Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 90644395 | 112211 | None | 0 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 5.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290102 | 112211 | None | 0 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 5.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 1574 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 1579 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 25077406 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 3830 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| CHEMBL407196 | 2809 | None | 18 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -275 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 90644399 | 112215 | None | 1 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290106 | 112215 | None | 1 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| 119192 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| 1582 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| CHEMBL506981 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| DB06455 | 2481 | None | 38 | Rat | Functional | pEC50 | = | 6.9 | 6.9 | -1 | 6 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| 118721825 | 116150 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 457 | 8 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3356854 | 116150 | None | 0 | Rat | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 457 | 8 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| 118721824 | 116149 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 469 | 6 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3356853 | 116149 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 469 | 6 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| 90644392 | 112208 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 513 | 8 | 2 | 6 | 5.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290099 | 112208 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 513 | 8 | 2 | 6 | 5.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 90644386 | 112202 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 524 | 6 | 2 | 5 | 5.8 | O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 | 10.1021/jm5003843 | |||
| CHEMBL3290093 | 112202 | None | 0 | Rat | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 524 | 6 | 2 | 5 | 5.8 | O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 | 10.1021/jm5003843 | |||
| 90644394 | 112210 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 5.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290101 | 112210 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 499 | 7 | 2 | 6 | 5.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 1580 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | |||
| 5311451 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | |||
| 90644398 | 112214 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290105 | 112214 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| 1580 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| 5311451 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| 90644390 | 112206 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 520 | 7 | 2 | 7 | 4.9 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290097 | 112206 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 520 | 7 | 2 | 7 | 4.9 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 90644388 | 112204 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 548 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290095 | 112204 | None | 0 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 548 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 90644383 | 112199 | None | 0 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 | 10.1021/jm5003843 | |||
| CHEMBL3290090 | 112199 | None | 0 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 | 10.1021/jm5003843 | |||
| 1581 | 3670 | None | 10 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | |||
| 9915499 | 3670 | None | 10 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | |||
| CHEMBL461604 | 3670 | None | 10 | Rat | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | |||
| 1580 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | |||
| 5311451 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | |||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | |||
| 90644393 | 112209 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290100 | 112209 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 90644385 | 112201 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 518 | 7 | 2 | 6 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290092 | 112201 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 518 | 7 | 2 | 6 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 90644397 | 112213 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 481 | 8 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290104 | 112213 | None | 0 | Rat | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 481 | 8 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| 146159772 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 1564 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 1586 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 54385 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 54385.0 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| CHEMBL1615438 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| DB01106 | 2311 | None | 22 | Rat | Functional | pEC50 | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 90644389 | 112205 | None | 0 | Rat | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 534 | 7 | 2 | 7 | 5.3 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290096 | 112205 | None | 0 | Rat | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 534 | 7 | 2 | 7 | 5.3 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 127051280 | 140812 | None | 3 | Rat | Functional | pEC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 523 | 11 | 2 | 6 | 5.6 | COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)O)nn1-c1ccc(F)cc1 | 10.1016/j.bmc.2016.06.018 | |||
| CHEMBL3817879 | 140812 | None | 3 | Rat | Functional | pEC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 523 | 11 | 2 | 6 | 5.6 | COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)O)nn1-c1ccc(F)cc1 | 10.1016/j.bmc.2016.06.018 | |||
| 127051011 | 140864 | None | 0 | Rat | Functional | pEC50 | = | 6.5 | 6.5 | 28 | 2 | ChEMBL | 495 | 9 | 2 | 6 | 4.8 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](CC(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmc.2016.06.018 | |||
| CHEMBL3818506 | 140864 | None | 0 | Rat | Functional | pEC50 | = | 6.5 | 6.5 | 28 | 2 | ChEMBL | 495 | 9 | 2 | 6 | 4.8 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](CC(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmc.2016.06.018 | |||
| 90644384 | 112200 | None | 0 | Rat | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 | 10.1021/jm5003843 | |||
| CHEMBL3290091 | 112200 | None | 0 | Rat | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 | 10.1021/jm5003843 | |||
| CHEMBL1766825 | 211318 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 118729840 | 118009 | None | 0 | Rat | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| CHEMBL3403507 | 118009 | None | 0 | Rat | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| CHEMBL1766946 | 211337 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 90644391 | 112207 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 504 | 6 | 2 | 6 | 5.3 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290098 | 112207 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 504 | 6 | 2 | 6 | 5.3 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 90644396 | 112212 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 519 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290103 | 112212 | None | 0 | Rat | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 519 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL1766945 | 211336 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 90644399 | 112215 | None | 1 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290106 | 112215 | None | 1 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL1766944 | 211335 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 90644387 | 112203 | None | 0 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 576 | 9 | 2 | 7 | 6.1 | CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC | 10.1021/jm5003843 | |||
| CHEMBL3290094 | 112203 | None | 0 | Rat | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 576 | 9 | 2 | 7 | 6.1 | CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC | 10.1021/jm5003843 | |||
| 118729841 | 118010 | None | 0 | Rat | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.7 | COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| CHEMBL3403508 | 118010 | None | 0 | Rat | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.7 | COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| 118721826 | 116151 | None | 0 | Rat | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 483 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3356855 | 116151 | None | 0 | Rat | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 483 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| 1574 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 1579 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 25077406 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 3830 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 90644398 | 112214 | None | 0 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290105 | 112214 | None | 0 | Rat | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| 90644399 | 112215 | None | 1 | Rat | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290106 | 112215 | None | 1 | Rat | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| 1574 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.7 | 7.7 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 1579 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.7 | 7.7 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 25077406 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.7 | 7.7 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 3830 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.7 | 7.7 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.7 | 7.7 | -338 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 118711921 | 114123 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 457 | 9 | 3 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 | 10.1021/jm500857r | |||
| CHEMBL3326832 | 114123 | None | 0 | Rat | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 457 | 9 | 3 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 | 10.1021/jm500857r | |||
| 101873359 | 114122 | None | 25 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 553 | 10 | 3 | 6 | 4.1 | Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 | 10.1021/jm500857r | |||
