GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1327	496	None	0	Human	Functional	pIC50	None	7.3	7.3	-6	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11705773
	13339	1207	None	7	Human	Functional	pKB	=	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	38628803
	146361282	1207	None	7	Human	Functional	pKB	=	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	38628803
	CHEMBL5414447	1207	None	7	Human	Functional	pKB	=	9.5	9.5	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	38628803
	13339	1207	None	7	Rat	Functional	pKB	=	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	38628803
	146361282	1207	None	7	Rat	Functional	pKB	=	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	38628803
	CHEMBL5414447	1207	None	7	Rat	Functional	pKB	=	9.6	9.6	1	3	UnclassifiedUnclassified	Guide to Pharmacology	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	38628803

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	146361194	195888	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	644	8	1	7	5.4	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5412684	195888	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	644	8	1	7	5.4	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361194	195888	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	644	8	1	7	5.4	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5412684	195888	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	644	8	1	7	5.4	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361364	196958	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	630	8	2	7	5.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCNC2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5435583	196958	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	630	8	2	7	5.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCNC2)n1	10.1021/acsmedchemlett.3c00514
	146361364	196958	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	630	8	2	7	5.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCNC2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5435583	196958	None	0	Human	Binding	pKi	=	9.5	9.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	630	8	2	7	5.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)N[C@@H]2CCNC2)n1	10.1021/acsmedchemlett.3c00514
	146361184	196809	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	632	10	1	7	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5432648	196809	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	632	10	1	7	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)n1	10.1021/acsmedchemlett.3c00514
	146361278	195987	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	642	8	1	7	5.3	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C34CCC(C(F)(F)F)(CC3)CC4)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5414709	195987	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	642	8	1	7	5.3	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C34CCC(C(F)(F)F)(CC3)CC4)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361184	196809	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	632	10	1	7	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5432648	196809	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	632	10	1	7	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)n1	10.1021/acsmedchemlett.3c00514
	146361278	195987	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	642	8	1	7	5.3	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C34CCC(C(F)(F)F)(CC3)CC4)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5414709	195987	None	0	Human	Binding	pKi	=	9.4	9.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	642	8	1	7	5.3	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C34CCC(C(F)(F)F)(CC3)CC4)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361317	195981	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	618	10	2	7	4.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5414552	195981	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	618	10	2	7	4.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)n1	10.1021/acsmedchemlett.3c00514
	146361317	195981	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	618	10	2	7	4.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5414552	195981	None	0	Human	Binding	pKi	=	9.3	9.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	618	10	2	7	4.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)n1	10.1021/acsmedchemlett.3c00514
	146361372	195079	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5396357	195079	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361372	195079	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5396357	195079	None	0	Human	Binding	pKi	=	9.2	9.2	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361524	196119	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	649	10	1	6	6.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1F	10.1021/acsmedchemlett.3c00514
	CHEMBL5417272	196119	None	0	Human	Binding	pKi	=	9.1	9.1	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	649	10	1	6	6.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1F	10.1021/acsmedchemlett.3c00514
	146361526	196478	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	617	10	2	6	5.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5424729	196478	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	617	10	2	6	5.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)c1	10.1021/acsmedchemlett.3c00514
	146361524	196119	None	0	Human	Binding	pKi	=	9	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	649	10	1	6	6.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1F	10.1021/acsmedchemlett.3c00514
	CHEMBL5417272	196119	None	0	Human	Binding	pKi	=	9	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	649	10	1	6	6.0	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1F	10.1021/acsmedchemlett.3c00514
	146361526	196478	None	0	Human	Binding	pKi	=	9	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	617	10	2	6	5.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5424729	196478	None	0	Human	Binding	pKi	=	9	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	617	10	2	6	5.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCNC)c1	10.1021/acsmedchemlett.3c00514
