GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Show entries

Search:

Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	CHEMBL2064011	211630	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant by degranulation assayAgonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant by degranulation assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O	10.1021/jm201609k
	CHEMBL1170042	211007	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170045	211010	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm1003705
	CHEMBL1170640	211030	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170231	211017	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O	10.1021/jm1003705
	CHEMBL5081621	217244	None	0	Human	Functional	pEC50	=	8.0	8.0	4	2	Agonist activity at human C3aR expressed in CHO cells assessed as induction of ERK1/2 phosphorylation at Thr202/Tyr204 residues incubated for 10 mins by AlphaLISA assayAgonist activity at human C3aR expressed in CHO cells assessed as induction of ERK1/2 phosphorylation at Thr202/Tyr204 residues incubated for 10 mins by AlphaLISA assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/acs.jmedchem.1c01174
	CHEMBL1170045	211010	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm1003705
	CHEMBL1170231	211017	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O	10.1021/jm1003705
	1599	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-630	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	3955	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-630	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	3955.0	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-630	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	7215	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-630	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	CHEMBL841	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-630	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	DB00836	2341	None	28	Human	Functional	pEC50	=	5.9	5.9	-630	32	GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1GPCR PRESTO-Tango dose-response in antagonist mode with target: C3AR1	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.6019/CHEMBL5442687
	CHEMBL1170635	211025	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170635	211025	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	101886248	115038	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3aAgonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3a	ChEMBL	434	10	6	4	2.0	N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O	10.1021/jm500956p
	CHEMBL3342688	115038	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3aAgonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3a	ChEMBL	434	10	6	4	2.0	N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O	10.1021/jm500956p
	44426497	85769	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at C3a receptor expressed on HMC1 cellsAgonist activity at C3a receptor expressed on HMC1 cells	ChEMBL	502	10	5	4	4.2	N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)o1)C(=O)O	10.1016/j.bmcl.2007.04.022
	CHEMBL229006	85769	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at C3a receptor expressed on HMC1 cellsAgonist activity at C3a receptor expressed on HMC1 cells	ChEMBL	502	10	5	4	4.2	N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)o1)C(=O)O	10.1016/j.bmcl.2007.04.022
	CHEMBL1170026	210998	None	0	Human	Functional	pEC50	=	6.9	6.9	48	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm1003705
	3915	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	49799079	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	5760	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	91933514	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170024	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170027	210999	None	0	Human	Functional	pEC50	=	5.9	5.9	30	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm1003705
	44426495	85768	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at C3aRAntagonist activity at C3aR	ChEMBL	470	10	5	4	3.2	N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(F)c2)c2cccc(F)c2)o1)C(=O)O	10.1016/j.bmcl.2007.04.022
	CHEMBL229005	85768	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at C3aRAntagonist activity at C3aR	ChEMBL	470	10	5	4	3.2	N=C(N)NCCC[C@@H](NC(=O)c1ccc(C(c2cccc(F)c2)c2cccc(F)c2)o1)C(=O)O	10.1016/j.bmcl.2007.04.022