| CHEMBL3326831 | 114122 | None | 25 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 553 | 10 | 3 | 6 | 4.1 | Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 | 10.1021/jm500857r | |||
| 1574 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | -338 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| 1579 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | -338 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| 25077406 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | -338 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| 3830 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | -338 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | -338 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| CHEMBL342252 | 214132 | None | 0 | Rat | Functional | pIC50 | = | 8.3 | 8.3 | -16 | 4 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm5003843 | |||||
| 146159772 | 2311 | None | 22 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1564 | 2311 | None | 22 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1586 | 2311 | None | 22 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 54385 | 2311 | None | 22 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 54385.0 | 2311 | None | 22 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| CHEMBL1615438 | 2311 | None | 22 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| DB01106 | 2311 | None | 22 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1578 | 2772 | None | 0 | Mouse | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 9940301 | 2772 | None | 0 | Mouse | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 2 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 1575 | 1165 | None | 0 | Rat | Functional | pIC50 | None | 6.1 | 6.1 | -1 | 3 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| 101205709 | 3814 | None | 0 | Rat | Functional | pIC50 | None | 6.8 | 6.8 | -6 | 3 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| 1573 | 3814 | None | 0 | Rat | Functional | pIC50 | None | 6.8 | 6.8 | -6 | 3 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| 119192 | 2481 | None | 38 | Mouse | Functional | pIC50 | None | 7.1 | 7.1 | -1 | 6 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 9480852 | |||
| 1582 | 2481 | None | 38 | Mouse | Functional | pIC50 | None | 7.1 | 7.1 | -1 | 6 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 9480852 | |||
| CHEMBL506981 | 2481 | None | 38 | Mouse | Functional | pIC50 | None | 7.1 | 7.1 | -1 | 6 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 9480852 | |||
| DB06455 | 2481 | None | 38 | Mouse | Functional | pIC50 | None | 7.1 | 7.1 | -1 | 6 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 9480852 | |||
| 1584 | 1496 | None | 0 | Mouse | Functional | pIC50 | None | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 146159772 | 2311 | None | 22 | Rat | Functional | pIC50 | None | 8 | 8.0 | -3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8647296 | |||
| 1564 | 2311 | None | 22 | Rat | Functional | pIC50 | None | 8 | 8.0 | -3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8647296 | |||
| 1586 | 2311 | None | 22 | Rat | Functional | pIC50 | None | 8 | 8.0 | -3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8647296 | |||
| 54385 | 2311 | None | 22 | Rat | Functional | pIC50 | None | 8 | 8.0 | -3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8647296 | |||
| 54385.0 | 2311 | None | 22 | Rat | Functional | pIC50 | None | 8 | 8.0 | -3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8647296 | |||
| CHEMBL1615438 | 2311 | None | 22 | Rat | Functional | pIC50 | None | 8 | 8.0 | -3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8647296 | |||
| DB01106 | 2311 | None | 22 | Rat | Functional | pIC50 | None | 8 | 8.0 | -3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8647296 | |||
| 1574 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 8.2 | 8.2 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| 1579 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 8.2 | 8.2 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| 25077406 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 8.2 | 8.2 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| 3830 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 8.2 | 8.2 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 8.2 | 8.2 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 10318778 | |||||
| 1578 | 2772 | None | 0 | Rat | Functional | pIC50 | None | 8.3 | 8.3 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 8647296 | |||||
| 9940301 | 2772 | None | 0 | Rat | Functional | pIC50 | None | 8.3 | 8.3 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 8647296 | |||||
| 146159772 | 2311 | None | 22 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | 3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 9480852 | |||
| 1564 | 2311 | None | 22 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | 3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 9480852 | |||
| 1586 | 2311 | None | 22 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | 3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 9480852 | |||
| 54385 | 2311 | None | 22 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | 3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 9480852 | |||
| 54385.0 | 2311 | None | 22 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | 3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 9480852 | |||
| CHEMBL1615438 | 2311 | None | 22 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | 3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 9480852 | |||
| DB01106 | 2311 | None | 22 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | 3 | 2 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 9480852 | |||
| 1574 | 2809 | None | 18 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | -63 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 1579 | 2809 | None | 18 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | -63 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 25077406 | 2809 | None | 18 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | -63 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 3830 | 2809 | None | 18 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | -63 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| CHEMBL407196 | 2809 | None | 18 | Mouse | Functional | pIC50 | None | 8.6 | 8.6 | -63 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 1587 | 4105 | None | 0 | Mouse | Functional | pIC50 | None | 8.8 | 8.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 16131039 | 4105 | None | 0 | Mouse | Functional | pIC50 | None | 8.8 | 8.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 90470037 | 4105 | None | 0 | Mouse | Functional | pIC50 | None | 8.8 | 8.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 1585 | 3870 | None | 0 | Mouse | Functional | pIC50 | None | 8.9 | 8.9 | - | 1 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 1574 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 9.1 | 9.1 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 8647296 | |||||
| 1579 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 9.1 | 9.1 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 8647296 | |||||
| 25077406 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 9.1 | 9.1 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 8647296 | |||||
| 3830 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 9.1 | 9.1 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 8647296 | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Functional | pIC50 | None | 9.1 | 9.1 | -338 | 6 | Guide to Pharmacology | None | None | None | None | 8647296 | |||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 16127648 | 14370 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | |||
| CHEMBL1172376 | 14370 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | |||
| CHEMBL1200171 | 14370 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | |||
| 44354086 | 116843 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 843 | 23 | 10 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL337721 | 116843 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 843 | 23 | 10 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL3622802 | 214341 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)O | 10.1021/acs.jmedchem.5b00841 | |||||
| CHEMBL336836 | 214047 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | None | None | None | CCNC(=N)NCCC[C@H](N)C(=O)/N=C(/N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC | 10.1021/jm0300633 | |||||
| CHEMBL258221 | 212975 | None | 16 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | |||||
| 44354244 | 168428 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 831 | 23 | 11 | 11 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL434227 | 168428 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 831 | 23 | 11 | 11 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354075 | 116830 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 803 | 24 | 10 | 11 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL337644 | 116830 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 803 | 24 | 10 | 11 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354087 | 22489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 845 | 24 | 12 | 13 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL132524 | 22489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 845 | 24 | 12 | 13 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354120 | 22352 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 816 | 23 | 11 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL132409 | 22352 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 816 | 23 | 11 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL258221 | 212975 | None | 16 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01848 | |||||
| 1574 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | |||||
| 1579 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | |||||
| 25077406 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | |||||
| 3830 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | |||||
| CHEMBL407196 | 2809 | None | 18 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -15 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2022.128983 | |||||
| 44354212 | 116765 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 803 | 24 | 10 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL337260 | 116765 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 803 | 24 | 10 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 11657884 | 116263 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 803 | 22 | 10 | 11 | -0.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL335846 | 116263 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 803 | 22 | 10 | 11 | -0.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL3622804 | 214343 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCCN)C(=O)O | 10.1021/acs.jmedchem.5b00841 | |||||