	146361312	194974	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	603	9	2	6	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5394322	194974	None	0	Human	Binding	pKi	=	9.0	9.0	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	603	9	2	6	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	146361312	194974	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	603	9	2	6	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5394322	194974	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	603	9	2	6	5.2	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	146361710	195578	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	587	8	1	6	4.7	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5406402	195578	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	587	8	1	6	4.7	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361710	195578	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	587	8	1	6	4.7	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5406402	195578	None	0	Human	Binding	pKi	=	8.9	8.9	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	587	8	1	6	4.7	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361256	196050	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	631	10	1	6	5.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5415832	196050	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	631	10	1	6	5.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1	10.1021/acsmedchemlett.3c00514
	146361487	195337	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5401503	195337	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	146361256	196050	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	631	10	1	6	5.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5415832	196050	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	631	10	1	6	5.9	CCOc1ncccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN(C)C)c1	10.1021/acsmedchemlett.3c00514
	172470186	197101	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	601	8	1	6	5.1	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5438739	197101	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	601	8	1	6	5.1	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	146361487	195337	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5401503	195337	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3C(F)(F)F)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	172470186	197101	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	601	8	1	6	5.1	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5438739	197101	None	0	Human	Binding	pKi	=	8.8	8.8	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	601	8	1	6	5.1	CCOc1ccccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	13339	1207	None	7	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	10.1021/acsmedchemlett.3c00514
	146361282	1207	None	7	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	10.1021/acsmedchemlett.3c00514
	CHEMBL5414447	1207	None	7	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	10.1021/acsmedchemlett.3c00514
	146361548	196330	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(C(F)(F)F)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5421498	196330	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(C(F)(F)F)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	146361680	196941	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	592	7	2	4	6.1	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5435301	196941	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	592	7	2	4	6.1	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	146361548	196330	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(C(F)(F)F)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5421498	196330	None	0	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	9	2	5	5.9	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(C(F)(F)F)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	13339	1207	None	7	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	10.1021/acsmedchemlett.3c00514
	146361282	1207	None	7	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	10.1021/acsmedchemlett.3c00514
	CHEMBL5414447	1207	None	7	Human	Binding	pKi	=	8.7	8.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	613	8	1	6	5.1	CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6	10.1021/acsmedchemlett.3c00514
	146361680	196941	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	592	7	2	4	6.1	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5435301	196941	None	0	Human	Binding	pKi	=	7.7	7.7	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	592	7	2	4	6.1	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	146361394	195108	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	583	7	2	5	5.3	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2C#N)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5396826	195108	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	583	7	2	5	5.3	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2C#N)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	146361394	195108	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	583	7	2	5	5.3	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2C#N)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5396826	195108	None	0	Human	Binding	pKi	=	7.6	7.6	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	583	7	2	5	5.3	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2C#N)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	172445098	195410	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5403170	195410	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	172445098	195410	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5403170	195410	None	0	Human	Binding	pKi	=	8.5	8.5	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	602	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)NC2CCN(C)CC2)n1	10.1021/acsmedchemlett.3c00514
	146361246	196395	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	588	8	1	7	4.1	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5422885	196395	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	588	8	1	7	4.1	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361308	195153	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	614	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CN3CCC2CC3)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5397644	195153	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	614	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CN3CCC2CC3)n1	10.1021/acsmedchemlett.3c00514
