Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 2168 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 2810 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 644077 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 644077.0 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| CHEMBL373742 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| DB00067 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 2168 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 2810 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 644077 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 644077.0 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| CHEMBL373742 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| DB00067 | 3976 | None | 29 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 12 | 6 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| CHEMBL1819441 | 211473 | None | 0 | Rat | Functional | pEC50 | = | 10.2 | 10.2 | 1 | 4 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1819441 | 211473 | None | 0 | Rat | Functional | pEC50 | = | 10.1 | 10.1 | 1 | 4 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1817706 | 211447 | None | 0 | Rat | Functional | pEC50 | = | 10 | 10.0 | 2 | 5 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1817706 | 211447 | None | 0 | Rat | Functional | pEC50 | = | 10.0 | 10.0 | 2 | 5 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1819542 | 211476 | None | 6 | Rat | Functional | pEC50 | = | 9.9 | 9.9 | 2 | 4 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||||
| CHEMBL1819542 | 211476 | None | 6 | Rat | Functional | pEC50 | = | 9.9 | 9.9 | 2 | 4 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||||
| CHEMBL1817704 | 211445 | None | 0 | Rat | Functional | pEC50 | = | 9.9 | 9.9 | 2 | 5 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||||
| 90285421 | 115046 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 9 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL3342789 | 115046 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 9 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 3601935 | 162457 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 271 | 3 | 1 | 4 | 1.9 | Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL4165132 | 162457 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | -1 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 271 | 3 | 1 | 4 | 1.9 | Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL1817704 | 211445 | None | 0 | Rat | Functional | pEC50 | = | 9.9 | 9.9 | 2 | 5 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||||
| CHEMBL1819540 | 211474 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 64 | 3 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1819540 | 211474 | None | 0 | Human | Functional | pEC50 | = | 9.9 | 9.9 | 64 | 3 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1819441 | 211473 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -1 | 4 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1819441 | 211473 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -1 | 4 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| 76685194 | 115047 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 5 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL3342790 | 115047 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | 5 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 5014150 | 162950 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -1 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 305 | 3 | 1 | 4 | 2.2 | Cn1nccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL4173036 | 162950 | None | 0 | Human | Functional | pEC50 | = | 9.8 | 9.8 | -1 | 2 | Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assayAntagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux preincubated for 5 mins followed by AVP addition measured after 5 mins for every 2 secs by Ca5 dye based FLIPR assay |
ChEMBL | 305 | 3 | 1 | 4 | 2.2 | Cn1nccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL1817707 | 211448 | None | 0 | Rat | Functional | pEC50 | = | 9.8 | 9.8 | 3 | 5 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1817707 | 211448 | None | 0 | Rat | Functional | pEC50 | = | 9.8 | 9.8 | 3 | 5 | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| 2042 | 2983 | None | 40 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -3 | 5 | Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2019.06.018 | ||||
| 2174 | 2983 | None | 40 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -3 | 5 | Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2019.06.018 | ||||
| 2176 | 2983 | None | 40 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -3 | 5 | Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2019.06.018 | ||||
| 439302 | 2983 | None | 40 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -3 | 5 | Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2019.06.018 | ||||
| 439302.0 | 2983 | None | 40 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -3 | 5 | Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2019.06.018 | ||||
| CHEMBL395429 | 2983 | None | 40 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -3 | 5 | Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2019.06.018 | ||||
| DB00107 | 2983 | None | 40 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -3 | 5 | Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric methodAgonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method |
ChEMBL | None | None | None | None | 10.1016/j.bmc.2019.06.018 | ||||
| CHEMBL1817706 | 211447 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 5 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1817706 | 211447 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | -2 | 5 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||||
| CHEMBL1819541 | 211475 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 14 | 4 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||||
| 2168 | 3976 | None | 29 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -15 | 6 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 2810 | 3976 | None | 29 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -15 | 6 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 644077 | 3976 | None | 29 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -15 | 6 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| 644077.0 | 3976 | None | 29 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -15 | 6 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| CHEMBL373742 | 3976 | None | 29 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -15 | 6 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
