c(F)c21
CHEMBL210215 5ht2c_human Human No 7.7 EC50 = 22 nM Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
272 1 1 4 1.7 C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1
CHEMBL4803134 5ht2c_human Human No 7.7 EC50 = 22.4 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
277 6 1 3 3.4 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCCF
CHEMBL4803350 5ht2c_human Human No 7.7 EC50 = 22.4 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
271 6 1 3 3.6 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCC=C
CHEMBL4116028 5ht2c_human Human No 7.6 EC50 = 22.7 nM Bind
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
341 9 1 3 4.3 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCC=C
CHEMBL4116620 5ht2c_human Human No 7.6 EC50 = 22.9 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
209 4 1 2 2.2 CNC[C@H]1C[C@@H]1C2=C(C=CC(=C2)F)OC
CHEMBL4116028 5ht2c_human Human No 7.6 EC50 = 22.9 nM Bind
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
341 9 1 3 4.3 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCC=C
CHEMBL4514905 5ht2c_human Human No 6.7 EC50 = 220 nM Funct
Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
253 2 1 3 2.1 Cc1c(Cc2ccccc2)nnc2c1CCNCC2
CHEMBL3770011 5ht2c_human Human No 6.7 EC50 = 223.9 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL3771394 5ht2c_human Human No 6.7 EC50 = 223.9 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL3770011 5ht2c_human Human No 6.7 EC50 = 224 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL3771394 5ht2c_human Human No 6.7 EC50 = 224 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL4070259 5ht2c_human Human No 6.6 EC50 = 228 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1cscc1CNCC1CC1c1cc(F)ccc1OC
CHEMBL4116195 5ht2c_human Human No 6.6 EC50 = 228 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1cscc1CNCC1CC1c1cc(F)ccc1OC
CHEMBL565735 5ht2c_human Human No 6.6 EC50 = 228 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
314 4 1 6 1.1 Cc1ccccc1OCc1nc(N2CCNCC2)cc(=O)n1C
CHEMBL4541617 5ht2c_human Human No 6.6 EC50 = 229 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL4597957 5ht2c_human Human No 6.6 EC50 = 229 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL4070259 5ht2c_human Human No 6.6 EC50 = 229.1 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1cscc1CNCC1CC1c1cc(F)ccc1OC
CHEMBL4116195 5ht2c_human Human No 6.6 EC50 = 229.1 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
321 7 1 4 3.8 COc1cscc1CNCC1CC1c1cc(F)ccc1OC
CHEMBL4067525 5ht2c_human Human No 6.6 EC50 = 229.1 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1
CHEMBL4116318 5ht2c_human Human No 6.6 EC50 = 229.1 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1
CHEMBL2331794 5ht2c_human Human No 6.6 EC50 = 229.1 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
244 3 1 4 1.9 c1ccc(COc2noc3c2CCNCC3)cc1
CHEMBL4541617 5ht2c_human Human No 6.6 EC50 = 229.1 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL4597957 5ht2c_human Human No 6.6 EC50 = 229.1 nM Funct
Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL4803350 5ht2c_human Human No 7.6 EC50 = 23 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
271 6 1 3 3.6 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCC=C
CHEMBL4116620 5ht2c_human Human No 7.6 EC50 = 23 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
209 4 1 2 2.2 CNC[C@H]1C[C@@H]1C2=C(C=CC(=C2)F)OC
CHEMBL1186115 5ht2c_human Human No 7.6 EC50 = 23 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL450599 5ht2c_human Human No 7.6 EC50 = 23 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL1643678 5ht2c_human Human No 7.6 EC50 = 23 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 1.8 Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1
CHEMBL210802 5ht2c_human Human Yes 7.6 EC50 = 23 nM Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 4 1.3 FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1
CHEMBL4117953 5ht2c_human Human No 7.6 EC50 = 23.5 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COC1=C(C=C(C=C1)F)[C@H]2C[C@@H]2CNCC3=CC=CC=C3OC
CHEMBL4117953 5ht2c_human Human No 7.6 EC50 = 24.0 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COC1=C(C=C(C=C1)F)[C@H]2C[C@@H]2CNCC3=CC=CC=C3OC
CHEMBL3769421 5ht2c_human Human No 7.6 EC50 = 24.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3771385 5ht2c_human Human No 7.6 EC50 = 24.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3770225 5ht2c_human Human No 7.6 EC50 = 24.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3771396 5ht2c_human Human No 7.6 EC50 = 24.0 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL2331794 5ht2c_human Human No 6.6 EC50 = 230 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
244 3 1 4 1.9 c1ccc(COc2noc3c2CCNCC3)cc1
CHEMBL178566 5ht2c_human Human Yes 6.6 EC50 = 230 nM Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 1 3.2 C[C@H]1CNCCc2ccc(Cl)c(Cl)c21
CHEMBL2393239 5ht2c_human Human No 5.6 EC50 = 2300 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
368 4 2 7 1.7 COc1cccc(Nc2nc(N3CCN(C)CC3)nc3c2CCNCC3)c1
CHEMBL3039631 5ht2c_human Human No 5.6 EC50 = 2300 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
