Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL595195 5ht2c_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL609306 5ht2c_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL595195 5ht2c_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL609306 5ht2c_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL494947 5ht2c_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at 5HT2C receptor (unknown origin) relative to controlAgonist activity at 5HT2C receptor (unknown origin) relative to control
305 4 1 5 2.0 C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
CHEMBL494947 5ht2c_human Human Yes 10.0 EC50 = 0.1 Funct
Agonist activity at 5HT2C receptor (unknown origin) relative to controlAgonist activity at 5HT2C receptor (unknown origin) relative to control
305 4 1 5 2.0 C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
CHEMBL350221 5ht2c_human Human Yes 9.7 EC50 = 0.2 Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 4 -1.2 C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
CHEMBL171774 5ht2c_human Human Yes 9.7 EC50 = 0.2 Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
200 2 1 1 1.6 C1CC2=CC=CC3=C2N(C1)C=C3CCN
CHEMBL350221 5ht2c_human Human Yes 9.7 EC50 = 0.2 Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 4 -1.2 C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
CHEMBL350221 5ht2c_human Human Yes 9.7 EC50 = 0.2 Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 4 -1.2 C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
CHEMBL172159 5ht2c_human Human No 9.6 EC50 = 0.2 Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
253 2 1 2 2.2 C1CSC2=C3N1C=C(C3=CC(=C2)Cl)CCN
CHEMBL2260569 5ht2c_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assay
249 0 1 1 3.4 CC1NCCC2=C(C3=C(N12)C(=C(C=C3)Cl)C)C
CHEMBL1224034 5ht2c_human Human No 9.1 EC50 = 0.7 Funct
Agonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assay
336 1 1 4 3.4 C1CCC(CC1)NC(=O)N2C3C(CO2)CSC4=C3C=C(C=C4)F
CHEMBL1224034 5ht2c_human Human No 9.1 EC50 = 0.7 Funct
Agonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assay
336 1 1 4 3.4 C1CCC(CC1)NC(=O)N2C3C(CO2)CSC4=C3C=C(C=C4)F
CHEMBL595645 5ht2c_human Human No 9.0 EC50 = 1 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
359 4 1 6 2.9 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)F)C=C2
CHEMBL1091106 5ht2c_human Human No 9.0 EC50 = 1 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
366 5 2 5 3.8 CC1(CCC(CC1)OC2=C(C=C(C(=C2)F)CNC(=O)C3CCCN3)F)C
CHEMBL407909 5ht2c_human Human Yes 9.0 EC50 = 1 Funct
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
243 3 1 3 2.2 CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N
CHEMBL595645 5ht2c_human Human No 9.0 EC50 = 1 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
359 4 1 6 2.9 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)F)C=C2
CHEMBL1091106 5ht2c_human Human No 9.0 EC50 = 1 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
366 5 2 5 3.8 CC1(CCC(CC1)OC2=C(C=C(C(=C2)F)CNC(=O)C3CCCN3)F)C
CHEMBL407909 5ht2c_human Human Yes 9.0 EC50 = 1 Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced phosphoinositide hydrolysis by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced phosphoinositide hydrolysis by cell based assay
243 3 1 3 2.2 CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N
CHEMBL407909 5ht2c_human Human Yes 9.0 EC50 = 1 Funct
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
243 3 1 3 2.2 CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N
CHEMBL223468 5ht2c_human Human No 8.9 EC50 = 1.4 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C2=C(C=C1)C3CNCCN3C2=O)OC
CHEMBL594469 5ht2c_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
345 4 1 6 2.5 C1CC2=C(C1OCC3=C(C=CC(=C3)F)F)N=C(C=C2)N4CCNCC4
CHEMBL223468 5ht2c_human Human No 8.9 EC50 = 1.4 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C2=C(C=C1)C3CNCCN3C2=O)OC
CHEMBL594469 5ht2c_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
345 4 1 6 2.5 C1CC2=C(C1OCC3=C(C=CC(=C3)F)F)N=C(C=C2)N4CCNCC4
CHEMBL590483 5ht2c_human Human No 8.7 EC50 = 1.8 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
252 0 2 3 1.6 C1CNCCN2C1NC(=O)C3=C2C=CC=C3Cl
CHEMBL590483 5ht2c_human Human No 8.8 EC50 = 1.8 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
252 0 2 3 1.6 C1CNCCN2C1NC(=O)C3=C2C=CC=C3Cl
CHEMBL360328 5ht2c_human Human Yes 8.7 EC50 = 1.8 Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_human Human Yes 8.7 EC50 = 1.8 Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL494947 5ht2c_human Human Yes 8.7 EC50 = 1.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
305 4 1 5 2.0 C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
CHEMBL2113264 5ht2c_human Human No 8.0 EC50 = 10 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 5 2.6 CC(C)C1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL595194 5ht2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL440752 5ht2c_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
240 0 1 1 2.8 CC1CNCCC2=C1C=C(C=C2)Br
CHEMBL254215 5ht2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL572228 5ht2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
319 5 1 5 2.5 C1CN(CCN1)C2=CN=CC(=N2)OCCC3=CC=CC=C3Cl
CHEMBL3286556 5ht2c_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.7 CC1CNCCC2=C1N=C(N=C2NC)CC3=CC=CC=C3
CHEMBL2113264 5ht2c_human Human No 8.0 EC50 = 10 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 5 2.6 CC(C)C1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL595194 5ht2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL2397877 5ht2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
237 0 1 2 1.5 C1CN2C(CC3=C(C2=O)C=C(C=C3)Cl)CN1
CHEMBL440752 5ht2c_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
240 0 1 1 2.8 CC1CNCCC2=C1C=C(C=C2)Br
CHEMBL254215 5ht2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL572228 5ht2c_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
319 5 1 5 2.5 C1CN(CCN1)C2=CN=CC(=N2)OCCC3=CC=CC=C3Cl
CHEMBL3286556 5ht2c_human Human Yes 8.0 EC50 = 10 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.7 CC1CNCCC2=C1N=C(N=C2NC)CC3=CC=CC=C3
CHEMBL1770373 5ht2c_canlf Dog Yes 8.0 EC50 = 10.8 Funct
Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770373 5ht2c_canlf Dog Yes 8.0 EC50 = 10.8 Funct
Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770380 5ht2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=C(C=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL1770380 5ht2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=C(C=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL2331794 5ht2c_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
244 3 1 4 2.1 C1CNCCC2=C1C(=NO2)OCC3=CC=CC=C3
CHEMBL318639 5ht2c_rat Rat No 7.0 EC50 = 100 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
270 3 1 2 2.6 CC(CN1C=CC2=C1C3=C(C2(C)C)C=CC(=C3)OC)N
CHEMBL316527 5ht2c_rat Rat Yes 6.0 EC50 = 1000 Funct
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor
235 3 1 4 1.2 COC1=C2C(=C(C3=C1OCC3)CCN)CCO2
CHEMBL317564 5ht2c_rat Rat No 5.0 EC50 = 10000 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
204 3 1 2 1.4 CC(CN1C=CC2=C1C=CC(=C2)OC)N
CHEMBL568897 5ht2c_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
379 5 1 4 1.2 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Br
CHEMBL568897 5ht2c_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
379 5 1 4 1.2 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Br
CHEMBL571733 5ht2c_human Human No 6.0 EC50 = 1020 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
328 6 1 4 1.2 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=CC=C3
CHEMBL571733 5ht2c_human Human No 6.0 EC50 = 1020 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
328 6 1 4 1.2 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=CC=C3
CHEMBL568437 5ht2c_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
367 5 1 6 1.9 CCN1C(=O)C=C(N=C1COC2=C(C=CC(=C2)F)Cl)N3CCNCC3
CHEMBL209714 5ht2c_human Human No 7.0 EC50 = 103 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
256 1 1 5 2.7 C1CN(C2C1CNC2)C3=CC=CC(=C3)C(F)(F)F
CHEMBL568437 5ht2c_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
367 5 1 6 1.9 CCN1C(=O)C=C(N=C1COC2=C(C=CC(=C2)F)Cl)N3CCNCC3
CHEMBL209714 5ht2c_human Human No 7.0 EC50 = 103 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
256 1 1 5 2.7 C1CN(C2C1CNC2)C3=CC=CC(=C3)C(F)(F)F
CHEMBL223628 5ht2c_human Human No 7.0 EC50 = 107 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CC(C)OC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL577410 5ht2c_human Human No 7.0 EC50 = 107 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
339 3 1 7 2.0 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3OC(F)(F)F
CHEMBL223628 5ht2c_human Human No 7.0 EC50 = 107 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CC(C)OC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL577410 5ht2c_human Human No 7.0 EC50 = 107 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
339 3 1 7 2.0 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3OC(F)(F)F
CHEMBL30713 5ht2c_human Human Yes 7.0 EC50 = 107.2 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
174 2 2 1 2.0 CC(CC1=CNC2=CC=CC=C21)N
CHEMBL2397899 5ht2c_human Human No 7.0 EC50 = 108 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
244 2 1 2 2.2 CCCC1=CC2=C(C=C1)C(=O)N3CCNCC3C2
CHEMBL220211 5ht2c_human Human No 8.0 EC50 = 11 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
286 1 1 6 1.2 COC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL570274 5ht2c_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
382 5 1 7 1.8 CC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C(F)(F)F
CHEMBL211153 5ht2c_human Human No 8.0 EC50 = 11 Funct
Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration
194 0 1 1 2.2 C1C2CNCC2C3=C1C=C(C=C3)Cl
CHEMBL220211 5ht2c_human Human No 8.0 EC50 = 11 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
286 1 1 6 1.2 COC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL3425756 5ht2c_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assayAgonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assay
281 4 2 3 3.4 CCNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL570274 5ht2c_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
382 5 1 7 1.8 CC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C(F)(F)F
CHEMBL360328 5ht2c_human Human Yes 8.0 EC50 = 11 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL181787 5ht2c_human Human No 8.0 EC50 = 11 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL181172 5ht2c_human Human Yes 8.0 EC50 = 11 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL426235 5ht2c_human Human No 8.0 EC50 = 11 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
284 2 1 2 3.1 CCC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL211153 5ht2c_human Human No 8.0 EC50 = 11 Funct
Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration
194 0 1 1 2.2 C1C2CNCC2C3=C1C=C(C=C3)Cl
CHEMBL1770374 5ht2c_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 3 1 3 2.4 C1CNCCC2=NC(=NC=C21)CCC3=CC=CC=C3
CHEMBL590482 5ht2c_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
238 0 2 3 1.2 C1CN2C(CN1)NC(=O)C3=C2C=CC(=C3)Cl
CHEMBL1770374 5ht2c_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 3 1 3 2.4 C1CNCCC2=NC(=NC=C21)CCC3=CC=CC=C3
CHEMBL590482 5ht2c_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
238 0 2 3 1.2 C1CN2C(CN1)NC(=O)C3=C2C=CC(=C3)Cl
CHEMBL576253 5ht2c_human Human No 7.0 EC50 = 112 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
339 5 1 6 0.9 CCN1C(=O)C=C(N=C1COC2=CC=CC(=C2)C#N)N3CCNCC3
CHEMBL3286565 5ht2c_human Human No 7.0 EC50 = 112 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.7 CC(C1=CC=CC=C1)C2=NC3=C(CCNCC3)C(=N2)NC
CHEMBL576253 5ht2c_human Human No 7.0 EC50 = 112 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
339 5 1 6 0.9 CCN1C(=O)C=C(N=C1COC2=CC=CC(=C2)C#N)N3CCNCC3
CHEMBL3286565 5ht2c_human Human No 7.0 EC50 = 112 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.7 CC(C1=CC=CC=C1)C2=NC3=C(CCNCC3)C(=N2)NC
CHEMBL572253 5ht2c_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
325 5 1 5 0.2 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C#N
CHEMBL572253 5ht2c_human Human No 6.9 EC50 = 114 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
325 5 1 5 0.2 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C#N
CHEMBL523169 5ht2c_human Human No 6.9 EC50 = 115 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
405 4 1 6 3.3 C1CN(CCC1OC2=CC=CC=C2F)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL523169 5ht2c_human Human No 6.9 EC50 = 115 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
405 4 1 6 3.3 C1CN(CCC1OC2=CC=CC=C2F)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL385577 5ht2c_human Human No 7.9 EC50 = 12 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C(C=CC2=C1C(=O)N3C2CNCC3)Cl
CHEMBL493757 5ht2c_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
393 4 1 5 3.1 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CC(C3)OC4=CC(=CC=C4)Cl
CHEMBL197664 5ht2c_human Human Yes 7.9 EC50 = 12 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay
218 3 1 2 1.9 CN1C=C(C2=C1C=CC=C2O)CCN(C)C
CHEMBL385577 5ht2c_human Human No 7.9 EC50 = 12 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C(C=CC2=C1C(=O)N3C2CNCC3)Cl
CHEMBL2397907 5ht2c_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.8 COC1=CC=CC2=C1CC3CNCCN3C2=O
CHEMBL2397894 5ht2c_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.8 COC1=CC=CC2=C1C(=O)N3CCNCC3C2
CHEMBL493757 5ht2c_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
393 4 1 5 3.1 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CC(C3)OC4=CC(=CC=C4)Cl
CHEMBL301466 5ht2c_human Human Yes 7.9 EC50 = 12 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