	146361246	196395	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	588	8	1	7	4.1	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5422885	196395	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	588	8	1	7	4.1	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CCN(C)C2)n1	10.1021/acsmedchemlett.3c00514
	146361514	196881	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	610	7	2	4	6.2	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2cccc(F)c2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5434090	196881	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	610	7	2	4	6.2	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2cccc(F)c2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	146361514	196881	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	610	7	2	4	6.2	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2cccc(F)c2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5434090	196881	None	0	Human	Binding	pKi	=	7.4	7.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	610	7	2	4	6.2	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2cccc(F)c2Cl)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	146361308	195153	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	614	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CN3CCC2CC3)n1	10.1021/acsmedchemlett.3c00514
	CHEMBL5397644	195153	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	614	8	1	7	4.5	CCOc1ncccc1-c1ccc(N2CCN(C(=O)C3(C(F)(F)F)CCC3)C[C@H]2CC)c(C(=O)N[C@@H]2CN3CCC2CC3)n1	10.1021/acsmedchemlett.3c00514
	146361589	195515	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	568	9	2	5	5.5	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5405192	195515	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	568	9	2	5	5.5	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	146361398	197100	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	576	7	2	4	5.6	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2F)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5438731	197100	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	576	7	2	4	5.6	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2F)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	146361589	195515	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	568	9	2	5	5.5	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	CHEMBL5405192	195515	None	0	Human	Binding	pKi	=	8.3	8.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	568	9	2	5	5.5	CCOc1ccccc1-c1ccc(N2CCN(C(=O)c3ccc(Cl)cc3Cl)C[C@H]2CC)c(C(=O)NCCN)c1	10.1021/acsmedchemlett.3c00514
	146361398	197100	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	576	7	2	4	5.6	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2F)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	CHEMBL5438731	197100	None	0	Human	Binding	pKi	=	7.3	7.3	-	1	Displacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting methodDisplacement of [[125I]-Tyr23]-ACTH (1-39) from human MC2R incubated for 1.5 hrs by Topcount scintillation counting method	ChEMBL	576	7	2	4	5.6	CC[C@@H]1CN(C(=O)c2ccc(C(F)(F)F)cc2Cl)CCN1c1ccc(-c2ccccc2F)cc1C(=O)NCCN	10.1021/acsmedchemlett.3c00514
	134611880	277	None	0	Mouse	Binding	pKd	=	8.0	8.0	-2	5	NoneNone	Drug Central		None	None	None		None	None
	16132265	277	None	0	Mouse	Binding	pKd	=	8.0	8.0	-2	5	NoneNone	Drug Central		None	None	None		None	None
	16132265.0	277	None	0	Mouse	Binding	pKd	=	8.0	8.0	-2	5	NoneNone	Drug Central		None	None	None		None	None
	3633	277	None	0	Mouse	Binding	pKd	=	8.0	8.0	-2	5	NoneNone	Drug Central		None	None	None		None	None
	4931	277	None	0	Mouse	Binding	pKd	=	8.0	8.0	-2	5	NoneNone	Drug Central		None	None	None		None	None
	CHEMBL1201610	277	None	0	Mouse	Binding	pKd	=	8.0	8.0	-2	5	NoneNone	Drug Central		None	None	None		None	None
	DB01285	277	None	0	Mouse	Binding	pKd	=	8.0	8.0	-2	5	NoneNone	Drug Central		None	None	None		None	None
	1331	278	None	0	Mouse	Binding	pKd	=	9.8	9.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	1332	279	None	0	Human	Binding	pKd	None	9	9.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	3037130	279	None	0	Human	Binding	pKd	None	9	9.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	CHEMBL3274101	279	None	0	Human	Binding	pKd	None	9	9.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	129627786	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	1330	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	16129617	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	16129674	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	16133751	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	16133802	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	16133802.0	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	16162116	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	3767	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	4516	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	60210072	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	6965	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	CHEMBL2103784	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	DB01284	280	None	26	Mouse	Binding	pKd	None	9.1	9.1	10	2	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8754753
	None	220225	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central	4538	145	63	61	-15.2	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O	None
	129627786	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	1330	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	16129617	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	16129674	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	16133751	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	16133802	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	16133802.0	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	16162116	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	3767	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	4516	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	60210072	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	6965	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	CHEMBL2103784	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None
	DB01284	280	None	26	Human	Binding	pKi	=	8.1	8.1	-10	2	125I-ACTH binding in OS3 cells expressing hMC2R wild type125I-ACTH binding in OS3 cells expressing hMC2R wild type	Drug Central		None	None	None		None	None

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Ligand source activities (1 row/activity)