| 44354245 | 167950 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 788 | 23 | 10 | 11 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL430910 | 167950 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 788 | 23 | 10 | 11 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL342252 | 214132 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -14 | 4 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||||
| 44354085 | 22472 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 817 | 24 | 9 | 11 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL132507 | 22472 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 817 | 24 | 9 | 11 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL3622806 | 214345 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.5b00841 | |||||
| CHEMBL3622803 | 214342 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | None | None | None | C[Si](C)(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O | 10.1021/acs.jmedchem.5b00841 | |||||
| CHEMBL3622805 | 214344 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | None | None | None | CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.5b00841 | |||||
| 44354304 | 117119 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 774 | 22 | 10 | 11 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL339139 | 117119 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 774 | 22 | 10 | 11 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354211 | 22791 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 846 | 25 | 10 | 10 | 0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL132794 | 22791 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 846 | 25 | 10 | 10 | 0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354305 | 24022 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 832 | 24 | 10 | 10 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL133798 | 24022 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 832 | 24 | 10 | 10 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354303 | 23466 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 788 | 23 | 10 | 11 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL133340 | 23466 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 788 | 23 | 10 | 11 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354113 | 24104 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 831 | 25 | 9 | 11 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL133850 | 24104 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 831 | 25 | 9 | 11 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL439494 | 216303 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | None | None | None | None | 10.1021/jm0300633 | |||||
| CHEMBL3622801 | 214340 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O | 10.1021/acs.jmedchem.5b00841 | |||||
| CHEMBL3622806 | 214345 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||||
| 44354302 | 23519 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 803 | 23 | 9 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL133378 | 23519 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 803 | 23 | 9 | 11 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354154 | 19542 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 818 | 23 | 10 | 10 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL129953 | 19542 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 818 | 23 | 10 | 10 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354121 | 168588 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 826 | 22 | 10 | 10 | 0.7 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL435199 | 168588 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 826 | 22 | 10 | 10 | 0.7 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 44354112 | 24103 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 817 | 25 | 10 | 11 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| CHEMBL133849 | 24103 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 817 | 25 | 10 | 11 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm0300633 | |||
| 1569 | 2126 | None | 31 | Human | Binding | pIC50 | = | 8.1 | 8.1 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b00841 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pIC50 | = | 8.1 | 8.1 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b00841 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pIC50 | = | 8.1 | 8.1 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b00841 | |||||
| CHEMBL1766928 | 211324 | None | 0 | Human | Binding | pKd | = | 8.9 | 8.9 | -5 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)CC1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| CHEMBL342252 | 214132 | None | 0 | Human | Binding | pKd | = | 8.9 | 8.9 | -14 | 4 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm401491e | |||||
| 1569 | 2126 | None | 31 | Human | Binding | pKd | = | 8.7 | 8.7 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2023.115386 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKd | = | 8.7 | 8.7 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2023.115386 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKd | = | 8.7 | 8.7 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2023.115386 | |||||
| 16127648 | 14370 | None | 0 | Rat | Binding | pKd | = | 7.6 | 7.6 | - | 1 | ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | |||
| CHEMBL1172376 | 14370 | None | 0 | Rat | Binding | pKd | = | 7.6 | 7.6 | - | 1 | ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | |||
| CHEMBL1200171 | 14370 | None | 0 | Rat | Binding | pKd | = | 7.6 | 7.6 | - | 1 | ChEMBL | 817 | 22 | 9 | 8 | 1.4 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O | 10.1021/jm100092s | |||
| 162675694 | 183549 | None | 0 | Human | Binding | pKi | = | 10.5 | 10.5 | 25 | 5 | ChEMBL | 1422 | 36 | 20 | 16 | -0.2 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4798887 | 183549 | None | 0 | Human | Binding | pKi | = | 10.5 | 10.5 | 25 | 5 | ChEMBL | 1422 | 36 | 20 | 16 | -0.2 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 162669697 | 182826 | None | 0 | Human | Binding | pKi | = | 10.1 | 10.1 | 4 | 5 | ChEMBL | 1394 | 36 | 20 | 16 | -0.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4789659 | 182826 | None | 0 | Human | Binding | pKi | = | 10.1 | 10.1 | 4 | 5 | ChEMBL | 1394 | 36 | 20 | 16 | -0.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 162646561 | 179747 | None | 0 | Human | Binding | pKi | = | 10.0 | 10.0 | 20 | 2 | ChEMBL | 859 | 23 | 13 | 10 | -0.1 | Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4742999 | 179747 | None | 0 | Human | Binding | pKi | = | 10.0 | 10.0 | 20 | 2 | ChEMBL | 859 | 23 | 13 | 10 | -0.1 | Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C | 10.1021/acs.jmedchem.0c01376 | |||
| 162657942 | 181093 | None | 0 | Human | Binding | pKi | = | 9.8 | 9.8 | 44 | 5 | ChEMBL | 1366 | 36 | 16 | 16 | 1.5 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4758754 | 181093 | None | 0 | Human | Binding | pKi | = | 9.8 | 9.8 | 44 | 5 | ChEMBL | 1366 | 36 | 16 | 16 | 1.5 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 162648776 | 179878 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 7 | 5 | ChEMBL | 1338 | 36 | 16 | 16 | 0.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4744531 | 179878 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 7 | 5 | ChEMBL | 1338 | 36 | 16 | 16 | 0.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 162649599 | 180271 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 21 | 5 | ChEMBL | 1380 | 37 | 16 | 16 | 1.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4749016 | 180271 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 21 | 5 | ChEMBL | 1380 | 37 | 16 | 16 | 1.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c(C)cc(O)cc2C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 162648890 | 180002 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 5 | 5 | ChEMBL | 1394 | 36 | 20 | 16 | -0.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4745899 | 180002 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | 5 | 5 | ChEMBL | 1394 | 36 | 20 | 16 | -0.8 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 155522777 | 176638 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 4 | 2 | ChEMBL | 816 | 22 | 13 | 10 | -1.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4452276 | 176638 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 4 | 2 | ChEMBL | 816 | 22 | 13 | 10 | -1.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4597094 | 176638 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 4 | 2 | ChEMBL | 816 | 22 | 13 | 10 | -1.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| 162649323 | 180123 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 7 | 5 | ChEMBL | 1338 | 36 | 16 | 16 | 0.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4747286 | 180123 | None | 0 | Human | Binding | pKi | = | 9.3 | 9.3 | 7 | 5 | ChEMBL | 1338 | 36 | 16 | 16 | 0.9 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cccc(O)c2)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 1569 | 2126 | None | 31 | Human | Binding | pKi | = | 9.3 | 9.3 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01376 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKi | = | 9.3 | 9.3 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01376 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKi | = | 9.3 | 9.3 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01376 | |||||
| 54582126 | 61309 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -2 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| CHEMBL1766935 | 61309 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -2 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| CHEMBL254769 | 212970 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | 2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 127032102 | 139285 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 2 | ChEMBL | 931 | 28 | 14 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786852 | 139285 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 2 | ChEMBL | 931 | 28 | 14 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787704 | 139285 | None | 0 | Human | Binding | pKi | = | 9.1 | 9.1 | -1 | 2 | ChEMBL | 931 | 28 | 14 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 1569 | 2126 | None | 31 | Human | Binding | pKi | = | 9.1 | 9.1 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00462 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKi | = | 9.1 | 9.1 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00462 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKi | = | 9.1 | 9.1 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acsmedchemlett.9b00462 | |||||