272 0 2 3 1.7 C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl
CHEMBL197664 5ht2c_human Human Yes 7.9 EC50 = 12 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay
218 3 1 2 1.9 CN1C=C(C2=C1C=CC=C2O)CCN(C)C
CHEMBL440752 5ht2c_human Human Yes 7.9 EC50 = 12 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
240 0 1 1 2.8 CC1CNCCC2=C1C=C(C=C2)Br
CHEMBL180668 5ht2c_human Human Yes 7.9 EC50 = 12 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
182 0 1 1 2.4 C1CNCCC2=C1C=CC(=C2)Cl
CHEMBL180668 5ht2c_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
182 0 1 1 2.4 C1CNCCC2=C1C=CC(=C2)Cl
CHEMBL181172 5ht2c_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL180668 5ht2c_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
182 0 1 1 2.4 C1CNCCC2=C1C=CC(=C2)Cl
CHEMBL181172 5ht2c_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL234464 5ht2c_rat Rat No 7.9 EC50 = 12.6 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
263 4 1 4 1.3 CC(CC1=C2CCOC2=C(C3=C1OCC3)COC)N
CHEMBL234464 5ht2c_rat Rat No 7.9 EC50 = 12.6 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
263 4 1 4 1.3 CC(CC1=C2CCOC2=C(C3=C1OCC3)COC)N
CHEMBL593545 5ht2c_human Human No 6.9 EC50 = 120 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL593545 5ht2c_human Human No 6.9 EC50 = 120 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL6557 5ht2c_human Human Yes 6.9 EC50 = 120 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
200 0 1 1 1.9 CN1C2=C(CCNCC2)C3=CC=CC=C31
CHEMBL595646 5ht2c_human Human No 5.9 EC50 = 1200 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
361 4 1 6 3.8 C1CN(CCN1)C2=NC(=C3C=CSC3=N2)OCC4=CC(=CC=C4)Cl
CHEMBL595646 5ht2c_human Human No 5.9 EC50 = 1200 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
361 4 1 6 3.8 C1CN(CCN1)C2=NC(=C3C=CSC3=N2)OCC4=CC(=CC=C4)Cl
CHEMBL2331792 5ht2c_human Human Yes 4.9 EC50 = 12022.6 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
168 1 1 4 0.6 COC1=NOC2=C1CCNCC2
CHEMBL1770376 5ht2c_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)F
CHEMBL576651 5ht2c_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
323 2 1 6 1.7 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL1770376 5ht2c_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)F
CHEMBL576651 5ht2c_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
323 2 1 6 1.7 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL2115252 5ht2c_rat Rat No 6.9 EC50 = 125.9 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
210 2 1 3 1.6 CC(CN1C=CC2=CC(=C(C=C21)F)F)N
CHEMBL594489 5ht2c_human Human Yes 5.9 EC50 = 1250 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
246 3 1 5 0.9 CCCN1C=NC2=C1N=CN=C2N3CCNCC3
CHEMBL594489 5ht2c_human Human Yes 5.9 EC50 = 1250 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
246 3 1 5 0.9 CCCN1C=NC2=C1N=CN=C2N3CCNCC3
CHEMBL181324 5ht2c_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 2.1 CC1CNCCC2=C1C=CC(=C2)OC
CHEMBL181324 5ht2c_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 2.1 CC1CNCCC2=C1C=CC(=C2)OC
CHEMBL92565 5ht2c_rat Rat No 5.9 EC50 = 1258.9 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
192 2 1 2 1.5 CC(CN1C=CC2=C1C=CC=C2F)N
CHEMBL96095 5ht2c_rat Rat No 4.9 EC50 = 12589.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
204 3 1 2 1.4 CC(CN1C=CC2=C1C=CC=C2OC)N
CHEMBL80246 5ht2c_human Human No 6.9 EC50 = 130 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
262 2 1 6 2.6 CC(CN1CCC2=CC(=C(C=C21)C(F)(F)F)F)N
CHEMBL590089 5ht2c_human Human No 6.9 EC50 = 133 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 CC1=CC2=C(C=C1)N3CCNCC3NC2=O
CHEMBL590089 5ht2c_human Human No 6.9 EC50 = 133 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 CC1=CC2=C(C=C1)N3CCNCC3NC2=O
CHEMBL2397883 5ht2c_human Human No 5.9 EC50 = 1358 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.0 CC12CC3=CC=CC=C3C(=O)N1CCNC2
CHEMBL376456 5ht2c_human Human No 6.9 EC50 = 136 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
218 1 1 3 0.3 COC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL376456 5ht2c_human Human No 6.9 EC50 = 136 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
218 1 1 3 0.3 COC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL304013 5ht2c_human Human No 6.9 EC50 = 136 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
306 0 2 6 1.9 C1CN2C(CN1)C(=O)NC3=C2C=C(C(=C3)C(F)(F)F)Cl
CHEMBL609595 5ht2c_human Human Yes 5.9 EC50 = 1360 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
282 1 1 4 1.5 C1CN(CCN1)C2=NC(=CN3C2=NC=C3)Br
CHEMBL609595 5ht2c_human Human Yes 5.9 EC50 = 1360 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
282 1 1 4 1.5 C1CN(CCN1)C2=NC(=CN3C2=NC=C3)Br
CHEMBL590077 5ht2c_human Human No 6.9 EC50 = 137 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
203 0 2 3 0.6 C1CN2C(CN1)NC(=O)C3=CC=CC=C32
CHEMBL590077 5ht2c_human Human No 6.9 EC50 = 137 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
203 0 2 3 0.6 C1CN2C(CN1)NC(=O)C3=CC=CC=C32
CHEMBL375170 5ht2c_human Human No 7.9 EC50 = 14 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
296 1 1 5 2.1 C1CC1C2=CC3=C(C(=C2)C(F)(F)F)C(=O)N4C3CNCC4
CHEMBL448971 5ht2c_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
407 4 1 5 3.4 C1CN(CC1OC2=CC=CC=C2Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL375170 5ht2c_human Human No 7.9 EC50 = 14 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
296 1 1 5 2.1 C1CC1C2=CC3=C(C(=C2)C(F)(F)F)C(=O)N4C3CNCC4
CHEMBL2397910 5ht2c_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 0 1 2 1.6 CC1=CC(=C2C(=C1)CC3CNCCN3C2=O)C
CHEMBL2397890 5ht2c_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 1 1 2 1.6 CCC1=CC=CC2=C1C(=O)N3CCNCC3C2
CHEMBL448971 5ht2c_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
407 4 1 5 3.4 C1CN(CC1OC2=CC=CC=C2Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL3286558 5ht2c_human Human Yes 5.8 EC50 = 1460 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
255 2 2 2 0.8 C1CNCCC2=C1C(=O)N=C(N2)CC3=CC=CC=C3
CHEMBL3286558 5ht2c_human Human Yes 5.8 EC50 = 1460 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
255 2 2 2 0.8 C1CNCCC2=C1C(=O)N=C(N2)CC3=CC=CC=C3
CHEMBL203013 5ht2c_human Human No 7.8 EC50 = 15 Funct
Efficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPR
273 4 1 4 1.6 CC1CNCC2N1C3=C(C2)C=CC(=N3)COCC4CC4
CHEMBL203013 5ht2c_human Human No 7.8 EC50 = 15 Funct
Efficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPR
273 4 1 4 1.6 CC1CNCC2N1C3=C(C2)C=CC(=N3)COCC4CC4
CHEMBL178365 5ht2c_human Human Yes 7.8 EC50 = 15.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL178365 5ht2c_human Human Yes 7.8 EC50 = 15.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL376455 5ht2c_human Human Yes 5.8 EC50 = 1500 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
188 0 1 2 0.3 C1CN2C(CN1)C3=CC=CC=C3C2=O
CHEMBL376455 5ht2c_human Human Yes 5.8 EC50 = 1500 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
188 0 1 2 0.3 C1CN2C(CN1)C3=CC=CC=C3C2=O
CHEMBL3286563 5ht2c_human Human No 6.8 EC50 = 154 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 1 4 2.5 CN(C)C1=NC(=NC2=C1CCNCC2)CC3=CC=CC=C3
CHEMBL3286563 5ht2c_human Human No 6.8 EC50 = 154 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 1 4 2.5 CN(C)C1=NC(=NC2=C1CCNCC2)CC3=CC=CC=C3
CHEMBL3589596 5ht2c_human Human No 4.8 EC50 = 15488.2 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
396 8 2 5 4.0 COC1=CC=CC(=C1O)CNCCC2=CC(=C(C=C2OC)Br)OC
CHEMBL3589596 5ht2c_human Human No 4.8 EC50 = 15488.2 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
396 8 2 5 4.0 COC1=CC=CC(=C1O)CNCCC2=CC(=C(C=C2OC)Br)OC
CHEMBL3425761 5ht2c_human Human No 6.8 EC50 = 158 Funct
Agonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assayAgonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assay
343 5 2 3 4.5 C1CNCCC2=C(N=C(C=C21)CC3=CC=CC=C3)NCC4=CC=CC=C4
CHEMBL96816 5ht2c_rat Rat Yes 6.8 EC50 = 158.5 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
192 2 2 2 1.1 CC(CC1=CNC2=C1C=C(C=C2)F)N
CHEMBL220789 5ht2c_human Human No 5.8 EC50 = 1580 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 0 1 5 1.8 CC1(CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F)C
CHEMBL220789 5ht2c_human Human No 5.8 EC50 = 1580 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 0 1 5 1.8 CC1(CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F)C
CHEMBL96883 5ht2c_rat Rat No 5.8 EC50 = 1584.9 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
192 2 1 2 1.5 CC(CN1C=CC2=C1C=CC(=C2)F)N
CHEMBL221113 5ht2c_human Human No 7.8 EC50 = 16 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.0 CCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL590816 5ht2c_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 C1CNCCN2C1NC(=O)C3=CC=CC=C32
CHEMBL3286557 5ht2c_human Human No 7.8 EC50 = 16 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
304 3 2 6 2.6 CNC1=NC(=NC2=C1CCNCC2)C(C3=CC=CC=C3)(F)F
CHEMBL221113 5ht2c_human Human No 7.8 EC50 = 16 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.0 CCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL2397892 5ht2c_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
270 0 1 5 1.7 C1CN2C(CC3=C(C2=O)C(=CC=C3)C(F)(F)F)CN1
CHEMBL2397914 5ht2c_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
258 0 1 3 1.2 C1CC2=C(C3=C(C=C2)C(=O)N4CCNCC4C3)OC1
CHEMBL590816 5ht2c_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 C1CNCCN2C1NC(=O)C3=CC=CC=C32
CHEMBL3286557 5ht2c_human Human No 7.8 EC50 = 16 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
304 3 2 6 2.6 CNC1=NC(=NC2=C1CCNCC2)C(C3=CC=CC=C3)(F)F
CHEMBL178365 5ht2c_human Human Yes 7.8 EC50 = 16 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_canlf Dog Yes 7.8 EC50 = 16.2 Funct
Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_canlf Dog Yes 7.8 EC50 = 16.2 Funct
Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL578365 5ht2c_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
349 4 1 5 1.8 CC1=C(C=C(C=C1)Cl)OCC2=NC(=CC(=O)N2C)N3CCNCC3
CHEMBL578365 5ht2c_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
349 4 1 5 1.8 CC1=C(C=C(C=C1)Cl)OCC2=NC(=CC(=O)N2C)N3CCNCC3
CHEMBL179329 5ht2c_human Human No 6.8 EC50 = 160 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
298 2 1 2 3.6 CC(C)C1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL583192 5ht2c_human Human No 6.8 EC50 = 163 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
342 6 1 4 1.6 CC1CNCCN1C2=NC(=CC(=O)N2CCCOC3=CC=CC=C3)C
CHEMBL583192 5ht2c_human Human No 6.8 EC50 = 163 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
342 6 1 4 1.6 CC1CNCCN1C2=NC(=CC(=O)N2CCCOC3=CC=CC=C3)C
CHEMBL595555 5ht2c_human Human Yes 6.8 EC50 = 164 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
203 1 1 4 1.1 C1CN(CCN1)C2=NC=CC3=C2C=CO3
CHEMBL570937 5ht2c_human Human No 6.8 EC50 = 164 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
335 5 1 4 1.1 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Cl
CHEMBL595555 5ht2c_human Human Yes 6.8 EC50 = 164 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
203 1 1 4 1.1 C1CN(CCN1)C2=NC=CC3=C2C=CO3
CHEMBL570937 5ht2c_human Human No 6.8 EC50 = 164 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
335 5 1 4 1.1 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Cl
CHEMBL2337102 5ht2c_human Human No 6.8 EC50 = 168 Funct
Agonist activity at 5-HT2C receptor (unknown origin)Agonist activity at 5-HT2C receptor (unknown origin)
388 2 1 6 4.5 COC1=CC(=C(C=C1)C2=CC3=C4C(=C2)C5CNCCC5N4CCC3)C(F)(F)F
CHEMBL374436 5ht2c_human Human No 7.8 EC50 = 17 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C=C2C(=C1)C3CNCCN3C2=O)OC
CHEMBL374436 5ht2c_human Human No 7.8 EC50 = 17 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C=C2C(=C1)C3CNCCN3C2=O)OC
CHEMBL492362 5ht2c_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
390 6 1 6 2.4 CN(CC1=CC=CC=C1)S(=O)(=O)C2=C(C3=C(CCNCC3)C(=C2)OC)OC
CHEMBL492362 5ht2c_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
390 6 1 6 2.4 CN(CC1=CC=CC=C1)S(=O)(=O)C2=C(C3=C(CCNCC3)C(=C2)OC)OC
CHEMBL2331807 5ht2c_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
244 2 1 3 1.3 C1CNCCC2=C1C(=O)N(O2)CC3=CC=CC=C3
CHEMBL2397901 5ht2c_human Human No 6.8 EC50 = 171 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
237 0 1 2 1.5 C1CN2C(CC3=C(C2=O)C=CC(=C3)Cl)CN1
CHEMBL223469 5ht2c_human Human No 5.8 EC50 = 1730 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
206 0 1 3 0.4 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)F
CHEMBL223469 5ht2c_human Human No 5.8 EC50 = 1730 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
206 0 1 3 0.4 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)F
CHEMBL2396668 5ht2c_human Human No 5.8 EC50 = 1744 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.3 CC1CN2C(CC3=CC=CC=C3C2=O)CN1
CHEMBL577903 5ht2c_human Human No 6.8 EC50 = 176 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
243 3 2 3 1.9 C1CNCCC2=C1C(=NN2)OCC3=CC=CC=C3
CHEMBL577903 5ht2c_human Human No 6.8 EC50 = 176 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
243 3 2 3 1.9 C1CNCCC2=C1C(=NN2)OCC3=CC=CC=C3
CHEMBL223272 5ht2c_human Human No 7.8 EC50 = 18 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL1643675 5ht2c_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
335 3 1 5 2.2 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5
CHEMBL76781 5ht2c_human Human Yes 7.8 EC50 = 18 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL223272 5ht2c_human Human No 7.8 EC50 = 18 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL2397915 5ht2c_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
270 0 1 5 1.7 C1CN2C(CC3=C(C2=O)C=C(C=C3)C(F)(F)F)CN1
CHEMBL1643675 5ht2c_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
335 3 1 5 2.2 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5
