Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 122185748 | 122794 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction |
ChEMBL | 401 | 4 | 1 | 4 | 4.9 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccn2)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604484 | 122794 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction |
ChEMBL | 401 | 4 | 1 | 4 | 4.9 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccn2)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 127049676 | 140745 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay |
ChEMBL | 342 | 3 | 1 | 3 | 4.7 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cnc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| CHEMBL3814804 | 140745 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay |
ChEMBL | 342 | 3 | 1 | 3 | 4.7 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cnc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| 10343454 | 3983 | None | 29 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| 9046 | 3983 | None | 29 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL2178578 | 3983 | None | 29 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| DB15250 | 3983 | None | 29 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| 10003401 | 133738 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 440 | 6 | 1 | 7 | 3.8 | O=C(c1ncccn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | nan | ||
| CHEMBL3714920 | 133738 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 440 | 6 | 1 | 7 | 3.8 | O=C(c1ncccn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | nan | ||
| 10049927 | 133745 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 460 | 7 | 1 | 5 | 4.1 | Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)c[n+]1[O-] | nan | ||
| CHEMBL3714940 | 133745 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 460 | 7 | 1 | 5 | 4.1 | Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)c[n+]1[O-] | nan | ||
| 10252082 | 133832 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 429 | 5 | 1 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cnccn2)cc1 | nan | ||
| CHEMBL3715204 | 133832 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 429 | 5 | 1 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cnccn2)cc1 | nan | ||
| 10435530 | 133848 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 486 | 6 | 1 | 5 | 4.2 | Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c[n+]1[O-] | nan | ||
| CHEMBL3715287 | 133848 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 486 | 6 | 1 | 5 | 4.2 | Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c[n+]1[O-] | nan | ||
| 20827700 | 133918 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 439 | 6 | 1 | 6 | 4.4 | O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cocn2)cc1 | nan | ||
| CHEMBL3715565 | 133918 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 439 | 6 | 1 | 6 | 4.4 | O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cocn2)cc1 | nan | ||
| 10476253 | 133925 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 402 | 6 | 1 | 5 | 3.8 | COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccn2)cc1 | nan | ||
| CHEMBL3715591 | 133925 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 402 | 6 | 1 | 5 | 3.8 | COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccn2)cc1 | nan | ||
| 22327329 | 133994 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 467 | 6 | 1 | 6 | 5.0 | Cc1nc(C)c(-c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)cc2)o1 | nan | ||
| CHEMBL3715810 | 133994 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 467 | 6 | 1 | 6 | 5.0 | Cc1nc(C)c(-c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)cc2)o1 | nan | ||
| 10072530 | 134113 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 450 | 5 | 1 | 4 | 4.5 | O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1 | nan | ||
| CHEMBL3716210 | 134113 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 450 | 5 | 1 | 4 | 4.5 | O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1 | nan | ||
| 20827703 | 134220 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 429 | 5 | 1 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ncccn2)cc1 | nan | ||
| CHEMBL3716565 | 134220 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 429 | 5 | 1 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ncccn2)cc1 | nan | ||
| 10003341 | 134256 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 439 | 6 | 1 | 6 | 4.4 | O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | nan | ||
| CHEMBL3716706 | 134256 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 439 | 6 | 1 | 6 | 4.4 | O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | nan | ||
| 10413664 | 134267 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 500 | 6 | 1 | 5 | 4.8 | O=C(c1ccncc1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL3716748 | 134267 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 500 | 6 | 1 | 5 | 4.8 | O=C(c1ccncc1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 20827692 | 134299 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 455 | 6 | 1 | 6 | 3.7 | O=C(c1cc[n+]([O-])cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | nan | ||
| CHEMBL3716851 | 134299 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 455 | 6 | 1 | 6 | 3.7 | O=C(c1cc[n+]([O-])cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 | nan | ||
| 10410294 | 134315 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 427 | 5 | 2 | 5 | 3.4 | O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)CNCC2 | nan | ||
| CHEMBL3716905 | 134315 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 427 | 5 | 2 | 5 | 3.4 | O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)CNCC2 | nan | ||