| 155547078 | 176641 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 3 | 2 | ChEMBL | 1456 | 42 | 15 | 15 | 5.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4534768 | 176641 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 3 | 2 | ChEMBL | 1456 | 42 | 15 | 15 | 5.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4597104 | 176641 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | 3 | 2 | ChEMBL | 1456 | 42 | 15 | 15 | 5.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| 1569 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 1569 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.10.039 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.10.039 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.10.039 | |||||
| 127030965 | 139290 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 2 | ChEMBL | 1396 | 38 | 14 | 12 | 6.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| 155559776 | 139290 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 2 | ChEMBL | 1396 | 38 | 14 | 12 | 6.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL3787709 | 139290 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 2 | ChEMBL | 1396 | 38 | 14 | 12 | 6.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4564746 | 139290 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | 5 | 2 | ChEMBL | 1396 | 38 | 14 | 12 | 6.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| 1569 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2022.116720 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2022.116720 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 2 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2022.116720 | |||||
| 162647042 | 179720 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 5 | ChEMBL | 1406 | 33 | 19 | 16 | -0.6 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4742666 | 179720 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -1 | 5 | ChEMBL | 1406 | 33 | 19 | 16 | -0.6 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL267714 | 213187 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | 17 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||||
| 162645305 | 179594 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4740987 | 179594 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL1766943 | 211334 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | 100 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccccn1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| CHEMBL254770 | 212971 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | 30 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(Cc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 90644386 | 112202 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 524 | 6 | 2 | 5 | 5.8 | O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 | 10.1021/jm5003843 | |||
| CHEMBL3290093 | 112202 | None | 0 | Rat | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 524 | 6 | 2 | 5 | 5.8 | O=C(N[C@H](C(=O)O)C1CCCCC1)c1cc(-c2c(F)cccc2F)n(-c2ccnc3cc(Cl)ccc23)n1 | 10.1021/jm5003843 | |||
| 90644390 | 112206 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 520 | 7 | 2 | 7 | 4.9 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290097 | 112206 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 520 | 7 | 2 | 7 | 4.9 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 90644396 | 112212 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 519 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290103 | 112212 | None | 0 | Rat | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 519 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| 134144300 | 150288 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 45 | 2 | ChEMBL | 892 | 23 | 10 | 10 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3951982 | 150288 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 45 | 2 | ChEMBL | 892 | 23 | 10 | 10 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 162667718 | 182636 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4787256 | 182636 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162664124 | 182177 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 813 | 13 | 9 | 10 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4781448 | 182177 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 813 | 13 | 9 | 10 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 134138287 | 147925 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | 3 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3932989 | 147925 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | 3 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 90644394 | 112210 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 499 | 7 | 2 | 6 | 5.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290101 | 112210 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 499 | 7 | 2 | 6 | 5.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 90644387 | 112203 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 576 | 9 | 2 | 7 | 6.1 | CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC | 10.1021/jm5003843 | |||
| CHEMBL3290094 | 112203 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 576 | 9 | 2 | 7 | 6.1 | CCc1c(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn(-c2ccnc3cc(Cl)ccc23)c1-c1c(OC)cccc1OC | 10.1021/jm5003843 | |||
| 134145547 | 149062 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 72 | 2 | ChEMBL | 920 | 23 | 12 | 10 | 0.2 | CC[C@H](C)[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3942198 | 149062 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 72 | 2 | ChEMBL | 920 | 23 | 12 | 10 | 0.2 | CC[C@H](C)[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 134155365 | 151282 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 859 | 23 | 13 | 11 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3959801 | 151282 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 859 | 23 | 13 | 11 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL2369509 | 212089 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | 5 | 2 | ChEMBL | None | None | None | CC[C@H](C)N(CC(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN | 10.1021/jm200006c | |||||
| 118729839 | 118008 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 79 | 2 | ChEMBL | 499 | 7 | 2 | 6 | 5.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1016/j.bmcl.2015.03.083 | |||
| CHEMBL3403506 | 118008 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 79 | 2 | ChEMBL | 499 | 7 | 2 | 6 | 5.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1016/j.bmcl.2015.03.083 | |||
| 162657409 | 181214 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 830 | 19 | 11 | 11 | -0.0 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4760222 | 181214 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 830 | 19 | 11 | 11 | -0.0 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL1766927 | 211323 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 2 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 162660324 | 181371 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 51 | 2 | ChEMBL | 828 | 19 | 12 | 10 | -0.9 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4761958 | 181371 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 51 | 2 | ChEMBL | 828 | 19 | 12 | 10 | -0.9 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| 172440132 | 195368 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 790 | 24 | 10 | 11 | -0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCON=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| CHEMBL5402152 | 195368 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 790 | 24 | 10 | 11 | -0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCON=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| 90644398 | 112214 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 22 | 2 | ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290105 | 112214 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 22 | 2 | ChEMBL | 467 | 7 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL1766932 | 211328 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | 6 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 118729838 | 118007 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 51 | 2 | ChEMBL | 534 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1016/j.bmcl.2015.03.083 | |||
| CHEMBL3403505 | 118007 | None | 0 | Rat | Binding | pKi | = | 6.9 | 6.9 | 51 | 2 | ChEMBL | 534 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1016/j.bmcl.2015.03.083 | |||
| 90644385 | 112201 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 518 | 7 | 2 | 6 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290092 | 112201 | None | 0 | Rat | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 518 | 7 | 2 | 6 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 134143837 | 150639 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 9 | 2 | ChEMBL | 807 | 19 | 11 | 9 | -0.3 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3954824 | 150639 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 9 | 2 | ChEMBL | 807 | 19 | 11 | 9 | -0.3 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 134142369 | 145664 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | 67 | 2 | ChEMBL | 892 | 23 | 10 | 10 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3915284 | 145664 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | 67 | 2 | ChEMBL | 892 | 23 | 10 | 10 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 162664045 | 182233 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 754 | 17 | 10 | 12 | -0.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4782113 | 182233 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 754 | 17 | 10 | 12 | -0.5 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 118711921 | 114123 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 457 | 9 | 3 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 | 10.1021/jm500857r | |||
| CHEMBL3326832 | 114123 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 457 | 9 | 3 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)cc1 | 10.1021/jm500857r | |||
| 90644389 | 112205 | None | 0 | Rat | Binding | pKi | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 534 | 7 | 2 | 7 | 5.3 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290096 | 112205 | None | 0 | Rat | Binding | pKi | = | 6.8 | 6.8 | 1 | 2 | ChEMBL | 534 | 7 | 2 | 7 | 5.3 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 90644399 | 112215 | None | 1 | Rat | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290106 | 112215 | None | 1 | Rat | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| 90644384 | 112200 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 | 10.1021/jm5003843 | |||
| CHEMBL3290091 | 112200 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c(OC)c1 | 10.1021/jm5003843 | |||
