Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 1599 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -676 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 3955 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -676 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 3955.0 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -676 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 7215 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -676 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL841 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -676 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| DB00836 | 2341 | None | 28 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -676 | 32 | GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2GPCR PRESTO-Tango dose-response in antagonist mode with target: C5AR2 |
ChEMBL | 476 | 7 | 1 | 3 | 5.1 | Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 | 10.6019/CHEMBL5442687 | ||
| 11344 | 776 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | β-arrestin recruitment determined in a BRET assayβ-arrestin recruitment determined in a BRET assay |
Guide to Pharmacology | None | None | None | None | 31036565 | ||||
| 574 | 774 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 69 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | None | ||||
| 573 | 771 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 11773063 | ||||
| 5768 | 775 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 12899627 | ||||
| 5770 | 914 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 17258808 | ||||
| 574 | 774 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 69 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 11773063 | ||||
| 574 | 774 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 69 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 12899627 | ||||
| 573 | 771 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 11773063 | ||||
| 573 | 771 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 12899627 | ||||
| 5780 | 213 | None | 0 | Mouse | Functional | pIC50 | ~ | 6 | 6.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 14570896 | ||||
Showing 1 to 16 of 16 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 155541442 | 173123 | None | 2 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 1119 | 29 | 17 | 13 | -0.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| CHEMBL4518532 | 173123 | None | 2 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 1119 | 29 | 17 | 13 | -0.9 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| 155555017 | 174415 | None | 0 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 1 | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| CHEMBL4550325 | 174415 | None | 0 | Human | Binding | pEC50 | = | 5.1 | 5.1 | - | 1 | Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| 155555017 | 174415 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assayDisplacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| CHEMBL4550325 | 174415 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assayDisplacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay |
ChEMBL | 898 | 28 | 14 | 9 | 0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | nan | ||
| 9384 | 2987 | None | 0 | Human | Binding | pKi | = | 3.7 | 3.7 | - | 1 | Binding assayBinding assay |
Guide to Pharmacology | None | None | None | None | 27108698 | ||||
| 9385 | 2989 | None | 0 | Human | Binding | pKi | = | 4.2 | 4.2 | - | 1 | Binding assayBinding assay |
Guide to Pharmacology | None | None | None | None | 27108698 | ||||
Showing 1 to 8 of 8 entries