| 10027807 | 134365 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 472 | 8 | 1 | 6 | 4.2 | COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccnc2C)cc1 | nan | ||
| CHEMBL3717061 | 134365 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 472 | 8 | 1 | 6 | 4.2 | COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccnc2C)cc1 | nan | ||
| 20827695 | 134484 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 458 | 6 | 1 | 5 | 5.1 | COc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 | nan | ||
| CHEMBL3717474 | 134484 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 458 | 6 | 1 | 5 | 5.1 | COc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 | nan | ||
| 10253739 | 134511 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 460 | 7 | 1 | 5 | 4.1 | Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)ccc[n+]1[O-] | nan | ||
| CHEMBL3717576 | 134511 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 460 | 7 | 1 | 5 | 4.1 | Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)ccc[n+]1[O-] | nan | ||
| 57834436 | 134561 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 490 | 6 | 1 | 5 | 5.3 | O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL3717749 | 134561 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 490 | 6 | 1 | 5 | 5.3 | O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 10074941 | 134605 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 506 | 6 | 1 | 6 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(S(C)(=O)=O)nc2)cc1 | nan | ||
| CHEMBL3717896 | 134605 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 506 | 6 | 1 | 6 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(S(C)(=O)=O)nc2)cc1 | nan | ||
| 10096942 | 134631 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 486 | 6 | 1 | 5 | 4.2 | Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)ccc[n+]1[O-] | nan | ||
| CHEMBL3717984 | 134631 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 486 | 6 | 1 | 5 | 4.2 | Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)ccc[n+]1[O-] | nan | ||
| 20827705 | 134666 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 458 | 6 | 1 | 5 | 5.1 | COc1c(Cl)ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C(=O)c1ccncc1 | nan | ||
| CHEMBL3718112 | 134666 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 458 | 6 | 1 | 5 | 5.1 | COc1c(Cl)ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C(=O)c1ccncc1 | nan | ||
| 10345667 | 134714 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 494 | 6 | 1 | 6 | 3.3 | CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 | nan | ||
| CHEMBL3718270 | 134714 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay |
ChEMBL | 494 | 6 | 1 | 6 | 3.3 | CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 | nan | ||
Showing 1 to 50 of 480 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 10586 | 2139 | None | 4 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cellsInhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cells |
ChEMBL | 379 | 5 | 1 | 6 | 4.3 | CC[C@@H](n1c(=S)[nH]c(c1C(=O)OC)c1ccno1)c1ccc(c(c1)F)F | 10.1021/acs.jmedchem.6b01309 | ||
| 11617815 | 2139 | None | 4 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cellsInhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cells |
ChEMBL | 379 | 5 | 1 | 6 | 4.3 | CC[C@@H](n1c(=S)[nH]c(c1C(=O)OC)c1ccno1)c1ccc(c(c1)F)F | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL5290248 | 2139 | None | 4 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cellsInhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cells |
ChEMBL | 379 | 5 | 1 | 6 | 4.3 | CC[C@@H](n1c(=S)[nH]c(c1C(=O)OC)c1ccno1)c1ccc(c(c1)F)F | 10.1021/acs.jmedchem.6b01309 | ||
| 122185757 | 122804 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 460 | 5 | 2 | 6 | 4.7 | CN(C)c1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604493 | 122804 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 460 | 5 | 2 | 6 | 4.7 | CN(C)c1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O | 10.1016/j.bmcl.2015.06.046 | ||
| 127053027 | 140735 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 384 | 4 | 1 | 4 | 4.5 | CC1(c2ccc(Cn3c(C(=O)O)cc4ncc(Cl)cc43)cc2)CCOCC1 | 10.1016/j.bmcl.2016.05.043 | ||
| CHEMBL3814683 | 140735 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 384 | 4 | 1 | 4 | 4.5 | CC1(c2ccc(Cn3c(C(=O)O)cc4ncc(Cl)cc43)cc2)CCOCC1 | 10.1016/j.bmcl.2016.05.043 | ||
| 10343454 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -34 | 2 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| 9046 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -34 | 2 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL2178578 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -34 | 2 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| DB15250 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.0 | 8.0 | -34 | 2 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.bmcl.2015.06.046 | ||
| 122185740 | 122785 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 416 | 4 | 2 | 4 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604476 | 122785 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 416 | 4 | 2 | 4 | 5.2 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 127050864 | 140709 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 341 | 3 | 1 | 2 | 5.3 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| CHEMBL3814202 | 140709 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 341 | 3 | 1 | 2 | 5.3 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| 122185763 | 122810 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay |
ChEMBL | 460 | 7 | 3 | 6 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604499 | 122810 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay |
ChEMBL | 460 | 7 | 3 | 6 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185745 | 122791 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 432 | 4 | 2 | 4 | 4.4 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2c(O)ccc[n+]2[O-])cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604481 | 122791 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 432 | 4 | 2 | 4 | 4.4 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2c(O)ccc[n+]2[O-])cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185758 | 122805 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 501 | 5 | 2 | 7 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nncc(N3CCOCC3)c2N)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604494 | 122805 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 501 | 5 | 2 | 7 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nncc(N3CCOCC3)c2N)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 10343454 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| 9046 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| CHEMBL2178578 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| DB15250 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| 10343454 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| 9046 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| CHEMBL2178578 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| DB15250 | 3983 | None | 29 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -34 | 2 | Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay |
ChEMBL | 444 | 5 | 1 | 4 | 4.3 | Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C | 10.1016/j.ejmech.2019.111805 | ||
| 127053025 | 140746 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 372 | 6 | 1 | 4 | 4.4 | COCC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| CHEMBL3814811 | 140746 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 372 | 6 | 1 | 4 | 4.4 | COCC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| 122185750 | 122796 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 416 | 4 | 2 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2N)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604486 | 122796 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 416 | 4 | 2 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2N)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185751 | 122797 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 416 | 4 | 2 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nnccc2N)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604487 | 122797 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 416 | 4 | 2 | 5 | 4.5 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nnccc2N)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185761 | 122808 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 430 | 5 | 2 | 5 | 4.9 | CNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604497 | 122808 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 430 | 5 | 2 | 5 | 4.9 | CNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 127053022 | 140700 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 342 | 3 | 1 | 3 | 4.7 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cc(Cl)ncc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| CHEMBL3814037 | 140700 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 342 | 3 | 1 | 3 | 4.7 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cc(Cl)ncc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| 127049675 | 140740 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 342 | 3 | 1 | 3 | 4.7 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| CHEMBL3814736 | 140740 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs |
ChEMBL | 342 | 3 | 1 | 3 | 4.7 | CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 | 10.1016/j.bmcl.2016.05.043 | ||
| 122185753 | 122799 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 432 | 4 | 3 | 6 | 4.2 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(N)ncc2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604489 | 122799 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 432 | 4 | 3 | 6 | 4.2 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(N)ncc2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185759 | 122806 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 447 | 5 | 3 | 6 | 4.1 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(CO)c2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604495 | 122806 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 447 | 5 | 3 | 6 | 4.1 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(CO)c2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185747 | 122793 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 446 | 5 | 3 | 5 | 4.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(CO)c2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604483 | 122793 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 446 | 5 | 3 | 5 | 4.7 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(CO)c2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185763 | 122810 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 460 | 7 | 3 | 6 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| CHEMBL3604499 | 122810 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 460 | 7 | 3 | 6 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
| 122185756 | 122803 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay |
ChEMBL | 432 | 4 | 3 | 6 | 4.2 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(N)c2O)cc1 | 10.1016/j.bmcl.2015.06.046 | ||
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