| 162660488 | 181471 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 10 | 2 | ChEMBL | 1646 | 51 | 24 | 21 | -3.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4763222 | 181471 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 10 | 2 | ChEMBL | 1646 | 51 | 24 | 21 | -3.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 54582127 | 61310 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -4 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)C[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| CHEMBL1766936 | 61310 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -4 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)C[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| 137645783 | 157840 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 726 | 25 | 9 | 10 | -0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| CHEMBL4082440 | 157840 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 726 | 25 | 9 | 10 | -0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| CHEMBL1766940 | 211331 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N(CC(=O)O)CC(C)C | 10.1021/jm200006c | |||||
| 134146201 | 149031 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | 7 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3941970 | 149031 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | 7 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL253527 | 212969 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 12 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CCc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 168269036 | 190123 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 895 | 28 | 14 | 13 | -1.4 | CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| CHEMBL5171551 | 190123 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 895 | 28 | 14 | 13 | -1.4 | CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| 90644388 | 112204 | None | 0 | Rat | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 548 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290095 | 112204 | None | 0 | Rat | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 548 | 7 | 2 | 7 | 5.7 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 1574 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 1579 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 25077406 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 3830 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm5003843 | |||||
| 134134595 | 143707 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 34 | 2 | ChEMBL | 808 | 21 | 8 | 10 | 0.6 | CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3899699 | 143707 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 34 | 2 | ChEMBL | 808 | 21 | 8 | 10 | 0.6 | CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 127032412 | 139287 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -4 | 2 | ChEMBL | 987 | 30 | 14 | 11 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3785364 | 139287 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -4 | 2 | ChEMBL | 987 | 30 | 14 | 11 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786291 | 139287 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -4 | 2 | ChEMBL | 987 | 30 | 14 | 11 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787706 | 139287 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -4 | 2 | ChEMBL | 987 | 30 | 14 | 11 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL4579623 | 139287 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -4 | 2 | ChEMBL | 987 | 30 | 14 | 11 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC | 10.1021/acs.jmedchem.5b01495 | |||
| 162668357 | 182579 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 2 | ChEMBL | 1614 | 47 | 22 | 20 | -3.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4786574 | 182579 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 2 | ChEMBL | 1614 | 47 | 22 | 20 | -3.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162644976 | 179555 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 1318 | 2 | ChEMBL | 787 | 20 | 8 | 10 | 1.2 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4740539 | 179555 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 1318 | 2 | ChEMBL | 787 | 20 | 8 | 10 | 1.2 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1Cc2cc(O)ccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL1766942 | 211333 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | 131 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccccc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 162662194 | 181563 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 813 | 18 | 10 | 11 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4764437 | 181563 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 813 | 18 | 10 | 11 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 101873359 | 114122 | None | 25 | Rat | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 553 | 10 | 3 | 6 | 4.1 | Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 | 10.1021/jm500857r | |||
| CHEMBL3326831 | 114122 | None | 25 | Rat | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 553 | 10 | 3 | 6 | 4.1 | Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)c(C(=O)C(F)(F)F)cn3CC(=O)N[C@@H](CC(C)C)C(=O)O)cc1 | 10.1021/jm500857r | |||
| 134136231 | 142562 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 10 | 2 | ChEMBL | 751 | 19 | 7 | 9 | 1.4 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3890335 | 142562 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 10 | 2 | ChEMBL | 751 | 19 | 7 | 9 | 1.4 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 1574 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| 1579 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| 25077406 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| 3830 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.7 | 7.7 | -107 | 6 | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2014.11.047 | |||||
| CHEMBL411195 | 215329 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CN(CCCCN)C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 44447826 | 97008 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -4 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| CHEMBL266230 | 97008 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -4 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| 162652765 | 180536 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4752398 | 180536 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 134140868 | 146828 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | 56 | 2 | ChEMBL | 864 | 23 | 8 | 10 | 2.0 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3924268 | 146828 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | 56 | 2 | ChEMBL | 864 | 23 | 8 | 10 | 2.0 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 162667305 | 182668 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 812 | 13 | 8 | 9 | 3.0 | CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CCCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4787727 | 182668 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 812 | 13 | 8 | 9 | 3.0 | CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CCCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162677287 | 183585 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | 3 | 2 | ChEMBL | 816 | 22 | 13 | 10 | -1.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cccc(O)c1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4799352 | 183585 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | 3 | 2 | ChEMBL | 816 | 22 | 13 | 10 | -1.1 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cccc(O)c1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL1766924 | 211320 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 54583075 | 61313 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)CC(C)C | 10.1021/jm200006c | |||
| CHEMBL1766939 | 61313 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -3 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)CC(C)C | 10.1021/jm200006c | |||
| 162658073 | 181111 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 813 | 17 | 10 | 11 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4758998 | 181111 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 813 | 17 | 10 | 11 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 137646112 | 158011 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | 21 | 2 | ChEMBL | 726 | 26 | 9 | 10 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| CHEMBL4084378 | 158011 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | 21 | 2 | ChEMBL | 726 | 26 | 9 | 10 | -0.2 | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| 90644393 | 112209 | None | 0 | Rat | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290100 | 112209 | None | 0 | Rat | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 483 | 7 | 2 | 5 | 5.5 | COc1ccccc1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 134136231 | 142562 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | 10 | 2 | ChEMBL | 751 | 19 | 7 | 9 | 1.4 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3890335 | 142562 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | 10 | 2 | ChEMBL | 751 | 19 | 7 | 9 | 1.4 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 118729840 | 118009 | None | 0 | Rat | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| CHEMBL3403507 | 118009 | None | 0 | Rat | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 467 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| 1574 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.6 | 7.6 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 1579 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.6 | 7.6 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 25077406 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.6 | 7.6 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 3830 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.6 | 7.6 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| CHEMBL407196 | 2809 | None | 18 | Rat | Binding | pKi | = | 7.6 | 7.6 | -107 | 6 | ChEMBL | None | None | None | None | 10.1021/jm500857r | |||||
| 134138287 | 147925 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | 3 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3932989 | 147925 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | 3 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 134153118 | 152689 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 1202 | 2 | ChEMBL | 802 | 21 | 13 | 11 | -2.2 | CC(C)C[C@H](NC(=O)CNC(=O)[C@@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@H]1c1ccc(O)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3971946 | 152689 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 1202 | 2 | ChEMBL | 802 | 21 | 13 | 11 | -2.2 | CC(C)C[C@H](NC(=O)CNC(=O)[C@@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@H]1c1ccc(O)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 162660385 | 181310 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -7 | 5 | ChEMBL | 1358 | 40 | 14 | 15 | 3.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4761165 | 181310 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -7 | 5 | ChEMBL | 1358 | 40 | 14 | 15 | 3.0 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C | 10.1021/acs.jmedchem.0c01376 | |||