CHEMBL76781 5ht2c_human Human Yes 7.8 EC50 = 18 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL76781 5ht2c_human Human Yes 7.8 EC50 = 18 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL1770382 5ht2c_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)Cl
CHEMBL208936 5ht2c_human Human No 6.8 EC50 = 180 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL1770382 5ht2c_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)Cl
CHEMBL170319 5ht2c_human Human No 6.8 EC50 = 180 Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
246 3 1 2 2.7 CC1CCC2=C3N1C=C(C3=CC(=C2)F)CCNC
CHEMBL208936 5ht2c_human Human No 6.8 EC50 = 180 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL1092167 5ht2c_human Human No 6.7 EC50 = 183 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
349 4 2 2 4.0 C1CC(NC1)C(=O)NCC2=CC=C(C=C2)C3=CC(=CC(=C3)Cl)Cl
CHEMBL1092167 5ht2c_human Human No 6.7 EC50 = 183 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
349 4 2 2 4.0 C1CC(NC1)C(=O)NCC2=CC=C(C=C2)C3=CC(=CC(=C3)Cl)Cl
CHEMBL223584 5ht2c_human Human No 5.7 EC50 = 1840 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL223584 5ht2c_human Human No 5.7 EC50 = 1840 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL492357 5ht2c_human Human No 6.7 EC50 = 186 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
296 2 1 5 0.6 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CCOCC3
CHEMBL492357 5ht2c_human Human No 6.7 EC50 = 186 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
296 2 1 5 0.6 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CCOCC3
CHEMBL608135 5ht2c_human Human Yes 6.7 EC50 = 187 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
219 1 1 4 1.7 C1CN(CCN1)C2=NC=CC3=C2C=CS3
CHEMBL608135 5ht2c_human Human Yes 6.7 EC50 = 187 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
219 1 1 4 1.7 C1CN(CCN1)C2=NC=CC3=C2C=CS3
CHEMBL1643858 5ht2c_human Human No 6.7 EC50 = 188 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
406 4 1 6 1.5 CC(=O)N(C)C1=CC=C(C=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL1643858 5ht2c_human Human No 6.7 EC50 = 188 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
406 4 1 6 1.5 CC(=O)N(C)C1=CC=C(C=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL305123 5ht2c_human Human No 7.7 EC50 = 19 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
292 0 2 6 2.7 C1CN2C(CN1)CNC3=C2C=C(C(=C3)C(F)(F)F)Cl
CHEMBL60280 5ht2c_human Human No 7.7 EC50 = 19 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
306 0 2 6 1.9 C1CN2C(CN1)C(=O)NC3=C2C=C(C(=C3)C(F)(F)F)Cl
CHEMBL179337 5ht2c_human Human Yes 7.7 EC50 = 20.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C(C=C(C=C12)Cl)Cl
CHEMBL253810 5ht2c_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL368016 5ht2c_human Human Yes 7.7 EC50 = 20.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=C1C(=C(C=C2)Cl)F
CHEMBL179337 5ht2c_human Human Yes 7.7 EC50 = 20.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C(C=C(C=C12)Cl)Cl
CHEMBL253810 5ht2c_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL368016 5ht2c_human Human Yes 7.7 EC50 = 20.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=C1C(=C(C=C2)Cl)F
CHEMBL1770373 5ht2c_human Human Yes 6.7 EC50 = 190 Funct
Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770373 5ht2c_human Human Yes 6.7 EC50 = 190 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770373 5ht2c_human Human Yes 6.7 EC50 = 190 Funct
Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770373 5ht2c_human Human Yes 6.7 EC50 = 190 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770367 5ht2c_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 4 1 3 2.3 C1CNCC2=CN=C(N=C21)CCCC3=CC=CC=C3
CHEMBL1770367 5ht2c_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 4 1 3 2.3 C1CNCC2=CN=C(N=C21)CCCC3=CC=CC=C3
CHEMBL1770383 5ht2c_human Human No 6.7 EC50 = 192 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)Cl
CHEMBL1770383 5ht2c_human Human No 6.7 EC50 = 192 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)Cl
CHEMBL2397884 5ht2c_human Human No 6.7 EC50 = 193 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 0 2 1.3 CN1CCN2C(C1)CC3=CC=CC=C3C2=O
CHEMBL1770375 5ht2c_human Human No 6.7 EC50 = 194 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3F
CHEMBL1770375 5ht2c_human Human No 6.7 EC50 = 194 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3F
CHEMBL522349 5ht2c_human Human No 6.7 EC50 = 197 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
320 3 2 5 2.4 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3F
CHEMBL522349 5ht2c_human Human No 6.7 EC50 = 197 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
320 3 2 5 2.4 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3F
CHEMBL361742 5ht2c_human Human Yes 6.7 EC50 = 199.5 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 2.1 CC1CNCCC2=C1C=C(C=C2)OC
CHEMBL398926 5ht2c_human Human Yes 6.7 EC50 = 199.5 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 0 1 1 3.3 CC1(CNCCC2=C1C=C(C=C2)Cl)C
CHEMBL361742 5ht2c_human Human Yes 6.7 EC50 = 199.5 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 2.1 CC1CNCCC2=C1C=C(C=C2)OC
CHEMBL398926 5ht2c_human Human Yes 6.7 EC50 = 199.5 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 0 1 1 3.3 CC1(CNCCC2=C1C=C(C=C2)Cl)C
CHEMBL328761 5ht2c_rat Rat No 6.7 EC50 = 199.5 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
254 2 1 1 3.0 CC1=CC2=C(C=C1)C(C3=C2N(C=C3)CC(C)N)(C)C
CHEMBL40726 5ht2c_rat Rat Yes 6.7 EC50 = 199.5 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
210 2 1 3 1.6 CC(CN1C=CC2=CC(=C(C=C21)F)F)N
CHEMBL76781 5ht2c_rat Rat Yes 6.7 EC50 = 199.5 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL94272 5ht2c_rat Rat No 6.7 EC50 = 199.5 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
258 2 1 2 2.7 CC(CN1C=CC2=C1C3=C(C2(C)C)C=CC(=C3)F)N
CHEMBL273304 5ht2c_rat Rat No 5.7 EC50 = 1995.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
242 3 1 2 1.7 CC(CN1C=CC2=C1C3=C(C2)C=C(C=C3)OC)N
CHEMBL276673 5ht2c_rat Rat No 5.7 EC50 = 1995.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
253 2 1 1 2.1 CC(CN1C=CC2=C1C=CC(=C2)Br)N
CHEMBL328844 5ht2c_rat Rat No 5.7 EC50 = 1995.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
209 2 1 1 2.1 CC(CN1C=CC2=C1C=CC(=C2)Cl)N
CHEMBL590580 5ht2c_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 1.3 CC1=C2C(=CC=C1)N3CCNCCC3NC2=O
CHEMBL590580 5ht2c_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 1.3 CC1=C2C(=CC=C1)N3CCNCCC3NC2=O
CHEMBL179378 5ht2c_human Human Yes 8.7 EC50 = 2 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
317 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)I)OC
CHEMBL360328 5ht2c_human Human Yes 8.7 EC50 = 2.1 Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL1091105 5ht2c_human Human Yes 8.6 EC50 = 2.3 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
378 6 2 5 3.7 CC1(CCC(CC1)OC2=C(C=C(C(=C2)OC)CNC(=O)C3CCCN3)F)C
CHEMBL1091105 5ht2c_human Human Yes 8.6 EC50 = 2.3 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
378 6 2 5 3.7 CC1(CCC(CC1)OC2=C(C=C(C(=C2)OC)CNC(=O)C3CCCN3)F)C
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.6 Funct
Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.7 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.7 Funct
Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_human Human Yes 8.6 EC50 = 2.7 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL201930 5ht2c_human Human Yes 8.5 EC50 = 2.9 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
225 2 1 2 1.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)N
CHEMBL201930 5ht2c_human Human Yes 8.5 EC50 = 2.9 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
225 2 1 2 1.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)N
CHEMBL220900 5ht2c_human Human No 7.7 EC50 = 20 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
257 0 1 2 1.6 C1CN2C(CN1)C3=C(C2=O)C(=C(C=C3)Cl)Cl
CHEMBL220900 5ht2c_human Human No 7.7 EC50 = 20 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
257 0 1 2 1.6 C1CN2C(CN1)C3=C(C2=O)C(=C(C=C3)Cl)Cl
CHEMBL179337 5ht2c_human Human Yes 7.7 EC50 = 20 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=C(C=C(C=C12)Cl)Cl
CHEMBL380763 5ht2c_human Human No 6.7 EC50 = 200 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
315 5 1 2 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4
CHEMBL380763 5ht2c_human Human No 6.7 EC50 = 200 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
315 5 1 2 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4
CHEMBL102347 5ht2c_rat Rat Yes 5.7 EC50 = 2000 Funct
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor
223 4 1 4 1.2 COC1=C(C2=C(CCO2)C(=C1)CCN)OC
CHEMBL319415 5ht2c_rat Rat Yes 5.7 EC50 = 2000 Funct
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor
225 6 1 4 1.2 CCOC1=C(C=C(C=C1OC)CCN)OC
CHEMBL181324 5ht2c_human Human Yes 5.7 EC50 = 2000 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
191 1 1 2 2.1 CC1CNCCC2=C1C=CC(=C2)OC
CHEMBL2023357 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL2023357 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilization
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL576453 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
347 5 1 4 2.0 CCN1C(=O)C=C(N=C1CCC2=CC=CC=C2Cl)N3CCNCC3
CHEMBL577250 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
347 4 1 4 2.1 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3Cl)C
CHEMBL2023357 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL2023357 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilization
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL3425758 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assayAgonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assay
307 5 2 3 3.7 C1CC1CNC2=C3CCNCCC3=CC(=N2)CC4=CC=CC=C4
CHEMBL576453 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
347 5 1 4 2.0 CCN1C(=O)C=C(N=C1CCC2=CC=CC=C2Cl)N3CCNCC3
CHEMBL577250 5ht2c_human Human No 7.7 EC50 = 21 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
347 4 1 4 2.1 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3Cl)C
CHEMBL80731 5ht2c_human Human No 7.7 EC50 = 21 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
254 4 1 4 2.5 CCSC1=C(C=C2CCN(C2=C1)CC(C)N)F
CHEMBL360328 5ht2c_human Human Yes 6.7 EC50 = 210 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL1770379 5ht2c_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC(=CC=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL360328 5ht2c_human Human Yes 6.7 EC50 = 210 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL1770379 5ht2c_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC(=CC=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL1643856 5ht2c_human Human No 6.7 EC50 = 211 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CN=CC=C5
CHEMBL1643856 5ht2c_human Human No 6.7 EC50 = 211 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CN=CC=C5
CHEMBL3589578 5ht2c_human Human No 6.7 EC50 = 218.8 Funct
Partial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay
394 7 1 5 3.7 COC1=CC(=C(C=C1CCNCC2=C3C(=CC=C2)OCO3)OC)Br
CHEMBL3589578 5ht2c_human Human No 6.7 EC50 = 218.8 Funct
Partial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay
394 7 1 5 3.7 COC1=CC(=C(C=C1CCNCC2=C3C(=CC=C2)OCO3)OC)Br
CHEMBL379223 5ht2c_human Human No 6.7 EC50 = 219 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
329 5 1 2 4.1 CC1=CC=CC=C1CNC(C)CN2C=CC3=C2C4=C(C=C3)N=CC=C4
CHEMBL379223 5ht2c_human Human No 6.7 EC50 = 219 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
329 5 1 2 4.1 CC1=CC=CC=C1CNC(C)CN2C=CC3=C2C4=C(C=C3)N=CC=C4
CHEMBL595553 5ht2c_human Human No 7.7 EC50 = 22 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL210215 5ht2c_human Human No 7.7 EC50 = 22 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL595553 5ht2c_human Human No 7.7 EC50 = 22 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL1091452 5ht2c_human Human No 7.7 EC50 = 22 Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assay
409 6 1 8 2.7 CC1CNCC(N1C(=O)OCC2=C(C=C(C=C2F)OCC3=C(ON=C3C)C)F)C
CHEMBL2397893 5ht2c_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
237 0 1 2 1.5 C1CN2C(CC3=C(C2=O)C(=CC=C3)Cl)CN1
CHEMBL368016 5ht2c_human Human Yes 7.7 EC50 = 22 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
214 0 1 2 2.8 CC1CNCCC2=C1C(=C(C=C2)Cl)F
CHEMBL210215 5ht2c_human Human No 7.7 EC50 = 22 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL565735 5ht2c_human Human No 6.6 EC50 = 228 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
314 4 1 5 1.2 CC1=CC=CC=C1OCC2=NC(=CC(=O)N2C)N3CCNCC3
CHEMBL565735 5ht2c_human Human No 6.6 EC50 = 228 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
314 4 1 5 1.2 CC1=CC=CC=C1OCC2=NC(=CC(=O)N2C)N3CCNCC3
CHEMBL2331794 5ht2c_human Human No 6.6 EC50 = 229.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
244 3 1 4 2.1 C1CNCCC2=C1C(=NO2)OCC3=CC=CC=C3
CHEMBL1643678 5ht2c_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=C(C=C5)F
CHEMBL210802 5ht2c_human Human Yes 7.6 EC50 = 23 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL1643678 5ht2c_human Human No 7.6 EC50 = 23 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=C(C=C5)F
CHEMBL210802 5ht2c_human Human Yes 7.6 EC50 = 23 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL178566 5ht2c_human Human Yes 6.6 EC50 = 230 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL220274 5ht2c_human Human No 7.6 EC50 = 24 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL220274 5ht2c_human Human No 7.6 EC50 = 24 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL2397902 5ht2c_human Human No 6.6 EC50 = 241 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.8 COC1=CC2=C(C=C1)C(=O)N3CCNCC3C2
CHEMBL222466 5ht2c_human Human No 6.6 EC50 = 246 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C(C=C2C3CNCCN3C(=O)C2=C1)Cl