	CHEMBL5080181	217156	None	0	Human	Functional	pEC50	=	6.9	6.9	-3	2	Agonist activity at human C3aR expressed in CHO cells assessed as induction of ERK1/2 phosphorylation at Thr202/Tyr204 residues incubated for 10 mins by AlphaLISA assayAgonist activity at human C3aR expressed in CHO cells assessed as induction of ERK1/2 phosphorylation at Thr202/Tyr204 residues incubated for 10 mins by AlphaLISA assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/acs.jmedchem.1c01174
	101886248	115038	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3aAgonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3a	ChEMBL	434	10	6	4	2.0	N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O	10.1021/jm500956p
	CHEMBL3342688	115038	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3aAgonist activity against C3AR in HMDMs assessed as increase in intracellular calcium release by Fluo-3 AM dye based FLIPR assay relative to 1 uM C3a	ChEMBL	434	10	6	4	2.0	N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O	10.1021/jm500956p
	CHEMBL1170026	210998	None	0	Human	Functional	pEC50	=	6.9	6.9	48	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm1003705
	3915	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	49799079	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	5760	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	91933514	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170024	1525	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170027	210999	None	0	Human	Functional	pEC50	=	5.9	5.9	30	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm1003705
	CHEMBL5075364	216858	None	0	Human	Functional	pEC50	=	4.8	4.8	-2511	3	Agonist activity at human C3aR expressed in CHO cells assessed as induction of ERK1/2 phosphorylation at Thr202/Tyr204 residues incubated for 10 mins by AlphaLISA assayAgonist activity at human C3aR expressed in CHO cells assessed as induction of ERK1/2 phosphorylation at Thr202/Tyr204 residues incubated for 10 mins by AlphaLISA assay	ChEMBL		None	None	None		CC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/acs.jmedchem.1c01174
	CHEMBL2064020	211639	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant by degranulation assayAgonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant by degranulation assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm201609k
	122392665	165536	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at C3aR in HMDM assessed as induction of Ca2+ releaseAgonist activity at C3aR in HMDM assessed as induction of Ca2+ release	ChEMBL	457	10	6	5	3.3	N=C(N)NCCC[C@H](Nc1nccc2[nH]c(C(c3ccccc3)c3ccccc3)nc12)C(=O)O	10.1021/acs.jmedchem.7b00882
	CHEMBL4239035	165536	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at C3aR in HMDM assessed as induction of Ca2+ releaseAgonist activity at C3aR in HMDM assessed as induction of Ca2+ release	ChEMBL	457	10	6	5	3.3	N=C(N)NCCC[C@H](Nc1nccc2[nH]c(C(c3ccccc3)c3ccccc3)nc12)C(=O)O	10.1021/acs.jmedchem.7b00882
	17753143	85974	None	3	Human	Functional	pEC50	=	6.8	6.8	-	1	Antagonist activity at C3aRAntagonist activity at C3aR	ChEMBL	434	10	5	4	2.9	N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O	10.1016/j.bmcl.2007.04.022
	CHEMBL230034	85974	None	3	Human	Functional	pEC50	=	6.8	6.8	-	1	Antagonist activity at C3aRAntagonist activity at C3aR	ChEMBL	434	10	5	4	2.9	N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)o1)C(=O)O	10.1016/j.bmcl.2007.04.022
	44430551	88038	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human C3a receptor expressed in HMC1 cells co-expressing aequorinAgonist activity at human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	483	7	1	3	5.6	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc2ccccc2c1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	CHEMBL234305	88038	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human C3a receptor expressed in HMC1 cells co-expressing aequorinAgonist activity at human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	483	7	1	3	5.6	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccc2ccccc2c1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	CHEMBL1170025	210997	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium releaseAgonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL		None	None	None		None	10.1021/jm1003705
	44426475	144757	None	0	Human	Functional	pEC50	=	4.8	4.8	-	1	Antagonist activity at C3aRAntagonist activity at C3aR	ChEMBL	394	8	5	4	2.5	N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)s1)C(=O)O	10.1016/j.bmcl.2007.04.022
	CHEMBL390834	144757	None	0	Human	Functional	pEC50	=	4.8	4.8	-	1	Antagonist activity at C3aRAntagonist activity at C3aR	ChEMBL	394	8	5	4	2.5	N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)s1)C(=O)O	10.1016/j.bmcl.2007.04.022