| 162659782 | 181427 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 845 | 22 | 13 | 10 | -0.5 | Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4762684 | 181427 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 845 | 22 | 13 | 10 | -0.5 | Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C | 10.1021/acs.jmedchem.0c01376 | |||
| 155569717 | 176344 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 1 | 2 | ChEMBL | 1657 | 48 | 16 | 20 | 4.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4537266 | 176344 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 1 | 2 | ChEMBL | 1657 | 48 | 16 | 20 | 4.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4594723 | 176344 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 1 | 2 | ChEMBL | 1657 | 48 | 16 | 20 | 4.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| 155569737 | 176740 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 1597 | 44 | 16 | 18 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4457798 | 176740 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 1597 | 44 | 16 | 18 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4597941 | 176740 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 1597 | 44 | 16 | 18 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| 146159772 | 2311 | None | 22 | Rat | Binding | pKi | = | 7.5 | 7.5 | -2 | 3 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 1564 | 2311 | None | 22 | Rat | Binding | pKi | = | 7.5 | 7.5 | -2 | 3 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 1586 | 2311 | None | 22 | Rat | Binding | pKi | = | 7.5 | 7.5 | -2 | 3 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 54385 | 2311 | None | 22 | Rat | Binding | pKi | = | 7.5 | 7.5 | -2 | 3 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| 54385.0 | 2311 | None | 22 | Rat | Binding | pKi | = | 7.5 | 7.5 | -2 | 3 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| CHEMBL1615438 | 2311 | None | 22 | Rat | Binding | pKi | = | 7.5 | 7.5 | -2 | 3 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| DB01106 | 2311 | None | 22 | Rat | Binding | pKi | = | 7.5 | 7.5 | -2 | 3 | ChEMBL | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 10.1021/jm5003843 | |||
| CHEMBL342252 | 214132 | None | 0 | Rat | Binding | pKi | = | 7.5 | 7.5 | -338 | 4 | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm5003843 | |||||
| CHEMBL2369509 | 212089 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | 5 | 2 | ChEMBL | None | None | None | CC[C@H](C)N(CC(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN | 10.1021/jm200006c | |||||
| 54580109 | 61314 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 251 | 2 | ChEMBL | 862 | 24 | 11 | 8 | 3.0 | C=C(N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCCNC(=N)N | 10.1021/jm200006c | |||
| CHEMBL1766947 | 61314 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 251 | 2 | ChEMBL | 862 | 24 | 11 | 8 | 3.0 | C=C(N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCCNC(=N)N | 10.1021/jm200006c | |||
| 162646717 | 179714 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 1671 | 50 | 23 | 21 | -4.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4742361 | 179714 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 1671 | 50 | 23 | 21 | -4.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL1766934 | 211330 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| CHEMBL1766941 | 211332 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | 1230 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(OC)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 162667051 | 182629 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 703 | 20 | 12 | 9 | -1.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4787163 | 182629 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 703 | 20 | 12 | 9 | -1.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 1574 | 2809 | None | 18 | Human | Binding | pKi | = | 8.4 | 8.4 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01726 | |||||
| 1579 | 2809 | None | 18 | Human | Binding | pKi | = | 8.4 | 8.4 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01726 | |||||
| 25077406 | 2809 | None | 18 | Human | Binding | pKi | = | 8.4 | 8.4 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01726 | |||||
| 3830 | 2809 | None | 18 | Human | Binding | pKi | = | 8.4 | 8.4 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01726 | |||||
| CHEMBL407196 | 2809 | None | 18 | Human | Binding | pKi | = | 8.4 | 8.4 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.0c01726 | |||||
| 168274909 | 190358 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 2 | 2 | ChEMBL | 995 | 31 | 15 | 14 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| CHEMBL5175252 | 190358 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 2 | 2 | ChEMBL | 995 | 31 | 15 | 14 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| CHEMBL1766946 | 211337 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 7413 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| CHEMBL1766945 | 211336 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 1905 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 162668803 | 182841 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 799 | 13 | 9 | 10 | 1.0 | CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4789911 | 182841 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 799 | 13 | 9 | 10 | 1.0 | CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)C/C=C/CNCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162655533 | 180887 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 1646 | 51 | 24 | 21 | -3.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4756326 | 180887 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 1646 | 51 | 24 | 21 | -3.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 1574 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 1579 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 25077406 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 3830 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| CHEMBL407196 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 1574 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm401491e | |||||
| 1579 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm401491e | |||||
| 25077406 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm401491e | |||||
| 3830 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm401491e | |||||
| CHEMBL407196 | 2809 | None | 18 | Human | Binding | pKi | = | 8.3 | 8.3 | -15 | 6 | ChEMBL | None | None | None | None | 10.1021/jm401491e | |||||
| 119192 | 2481 | None | 38 | Human | Binding | pKi | = | 6.4 | 6.4 | -114 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmc.2013.04.075 | |||
| 1582 | 2481 | None | 38 | Human | Binding | pKi | = | 6.4 | 6.4 | -114 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmc.2013.04.075 | |||
| CHEMBL506981 | 2481 | None | 38 | Human | Binding | pKi | = | 6.4 | 6.4 | -114 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmc.2013.04.075 | |||
| DB06455 | 2481 | None | 38 | Human | Binding | pKi | = | 6.4 | 6.4 | -114 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmc.2013.04.075 | |||
| 137651580 | 157198 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 712 | 24 | 9 | 10 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| CHEMBL4074624 | 157198 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 712 | 24 | 9 | 10 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| 54585023 | 61311 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -5 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| CHEMBL1766937 | 61311 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -5 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](NC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||
| 118721826 | 116151 | None | 0 | Rat | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 483 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3356855 | 116151 | None | 0 | Rat | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 483 | 7 | 2 | 6 | 4.7 | COc1cccc(OC)c1-c1nc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| 137651867 | 157340 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -1 | 2 | ChEMBL | 734 | 24 | 9 | 10 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| CHEMBL4076517 | 157340 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -1 | 2 | ChEMBL | 734 | 24 | 9 | 10 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| 134143837 | 150639 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | 9 | 2 | ChEMBL | 807 | 19 | 11 | 9 | -0.3 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3954824 | 150639 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | 9 | 2 | ChEMBL | 807 | 19 | 11 | 9 | -0.3 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 168283408 | 191000 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | 3 | 2 | ChEMBL | 1009 | 32 | 15 | 14 | -0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| CHEMBL5184967 | 191000 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | 3 | 2 | ChEMBL | 1009 | 32 | 15 | 14 | -0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| 54585990 | 61312 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | 46 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N | 10.1021/jm200006c | |||
| CHEMBL1766938 | 61312 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | 46 | 2 | ChEMBL | 831 | 25 | 13 | 10 | -0.7 | CC[C@H](C)[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N | 10.1021/jm200006c | |||
| CHEMBL1766929 | 211325 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -8 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 172460862 | 196280 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 818 | 24 | 11 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCON=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| CHEMBL5420374 | 196280 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 818 | 24 | 11 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCON=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| 172468416 | 196926 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -1 | 2 | ChEMBL | 818 | 24 | 11 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCON=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| CHEMBL5434985 | 196926 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -1 | 2 | ChEMBL | 818 | 24 | 11 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCON=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| 1580 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | |||
| 5311451 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | |||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm500857r | |||