CHEMBL222466 5ht2c_human Human No 6.6 EC50 = 246 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C(C=C2C3CNCCN3C(=O)C2=C1)Cl
CHEMBL593547 5ht2c_human Human Yes 7.6 EC50 = 25 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
217 1 1 3 1.9 C1CCC2=C(C1)C=CC(=N2)N3CCNCC3
CHEMBL570023 5ht2c_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Cl
CHEMBL572252 5ht2c_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(COC1=CC=CC=C1Cl)N2C(=O)C=CC(=N2)N3CCNCC3
CHEMBL1643677 5ht2c_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC(=CC=C5)F
CHEMBL593547 5ht2c_human Human Yes 7.6 EC50 = 25 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
217 1 1 3 1.9 C1CCC2=C(C1)C=CC(=N2)N3CCNCC3
CHEMBL2397908 5ht2c_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
246 2 1 3 1.2 CCOC1=CC=CC2=C1CC3CNCCN3C2=O
CHEMBL570023 5ht2c_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Cl
CHEMBL572252 5ht2c_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(COC1=CC=CC=C1Cl)N2C(=O)C=CC(=N2)N3CCNCC3
CHEMBL1643677 5ht2c_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC(=CC=C5)F
CHEMBL181672 5ht2c_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=CC(=C2)Cl
CHEMBL253811 5ht2c_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
203 2 1 4 2.5 CC(CC1=CC(=CC=C1)C(F)(F)F)N
CHEMBL181672 5ht2c_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=CC(=C2)Cl
CHEMBL253811 5ht2c_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
203 2 1 4 2.5 CC(CC1=CC(=CC=C1)C(F)(F)F)N
CHEMBL42 5ht2c_human Human Yes 6.6 EC50 = 250 Funct
Inverse agonist activity at human 5HT2C receptor by R-SAT assayInverse agonist activity at human 5HT2C receptor by R-SAT assay
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL2114265 5ht2c_rat Rat Yes 6.6 EC50 = 251.2 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
242 3 1 2 1.7 CC(CN1C=CC2=C1C3=C(C2)C=CC(=C3)OC)N
CHEMBL93850 5ht2c_rat Rat Yes 5.6 EC50 = 2511.9 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
188 2 1 1 1.8 CC1=CC2=C(C=C1)N(C=C2)CC(C)N
CHEMBL317677 5ht2c_rat Rat No 5.6 EC50 = 2511.9 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
188 2 1 1 1.8 CC1=C2C=CN(C2=CC=C1)CC(C)N
CHEMBL320145 5ht2c_rat Rat No 5.6 EC50 = 2511.9 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
291 2 1 1 2.4 CC(CN1C=CC2=C1C3=C(C2)C=CC(=C3)Br)N
CHEMBL91855 5ht2c_rat Rat No 5.6 EC50 = 2511.9 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
247 2 1 1 2.4 CC(CN1C=CC2=C1C3=C(C2)C=CC(=C3)Cl)N
CHEMBL202324 5ht2c_human Human No 6.6 EC50 = 257 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
265 5 1 2 2.8 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC=C
CHEMBL202324 5ht2c_human Human No 6.6 EC50 = 257 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
265 5 1 2 2.8 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC=C
CHEMBL219734 5ht2c_human Human No 7.6 EC50 = 26 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
272 1 1 6 1.5 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)OC(F)(F)F
CHEMBL577690 5ht2c_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
326 4 1 4 1.8 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3C)C
CHEMBL583193 5ht2c_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
347 4 1 4 2.1 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC(=CC=C3)Cl)C
CHEMBL568692 5ht2c_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
295 3 1 3 1.7 C1CC1C2=CC=C(C=C2)CN3C(=O)C=C4CCNCCC4=N3
CHEMBL219734 5ht2c_human Human No 7.6 EC50 = 26 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
272 1 1 6 1.5 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)OC(F)(F)F
CHEMBL577690 5ht2c_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
326 4 1 4 1.8 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3C)C
CHEMBL583193 5ht2c_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
347 4 1 4 2.1 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC(=CC=C3)Cl)C
CHEMBL568692 5ht2c_human Human No 7.6 EC50 = 26 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
295 3 1 3 1.7 C1CC1C2=CC=C(C=C2)CN3C(=O)C=C4CCNCCC4=N3
CHEMBL451543 5ht2c_human Human No 7.6 EC50 = 26 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
222 3 1 3 2.1 CC(CN1CCC2=C1C=C(C=C2)SC)N
CHEMBL594718 5ht2c_human Human No 5.6 EC50 = 2600 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
361 4 1 6 3.5 C1CN(CCN1)C2=NC3=C(C(=N2)OCC4=CC(=CC=C4)Cl)SC=C3
CHEMBL594718 5ht2c_human Human No 5.6 EC50 = 2600 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
361 4 1 6 3.5 C1CN(CCN1)C2=NC3=C(C(=N2)OCC4=CC(=CC=C4)Cl)SC=C3
CHEMBL59619 5ht2c_human Human No 5.6 EC50 = 2600 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
306 0 2 6 1.9 C1CN2C(CN1)C(=O)NC3=C2C=C(C(=C3)C(F)(F)F)Cl
CHEMBL258465 5ht2c_human Human No 6.6 EC50 = 261 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
226 0 1 1 2.3 C1CCC2=C(C1)C3=C4N2CCNCC4=CC=C3
CHEMBL258465 5ht2c_human Human No 6.6 EC50 = 261 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
226 0 1 1 2.3 C1CCC2=C(C1)C3=C4N2CCNCC4=CC=C3
CHEMBL565764 5ht2c_human Human No 6.6 EC50 = 262 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
363 6 1 4 1.8 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC(=CC=C3)Cl
CHEMBL579042 5ht2c_human Human No 6.6 EC50 = 262 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
312 4 1 4 1.5 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3)C
CHEMBL565764 5ht2c_human Human No 6.6 EC50 = 262 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
363 6 1 4 1.8 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC(=CC=C3)Cl
CHEMBL579042 5ht2c_human Human No 6.6 EC50 = 262 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
312 4 1 4 1.5 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3)C
CHEMBL313833 5ht2c_human Human Yes 5.6 EC50 = 2697 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
133 1 1 1 1.5 C1C(C1N)C2=CC=CC=C2
CHEMBL492302 5ht2c_human Human No 6.6 EC50 = 273 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
421 4 1 5 3.8 C1CN(CCC1OC2=CC(=CC=C2)Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL492302 5ht2c_human Human No 6.6 EC50 = 273 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
421 4 1 5 3.8 C1CN(CCC1OC2=CC(=CC=C2)Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL568236 5ht2c_human Human No 6.6 EC50 = 275 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
298 4 1 4 1.0 CN1C(=O)C=C(N=C1CCC2=CC=CC=C2)N3CCNCC3
CHEMBL568236 5ht2c_human Human No 6.6 EC50 = 275 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
298 4 1 4 1.0 CN1C(=O)C=C(N=C1CCC2=CC=CC=C2)N3CCNCC3
CHEMBL219837 5ht2c_human Human No 7.6 EC50 = 28 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL523521 5ht2c_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
393 4 1 5 3.1 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CC(C3)OC4=CC=C(C=C4)Cl
CHEMBL219837 5ht2c_human Human No 7.6 EC50 = 28 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL2397904 5ht2c_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 CC1=CC=CC2=C1CC3CNCCN3C2=O
CHEMBL523521 5ht2c_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
393 4 1 5 3.1 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CC(C3)OC4=CC=C(C=C4)Cl
CHEMBL360968 5ht2c_human Human No 7.6 EC50 = 28 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
284 2 1 2 3.1 CCOC1=C(C=C2C(CNCCC2=C1)C)Br
CHEMBL80482 5ht2c_human Human No 7.6 EC50 = 28 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
232 2 1 3 1.9 CC(CN1CCC2=C1C3=C(C=C2)OCCC3)N
CHEMBL223090 5ht2c_human Human No 6.6 EC50 = 281 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
213 0 1 3 0.1 C1CN2C(CN1)C3=CC=CC(=C3C2=O)C#N
CHEMBL223090 5ht2c_human Human No 6.6 EC50 = 281 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
213 0 1 3 0.1 C1CN2C(CN1)C3=CC=CC(=C3C2=O)C#N
CHEMBL3589595 5ht2c_human Human No 6.6 EC50 = 281.8 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
398 8 1 5 4.0 COC1=CC=CC(=C1F)CNCCC2=CC(=C(C=C2OC)Br)OC
CHEMBL3589595 5ht2c_human Human No 6.6 EC50 = 281.8 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
398 8 1 5 4.0 COC1=CC=CC(=C1F)CNCCC2=CC(=C(C=C2OC)Br)OC
CHEMBL60830 5ht2c_human Human No 6.5 EC50 = 290 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
272 0 2 3 1.7 C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl
CHEMBL576912 5ht2c_human Human No 5.5 EC50 = 2930 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
257 2 1 3 1.4 CN1C2=C(CCNCC2)C(=O)N1CC3=CC=CC=C3
CHEMBL576912 5ht2c_human Human No 5.5 EC50 = 2930 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
257 2 1 3 1.4 CN1C2=C(CCNCC2)C(=O)N1CC3=CC=CC=C3
CHEMBL2331793 5ht2c_human Human No 5.5 EC50 = 2951.2 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
182 2 1 4 0.9 CCOC1=NOC2=C1CCNCC2
CHEMBL375642 5ht2c_human Human No 6.5 EC50 = 296 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 0 5 1.7 CN1CCN2C(C1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL375642 5ht2c_human Human No 6.5 EC50 = 296 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 0 5 1.7 CN1CCN2C(C1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL202656 5ht2c_human Human No 6.5 EC50 = 297 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=NC=C3)N
CHEMBL202656 5ht2c_human Human No 6.5 EC50 = 297 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=NC=C3)N
CHEMBL2260567 5ht2c_human Human No 8.5 EC50 = 3 Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptorAgonist activity at Homo sapiens (human) 5-HT2C receptor
453 2 1 3 6.4 C1CN2C3CNCC3C4=C2C(=CC(=C4)C5=CC=C(C=C5)C6=C(C=C(C=C6)Cl)Cl)SC1
CHEMBL2397887 5ht2c_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.3 CC1CNCC2N1C(=O)C3=CC=CC=C3C2
CHEMBL2397878 5ht2c_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.8 COC1=CC2=C(CC3CNCCN3C2=O)C=C1
CHEMBL180867 5ht2c_human Human No 8.5 EC50 = 3 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
270 1 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL178313 5ht2c_human Human No 8.5 EC50 = 3 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
256 0 2 2 2.5 CC1CNCCC2=CC(=C(C=C12)Br)O
CHEMBL181076 5ht2c_human Human Yes 8.5 EC50 = 3 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL31115 5ht2c_rat Rat Yes 8.5 EC50 = 3.1 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
204 3 2 2 1.0 CC(CC1=CNC2=C1C=C(C=C2)OC)N
CHEMBL31115 5ht2c_rat Rat Yes 8.5 EC50 = 3.1 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
204 3 2 2 1.0 CC(CC1=CNC2=C1C=C(C=C2)OC)N
CHEMBL181076 5ht2c_human Human Yes 8.5 EC50 = 3.2 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL181076 5ht2c_human Human Yes 8.5 EC50 = 3.2 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL594717 5ht2c_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
355 4 1 5 3.2 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)C)C=C2
CHEMBL594717 5ht2c_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
355 4 1 5 3.2 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)C)C=C2
CHEMBL360328 5ht2c_human Human Yes 8.4 EC50 = 3.6 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_human Human Yes 8.4 EC50 = 3.6 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL371300 5ht2c_rat Rat Yes 8.4 EC50 = 3.7 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL371300 5ht2c_rat Rat Yes 8.4 EC50 = 3.7 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL178366 5ht2c_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL253591 5ht2c_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL253807 5ht2c_human Human Yes 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=C1C(=C(C=C2)Cl)F
CHEMBL76781 5ht2c_human Human Yes 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL178366 5ht2c_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL253591 5ht2c_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL253807 5ht2c_human Human Yes 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=C1C(=C(C=C2)Cl)F
CHEMBL76781 5ht2c_human Human Yes 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL578364 5ht2c_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
368 4 1 8 1.7 CN1C(=O)C=C(N=C1COC2=CC=CC=C2C(F)(F)F)N3CCNCC3
CHEMBL577691 5ht2c_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC(=CC=C3)Cl
CHEMBL578364 5ht2c_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
368 4 1 8 1.7 CN1C(=O)C=C(N=C1COC2=CC=CC=C2C(F)(F)F)N3CCNCC3
CHEMBL577691 5ht2c_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC(=CC=C3)Cl
CHEMBL134519 5ht2c_rat Rat Yes 7.5 EC50 = 30.2 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL134519 5ht2c_rat Rat Yes 7.5 EC50 = 30.2 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL134519 5ht2c_rat Rat Yes 7.5 EC50 = 30.2 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL134519 5ht2c_rat Rat Yes 7.5 EC50 = 30.2 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL1770385 5ht2c_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
307 2 1 6 2.9 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)C(F)(F)F
CHEMBL1770385 5ht2c_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
307 2 1 6 2.9 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)C(F)(F)F
CHEMBL524778 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
255 2 1 3 0.8 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3
CHEMBL585012 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)Cl
CHEMBL524171 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
393 4 1 5 3.1 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CC(C3)OC4=CC=CC=C4Cl
CHEMBL492301 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
421 4 1 5 3.8 C1CN(CCC1OC2=CC=CC=C2Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL492557 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
407 4 1 5 3.4 C1CN(CC1OC2=CC=CC=C2Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL524778 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