| DB00067 | 3976 | None | 29 | Human | Functional | pEC50 | = | 9.6 | 9.6 | -15 | 6 | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assayAgonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay |
ChEMBL | None | None | None | None | 10.1021/jm200278m | ||||
Showing 1 to 50 of 922 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 16362 | 3125 | None | 49 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 16362.0 | 3125 | None | 49 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 2172 | 3125 | None | 49 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 90 | 3125 | None | 49 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1423 | 3125 | None | 49 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| DB01100 | 3125 | None | 49 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 29 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | ||
| 3149 | 12618 | None | 11 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1187011 | 12618 | None | 11 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 448537 | 160344 | None | 54 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -45 | 25 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL411 | 160344 | None | 54 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -45 | 25 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | 10.1038/s41467-023-40064-9 | ||
| 11980903 | 14498 | None | 13 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 22526 | 14498 | None | 13 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 5281035 | 14498 | None | 13 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1201303 | 14498 | None | 13 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 1222 | 1664 | None | 37 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 32 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 3396 | 1664 | None | 37 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 32 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 3396.0 | 1664 | None | 37 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 32 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 85 | 1664 | None | 37 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 32 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL46516 | 1664 | None | 37 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 32 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| DB04842 | 1664 | None | 37 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 32 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 72093 | 35070 | None | 5 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1433361 | 35070 | None | 5 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL2103773 | 35070 | None | 5 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | ||
| 6436173 | 55132 | None | 30 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1617 | 55132 | None | 30 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | ||
| 2713 | 207729 | None | 57 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | ||
| 5353524 | 207729 | None | 57 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | ||
| 5360566 | 207729 | None | 57 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | ||
| 88536661 | 207729 | None | 57 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | ||
| 9552079 | 207729 | None | 57 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1330113 | 207729 | None | 57 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL790 | 207729 | None | 57 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 504 | 9 | 10 | 4 | 4.2 | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 | 10.1038/s41467-023-40064-9 | ||
| 103 | 4153 | None | 44 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 53 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| 2875 | 4153 | None | 44 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 53 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| 5736 | 4153 | None | 44 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 53 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL285802 | 4153 | None | 44 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 53 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| DB09225 | 4153 | None | 44 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 53 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 10.1038/s41467-023-40064-9 | ||
| 2335 | 11852 | None | 18 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 12 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| 8478 | 11852 | None | 18 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 12 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1182210 | 11852 | None | 18 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 12 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL221753 | 11852 | None | 18 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 12 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| 41684 | 31229 | None | 62 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1401 | 31229 | None | 62 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | ||
| 2213 | 518 | None | 30 | Human | Binding | pAC50 | = | 7.7 | 7.7 | 28 | 5 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | ||||
| 3008 | 518 | None | 30 | Human | Binding | pAC50 | = | 7.7 | 7.7 | 28 | 5 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | ||||
| 5311010 | 518 | None | 30 | Human | Binding | pAC50 | = | 7.7 | 7.7 | 28 | 5 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | ||||
| 5311010.0 | 518 | None | 30 | Human | Binding | pAC50 | = | 7.7 | 7.7 | 28 | 5 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | ||||
| 68613 | 518 | None | 30 | Human | Binding | pAC50 | = | 7.7 | 7.7 | 28 | 5 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | ||||
| 68613.0 | 518 | None | 30 | Human | Binding | pAC50 | = | 7.7 | 7.7 | 28 | 5 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | ||||
| CHEMBL378642 | 518 | None | 30 | Human | Binding | pAC50 | = | 7.7 | 7.7 | 28 | 5 | Binding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AVPR1A in an in vitro assay with cellular components measured by scintillation proximity assay |
ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | ||||
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