| 162669302 | 182768 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4788991 | 182768 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 716 | 17 | 10 | 10 | -0.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C/C=C\C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 134134595 | 143707 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 34 | 2 | ChEMBL | 808 | 21 | 8 | 10 | 0.6 | CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3899699 | 143707 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 34 | 2 | ChEMBL | 808 | 21 | 8 | 10 | 0.6 | CC(C)C[C@H](NC(=O)CNC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL1766930 | 211326 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 90644391 | 112207 | None | 0 | Rat | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 504 | 6 | 2 | 6 | 5.3 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290098 | 112207 | None | 0 | Rat | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 504 | 6 | 2 | 6 | 5.3 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 90644392 | 112208 | None | 0 | Rat | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 513 | 8 | 2 | 6 | 5.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290099 | 112208 | None | 0 | Rat | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 513 | 8 | 2 | 6 | 5.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 172452068 | 195713 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 820 | 24 | 11 | 12 | -2.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCON=C(N)N)NC(=O)[C@@H](N)CCON=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| CHEMBL5409459 | 195713 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 820 | 24 | 11 | 12 | -2.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCON=C(N)N)NC(=O)[C@@H](N)CCON=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| 168291832 | 191971 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -1 | 2 | ChEMBL | 881 | 27 | 14 | 13 | -1.8 | CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| CHEMBL5199274 | 191971 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -1 | 2 | ChEMBL | 881 | 27 | 14 | 13 | -1.8 | CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmc.2022.116720 | |||
| CHEMBL1766923 | 211319 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -12 | 2 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| CHEMBL408057 | 215156 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||||
| CHEMBL1766931 | 211327 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 1580 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| 5311451 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| CHEMBL258221 | 212975 | None | 16 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 168475922 | 197197 | None | 2 | Human | Binding | pKi | = | 8.2 | 8.2 | 1 | 2 | ChEMBL | 790 | 24 | 10 | 11 | -0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCON=C(N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| CHEMBL5441066 | 197197 | None | 2 | Human | Binding | pKi | = | 8.2 | 8.2 | 1 | 2 | ChEMBL | 790 | 24 | 10 | 11 | -0.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCON=C(N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.ejmech.2023.115386 | |||
| 1569 | 2126 | None | 31 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01848 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01848 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01848 | |||||
| CHEMBL1766944 | 211335 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | 11748 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 162651256 | 180440 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | 1630 | 48 | 23 | 21 | -4.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4751221 | 180440 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | 1630 | 48 | 23 | 21 | -4.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 134146201 | 149031 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | 7 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3941970 | 149031 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | 7 | 2 | ChEMBL | 779 | 19 | 9 | 9 | 0.6 | CC(C)C[C@H](NC(=O)C1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)CCOC1c1ccc(Br)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 90644383 | 112199 | None | 0 | Rat | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 | 10.1021/jm5003843 | |||
| CHEMBL3290090 | 112199 | None | 0 | Rat | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1ccc(OC)c(-c2cc(C(=O)N[C@H](C(=O)O)C3CCCCC3)nn2-c2ccnc3cc(Cl)ccc23)c1 | 10.1021/jm5003843 | |||
| 134145567 | 149206 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | 16 | 2 | ChEMBL | 920 | 23 | 12 | 10 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3943248 | 149206 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | 16 | 2 | ChEMBL | 920 | 23 | 12 | 10 | 0.2 | CC[C@H](C)[C@H](NC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(Br)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 137656771 | 159758 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 712 | 25 | 9 | 10 | -0.6 | CC[C@H](C)[C@H](NC(=O)C(CCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| CHEMBL4103884 | 159758 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 712 | 25 | 9 | 10 | -0.6 | CC[C@H](C)[C@H](NC(=O)C(CCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| 119192 | 2481 | None | 38 | Rat | Binding | pKi | = | 7.2 | 7.2 | -17 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| 1582 | 2481 | None | 38 | Rat | Binding | pKi | = | 7.2 | 7.2 | -17 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| CHEMBL506981 | 2481 | None | 38 | Rat | Binding | pKi | = | 7.2 | 7.2 | -17 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| DB06455 | 2481 | None | 38 | Rat | Binding | pKi | = | 7.2 | 7.2 | -17 | 9 | ChEMBL | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm5003843 | |||
| 90644400 | 112198 | None | 0 | Rat | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 542 | 6 | 1 | 6 | 6.3 | COc1cccc(OC)c1-c1cc(C(=O)NC2C3CC4CC(C3)CC2C4)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290089 | 112198 | None | 0 | Rat | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 542 | 6 | 1 | 6 | 6.3 | COc1cccc(OC)c1-c1cc(C(=O)NC2C3CC4CC(C3)CC2C4)nn1-c1ccnc2cc(Cl)ccc12 | 10.1021/jm5003843 | |||
| 44594765 | 182609 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 703 | 20 | 12 | 9 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4786965 | 182609 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 703 | 20 | 12 | 9 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 90644397 | 112213 | None | 0 | Rat | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 481 | 8 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL3290104 | 112213 | None | 0 | Rat | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 481 | 8 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](C(=O)O)C2CCCCC2)nn1-c1ccc(F)cc1 | 10.1021/jm5003843 | |||
| CHEMBL172313 | 211311 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -14 | 3 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| CHEMBL1766925 | 211321 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -2 | 2 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| 118729841 | 118010 | None | 0 | Rat | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.7 | COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| CHEMBL3403508 | 118010 | None | 0 | Rat | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 437 | 6 | 2 | 5 | 4.7 | COc1ccccc1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2015.03.083 | |||
| 1581 | 3670 | None | 10 | Rat | Binding | pKi | = | 6.2 | 6.2 | -12 | 2 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | |||
| 9915499 | 3670 | None | 10 | Rat | Binding | pKi | = | 6.2 | 6.2 | -12 | 2 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | |||
| CHEMBL461604 | 3670 | None | 10 | Rat | Binding | pKi | = | 6.2 | 6.2 | -12 | 2 | ChEMBL | 548 | 8 | 2 | 7 | 5.5 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC | 10.1021/jm5003843 | |||
| 162651757 | 180314 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 1630 | 48 | 23 | 21 | -4.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4749690 | 180314 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 1630 | 48 | 23 | 21 | -4.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 137660279 | 159462 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | 9 | 2 | ChEMBL | 756 | 26 | 9 | 10 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C[Si](C)(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| CHEMBL4100456 | 159462 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | 9 | 2 | ChEMBL | 756 | 26 | 9 | 10 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C[Si](C)(C)C)C(=O)O | 10.1021/acs.jmedchem.6b01848 | |||
| 72737612 | 103645 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -70 | 2 | ChEMBL | 958 | 20 | 5 | 15 | 4.6 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)CCCCc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)cc1C(C)C | 10.1021/jm401491e | |||
| CHEMBL3086356 | 103645 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -70 | 2 | ChEMBL | 958 | 20 | 5 | 15 | 4.6 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)CCCCc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)cc1C(C)C | 10.1021/jm401491e | |||
| CHEMBL3979668 | 214972 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | 1 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||||
| CHEMBL1766933 | 211329 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | 18 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| 90644395 | 112211 | None | 0 | Rat | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 5.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| CHEMBL3290102 | 112211 | None | 0 | Rat | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 469 | 6 | 2 | 5 | 5.2 | COc1ccccc1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 | 10.1021/jm5003843 | |||
| 1580 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | |||
| 5311451 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3040381 | 3665 | None | 36 | Rat | Binding | pKi | = | 8.2 | 8.2 | -6 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1016/j.bmcl.2014.11.047 | |||
| 155569719 | 176477 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -2 | 2 | ChEMBL | 1577 | 47 | 15 | 18 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4592541 | 176477 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -2 | 2 | ChEMBL | 1577 | 47 | 15 | 18 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| CHEMBL4595797 | 176477 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -2 | 2 | ChEMBL | 1577 | 47 | 15 | 18 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acsmedchemlett.9b00462 | |||
| 132547200 | 149087 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | 28 | 2 | ChEMBL | 802 | 21 | 13 | 11 | -2.2 | CC(C)C[C@H](NC(=O)CNC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| CHEMBL3942339 | 149087 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | 28 | 2 | ChEMBL | 802 | 21 | 13 | 11 | -2.2 | CC(C)C[C@H](NC(=O)CNC(=O)[C@]1(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCO[C@@H]1c1ccc(O)cc1)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||
| 1580 | 3665 | None | 36 | Human | Binding | pKi | = | 7.1 | 7.1 | -70 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm401491e | |||
| 5311451 | 3665 | None | 36 | Human | Binding | pKi | = | 7.1 | 7.1 | -70 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm401491e | |||
| CHEMBL3040381 | 3665 | None | 36 | Human | Binding | pKi | = | 7.1 | 7.1 | -70 | 4 | ChEMBL | 685 | 13 | 2 | 8 | 5.7 | COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 10.1021/jm401491e | |||
| 162658930 | 181131 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -3 | 2 | ChEMBL | 1630 | 48 | 23 | 21 | -4.4 | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4759247 | 181131 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -3 | 2 | ChEMBL | 1630 | 48 | 23 | 21 | -4.4 | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162651726 | 180395 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -12 | 5 | ChEMBL | 1350 | 33 | 15 | 16 | 1.1 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| CHEMBL4750783 | 180395 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -12 | 5 | ChEMBL | 1350 | 33 | 15 | 16 | 1.1 | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2Cc3ccc(O)cc3C[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C)C1=O | 10.1021/acs.jmedchem.0c01376 | |||
| 162674795 | 183563 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 2 | ChEMBL | 1580 | 48 | 22 | 20 | -4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4799000 | 183563 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 2 | ChEMBL | 1580 | 48 | 22 | 20 | -4.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162677029 | 183610 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -4 | 2 | ChEMBL | 1632 | 50 | 23 | 21 | -3.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4799695 | 183610 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -4 | 2 | ChEMBL | 1632 | 50 | 23 | 21 | -3.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162674076 | 183191 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 2 | ChEMBL | 1629 | 48 | 22 | 20 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4794420 | 183191 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 2 | ChEMBL | 1629 | 48 | 22 | 20 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL1766825 | 211318 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | 3235 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/jm200006c | |||||
| CHEMBL1766926 | 211322 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | 15 | 2 | ChEMBL | None | None | None | None | 10.1021/jm200006c | |||||
| CHEMBL3950695 | 214942 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | 2 | 2 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1016/j.bmc.2016.10.039 | |||||
| 118721825 | 116150 | None | 0 | Rat | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 457 | 8 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3356854 | 116150 | None | 0 | Rat | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 457 | 8 | 2 | 6 | 4.2 | COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| 162667468 | 182662 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 1615 | 46 | 22 | 20 | -3.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4787611 | 182662 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 1615 | 46 | 22 | 20 | -3.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162676199 | 183373 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 718 | 17 | 10 | 10 | -0.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4796587 | 183373 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 718 | 17 | 10 | 10 | -0.4 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 162653994 | 180654 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 1587 | 46 | 20 | 20 | -2.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| CHEMBL4753810 | 180654 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | ChEMBL | 1587 | 46 | 20 | 20 | -2.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O | 10.1021/acs.jmedchem.0c01726 | |||
| 118721824 | 116149 | None | 0 | Rat | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 469 | 6 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| CHEMBL3356853 | 116149 | None | 0 | Rat | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 469 | 6 | 2 | 6 | 4.5 | COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)CCCCC2)nc2ccc(Cl)cc12 | 10.1016/j.bmcl.2014.11.047 | |||
| 1569 | 2126 | None | 31 | Human | Binding | pKd | None | 7 | 7.0 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 5311318 | 2126 | None | 31 | Human | Binding | pKd | None | 7 | 7.0 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| CHEMBL415788 | 2126 | None | 31 | Human | Binding | pKd | None | 7 | 7.0 | -2 | 2 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 1574 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 8795617 | |||||
| 1574 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 1579 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 8795617 | |||||
| 1579 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 25077406 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 8795617 | |||||
| 25077406 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| 3830 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 8795617 | |||||
| 3830 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| CHEMBL407196 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 8795617 | |||||
| CHEMBL407196 | 2809 | None | 18 | Mouse | Binding | pKd | None | 8.6 | 8.6 | -19 | 6 | Guide to Pharmacology | None | None | None | None | 9480852 | |||||
| None | 218853 | 125I-Neurotensin | 0 | Mouse | Binding | pKi | = | 7.8 | 7.8 | 588 | 2 | PDSP KiDatabase | 420 | 4 | 1 | 3 | 4.9 | CC1CN(CCC1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F | None | |||
| 146159772 | 2311 | None | 22 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1564 | 2311 | None | 22 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1586 | 2311 | None | 22 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 54385 | 2311 | None | 22 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 54385.0 | 2311 | None | 22 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| CHEMBL1615438 | 2311 | None | 22 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| DB01106 | 2311 | None | 22 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1574 | 2809 | 125I-Neurotensin | 18 | Mouse | Binding | pKi | = | 8.2 | 8.2 | -19 | 6 | PDSP KiDatabase | None | None | None | None | None | |||||
| 1579 | 2809 | 125I-Neurotensin | 18 | Mouse | Binding | pKi | = | 8.2 | 8.2 | -19 | 6 | PDSP KiDatabase | None | None | None | None | None | |||||
| 25077406 | 2809 | 125I-Neurotensin | 18 | Mouse | Binding | pKi | = | 8.2 | 8.2 | -19 | 6 | PDSP KiDatabase | None | None | None | None | None | |||||
| 3830 | 2809 | 125I-Neurotensin | 18 | Mouse | Binding | pKi | = | 8.2 | 8.2 | -19 | 6 | PDSP KiDatabase | None | None | None | None | None | |||||
| CHEMBL407196 | 2809 | 125I-Neurotensin | 18 | Mouse | Binding | pKi | = | 8.2 | 8.2 | -19 | 6 | PDSP KiDatabase | None | None | None | None | None | |||||
| 146159772 | 2311 | None | 22 | Rat | Binding | pKi | = | 8.1 | 8.1 | -2 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1564 | 2311 | None | 22 | Rat | Binding | pKi | = | 8.1 | 8.1 | -2 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 1586 | 2311 | None | 22 | Rat | Binding | pKi | = | 8.1 | 8.1 | -2 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 54385 | 2311 | None | 22 | Rat | Binding | pKi | = | 8.1 | 8.1 | -2 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 54385.0 | 2311 | None | 22 | Rat | Binding | pKi | = | 8.1 | 8.1 | -2 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| CHEMBL1615438 | 2311 | None | 22 | Rat | Binding | pKi | = | 8.1 | 8.1 | -2 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| DB01106 | 2311 | None | 22 | Rat | Binding | pKi | = | 8.1 | 8.1 | -2 | 3 | Drug Central | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | None | |||
| 146159772 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 11723247 | |||
| 146159772 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8795617 | |||
| 1564 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 11723247 | |||
| 1564 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8795617 | |||
| 1586 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 11723247 | |||
| 1586 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8795617 | |||
| 54385 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 11723247 | |||
| 54385 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8795617 | |||
| 54385.0 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 11723247 | |||
| 54385.0 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8795617 | |||
| CHEMBL1615438 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 11723247 | |||
| CHEMBL1615438 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8795617 | |||
| DB01106 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 11723247 | |||
| DB01106 | 2311 | None | 22 | Human | Binding | pKi | = | 6.8 | 6.8 | -4 | 3 | Guide to Pharmacology | 420 | 4 | 1 | 3 | 4.9 | N#C[C@@]1(CC[C@@H](CC1)N1CC[C@]([C@@H](C1)C)(C(=O)O)c1ccccc1)c1ccc(cc1)F | 8795617 | |||
| 119192 | 2481 | None | 38 | Human | Binding | pKi | None | 6.4 | 6.4 | -114 | 9 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 11723247 | |||
| 1582 | 2481 | None | 38 | Human | Binding | pKi | None | 6.4 | 6.4 | -114 | 9 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 11723247 | |||
| CHEMBL506981 | 2481 | None | 38 | Human | Binding | pKi | None | 6.4 | 6.4 | -114 | 9 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 11723247 | |||
| DB06455 | 2481 | None | 38 | Human | Binding | pKi | None | 6.4 | 6.4 | -114 | 9 | Guide to Pharmacology | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | 11723247 | |||
| 1571 | 2128 | None | 0 | Human | Binding | pKi | None | 6.8 | 6.8 | 10 | 2 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 1568 | 2123 | None | 0 | Human | Binding | pKi | None | 7.2 | 7.2 | 31 | 2 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 1572 | 2129 | None | 0 | Human | Binding | pKi | None | 8.7 | 8.7 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 5311320 | 2129 | None | 0 | Human | Binding | pKi | None | 8.7 | 8.7 | -1 | 2 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 1574 | 2809 | None | 18 | Human | Binding | pKi | None | 8.8 | 8.8 | -15 | 6 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 1579 | 2809 | None | 18 | Human | Binding | pKi | None | 8.8 | 8.8 | -15 | 6 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 25077406 | 2809 | None | 18 | Human | Binding | pKi | None | 8.8 | 8.8 | -15 | 6 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| 3830 | 2809 | None | 18 | Human | Binding | pKi | None | 8.8 | 8.8 | -15 | 6 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||
| CHEMBL407196 | 2809 | None | 18 | Human | Binding | pKi | None | 8.8 | 8.8 | -15 | 6 | Guide to Pharmacology | None | None | None | None | 11723247 | |||||