368 4 2 7 1.7 COc1cccc(Nc2nc(N3CCN(C)CC3)nc3c2CCNCC3)c1
CHEMBL4067525 5ht2c_human Human No 6.6 EC50 = 231 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1
CHEMBL4116318 5ht2c_human Human No 6.6 EC50 = 231 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1
CHEMBL1186673 5ht2c_human Human No 6.6 EC50 = 232 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 2 2 2.3 NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO
CHEMBL474230 5ht2c_human Human No 6.6 EC50 = 232 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 2 2 2.3 NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO
CHEMBL3770011 5ht2c_human Human No 6.6 EC50 = 232 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL3771394 5ht2c_human Human No 6.6 EC50 = 232 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL3770011 5ht2c_human Human No 6.6 EC50 = 234.4 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL3771394 5ht2c_human Human No 6.6 EC50 = 234.4 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
277 5 1 2 3.4 NCC1CC1c1c(OCCF)ccc(Cl)c1Cl
CHEMBL220274 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 2 1.8 O=C1c2c(cccc2C(F)(F)F)C2CNCCN12
CHEMBL2022186 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
205 5 1 2 2.5 CCCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL2027987 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
205 5 1 2 2.5 CCCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL39 5ht2c_human Human Yes 7.6 EC50 = 24 nM Funct
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4072217 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
336 2 0 3 4.9 Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCCCC1
CHEMBL3769421 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3771385 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3770225 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3771396 5ht2c_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL157138 5ht2c_human Human Yes 7.6 EC50 = 24.6 nM Bind
Agonist activity at 5HT2C receptor VGV isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assayAgonist activity at 5HT2C receptor VGV isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assay
338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
CHEMBL26687 5ht2c_rat Rat Yes 4.6 EC50 = 24000 nM Funct
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor
211 5 1 4 1.2 COc1cc(CCN)cc(OC)c1OC
CHEMBL2397902 5ht2c_human Human No 6.6 EC50 = 241 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.7 COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O
CHEMBL3416045 5ht2c_human Human No 6.6 EC50 = 244 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
271 6 1 3 3.1 CSCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546954 5ht2c_human Human No 6.6 EC50 = 244 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
271 6 1 3 3.1 CSCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL4064809 5ht2c_human Human No 6.6 EC50 = 245 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL4116194 5ht2c_human Human No 6.6 EC50 = 245 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL4064809 5ht2c_human Human No 6.6 EC50 = 245.5 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL4116194 5ht2c_human Human No 6.6 EC50 = 245.5 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL1901802 5ht2c_human Human Yes 5.6 EC50 = 2450 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
159 1 1 1 2.1 C1=C(c2ccccc2)CCNC1
CHEMBL6224 5ht2c_human Human Yes 5.6 EC50 = 2450 nM Funct
Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay
159 1 1 1 2.1 C1=C(c2ccccc2)CCNC1
CHEMBL222466 5ht2c_human Human No 6.6 EC50 = 246 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
252 1 1 3 1.4 COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O
CHEMBL3416038 5ht2c_human Human No 5.6 EC50 = 2481 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 4 1 2 3.2 CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546893 5ht2c_human Human No 5.6 EC50 = 2481 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 4 1 2 3.2 CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL593547 5ht2c_human Human Yes 7.6 EC50 = 25 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
217 1 1 3 1.4 c1cc2c(nc1N1CCNCC1)CCCC2
CHEMBL4803350 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
271 6 1 3 3.6 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCC=C
CHEMBL4803306 5ht2c_human Human No 7.6 EC50 = 25 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL2397908 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
246 2 1 3 1.1 CCOc1cccc2c1C[C@@H]1CNCCN1C2=O
CHEMBL4753812 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802839 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL39 5ht2c_human Human Yes 7.6 EC50 = 25 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL570023 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
348 5 1 6 1.8 C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1
CHEMBL572252 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
348 5 1 6 1.9 C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O
CHEMBL1643677 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 1.8 Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1