Showing 1 to 50 of 468 entries

Previous1 2 3 4 5…10Next

Get vendors

Show entries

Search:

Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	CHEMBL1170042	211007	None	0	Human	Binding	pIC50	=	9.7	9.7	-	0	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingDisplacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL		None	None	None		None	10.1021/jm1003705
	155534696	172082	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Antagonist at C3a receptor in human LAD2 cells assessed as inhibition of C3a-induced beta-hexosaminidase release preincubated for 30 mins followed by C3a additionAntagonist at C3a receptor in human LAD2 cells assessed as inhibition of C3a-induced beta-hexosaminidase release preincubated for 30 mins followed by C3a addition	ChEMBL	464	10	5	4	3.7	Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/acs.jmedchem.9b00927
	CHEMBL4470864	172082	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Antagonist at C3a receptor in human LAD2 cells assessed as inhibition of C3a-induced beta-hexosaminidase release preincubated for 30 mins followed by C3a additionAntagonist at C3a receptor in human LAD2 cells assessed as inhibition of C3a-induced beta-hexosaminidase release preincubated for 30 mins followed by C3a addition	ChEMBL	464	10	5	4	3.7	Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/acs.jmedchem.9b00927
	3915	1525	None	14	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingDisplacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL		None	None	None		None	10.1021/jm1003705
	49799079	1525	None	14	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingDisplacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL		None	None	None		None	10.1021/jm1003705
	5760	1525	None	14	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingDisplacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL		None	None	None		None	10.1021/jm1003705
	91933514	1525	None	14	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingDisplacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL		None	None	None		None	10.1021/jm1003705
	CHEMBL1170024	1525	None	14	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingDisplacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL		None	None	None		None	10.1021/jm1003705
	8381	1029	None	7	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	448	10	6	4	2.3	O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N	10.1021/jm500956p
	91827354	1029	None	7	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	448	10	6	4	2.3	O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N	10.1021/jm500956p
	CHEMBL3342689	1029	None	7	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	448	10	6	4	2.3	O=C(c1nc([nH]c1C)C(c1ccccc1)c1ccccc1)N[C@H](C(=O)O)CCCNC(=N)N	10.1021/jm500956p
	3529	3517	None	6	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	412	12	4	4	1.5	O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1	10.1021/jm500956p
	5311120	3517	None	6	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	412	12	4	4	1.5	O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1	10.1021/jm500956p
	CHEMBL389348	3517	None	6	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	412	12	4	4	1.5	O=C(N[C@H](C(=O)O)CCCN=C(N)N)COCC(c1ccccc1)c1ccccc1	10.1021/jm500956p
	89570442	115036	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	449	10	5	5	2.6	Cc1oc(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm500956p
	CHEMBL3342686	115036	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	449	10	5	5	2.6	Cc1oc(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm500956p
	127035774	136524	None	0	Human	Binding	pIC50	=	8	8.0	-	1	Displacement of [125I]-C3a from human C3aR expressed in rat RBL-2H3 cellsDisplacement of [125I]-C3a from human C3aR expressed in rat RBL-2H3 cells	ChEMBL	413	12	4	4	1.9	NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O	10.1016/j.bmcl.2015.10.038
	CHEMBL3735614	136524	None	0	Human	Binding	pIC50	=	8	8.0	-	1	Displacement of [125I]-C3a from human C3aR expressed in rat RBL-2H3 cellsDisplacement of [125I]-C3a from human C3aR expressed in rat RBL-2H3 cells	ChEMBL	413	12	4	4	1.9	NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O	10.1016/j.bmcl.2015.10.038
	118716617	115027	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	410	12	5	3	2.8	N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O	10.1021/jm500956p
	CHEMBL3342677	115027	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	410	12	5	3	2.8	N=C(N)NCCC[C@H](NC(=O)CCCC(c1ccccc1)c1ccccc1)C(=O)O	10.1021/jm500956p
	101886251	115029	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	449	10	5	5	2.6	Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm500956p
	CHEMBL3342679	115029	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	449	10	5	5	2.6	Cc1nc(C(c2ccccc2)c2ccccc2)oc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm500956p
	101886252	115033	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	511	11	5	5	4.0	N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O	10.1021/jm500956p
	CHEMBL3342683	115033	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	511	11	5	5	4.0	N=C(N)NCCC[C@H](NC(=O)c1oc(C(c2ccccc2)c2ccccc2)nc1-c1ccccc1)C(=O)O	10.1021/jm500956p
	44430549	151355	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	487	7	1	3	4.9	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cc(F)c(F)c(F)c1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	CHEMBL396030	151355	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	487	7	1	3	4.9	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1cc(F)c(F)c(F)c1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	117634981	115032	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	436	10	5	6	1.7	N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O	10.1021/jm500956p
	CHEMBL3342682	115032	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodDisplacement of [125I]-C3a from C3AR in HMDMs by scintillation counting method	ChEMBL	436	10	5	6	1.7	N=C(N)NCCC[C@H](NC(=O)c1nnc(C(c2ccccc2)c2ccccc2)o1)C(=O)O	10.1021/jm500956p
	44430552	88039	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	439	7	1	3	4.9	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(C1CCCCC1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	CHEMBL234306	88039	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	439	7	1	3	4.9	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(C1CCCCC1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	44430556	88085	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	431	6	1	3	4.6	O=C(NC1CCN(C(=O)/C=C/c2cccnc2)CC1)C(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	CHEMBL234523	88085	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	431	6	1	3	4.6	O=C(NC1CCN(C(=O)/C=C/c2cccnc2)CC1)C(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	44430526	144323	None	1	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	461	7	1	3	5.1	CC1(C)CCC(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)c2ccccc2)CC1	10.1016/j.bmcl.2007.04.023
	CHEMBL390464	144323	None	1	Human	Binding	pIC50	=	6	6.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	461	7	1	3	5.1	CC1(C)CCC(C(C(=O)NC2CCN(C(=O)CCc3cccnc3)CC2)c2ccccc2)CC1	10.1016/j.bmcl.2007.04.023
	44430559	88204	None	0	Human	Binding	pIC50	=	5	5.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	454	6	1	2	5.0	O=C(NC1CCN(C(=O)Cc2cccc(F)c2F)CC1)C(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	CHEMBL234730	88204	None	0	Human	Binding	pIC50	=	5	5.0	-	0	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorinDisplacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	454	6	1	2	5.0	O=C(NC1CCN(C(=O)Cc2cccc(F)c2F)CC1)C(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.04.023
	44426471	85737	None	0	Human	Binding	pIC50	=	4	4.0	-	0	Inhibition of human C3a receptor expressed on HMC1 cells by SPA assayInhibition of human C3a receptor expressed on HMC1 cells by SPA assay	ChEMBL	388	8	5	3	2.5	N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)cc1)C(=O)O	10.1016/j.bmcl.2007.04.022
	CHEMBL228846	85737	None	0	Human	Binding	pIC50	=	4	4.0	-	0	Inhibition of human C3a receptor expressed on HMC1 cells by SPA assayInhibition of human C3a receptor expressed on HMC1 cells by SPA assay	ChEMBL	388	8	5	3	2.5	N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2cccc(Cl)c2)cc1)C(=O)O	10.1016/j.bmcl.2007.04.022
	117634952	136621	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	490	13	6	6	1.7	CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038
	CHEMBL3736505	136621	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	490	13	6	6	1.7	CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038
	117634952	136621	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	490	13	6	6	1.7	CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038
	CHEMBL3736505	136621	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	490	13	6	6	1.7	CC(C)C[C@H](NC(=O)Cc1ccc(F)cc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038
	127034743	136620	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	542	15	6	6	3.3	CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1	10.1016/j.bmcl.2015.10.038
	CHEMBL3736489	136620	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	542	15	6	6	3.3	CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1	10.1016/j.bmcl.2015.10.038
	127034743	136620	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	542	15	6	6	3.3	CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1	10.1016/j.bmcl.2015.10.038
	CHEMBL3736489	136620	None	0	Human	Binding	pIC50	=	6.0	6.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	542	15	6	6	3.3	CC(C)Cc1ccc(C(C)C(=O)N[C@@H](CC(C)C)c2nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co2)cc1	10.1016/j.bmcl.2015.10.038
	89570392	136564	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	512	12	6	6	2.4	CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038
	CHEMBL3736020	136564	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	512	12	6	6	2.4	CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038
	89570392	136564	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	512	12	6	6	2.4	CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038
	CHEMBL3736020	136564	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Displacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysisDisplacement of [125I]-C3a from C3aR in human MDM cells after 60 mins by microbeta scintillation counting analysis	ChEMBL	512	12	6	6	2.4	CC[C@H](C)[C@H](NC(=O)C1CCCc2ccccc21)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1	10.1016/j.bmcl.2015.10.038

Showing 1 to 50 of 381 entries

Previous1 2 3 4 5…8Next

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)