255 2 1 3 0.8 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3
CHEMBL585012 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)Cl
CHEMBL524171 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
393 4 1 5 3.1 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)N3CC(C3)OC4=CC=CC=C4Cl
CHEMBL492301 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
421 4 1 5 3.8 C1CN(CCC1OC2=CC=CC=C2Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL492557 5ht2c_human Human No 7.5 EC50 = 31 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
407 4 1 5 3.4 C1CN(CC1OC2=CC=CC=C2Cl)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL80366 5ht2c_human Human No 7.5 EC50 = 31 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
229 2 1 3 2.3 CC(CN1CCC2=CC(=C(C=C21)Cl)F)N
CHEMBL1770377 5ht2c_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)F
CHEMBL1770377 5ht2c_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)F
CHEMBL178566 5ht2c_human Human Yes 6.5 EC50 = 316.2 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL367796 5ht2c_human Human Yes 6.5 EC50 = 316.2 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
161 0 1 1 2.1 CC1CNCCC2=CC=CC=C12
CHEMBL178566 5ht2c_human Human Yes 6.5 EC50 = 316.2 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL367796 5ht2c_human Human Yes 6.5 EC50 = 316.2 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
161 0 1 1 2.1 CC1CNCCC2=CC=CC=C12
CHEMBL2114266 5ht2c_rat Rat No 6.5 EC50 = 316.2 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
227 2 1 2 2.2 CC(CN1C=CC2=C1C=CC(=C2Cl)F)N
CHEMBL253155 5ht2c_human Human Yes 5.5 EC50 = 3162.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
147 0 1 1 1.8 C1CNCCC2=CC=CC=C21
CHEMBL253155 5ht2c_human Human Yes 5.5 EC50 = 3162.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
147 0 1 1 1.8 C1CNCCC2=CC=CC=C21
CHEMBL574985 5ht2c_rat Rat No 5.5 EC50 = 3162.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL578564 5ht2c_human Human No 6.5 EC50 = 319 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
325 4 1 6 0.6 CN1C(=O)C=C(N=C1COC2=CC=CC(=C2)C#N)N3CCNCC3
CHEMBL209106 5ht2c_human Human Yes 6.5 EC50 = 319 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
206 1 1 3 1.9 C1CN(C2C1CNC2)C3=CC(=CC=C3)F
CHEMBL578564 5ht2c_human Human No 6.5 EC50 = 319 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
325 4 1 6 0.6 CN1C(=O)C=C(N=C1COC2=CC=CC(=C2)C#N)N3CCNCC3
CHEMBL209106 5ht2c_human Human Yes 6.5 EC50 = 319 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
206 1 1 3 1.9 C1CN(C2C1CNC2)C3=CC(=CC=C3)F
CHEMBL3589582 5ht2c_human Human No 7.5 EC50 = 32.4 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
392 7 1 4 3.9 COC1=CC(=C(C=C1CCNCC2=CC=CC3=C2OCC3)OC)Br
CHEMBL3589582 5ht2c_human Human No 7.5 EC50 = 32.4 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
392 7 1 4 3.9 COC1=CC(=C(C=C1CCNCC2=CC=CC3=C2OCC3)OC)Br
CHEMBL2397895 5ht2c_human Human No 6.5 EC50 = 320 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
227 0 1 3 0.5 C1CN2C(CC3=CC=CC(=C3C2=O)C#N)CN1
CHEMBL584210 5ht2c_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3Cl
CHEMBL3286564 5ht2c_human Human No 7.5 EC50 = 33 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
324 3 1 5 2.1 C1CNCCC2=C1C(=NC(=N2)CC3=CC=CC=C3)N4CCOCC4
CHEMBL2397886 5ht2c_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.3 CC1CNCC2N1C(=O)C3=CC=CC=C3C2
CHEMBL584210 5ht2c_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3Cl
CHEMBL3286564 5ht2c_human Human No 7.5 EC50 = 33 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
324 3 1 5 2.1 C1CNCCC2=C1C(=NC(=N2)CC3=CC=CC=C3)N4CCOCC4
CHEMBL1770378 5ht2c_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=CC=C1CC2=NC=C3CCNCCC3=N2
CHEMBL2397885 5ht2c_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.3 CC1CN2C(CC3=CC=CC=C3C2=O)CN1
CHEMBL1770378 5ht2c_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=CC=C1CC2=NC=C3CCNCCC3=N2
CHEMBL2397906 5ht2c_human Human No 5.5 EC50 = 3337 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
270 0 1 5 1.7 C1CN2C(CC3=C(C2=O)C=CC=C3C(F)(F)F)CN1
CHEMBL571512 5ht2c_human Human No 6.5 EC50 = 338 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
179 0 1 3 -0.7 CN1C(=O)C=C2CCNCCC2=N1
CHEMBL571512 5ht2c_human Human No 6.5 EC50 = 338 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
179 0 1 3 -0.7 CN1C(=O)C=C2CCNCCC2=N1
CHEMBL590331 5ht2c_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 CC1=CC2=C(C=C1)C(=O)NC3N2CCNC3
CHEMBL590331 5ht2c_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 CC1=CC2=C(C=C1)C(=O)NC3N2CCNC3
CHEMBL367796 5ht2c_human Human Yes 6.5 EC50 = 340 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
161 0 1 1 2.1 CC1CNCCC2=CC=CC=C12
CHEMBL492696 5ht2c_human Human No 5.5 EC50 = 3416 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
189 4 1 1 3.0 CC(C)NCC1CC1C2=CC=CC=C2
CHEMBL492696 5ht2c_human Human No 5.5 EC50 = 3416 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
189 4 1 1 3.0 CC(C)NCC1CC1C2=CC=CC=C2
CHEMBL201117 5ht2c_human Human No 6.5 EC50 = 348 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
321 5 1 2 4.6 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4CCCCC4
CHEMBL201117 5ht2c_human Human No 6.5 EC50 = 348 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
321 5 1 2 4.6 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4CCCCC4
CHEMBL375575 5ht2c_human Human No 7.5 EC50 = 35 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
291 0 1 5 1.8 C1CN2C(CN1)C3=C(C=CC(=C3C2=O)C(F)(F)F)Cl
CHEMBL375575 5ht2c_human Human No 7.5 EC50 = 35 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
291 0 1 5 1.8 C1CN2C(CN1)C3=C(C=CC(=C3C2=O)C(F)(F)F)Cl
CHEMBL181672 5ht2c_human Human Yes 7.5 EC50 = 35 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=CC(=C2)Cl
CHEMBL2397881 5ht2c_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
202 0 1 2 0.8 C1CN2C(CC3=CC=CC=C3C2=O)CN1
CHEMBL3425757 5ht2c_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assayAgonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assay
309 5 2 3 4.3 CC(C)CNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL571826 5ht2c_human Human No 6.4 EC50 = 360 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(CN1C(=O)C=CC(=N1)N2CCNCC2)OC3=CC=CC=C3Cl
CHEMBL571826 5ht2c_human Human No 6.4 EC50 = 360 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(CN1C(=O)C=CC(=N1)N2CCNCC2)OC3=CC=CC=C3Cl
CHEMBL568741 5ht2c_human Human No 6.4 EC50 = 361 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
353 4 1 6 1.6 CN1C(=O)C=C(N=C1COC2=C(C=CC(=C2)F)Cl)N3CCNCC3
CHEMBL568741 5ht2c_human Human No 6.4 EC50 = 361 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
353 4 1 6 1.6 CN1C(=O)C=C(N=C1COC2=C(C=CC(=C2)F)Cl)N3CCNCC3
CHEMBL1643673 5ht2c_human Human No 6.4 EC50 = 362 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
245 2 1 4 1.0 CCN(C)C1=C2CCNCCC2=NC3=CC=NN31
CHEMBL1643673 5ht2c_human Human No 6.4 EC50 = 362 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
245 2 1 4 1.0 CCN(C)C1=C2CCNCCC2=NC3=CC=NN31
CHEMBL373483 5ht2c_human Human No 6.4 EC50 = 363 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
312 3 1 5 3.1 CCCCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL373483 5ht2c_human Human No 6.4 EC50 = 363 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
312 3 1 5 3.1 CCCCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL492303 5ht2c_human Human No 6.4 EC50 = 365 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
481 6 1 7 3.7 COC1=CC(=C(C2=C1CCNCC2)OC)S(=O)(=O)N3CCC(CC3)OC4=CC=CC=C4Cl
CHEMBL492303 5ht2c_human Human No 6.4 EC50 = 365 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
481 6 1 7 3.7 COC1=CC(=C(C2=C1CCNCC2)OC)S(=O)(=O)N3CCC(CC3)OC4=CC=CC=C4Cl
CHEMBL223896 5ht2c_human Human No 7.4 EC50 = 37 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
223 0 1 2 1.0 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)Cl
CHEMBL1643855 5ht2c_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.5 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=N5
CHEMBL223896 5ht2c_human Human No 7.4 EC50 = 37 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
223 0 1 2 1.0 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)Cl
CHEMBL1643855 5ht2c_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.5 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=N5
CHEMBL1090757 5ht2c_human Human No 7.4 EC50 = 38 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
314 5 2 4 2.8 C1CC(NC1)C(=O)NCC2=CC=C(C=C2)OC3=CC(=CC=C3)F
CHEMBL1090757 5ht2c_human Human No 7.4 EC50 = 38 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
314 5 2 4 2.8 C1CC(NC1)C(=O)NCC2=CC=C(C=C2)OC3=CC(=CC=C3)F
CHEMBL1770368 5ht2c_human Human Yes 6.4 EC50 = 380 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
211 1 1 3 1.3 C1CNCC2=NC(=NC=C21)C3=CC=CC=C3
CHEMBL1770368 5ht2c_human Human Yes 6.4 EC50 = 380 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
211 1 1 3 1.3 C1CNCC2=NC(=NC=C21)C3=CC=CC=C3
CHEMBL391196 5ht2c_rat Rat No 7.4 EC50 = 39 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
314 2 2 4 1.3 CC(C(C1=C2CCOC2=C(C3=C1OCC3)Br)O)N
CHEMBL3286561 5ht2c_human Human No 7.4 EC50 = 39 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
268 3 2 4 2.4 CNC1=NC(=NC2=C1CCNCC2)CC3=CC=CC=C3
CHEMBL391196 5ht2c_rat Rat No 7.4 EC50 = 39 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
314 2 2 4 1.3 CC(C(C1=C2CCOC2=C(C3=C1OCC3)Br)O)N
CHEMBL3286561 5ht2c_human Human No 7.4 EC50 = 39 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
268 3 2 4 2.4 CNC1=NC(=NC2=C1CCNCC2)CC3=CC=CC=C3
CHEMBL253809 5ht2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_human Human Yes 7.4 EC50 = 39.8 Funct
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL253809 5ht2c_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL178252 5ht2c_human Human Yes 6.4 EC50 = 398.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
179 0 1 2 2.2 CC1CNCCC2=C1C=C(C=C2)F
CHEMBL178252 5ht2c_human Human Yes 6.4 EC50 = 398.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
179 0 1 2 2.2 CC1CNCCC2=C1C=C(C=C2)F
CHEMBL414163 5ht2c_rat Rat No 6.4 EC50 = 398.1 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
242 3 1 2 1.7 CC(CN1C=CC2=C1C3=C(C2)C=CC(=C3)OC)N
CHEMBL313856 5ht2c_rat Rat No 6.4 EC50 = 398.1 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)F)Cl)N
CHEMBL2260565 5ht2c_human Human No 8.4 EC50 = 4 Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assay
258 4 1 2 2.5 CCOC1=CC2=C(C=C1)N3CCCC3=C2CC(C)N
CHEMBL2397897 5ht2c_human Human No 8.4 EC50 = 4 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 1 1 2 1.6 CCC1=CC2=C(CC3CNCCN3C2=O)C=C1
CHEMBL179915 5ht2c_human Human No 8.4 EC50 = 4 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
259 1 1 5 3.0 CC1CNCCC2=CC(=C(C=C12)C(F)(F)F)OC
CHEMBL178366 5ht2c_human Human No 8.4 EC50 = 4 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL199385 5ht2c_rat Rat Yes 8.4 EC50 = 4.5 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
177 2 2 4 -0.3 C1=CC2=CNN(C2=CC1=O)CCN
CHEMBL232995 5ht2c_rat Rat No 8.4 EC50 = 4.5 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
383 8 1 6 2.8 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCC(=O)OC4=CC=CC=C4)N
CHEMBL1770373 5ht2c_human Human Yes 8.4 EC50 = 4.5 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770373 5ht2c_human Human Yes 8.4 EC50 = 4.5 Funct
Agonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL199385 5ht2c_rat Rat Yes 8.4 EC50 = 4.5 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
177 2 2 4 -0.3 C1=CC2=CNN(C2=CC1=O)CCN
CHEMBL232995 5ht2c_rat Rat No 8.4 EC50 = 4.5 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
383 8 1 6 2.8 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCC(=O)OC4=CC=CC=C4)N
CHEMBL1770373 5ht2c_human Human Yes 8.4 EC50 = 4.5 Funct
Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL1770373 5ht2c_human Human Yes 8.4 EC50 = 4.5 Funct
Agonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay
239 2 1 3 2.1 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3
CHEMBL77880 5ht2c_human Human Yes 8.4 EC50 = 4.5 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
218 2 1 3 1.6 CC(CN1CCC2=C1C3=C(C=C2)OCC3)N
CHEMBL373245 5ht2c_rat Rat Yes 8.3 EC50 = 4.9 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
226 2 2 4 1.0 CC(CN1C2=C(C(=O)C=CC2=CN1)Cl)N
CHEMBL373245 5ht2c_rat Rat Yes 8.3 EC50 = 4.9 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
226 2 2 4 1.0 CC(CN1C2=C(C(=O)C=CC2=CN1)Cl)N
CHEMBL1093699 5ht2c_human Human No 8.3 EC50 = 5.0 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
364 7 2 5 3.6 COC1=CC(=C(C=C1CNC(=O)C2CCCN2)F)OCC3CCCCC3
CHEMBL1093699 5ht2c_human Human No 8.3 EC50 = 5.0 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
364 7 2 5 3.6 COC1=CC(=C(C=C1CNC(=O)C2CCCN2)F)OCC3CCCCC3
CHEMBL360328 5ht2c_human Human Yes 7.4 EC50 = 40 Funct
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assayAgonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL80862 5ht2c_human Human No 7.4 EC50 = 40 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
236 4 1 3 2.4 CCSC1=CC2=C(CCN2CC(C)N)C=C1
CHEMBL594477 5ht2c_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
220 1 1 5 0.6 C1CN(CCN1)C2=NC=NC3=C2SC=C3
CHEMBL594477 5ht2c_human Human Yes 6.4 EC50 = 400 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
220 1 1 5 0.6 C1CN(CCN1)C2=NC=NC3=C2SC=C3
CHEMBL572231 5ht2c_human Human No 6.4 EC50 = 407 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
363 6 1 4 2.1 CCC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Cl
CHEMBL572231 5ht2c_human Human No 6.4 EC50 = 407 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
363 6 1 4 2.1 CCC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3Cl
CHEMBL492556 5ht2c_human Human No 7.4 EC50 = 41 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
372 4 1 5 2.4 CN(CC1COC2=CC=CC=C12)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL492556 5ht2c_human Human No 7.4 EC50 = 41 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
372 4 1 5 2.4 CN(CC1COC2=CC=CC=C12)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL353998 5ht2c_human Human No 7.4 EC50 = 41 Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
246 2 1 2 2.5 CC1CCC2=C3N1C(=C(C3=CC(=C2)F)CCN)C
CHEMBL178252 5ht2c_human Human Yes 6.4 EC50 = 410 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
179 0 1 2 2.2 CC1CNCCC2=C1C=C(C=C2)F
CHEMBL2331807 5ht2c_human Human No 6.4 EC50 = 416.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
244 2 1 3 1.3 C1CNCCC2=C1C(=O)N(O2)CC3=CC=CC=C3
CHEMBL590332 5ht2c_human Human No 5.4 EC50 = 4197 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 CC1=CC=CC2=C1N3CCNCC3NC2=O
CHEMBL590332 5ht2c_human Human No 5.4 EC50 = 4197 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 CC1=CC=CC2=C1N3CCNCC3NC2=O
CHEMBL220207 5ht2c_human Human No 7.4 EC50 = 42 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
234 1 1 3 0.8 CSC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL202458 5ht2c_human Human No 7.4 EC50 = 42 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
359 5 1 4 3.5 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=C(C=C4)OCO5
CHEMBL220207 5ht2c_human Human No 7.4 EC50 = 42 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
234 1 1 3 0.8 CSC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL202458 5ht2c_human Human No 7.4 EC50 = 42 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
359 5 1 4 3.5 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=C(C=C4)OCO5
CHEMBL209155 5ht2c_human Human No 6.4 EC50 = 420 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
255 1 1 4 3.4 C1CC(C2C1CNC2)C3=CC(=CC=C3)C(F)(F)F
CHEMBL361742 5ht2c_human Human Yes 6.4 EC50 = 420 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
191 1 1 2 2.1 CC1CNCCC2=C1C=C(C=C2)OC
CHEMBL209155 5ht2c_human Human No 6.4 EC50 = 420 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
255 1 1 4 3.4 C1CC(C2C1CNC2)C3=CC(=CC=C3)C(F)(F)F
CHEMBL222566 5ht2c_human Human No 7.4 EC50 = 43 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
282 1 1 5 2.0 C=CC1=CC2=C(C(=C1)C(F)(F)F)C(=O)N3C2CNCC3
CHEMBL605402 5ht2c_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
238 0 2 3 1.2 C1CN2C(CN1)NC(=O)C3=C2C=CC=C3Cl
CHEMBL222566 5ht2c_human Human No 7.4 EC50 = 43 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
282 1 1 5 2.0 C=CC1=CC2=C(C(=C1)C(F)(F)F)C(=O)N3C2CNCC3
CHEMBL605402 5ht2c_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
238 0 2 3 1.2 C1CN2C(CN1)NC(=O)C3=C2C=CC=C3Cl
CHEMBL1093698 5ht2c_human Human No 7.4 EC50 = 44 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
352 5 2 5 3.4 CC1CCC(CC1)OC2=C(C=C(C=C2F)CNC(=O)C3CCCN3)F
CHEMBL1093698 5ht2c_human Human No 7.4 EC50 = 44 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
352 5 2 5 3.4 CC1CCC(CC1)OC2=C(C=C(C=C2F)CNC(=O)C3CCCN3)F
CHEMBL76307 5ht2c_human Human No 7.4 EC50 = 44 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
211 2 1 2 2.2 CC(CN1CCC2=C1C=C(C=C2)Cl)N
CHEMBL309760 5ht2c_human Human Yes 7.4 EC50 = 44 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
255 2 1 2 2.3 CC(CN1CCC2=C1C=C(C=C2)Br)N
CHEMBL590078 5ht2c_human Human No 7.4 EC50 = 45 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 CC1=C2C(=CC=C1)N3CCNCC3NC2=O
CHEMBL61695 5ht2c_human Human No 7.4 EC50 = 45 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
258 0 2 3 2.5 C1CN2C(CN1)CNC3=CC(=C(C=C32)Cl)Cl
CHEMBL1643672 5ht2c_human Human No 5.3 EC50 = 4564 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
271 1 1 4 1.5 C1CCN(CC1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL1643672 5ht2c_human Human No 5.3 EC50 = 4564 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
271 1 1 4 1.5 C1CCN(CC1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL223466 5ht2c_human Human No 7.3 EC50 = 46 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
251 1 1 2 1.8 CCC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL577832 5ht2c_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
332 4 1 6 1.3 CC1=C(C=C(C=C1)F)OCC2=NC(=CC(=O)N2C)N3CCNCC3
CHEMBL492349 5ht2c_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
351 4 2 4 2.9 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NCC3=CC=CC=C3Cl
CHEMBL223466 5ht2c_human Human No 7.3 EC50 = 46 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
251 1 1 2 1.8 CCC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL577832 5ht2c_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
332 4 1 6 1.3 CC1=C(C=C(C=C1)F)OCC2=NC(=CC(=O)N2C)N3CCNCC3
CHEMBL492349 5ht2c_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
351 4 2 4 2.9 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NCC3=CC=CC=C3Cl
CHEMBL570274 5ht2c_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
382 5 1 7 1.8 CC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C(F)(F)F
CHEMBL492949 5ht2c_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
254 2 1 4 0.9 CN(C)S(=O)(=O)C1=CC2=C(CCNCC2)C=C1
CHEMBL569342 5ht2c_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
368 5 1 7 1.4 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C(F)(F)F
CHEMBL570274 5ht2c_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
382 5 1 7 1.8 CC1CNCCN1C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C(F)(F)F
CHEMBL492949 5ht2c_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
254 2 1 4 0.9 CN(C)S(=O)(=O)C1=CC2=C(CCNCC2)C=C1
CHEMBL569342 5ht2c_human Human No 7.3 EC50 = 47 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
368 5 1 7 1.4 C1CN(CCN1)C2=NN(C(=O)C=C2)CCOC3=CC=CC=C3C(F)(F)F
CHEMBL373402 5ht2c_human Human No 6.3 EC50 = 478 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL373402 5ht2c_human Human No 6.3 EC50 = 478 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL571288 5ht2c_human Human No 7.3 EC50 = 48 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
339 3 1 7 2.0 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)OC(F)(F)F
CHEMBL2397905 5ht2c_human Human No 7.3 EC50 = 48 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 1 1 2 1.6 CCC1=CC=CC2=C1CC3CNCCN3C2=O
CHEMBL571288 5ht2c_human Human No 7.3 EC50 = 48 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
339 3 1 7 2.0 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)OC(F)(F)F
CHEMBL375302 5ht2c_human Human No 6.3 EC50 = 480 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.2 CCC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL375302 5ht2c_human Human No 6.3 EC50 = 480 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.2 CCC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL1770374 5ht2c_human Human No 5.3 EC50 = 4800 Funct
Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay
253 3 1 3 2.4 C1CNCCC2=NC(=NC=C21)CCC3=CC=CC=C3
CHEMBL1770374 5ht2c_human Human No 5.3 EC50 = 4800 Funct
Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay
253 3 1 3 2.4 C1CNCCC2=NC(=NC=C21)CCC3=CC=CC=C3
CHEMBL565736 5ht2c_human Human No 6.3 EC50 = 487 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
368 4 1 8 1.7 CN1C(=O)C=C(N=C1COC2=CC=CC(=C2)C(F)(F)F)N3CCNCC3
CHEMBL565736 5ht2c_human Human No 6.3 EC50 = 487 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
368 4 1 8 1.7 CN1C(=O)C=C(N=C1COC2=CC=CC(=C2)C(F)(F)F)N3CCNCC3
CHEMBL223440 5ht2c_human Human No 7.3 EC50 = 49 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
251 1 1 2 1.8 CCC1=CC(=C2C(=C1)C3CNCCN3C2=O)Cl
CHEMBL223440 5ht2c_human Human No 7.3 EC50 = 49 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
251 1 1 2 1.8 CCC1=CC(=C2C(=C1)C3CNCCN3C2=O)Cl
CHEMBL291794 5ht2c_human Human No 7.3 EC50 = 49 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
258 0 2 3 2.5 C1CN2C(CN1)CNC3=CC(=C(C=C32)Cl)Cl
CHEMBL572183 5ht2c_human Human No 6.3 EC50 = 493 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
335 4 1 5 1.5 CN1C(=O)C=C(N=C1COC2=CC(=CC=C2)Cl)N3CCNCC3
CHEMBL572183 5ht2c_human Human No 6.3 EC50 = 493 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
335 4 1 5 1.5 CN1C(=O)C=C(N=C1COC2=CC(=CC=C2)Cl)N3CCNCC3
CHEMBL568005 5ht2c_human Human No 5.3 EC50 = 4980 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
227 2 1 2 1.7 C1CNCCC2=NN(C=C21)CC3=CC=CC=C3
CHEMBL568005 5ht2c_human Human No 5.3 EC50 = 4980 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
227 2 1 2 1.7 C1CNCCC2=NN(C=C21)CC3=CC=CC=C3
CHEMBL373531 5ht2c_human Human No 8.3 EC50 = 5 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL1643676 5ht2c_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5F
CHEMBL373531 5ht2c_human Human No 8.3 EC50 = 5 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL2397889 5ht2c_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 CC1=CC=CC2=C1C(=O)N3CCNCC3C2
CHEMBL1643676 5ht2c_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5F
CHEMBL180815 5ht2c_human Human No 8.3 EC50 = 5 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
270 1 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL182184 5ht2c_human Human No 8.3 EC50 = 5 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
270 1 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL1643670 5ht2c_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
243 1 1 4 0.8 C1CN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL1643670 5ht2c_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
243 1 1 4 0.8 C1CN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL197653 5ht2c_rat Rat Yes 8.3 EC50 = 5.5 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
209 2 2 5 0.5 CC(CN1C2=C(C(=O)C=CC2=CN1)F)N
CHEMBL197653 5ht2c_rat Rat Yes 8.3 EC50 = 5.5 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
209 2 2 5 0.5 CC(CN1C2=C(C(=O)C=CC2=CN1)F)N
CHEMBL355474 5ht2c_human Human No 8.2 EC50 = 5.7 Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
232 2 1 2 2.1 CC1CCC2=C3N1C=C(C3=CC(=C2)F)CCN
CHEMBL522514 5ht2c_human Human No 7.3 EC50 = 50 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
280 2 1 4 1.4 C1CCN(C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL522514 5ht2c_human Human No 7.3 EC50 = 50 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
280 2 1 4 1.4 C1CCN(C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL399750 5ht2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)OC)Cl
CHEMBL399750 5ht2c_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)OC)Cl
CHEMBL595196 5ht2c_human Human No 5.3 EC50 = 5000 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
248 2 1 5 1.5 COC1=NC(=NC2=C1CCCC2)N3CCNCC3
CHEMBL595196 5ht2c_human Human No 5.3 EC50 = 5000 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
248 2 1 5 1.5 COC1=NC(=NC2=C1CCCC2)N3CCNCC3
CHEMBL96312 5ht2c_rat Rat No 6.3 EC50 = 501.2 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
226 2 1 1 2.1 CC1=CC2=C(CC3=C2N(C=C3)CC(C)N)C=C1
CHEMBL209254 5ht2c_human Human No 6.3 EC50 = 503 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
223 1 1 2 2.5 C1CN(C2C1CNC2)C3=CC(=CC=C3)Cl
CHEMBL209254 5ht2c_human Human No 6.3 EC50 = 503 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
223 1 1 2 2.5 C1CN(C2C1CNC2)C3=CC(=CC=C3)Cl
CHEMBL194378 5ht2c_human Human Yes 6.3 EC50 = 506 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay
284 5 3 5 -1.6 CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O
CHEMBL194378 5ht2c_human Human Yes 6.3 EC50 = 506 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay
284 5 3 5 -1.6 CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O
CHEMBL521644 5ht2c_human Human No 6.3 EC50 = 508 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
387 4 1 5 3.2 C1CN(CCC1OC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL521644 5ht2c_human Human No 6.3 EC50 = 508 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
387 4 1 5 3.2 C1CN(CCC1OC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(CCNCC4)C=C3
CHEMBL3286560 5ht2c_human Human Yes 7.3 EC50 = 51 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
269 3 1 4 2.4 COC1=NC(=NC2=C1CCNCC2)CC3=CC=CC=C3
CHEMBL3286560 5ht2c_human Human Yes 7.3 EC50 = 51 Funct
Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
269 3 1 4 2.4 COC1=NC(=NC2=C1CCNCC2)CC3=CC=CC=C3
CHEMBL569208 5ht2c_human Human No 6.3 EC50 = 510 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC1=CC(=O)N(N=C1N2CCNCC2)CCOC3=CC=CC=C3Cl
CHEMBL569208 5ht2c_human Human No 6.3 EC50 = 510 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC1=CC(=O)N(N=C1N2CCNCC2)CCOC3=CC=CC=C3Cl
CHEMBL387344 5ht2c_human Human No 6.3 EC50 = 514 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
204 0 2 3 0.5 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)O
CHEMBL387344 5ht2c_human Human No 6.3 EC50 = 514 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
204 0 2 3 0.5 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)O
CHEMBL425423 5ht2c_human Human No 6.3 EC50 = 519 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL425423 5ht2c_human Human No 6.3 EC50 = 519 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL76781 5ht2c_human Human Yes 7.3 EC50 = 52 Funct
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL202616 5ht2c_human Human No 7.3 EC50 = 52 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
365 5 1 2 4.9 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=CC=CC=C5C=C4
CHEMBL76781 5ht2c_human Human Yes 7.3 EC50 = 52 Funct
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL202616 5ht2c_human Human No 7.3 EC50 = 52 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
365 5 1 2 4.9 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=CC=CC=C5C=C4
CHEMBL596108 5ht2c_human Human Yes 6.3 EC50 = 530 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
220 1 1 5 0.9 C1CN(CCN1)C2=C3C=CSC3=NC=N2
CHEMBL596108 5ht2c_human Human Yes 6.3 EC50 = 530 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
220 1 1 5 0.9 C1CN(CCN1)C2=C3C=CSC3=NC=N2
CHEMBL220833 5ht2c_human Human No 7.3 EC50 = 54 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
310 1 1 5 2.7 CC1(CC1)C2=CC3=C(C(=C2)C(F)(F)F)C(=O)N4C3CNCC4
CHEMBL223292 5ht2c_human Human No 7.3 EC50 = 54 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
237 0 1 2 1.3 CC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL438611 5ht2c_human Human No 7.3 EC50 = 54 Funct
Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration
208 0 1 1 2.6 CC1C2CNCC2C3=C1C=C(C=C3)Cl
CHEMBL220833 5ht2c_human Human No 7.3 EC50 = 54 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
310 1 1 5 2.7 CC1(CC1)C2=CC3=C(C(=C2)C(F)(F)F)C(=O)N4C3CNCC4
CHEMBL223292 5ht2c_human Human No 7.3 EC50 = 54 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
237 0 1 2 1.3 CC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL438611 5ht2c_human Human No 7.3 EC50 = 54 Funct
Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration
208 0 1 1 2.6 CC1C2CNCC2C3=C1C=C(C=C3)Cl
CHEMBL2397880 5ht2c_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 CC1=CC2=C(C=C1)C(=O)N3CCNCC3C2
CHEMBL2397898 5ht2c_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 1 1 2 1.6 CCC1=CC2=C(C=C1)C(=O)N3CCNCC3C2
CHEMBL383042 5ht2c_human Human No 6.3 EC50 = 551 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
345 6 1 3 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4OC
CHEMBL383042 5ht2c_human Human No 6.3 EC50 = 551 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
345 6 1 3 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4OC
CHEMBL565531 5ht2c_human Human No 7.3 EC50 = 56 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
363 6 1 4 1.8 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=CC=C3Cl
CHEMBL2397888 5ht2c_human Human No 7.3 EC50 = 56 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 CC1C2CNCCN2C(=O)C3=CC=CC=C13
CHEMBL565531 5ht2c_human Human No 7.3 EC50 = 56 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
363 6 1 4 1.8 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=CC=C3Cl
CHEMBL179244 5ht2c_human Human No 7.3 EC50 = 56 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
346 3 1 2 4.3 CC1CNCCC2=CC(=C(C=C12)Br)OCC3=CC=CC=C3
CHEMBL492698 5ht2c_human Human No 5.2 EC50 = 5697 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
237 5 1 1 3.4 C1C(C1C2=CC=CC=C2)CNCC3=CC=CC=C3
CHEMBL492698 5ht2c_human Human No 5.2 EC50 = 5697 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
237 5 1 1 3.4 C1C(C1C2=CC=CC=C2)CNCC3=CC=CC=C3
CHEMBL210484 5ht2c_human Human No 7.2 EC50 = 57 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL210484 5ht2c_human Human No 7.2 EC50 = 57 Funct
Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL1643857 5ht2c_human Human No 6.2 EC50 = 574 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=NC=C5
CHEMBL1643857 5ht2c_human Human No 6.2 EC50 = 574 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=NC=C5
CHEMBL2397900 5ht2c_human Human No 6.2 EC50 = 583 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
270 0 1 5 1.7 C1CN2C(CC3=C(C2=O)C=CC(=C3)C(F)(F)F)CN1
CHEMBL198124 5ht2c_human Human Yes 6.2 EC50 = 595 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay
260 6 1 2 3.1 CCCCN1C=C(C2=C1C=CC=C2O)CCN(C)C
CHEMBL198124 5ht2c_human Human Yes 6.2 EC50 = 595 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay
260 6 1 2 3.1 CCCCN1C=C(C2=C1C=CC=C2O)CCN(C)C
CHEMBL374562 5ht2c_human Human No 8.2 EC50 = 6 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.6 CC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL425777 5ht2c_human Human No 8.2 EC50 = 6 Funct
Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration
238 1 1 2 2.5 CC1C2CNCC2C3=CC(=C(C=C13)Cl)OC
CHEMBL374562 5ht2c_human Human No 8.2 EC50 = 6 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.6 CC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL2397912 5ht2c_human Human No 8.2 EC50 = 6 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
246 1 1 3 1.2 CC1=C2C(=C(C=C1)OC)CC3CNCCN3C2=O
CHEMBL178231 5ht2c_human Human Yes 8.2 EC50 = 6 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL425777 5ht2c_human Human No 8.2 EC50 = 6 Funct
Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration
238 1 1 2 2.5 CC1C2CNCC2C3=CC(=C(C=C13)Cl)OC
CHEMBL178124 5ht2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL360492 5ht2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Cl)F
CHEMBL400600 5ht2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL178124 5ht2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL360492 5ht2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Cl)F
CHEMBL400600 5ht2c_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL590531 5ht2c_human Human No 8.2 EC50 = 6.6 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 1.3 CC1=CC2=C(C=C1)C(=O)NC3N2CCNCC3
CHEMBL199775 5ht2c_rat Rat Yes 8.2 EC50 = 6.7 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
205 3 1 3 1.0 CC(CN1C2=C(C=CC(=C2)OC)C=N1)N
CHEMBL199775 5ht2c_rat Rat Yes 8.2 EC50 = 6.7 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
205 3 1 3 1.0 CC(CN1C2=C(C=CC(=C2)OC)C=N1)N
CHEMBL76474 5ht2c_human Human Yes 8.2 EC50 = 6.7 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
240 3 1 4 2.2 CC(CN1CCC2=CC(=C(C=C21)SC)F)N
CHEMBL201454 5ht2c_human Human No 8.2 EC50 = 6.9 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
260 2 1 2 2.3 CC(CN1C=CC2=CC(=C3C(=C21)C=CC=N3)Cl)N
CHEMBL201454 5ht2c_human Human No 8.2 EC50 = 6.9 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
260 2 1 2 2.3 CC(CN1C=CC2=CC(=C3C(=C21)C=CC=N3)Cl)N
CHEMBL2397879 5ht2c_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
227 0 1 3 0.5 C1CN2C(CC3=C(C2=O)C=C(C=C3)C#N)CN1
CHEMBL590580 5ht2c_rat Rat No 7.2 EC50 = 61 Funct
Agonist activity at 5HT2C receptor in rat fundusAgonist activity at 5HT2C receptor in rat fundus
231 0 2 3 1.3 CC1=C2C(=CC=C1)N3CCNCCC3NC2=O
CHEMBL590580 5ht2c_rat Rat No 7.2 EC50 = 61 Funct
Agonist activity at 5HT2C receptor in rat fundusAgonist activity at 5HT2C receptor in rat fundus
231 0 2 3 1.3 CC1=C2C(=CC=C1)N3CCNCCC3NC2=O
CHEMBL2397903 5ht2c_human Human No 6.2 EC50 = 610 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
227 0 1 3 0.5 C1CN2C(CC3=C(C2=O)C=CC(=C3)C#N)CN1
CHEMBL596327 5ht2c_human Human Yes 6.2 EC50 = 616 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
255 1 1 5 2.3 C1CN(CCN1)C2=NC3=C(C=CS3)C(=N2)Cl
CHEMBL596327 5ht2c_human Human Yes 6.2 EC50 = 616 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
255 1 1 5 2.3 C1CN(CCN1)C2=NC3=C(C=CS3)C(=N2)Cl
CHEMBL571064 5ht2c_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
235 3 1 3 1.0 CC(C)CCN1C(=O)C=C2CCNCCC2=N1
CHEMBL571064 5ht2c_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
235 3 1 3 1.0 CC(C)CCN1C(=O)C=C2CCNCCC2=N1
CHEMBL374660 5ht2c_human Human No 7.2 EC50 = 63 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
300 2 1 6 1.6 CCOC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL1643674 5ht2c_human Human No 7.2 EC50 = 63 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
231 2 2 4 0.9 CCNC1=C2CCNCCC2=NC3=CC=NN31
CHEMBL374660 5ht2c_human Human No 7.2 EC50 = 63 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
300 2 1 6 1.6 CCOC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL1643674 5ht2c_human Human No 7.2 EC50 = 63 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
231 2 2 4 0.9 CCNC1=C2CCNCCC2=NC3=CC=NN31
CHEMBL93154 5ht2c_rat Rat No 6.2 EC50 = 631.0 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
230 2 1 2 1.9 CC(CN1C=CC2=C1C3=C(C2)C=CC(=C3)F)N
CHEMBL92656 5ht2c_rat Rat No 6.2 EC50 = 631.0 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
192 2 1 2 1.5 CC(CN1C=CC2=C1C=C(C=C2)F)N
CHEMBL96876 5ht2c_rat Rat No 5.2 EC50 = 6309.6 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
242 3 1 2 1.7 CC(CN1C=CC2=C1C3=C(C2)C=CC=C3OC)N
CHEMBL511044 5ht2c_human Human No 6.2 EC50 = 631 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
280 4 2 4 1.5 C1CC1CNS(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL511044 5ht2c_human Human No 6.2 EC50 = 631 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
280 4 2 4 1.5 C1CC1CNS(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL492700 5ht2c_human Human No 6.2 EC50 = 634 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 3 1 1 2.2 CNCC1CC1C2=CC=CC=C2
CHEMBL492700 5ht2c_human Human No 6.2 EC50 = 634 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 3 1 1 2.2 CNCC1CC1C2=CC=CC=C2
CHEMBL565351 5ht2c_human Human No 7.2 EC50 = 64 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
380 4 1 7 2.3 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3C(F)(F)F)C
CHEMBL2397891 5ht2c_human Human No 7.2 EC50 = 64 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
242 1 1 2 1.7 C1CC1C2=CC=CC3=C2C(=O)N4CCNCC4C3
CHEMBL565351 5ht2c_human Human No 7.2 EC50 = 64 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
380 4 1 7 2.3 CC1CNCCN1C2=CC(=O)N(C(=N2)CCC3=CC=CC=C3C(F)(F)F)C
CHEMBL76301 5ht2c_human Human No 7.2 EC50 = 64 Funct
Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader
320 2 1 3 2.3 CC(CN1CCC2=CC(=C(C=C21)I)F)N
CHEMBL1643853 5ht2c_human Human No 7.2 EC50 = 65 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC(=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL1643853 5ht2c_human Human No 7.2 EC50 = 65 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC(=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL596328 5ht2c_human Human Yes 6.2 EC50 = 660 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
218 1 1 5 1.1 CC1=CC2=C(N=CN=C2O1)N3CCNCC3
CHEMBL596328 5ht2c_human Human Yes 6.2 EC50 = 660 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
218 1 1 5 1.1 CC1=CC2=C(N=CN=C2O1)N3CCNCC3
CHEMBL567587 5ht2c_human Human No 5.2 EC50 = 6630 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
280 2 1 4 0.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)C#N
CHEMBL567587 5ht2c_human Human No 5.2 EC50 = 6630 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay
280 2 1 4 0.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)C#N
CHEMBL415029 5ht2c_human Human No 7.2 EC50 = 68 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
298 2 1 2 3.6 CC1CNCCC2=CC(=C(C=C12)Br)OC(C)C
CHEMBL234837 5ht2c_rat Rat No 6.2 EC50 = 689 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
315 4 1 6 2.3 CC1=NOC(=N1)CC2=C3CCOC3=C(C4=C2OCC4)CC(C)N
CHEMBL234837 5ht2c_rat Rat No 6.2 EC50 = 689 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
315 4 1 6 2.3 CC1=NOC(=N1)CC2=C3CCOC3=C(C4=C2OCC4)CC(C)N
CHEMBL493152 5ht2c_human Human No 6.2 EC50 = 697 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
302 3 2 4 2.3 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3
CHEMBL493152 5ht2c_human Human No 6.2 EC50 = 697 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
302 3 2 4 2.3 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3
CHEMBL222514 5ht2c_human Human No 8.2 EC50 = 7 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL449999 5ht2c_human Human No 8.2 EC50 = 7 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3F
CHEMBL222514 5ht2c_human Human No 8.2 EC50 = 7 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL449999 5ht2c_human Human No 8.2 EC50 = 7 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3F
CHEMBL178124 5ht2c_human Human No 8.2 EC50 = 7 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL360492 5ht2c_human Human No 8.2 EC50 = 7 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
214 0 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Cl)F
CHEMBL200104 5ht2c_rat Rat Yes 8.1 EC50 = 7.3 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
205 2 2 4 0.5 CC1=C2C(=CNN2CC(C)N)C=CC1=O
CHEMBL200104 5ht2c_rat Rat Yes 8.1 EC50 = 7.3 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
205 2 2 4 0.5 CC1=C2C(=CNN2CC(C)N)C=CC1=O
CHEMBL301466 5ht2c_human Human Yes 8.1 EC50 = 7.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
272 0 2 3 1.7 C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl
CHEMBL58009 5ht2c_human Human Yes 8.1 EC50 = 7.6 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
258 0 2 3 2.5 C1CN2C(CN1)CNC3=CC(=C(C=C32)Cl)Cl
CHEMBL6557 5ht2c_human Human Yes 8.1 EC50 = 7.7 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay
200 0 1 1 1.9 CN1C2=C(CCNCC2)C3=CC=CC=C31
CHEMBL253805 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL360328 5ht2c_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL178231 5ht2c_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL181787 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL254009 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL253806 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL253805 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL360328 5ht2c_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL178231 5ht2c_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL181787 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL254009 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL253806 5ht2c_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL2397909 5ht2c_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
260 3 1 3 1.7 CCCOC1=CC=CC2=C1CC3CNCCN3C2=O
CHEMBL493951 5ht2c_human Human No 7.2 EC50 = 71 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
294 4 1 4 1.7 CN(CC1CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL493951 5ht2c_human Human No 7.2 EC50 = 71 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
294 4 1 4 1.7 CN(CC1CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL373695 5ht2c_human Human No 7.1 EC50 = 72 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 5 2.3 CC(C)C1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL373695 5ht2c_human Human No 7.1 EC50 = 72 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 5 2.3 CC(C)C1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL1091104 5ht2c_human Human No 7.1 EC50 = 73 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
310 6 2 3 2.6 C1CC(NC1)C(=O)NCC2=CC=C(C=C2)OCC3=CC=CC=C3
CHEMBL577619 5ht2c_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
335 4 1 5 1.5 CN1C(=O)C=C(N=C1COC2=CC=CC=C2Cl)N3CCNCC3
CHEMBL201897 5ht2c_human Human No 7.1 EC50 = 73 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=CN=C3)N
CHEMBL1091104 5ht2c_human Human No 7.1 EC50 = 73 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
310 6 2 3 2.6 C1CC(NC1)C(=O)NCC2=CC=C(C=C2)OCC3=CC=CC=C3
CHEMBL577619 5ht2c_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
335 4 1 5 1.5 CN1C(=O)C=C(N=C1COC2=CC=CC=C2Cl)N3CCNCC3
CHEMBL201897 5ht2c_human Human No 7.1 EC50 = 73 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=CN=C3)N
CHEMBL202538 5ht2c_human Human No 7.1 EC50 = 74 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
350 5 1 2 4.3 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4Cl
CHEMBL202538 5ht2c_human Human No 7.1 EC50 = 74 Funct
Binding to human 5HT2C receptor expressed in CHO cellsBinding to human 5HT2C receptor expressed in CHO cells
350 5 1 2 4.3 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4Cl
CHEMBL595554 5ht2c_human Human Yes 6.1 EC50 = 755 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
203 1 2 4 0.5 C1CN(CCN1)C2=NC=NC3=C2C=CN3
CHEMBL595554 5ht2c_human Human Yes 6.1 EC50 = 755 Funct
Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay
203 1 2 4 0.5 C1CN(CCN1)C2=NC=NC3=C2C=CN3
CHEMBL2260568 5ht2c_human Human No 7.1 EC50 = 76 Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptorAgonist activity at Homo sapiens (human) 5-HT2C receptor
220 0 1 2 2.2 C1CC2CNCCN3C2C(C1)C4C3CCC4
CHEMBL1643671 5ht2c_human Human No 6.1 EC50 = 764 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
257 1 1 4 1.2 C1CCN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL1643671 5ht2c_human Human No 6.1 EC50 = 764 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
257 1 1 4 1.2 C1CCN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL577618 5ht2c_human Human No 7.1 EC50 = 77 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
346 6 1 5 1.3 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=CC=C3F
CHEMBL2397913 5ht2c_human Human No 7.1 EC50 = 77 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
246 1 1 3 1.2 CC1=C(C2=C(C=C1)C(=O)N3CCNCC3C2)OC
CHEMBL577618 5ht2c_human Human No 7.1 EC50 = 77 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
346 6 1 5 1.3 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=CC=C3F
CHEMBL360479 5ht2c_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C(=CC=C2)Cl
CHEMBL362073 5ht2c_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=CC=C2Cl
CHEMBL360479 5ht2c_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C(=CC=C2)Cl
CHEMBL362073 5ht2c_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=CC=C2Cl
CHEMBL2115254 5ht2c_rat Rat No 6.1 EC50 = 794.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
227 2 1 2 2.2 CC(CN1C=CC2=C1C=CC(=C2Cl)F)N
CHEMBL92040 5ht2c_rat Rat No 5.1 EC50 = 7943.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
188 2 1 1 1.8 CC1=CC2=C(C=C1)C=CN2CC(C)N
CHEMBL3350300 5ht2c_rat Rat No 5.1 EC50 = 7943.3 Funct
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat
242 3 1 2 1.7 CC(CN1C=CC2=C1C3=C(C2)C=CC(=C3)OC)N
CHEMBL2110670 5ht2c_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at 5HT2C receptor (unknown origin) relative to controlAgonist activity at 5HT2C receptor (unknown origin) relative to control
228 0 1 2 2.5 C1CC2CN3CCNCC4=C3C(=CC=C4)C2C1
CHEMBL1628670 5ht2c_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at 5HT2C receptor (unknown origin) relative to controlAgonist activity at 5HT2C receptor (unknown origin) relative to control
214 0 1 2 1.9 C1CC2C(C1)N3CCNCC4=C3C2=CC=C4
CHEMBL2110670 5ht2c_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at 5HT2C receptor (unknown origin) relative to controlAgonist activity at 5HT2C receptor (unknown origin) relative to control
228 0 1 2 2.5 C1CC2CN3CCNCC4=C3C(=CC=C4)C2C1
CHEMBL1628670 5ht2c_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at 5HT2C receptor (unknown origin) relative to controlAgonist activity at 5HT2C receptor (unknown origin) relative to control
214 0 1 2 1.9 C1CC2C(C1)N3CCNCC4=C3C2=CC=C4
CHEMBL303516 5ht2c_human Human No 8.1 EC50 = 8 Funct
Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as inositol formation by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as inositol formation by cell based assay
272 0 2 3 1.7 C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl
CHEMBL2110670 5ht2c_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilizationAgonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilization
228 0 1 2 2.5 C1CC2CN3CCNCC4=C3C(=CC=C4)C2C1
CHEMBL1628670 5ht2c_human Human Yes 8.1 EC50 = 8 Funct
Agonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilizationAgonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilization
214 0 1 2 1.9 C1CC2C(C1)N3CCNCC4=C3C2=CC=C4
CHEMBL2397896 5ht2c_human Human No 8.1 EC50 = 8 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 CC1=CC2=C(CC3CNCCN3C2=O)C=C1
CHEMBL303516 5ht2c_human Human No 8.1 EC50 = 8 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
272 0 2 3 1.7 C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl
CHEMBL180166 5ht2c_human Human No 8.1 EC50 = 8 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
256 1 1 2 2.4 COC1=C(C=C2CCNCCC2=C1)Br
CHEMBL494947 5ht2c_human Human Yes 8.1 EC50 = 8.1 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay
305 4 1 5 2.0 C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
CHEMBL1643859 5ht2c_human Human No 8.1 EC50 = 8.4 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
390 3 2 6 1.0 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC6=C(C=C5)NC(=O)C6
CHEMBL1643859 5ht2c_human Human No 8.1 EC50 = 8.4 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
390 3 2 6 1.0 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC6=C(C=C5)NC(=O)C6
CHEMBL397321 5ht2c_rat Rat No 8.1 EC50 = 8.6 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
307 7 1 5 1.2 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCCOC)N
CHEMBL397321 5ht2c_rat Rat No 8.1 EC50 = 8.6 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
307 7 1 5 1.2 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCCOC)N
CHEMBL492911 5ht2c_human Human No 7.1 EC50 = 80 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=C(C=C3)F
CHEMBL492911 5ht2c_human Human No 7.1 EC50 = 80 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=C(C=C3)F
CHEMBL376676 5ht2c_human Human No 7.1 EC50 = 82 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL234682 5ht2c_rat Rat No 7.1 EC50 = 82 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
311 4 1 6 3.1 CC1=NOC(=N1)CC2=C3C=COC3=C(C4=C2OC=C4)CC(C)N
CHEMBL376676 5ht2c_human Human No 7.1 EC50 = 82 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL234682 5ht2c_rat Rat No 7.1 EC50 = 82 Funct
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT
311 4 1 6 3.1 CC1=NOC(=N1)CC2=C3C=COC3=C(C4=C2OC=C4)CC(C)N
CHEMBL455039 5ht2c_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
294 2 1 4 1.8 C1CCN(CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL1643679 5ht2c_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC=C1OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL455039 5ht2c_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
294 2 1 4 1.8 C1CCN(CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL1643679 5ht2c_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC=C1OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL492348 5ht2c_human Human No 6.1 EC50 = 857 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
337 3 2 4 2.5 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3Cl
CHEMBL492348 5ht2c_human Human No 6.1 EC50 = 857 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
337 3 2 4 2.5 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3Cl
CHEMBL568982 5ht2c_human Human No 6.1 EC50 = 858 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(CN1C(=O)C=CC(=N1)N2CCNCC2)OC3=CC=CC=C3Cl
CHEMBL568982 5ht2c_human Human No 6.1 EC50 = 858 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(CN1C(=O)C=CC(=N1)N2CCNCC2)OC3=CC=CC=C3Cl
CHEMBL220157 5ht2c_human Human No 7.1 EC50 = 86 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=CC(=C2C(=C1)C3CNCCN3C2=O)Cl
CHEMBL220157 5ht2c_human Human No 7.1 EC50 = 86 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=CC(=C2C(=C1)C3CNCCN3C2=O)Cl
CHEMBL59631 5ht2c_human Human No 7.1 EC50 = 86 Funct
Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed
238 0 2 3 1.0 C1CN2C(CN1)C(=O)NC3=C2C=C(C=C3)Cl
CHEMBL362073 5ht2c_human Human Yes 6.1 EC50 = 860 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=CC=C2Cl
CHEMBL437314 5ht2c_rat Rat No 7.1 EC50 = 87.3 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL437314 5ht2c_rat Rat No 7.1 EC50 = 87.3 Funct
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL3589594 5ht2c_human Human No 4.1 EC50 = 87096.4 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
410 9 1 5 4.1 COC1=C(C(=CC=C1)OC)CNCCC2=CC(=C(C=C2OC)Br)OC
CHEMBL3589594 5ht2c_human Human No 4.1 EC50 = 87096.4 Funct
Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assayPartial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at room temperature by IP-One assay
410 9 1 5 4.1 COC1=C(C(=CC=C1)OC)CNCCC2=CC(=C(C=C2OC)Br)OC
CHEMBL1092029 5ht2c_human Human No 7.1 EC50 = 88 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
286 4 2 2 3.7 C1CCC(CC1)C2=CC=C(C=C2)CNC(=O)C3CCCN3
CHEMBL1092029 5ht2c_human Human No 7.1 EC50 = 88 Funct
Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor
286 4 2 2 3.7 C1CCC(CC1)C2=CC=C(C=C2)CNC(=O)C3CCCN3
CHEMBL577258 5ht2c_human Human No 6.1 EC50 = 899 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
363 6 1 4 1.8 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=C(C=C3)Cl
CHEMBL577258 5ht2c_human Human No 6.1 EC50 = 899 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay
363 6 1 4 1.8 CC1=CC(=O)N(C(=N1)N2CCNCC2)CCCOC3=CC=C(C=C3)Cl
CHEMBL360328 5ht2c_human Human Yes 8.1 EC50 = 9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells by inositol phosphate accumulation assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL492910 5ht2c_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC(=C3)F
CHEMBL521805 5ht2c_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
287 2 1 3 2.6 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3
CHEMBL360328 5ht2c_human Human Yes 8.1 EC50 = 9 Funct
Agonist activity at 5-HT2C receptor (unknown origin)Agonist activity at 5-HT2C receptor (unknown origin)
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2c_human Human Yes 8.1 EC50 = 9 Funct
Agonist activity at human 5HT2C receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells by inositol phosphate accumulation assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL3425755 5ht2c_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assayAgonist activity at human recombinant 5-HT2C receptor expressed in Swiss mouse 3T3 cell membranes after 30 to 40 mins by GTPgammaS recruitment assay
267 3 2 3 3.0 CNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL492910 5ht2c_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC(=C3)F
CHEMBL521805 5ht2c_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
287 2 1 3 2.6 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3
CHEMBL170854 5ht2c_human Human Yes 8.1 EC50 = 9 Funct
Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line
214 2 1 1 2.0 CC1=C(C2=C3N1CCCC3=CC=C2)CCN
CHEMBL2391541 5ht2c_human Human Yes 8.0 EC50 = 9.4 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
270 8 1 2 2.8 COC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL590531 5ht2c_human Human No 7.0 EC50 = 92 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 1.3 CC1=CC2=C(C=C1)C(=O)NC3N2CCNCC3
CHEMBL590333 5ht2c_human Human No 7.0 EC50 = 92 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
271 0 2 6 1.5 C1CN2C(CN1)NC(=O)C3=C(C=CC=C32)C(F)(F)F
CHEMBL2397911 5ht2c_human Human No 7.0 EC50 = 92 Funct
Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
244 1 1 2 2.0 CCC1=CC(=C2C(=C1)CC3CNCCN3C2=O)C
CHEMBL590531 5ht2c_human Human No 7.0 EC50 = 92 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 1.3 CC1=CC2=C(C=C1)C(=O)NC3N2CCNCC3
CHEMBL590333 5ht2c_human Human No 7.0 EC50 = 92 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay
271 0 2 6 1.5 C1CN2C(CN1)NC(=O)C3=C(C=CC=C32)C(F)(F)F
CHEMBL360479 5ht2c_human Human Yes 6.0 EC50 = 930 Funct
Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C(=CC=C2)Cl
CHEMBL373905 5ht2c_human Human No 7.0 EC50 = 94 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 2 1 5 2.6 CCCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL493950 5ht2c_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
330 4 1 4 2.4 CN(CC1=CC=CC=C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL373905 5ht2c_human Human No 7.0 EC50 = 94 Funct
Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 2 1 5 2.6 CCCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL493950 5ht2c_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
330 4 1 4 2.4 CN(CC1=CC=CC=C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL2337103 5ht2c_human Human No 6.0 EC50 = 943 Funct
Agonist activity at 5-HT2C receptor (unknown origin)Agonist activity at 5-HT2C receptor (unknown origin)
246 0 1 3 2.3 C1CN2C3CCNCC3C4=C2C(=CC=C4)SC1
CHEMBL1643854 5ht2c_human Human No 7.0 EC50 = 95