CHEMBL4100745 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
286 2 0 4 3.7 Cn1nc(-c2cccc3ccccc23)cc1-c1cccnn1
CHEMBL3770599 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL3771378 5ht2c_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL2393245 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
364 4 2 4 4.2 Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL3040361 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay
364 4 2 4 4.2 Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL4803350 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
271 6 1 3 3.6 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCC=C
CHEMBL4803306 5ht2c_human Human No 7.6 EC50 = 25.1 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL4753812 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802839 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL39 5ht2c_human Human Yes 7.6 EC50 = 25.1 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL253811 5ht2c_human Human Yes 7.6 EC50 = 25.1 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
203 2 1 1 2.6 C[C@@H](Cc1cccc(c1)C(F)(F)F)N
CHEMBL181672 5ht2c_human Human Yes 7.6 EC50 = 25.1 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
195 0 1 1 2.6 CC1CNCCc2cc(Cl)ccc21
CHEMBL3770599 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL3771378 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL3933563 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
220 0 1 2 1.9 Fc1ccc2c(c1)CC[C@@H]1CNCCCN21
CHEMBL3961026 5ht2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
250 0 1 2 2.8 Clc1cccc2c1N1CCCNCCC1CC2
CHEMBL4800666 5ht2c_human Human No 7.6 EC50 = 25.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4804119 5ht2c_human Human No 7.6 EC50 = 25.7 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4642094 5ht2c_human Human No 6.6 EC50 = 250 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
188 0 1 2 1.5 Cc1ccc2c3c1CCN3CCNC2
CHEMBL42 5ht2c_human Human Yes 6.6 EC50 = 250 nM Bind
Inverse agonist activity at human 5HT2C receptor by R-SAT assayInverse agonist activity at human 5HT2C receptor by R-SAT assay
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL4642935 5ht2c_human Human No 5.6 EC50 = 2500 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
192 0 1 2 1.3 Fc1ccc2c3c1CCN3CCNC2
CHEMBL3416041 5ht2c_human Human No 6.6 EC50 = 251 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL3546951 5ht2c_human Human No 6.6 EC50 = 251 nM Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL3975593 5ht2c_human Human No 6.6 EC50 = 251.2 nM Funct
Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
218 1 1 3 1.4 COc1ccc2c(c1)CCC1CNCCN21
CHEMBL2114265 5ht2c_rat Rat Yes 6.6 EC50 = 251.2 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
242 3 1 3 2.4 COc1ccc2c(c1)-c1c(ccn1C[C@H](C)N)C2
CHEMBL317677 5ht2c_rat Rat Yes 5.6 EC50 = 2511.9 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
188 2 1 2 2.3 Cc1cccc2c1ccn2CC(C)N
CHEMBL320145 5ht2c_rat Rat No 5.6 EC50 = 2511.9 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
290 2 1 2 3.2 CC(N)Cn1ccc2c1-c1cc(Br)ccc1C2
CHEMBL91855 5ht2c_rat Rat No 5.6 EC50 = 2511.9 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
246 2 1 2 3.1 CC(N)Cn1ccc2c1-c1cc(Cl)ccc1C2
CHEMBL93850 5ht2c_rat Rat No 5.6 EC50 = 2511.9 nM Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
188 2 1 2 2.3 Cc1ccc2c(ccn2CC(C)N)c1
CHEMBL2022187 5ht2c_human Human No 6.6 EC50 = 254 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
219 5 1 2 2.8 CC(C)COc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL2027941 5ht2c_human Human No 6.6 EC50 = 254 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
219 5 1 2 2.8 CC(C)COc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL4586582 5ht2c_human Human Yes 5.6 EC50 = 2549 nM Funct
Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay
471 11 2 2 6.5 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl
CHEMBL4596341 5ht2c_human Human Yes 5.6 EC50 = 2549 nM Funct
Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay
471 11 2 2 6.5 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl
CHEMBL4066538 5ht2c_human Human No 5.6 EC50 = 2550 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
329 7 1 3 4.3 COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC
CHEMBL4116576 5ht2c_human Human No 5.6 EC50 = 2550 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
329 7 1 3 4.3 COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC
CHEMBL202324 5ht2c_human Human No 6.6 EC50 = 257 nM Bind
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
265 5 1 3 3.4 C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21
CHEMBL4066538 5ht2c_human Human No 5.6 EC50 = 2570.4 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
329 7 1 3 4.3 COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC
CHEMBL4116576 5ht2c_human Human No 5.6 EC50 = 2570.4 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
329 7 1 3 4.3 COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC
CHEMBL219734 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
272 1 1 3 1.7 O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12
CHEMBL2337497 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
250 1 2 2 1.7 CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL2364998 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
250 1 2 2 1.7 CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL4802486 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL4758641 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL4803076 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL4800666 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4804119 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL1186135 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL451368 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL577690 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
326 4 1 5 1.7 Cc1ccccc1CCc1nc(N2CCNC[C@H]2C)cc(=O)n1C
CHEMBL583193 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
346 4 1 5 2.0 C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2cccc(Cl)c2)n1
CHEMBL568692 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
295 3 1 4 1.9 O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2
CHEMBL478 5ht2c_human Human Yes 7.6 EC50 = 26 nM Bind
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL478 5ht2c_human Human Yes 7.6 EC50 = 26 nM Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL451543 5ht2c_human Human No 7.6 EC50 = 26 nM Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
222 3 1 3 2.1 CSc1ccc2c(c1)N(C[C@H](C)N)CC2
CHEMBL4802486 5ht2c_human Human No 7.6 EC50 = 26.3 nM Funct
Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL4758641 5ht2c_human Human No 7.6 EC50 = 26.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL4803076 5ht2c_human Human No 7.6 EC50 = 26.3 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL4642956 5ht2c_human Human No 6.6 EC50 = 260 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
280 0 1 2 2.7 Brc1ccc2c3c1CCCCN3CCNC2
CHEMBL594718 5ht2c_human Human No 5.6 EC50 = 2600 nM Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
360 4 1 6 3.3 Clc1cccc(COc2nc(N3CCNCC3)nc3ccsc23)c1
CHEMBL4093447 5ht2c_human Human No 5.6 EC50 = 2600 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1
CHEMBL4117067 5ht2c_human Human No 5.6 EC50 = 2600 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1
CHEMBL59619 5ht2c_human Human No 5.6 EC50 = 2600 nM Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
305 0 2 3 2.1 O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNC[C@@H]12
CHEMBL4762722 5ht2c_human Human No 6.6 EC50 = 261 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803207 5ht2c_human Human No 6.6 EC50 = 261 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL258465 5ht2c_human Human Yes 6.6 EC50 = 261 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
226 0 1 2 2.6 c1cc2c3c(c1)c1c(n3CCNC2)CCCC1
CHEMBL565764 5ht2c_human Human No 6.6 EC50 = 262 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
362 6 1 6 2.1 Cc1cc(=O)n(CCCOc2cccc(Cl)c2)c(N2CCNCC2)n1
CHEMBL579042 5ht2c_human Human No 6.6 EC50 = 262 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
312 4 1 5 1.4 C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2)n1
CHEMBL4762722 5ht2c_human Human No 6.6 EC50 = 263.0 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803207 5ht2c_human Human No 6.6 EC50 = 263.0 nM Funct
Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4093447 5ht2c_human Human No 5.6 EC50 = 2630.3 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1
CHEMBL4117067 5ht2c_human Human No 5.6 EC50 = 2630.3 nM Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1
CHEMBL4635293 5ht2c_human Human No 5.6 EC50 = 2650 nM Bind
Agonist activity at 5HT2C receptor (unknown origin)Agonist activity at 5HT2C receptor (unknown origin)
256 0 1 3 1.4 [O-][S+]1CCN2CCNCc3ccc(Cl)c1c32
CHEMBL4802486 5ht2c_human Human No 6.6 EC50 = 267 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL4802486 5ht2c_human Human No 6.6 EC50 = 269.2 nM Bind
Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assayAgonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 hrs by Tango assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL3989843 5ht2c_human Human No 5.6 EC50 = 2697 nM Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
266 2 2 2 3.0 N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1
CHEMBL2337104 5ht2c_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
242 1 2 2 1.7 Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21
CHEMBL2365468 5ht2c_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
242 1 2 2 1.7 Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21
CHEMBL4093978 5ht2c_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
302 3 0 4 4.1 CCn1nc(-c2cccc3ccccc23)cc1-c1nccn1C
CHEMBL492302 5ht2c_human Human No 6.6 EC50 = 273 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
420 4 1 4 3.3 O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2cccc(Cl)c2)CC1
CHEMBL568236 5ht2c_human Human No 6.6 EC50 = 275 nM Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
298 4 1 5 1.0 Cn1c(CCc2ccccc2)nc(N2CCNCC2)cc1=O
CHEMBL3771152 5ht2c_human Human No 6.6 EC50 = 275.4 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL3771392 5ht2c_human Human No 6.6 EC50 = 275.4 nM Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity