Ligand source activities (1 row/activity)



Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
122185748 122794 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 401 4 1 4 4.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccn2)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604484 122794 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 401 4 1 4 4.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccn2)cc1 10.1016/j.bmcl.2015.06.046
127049676 140745 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cnc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814804 140745 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cnc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
10343454 3983 None 29 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
9046 3983 None 29 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
CHEMBL2178578 3983 None 29 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
DB15250 3983 None 29 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
10003401 133738 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 440 6 1 7 3.8 O=C(c1ncccn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3714920 133738 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 440 6 1 7 3.8 O=C(c1ncccn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10049927 133745 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 460 7 1 5 4.1 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)c[n+]1[O-] nan
CHEMBL3714940 133745 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 460 7 1 5 4.1 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)c[n+]1[O-] nan
10252082 133832 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cnccn2)cc1 nan
CHEMBL3715204 133832 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cnccn2)cc1 nan
10435530 133848 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 486 6 1 5 4.2 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c[n+]1[O-] nan
CHEMBL3715287 133848 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 486 6 1 5 4.2 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c[n+]1[O-] nan
20827700 133918 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cocn2)cc1 nan
CHEMBL3715565 133918 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cocn2)cc1 nan
10476253 133925 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 402 6 1 5 3.8 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccn2)cc1 nan
CHEMBL3715591 133925 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 402 6 1 5 3.8 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccn2)cc1 nan
22327329 133994 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 467 6 1 6 5.0 Cc1nc(C)c(-c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)cc2)o1 nan
CHEMBL3715810 133994 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 467 6 1 6 5.0 Cc1nc(C)c(-c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)cc2)o1 nan
10072530 134113 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 450 5 1 4 4.5 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1 nan
CHEMBL3716210 134113 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 450 5 1 4 4.5 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1 nan
20827703 134220 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ncccn2)cc1 nan
CHEMBL3716565 134220 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ncccn2)cc1 nan
10003341 134256 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3716706 134256 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10413664 134267 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 500 6 1 5 4.8 O=C(c1ccncc1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL3716748 134267 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 500 6 1 5 4.8 O=C(c1ccncc1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
20827692 134299 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 455 6 1 6 3.7 O=C(c1cc[n+]([O-])cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3716851 134299 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 455 6 1 6 3.7 O=C(c1cc[n+]([O-])cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10410294 134315 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 427 5 2 5 3.4 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)CNCC2 nan
CHEMBL3716905 134315 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 427 5 2 5 3.4 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)CNCC2 nan
10027807 134365 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccnc2C)cc1 nan
CHEMBL3717061 134365 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccnc2C)cc1 nan
20827695 134484 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 458 6 1 5 5.1 COc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
CHEMBL3717474 134484 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 458 6 1 5 5.1 COc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
10253739 134511 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 460 7 1 5 4.1 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)ccc[n+]1[O-] nan
CHEMBL3717576 134511 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 460 7 1 5 4.1 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)ccc[n+]1[O-] nan
57834436 134561 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 490 6 1 5 5.3 O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL3717749 134561 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 490 6 1 5 5.3 O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
10074941 134605 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 506 6 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(S(C)(=O)=O)nc2)cc1 nan
CHEMBL3717896 134605 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 506 6 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(S(C)(=O)=O)nc2)cc1 nan
10096942 134631 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 486 6 1 5 4.2 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)ccc[n+]1[O-] nan
CHEMBL3717984 134631 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 486 6 1 5 4.2 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)ccc[n+]1[O-] nan
20827705 134666 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 458 6 1 5 5.1 COc1c(Cl)ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C(=O)c1ccncc1 nan
CHEMBL3718112 134666 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 458 6 1 5 5.1 COc1c(Cl)ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C(=O)c1ccncc1 nan
10345667 134714 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 494 6 1 6 3.3 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718270 134714 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 494 6 1 6 3.3 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
20827653 134764 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 486 8 1 6 4.6 CC(=O)OCC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718417 134764 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 486 8 1 6 4.6 CC(=O)OCC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
20827661 134766 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 428 5 1 4 5.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2c(Cl)cccc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718419 134766 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 428 5 1 4 5.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2c(Cl)cccc2C(=O)c2ccncc2)cc1 nan
22327299 134893 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 460 7 2 5 3.3 CC(C)(CO)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
CHEMBL3718816 134893 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 460 7 2 5 3.3 CC(C)(CO)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
20827702 134946 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 386 5 1 4 4.1 Cc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3719028 134946 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 386 5 1 4 4.1 Cc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
10322607 134957 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
CHEMBL3719064 134957 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
10096486 134964 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 474 6 1 5 5.8 CSc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
CHEMBL3719075 134964 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 474 6 1 5 5.8 CSc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
10366214 134977 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 444 6 1 4 4.4 CCc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3719122 134977 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 444 6 1 4 4.4 CCc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
10254153 134997 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 470 6 1 5 5.0 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL3719213 134997 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 470 6 1 5 5.0 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
20827691 135032 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 444 5 1 4 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccc[n+]2[O-])cc1 nan
CHEMBL3719306 135032 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 444 5 1 4 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccc[n+]2[O-])cc1 nan
10367205 135052 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 464 6 1 6 3.5 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cn1 nan
CHEMBL3719382 135052 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 464 6 1 6 3.5 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cn1 nan
10003401 133738 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 440 6 1 7 3.8 O=C(c1ncccn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3714920 133738 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 440 6 1 7 3.8 O=C(c1ncccn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10049927 133745 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 460 7 1 5 4.1 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)c[n+]1[O-] nan
CHEMBL3714940 133745 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 460 7 1 5 4.1 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)c[n+]1[O-] nan
10252082 133832 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cnccn2)cc1 nan
CHEMBL3715204 133832 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cnccn2)cc1 nan
10435530 133848 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 486 6 1 5 4.2 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c[n+]1[O-] nan
CHEMBL3715287 133848 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 486 6 1 5 4.2 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c[n+]1[O-] nan
20827700 133918 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cocn2)cc1 nan
CHEMBL3715565 133918 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cocn2)cc1 nan
10476253 133925 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 402 6 1 5 3.8 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccn2)cc1 nan
CHEMBL3715591 133925 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 402 6 1 5 3.8 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccccn2)cc1 nan
22327329 133994 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 467 6 1 6 5.0 Cc1nc(C)c(-c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)cc2)o1 nan
CHEMBL3715810 133994 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 467 6 1 6 5.0 Cc1nc(C)c(-c2ccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)cc2)o1 nan
10072530 134113 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 450 5 1 4 4.5 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1 nan
CHEMBL3716210 134113 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 450 5 1 4 4.5 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Br)cc1 nan
20827703 134220 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ncccn2)cc1 nan
CHEMBL3716565 134220 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 429 5 1 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ncccn2)cc1 nan
10003341 134256 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3716706 134256 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 439 6 1 6 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10413664 134267 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 500 6 1 5 4.8 O=C(c1ccncc1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL3716748 134267 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 500 6 1 5 4.8 O=C(c1ccncc1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
20827692 134299 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 455 6 1 6 3.7 O=C(c1cc[n+]([O-])cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3716851 134299 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 455 6 1 6 3.7 O=C(c1cc[n+]([O-])cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10410294 134315 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 427 5 2 5 3.4 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)CNCC2 nan
CHEMBL3716905 134315 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 427 5 2 5 3.4 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)CNCC2 nan
10027807 134365 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccnc2C)cc1 nan
CHEMBL3717061 134365 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccnc2C)cc1 nan
20827695 134484 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 458 6 1 5 5.1 COc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
CHEMBL3717474 134484 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 458 6 1 5 5.1 COc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
10253739 134511 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 460 7 1 5 4.1 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)ccc[n+]1[O-] nan
CHEMBL3717576 134511 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 460 7 1 5 4.1 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(C)C)cc2)ccc[n+]1[O-] nan
57834436 134561 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 490 6 1 5 5.3 O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL3717749 134561 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 490 6 1 5 5.3 O=C(c1ccc(Cl)nc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
10074941 134605 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 506 6 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(S(C)(=O)=O)nc2)cc1 nan
CHEMBL3717896 134605 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 506 6 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(S(C)(=O)=O)nc2)cc1 nan
10096942 134631 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 486 6 1 5 4.2 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)ccc[n+]1[O-] nan
CHEMBL3717984 134631 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 486 6 1 5 4.2 Cc1c(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)ccc[n+]1[O-] nan
20827705 134666 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 458 6 1 5 5.1 COc1c(Cl)ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C(=O)c1ccncc1 nan
CHEMBL3718112 134666 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 458 6 1 5 5.1 COc1c(Cl)ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C(=O)c1ccncc1 nan
10345667 134714 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 494 6 1 6 3.3 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718270 134714 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 494 6 1 6 3.3 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
20827653 134764 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 486 8 1 6 4.6 CC(=O)OCC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718417 134764 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 486 8 1 6 4.6 CC(=O)OCC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
20827661 134766 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 428 5 1 4 5.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2c(Cl)cccc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718419 134766 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 428 5 1 4 5.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2c(Cl)cccc2C(=O)c2ccncc2)cc1 nan
22327299 134893 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 460 7 2 5 3.3 CC(C)(CO)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
CHEMBL3718816 134893 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 460 7 2 5 3.3 CC(C)(CO)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
20827702 134946 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 386 5 1 4 4.1 Cc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3719028 134946 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 386 5 1 4 4.1 Cc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
10322607 134957 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
CHEMBL3719064 134957 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 472 8 1 6 4.2 COC(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
10096486 134964 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 474 6 1 5 5.8 CSc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
CHEMBL3719075 134964 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 474 6 1 5 5.8 CSc1cc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ccn1 nan
10366214 134977 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 444 6 1 4 4.4 CCc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3719122 134977 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 444 6 1 4 4.4 CCc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
10254153 134997 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 470 6 1 5 5.0 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
CHEMBL3719213 134997 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 470 6 1 5 5.0 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 nan
20827691 135032 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 444 5 1 4 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccc[n+]2[O-])cc1 nan
CHEMBL3719306 135032 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 444 5 1 4 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2cccc[n+]2[O-])cc1 nan
10367205 135052 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 464 6 1 6 3.5 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cn1 nan
CHEMBL3719382 135052 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 464 6 1 6 3.5 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cn1 nan
10343213 133810 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 440 6 1 7 3.8 O=C(c1ccncn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3715134 133810 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 440 6 1 7 3.8 O=C(c1ccncn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10386667 133838 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 406 5 1 4 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL3715242 133838 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 406 5 1 4 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)cc1 nan
20827690 133854 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 405 6 1 6 3.1 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2nccn2C)cc1 nan
CHEMBL3715314 133854 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 405 6 1 6 3.1 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2nccn2C)cc1 nan
20827701 133985 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 454 6 1 7 4.1 Cc1nnc(-c2cccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)c2)o1 nan
CHEMBL3715768 133985 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 454 6 1 7 4.1 Cc1nnc(-c2cccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)c2)o1 nan
20827696 134071 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 453 6 1 6 4.7 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3716071 134071 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 453 6 1 6 4.7 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10388551 134145 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 440 5 1 4 4.8 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL3716303 134145 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 440 5 1 4 4.8 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 nan
10433936 134158 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 450 6 1 6 3.2 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3716345 134158 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 450 6 1 6 3.2 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
22327326 134397 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 513 6 1 6 4.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(N3CCOCC3)nc2)cc1 nan
CHEMBL3717165 134397 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 513 6 1 6 4.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(N3CCOCC3)nc2)cc1 nan
10387892 134443 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
CHEMBL3717340 134443 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
10369638 134504 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 527 7 1 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3717556 134504 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 527 7 1 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2ccncc2)cc1 nan
20827657 134661 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 414 6 1 5 4.0 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718096 134661 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 414 6 1 5 4.0 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
20827654 134690 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 485 7 1 5 4.1 CN(C)C(=O)C(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718191 134690 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 485 7 1 5 4.1 CN(C)C(=O)C(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
57834432 134782 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 484 8 1 4 4.7 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(CCC(=O)N(C)C)cc2)cc1 nan
CHEMBL3718491 134782 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 484 8 1 4 4.7 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(CCC(=O)N(C)C)cc2)cc1 nan
20827656 134808 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 471 8 1 5 3.8 CN(C)C(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718571 134808 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 471 8 1 5 3.8 CN(C)C(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
10098884 134865 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 543 7 1 6 3.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
CHEMBL3718738 134865 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 543 7 1 6 3.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
10432752 134878 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccnc(C)c2)cc1 nan
CHEMBL3718779 134878 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccnc(C)c2)cc1 nan
10049261 135029 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 446 6 1 5 3.9 COc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3719297 135029 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 446 6 1 5 3.9 COc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
20827699 135030 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 467 6 1 6 5.0 Cc1cccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(-c3cnc(C)o3)cc2)n1 nan
CHEMBL3719300 135030 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced calcium response pre-treated before TECK stimulation by Flou-4-AM dye based FLIPR assay
ChEMBL 467 6 1 6 5.0 Cc1cccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(-c3cnc(C)o3)cc2)n1 nan
10343213 133810 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 440 6 1 7 3.8 O=C(c1ccncn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3715134 133810 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 440 6 1 7 3.8 O=C(c1ccncn1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10386667 133838 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 406 5 1 4 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL3715242 133838 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 406 5 1 4 4.4 O=C(c1cccnc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)cc1 nan
20827690 133854 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 405 6 1 6 3.1 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2nccn2C)cc1 nan
CHEMBL3715314 133854 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 405 6 1 6 3.1 COc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2nccn2C)cc1 nan
20827701 133985 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 454 6 1 7 4.1 Cc1nnc(-c2cccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)c2)o1 nan
CHEMBL3715768 133985 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 454 6 1 7 4.1 Cc1nnc(-c2cccc(S(=O)(=O)Nc3ccc(Cl)cc3C(=O)c3ccncc3)c2)o1 nan
20827696 134071 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 453 6 1 6 4.7 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
CHEMBL3716071 134071 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 453 6 1 6 4.7 Cc1ncccc1C(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(-c2cnco2)cc1 nan
10388551 134145 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 440 5 1 4 4.8 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 nan
CHEMBL3716303 134145 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 440 5 1 4 4.8 O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 nan
10433936 134158 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 450 6 1 6 3.2 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3716345 134158 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 450 6 1 6 3.2 CS(=O)(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
22327326 134397 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 513 6 1 6 4.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(N3CCOCC3)nc2)cc1 nan
CHEMBL3717165 134397 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 513 6 1 6 4.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(N3CCOCC3)nc2)cc1 nan
10387892 134443 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
CHEMBL3717340 134443 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccc(C)nc2)cc1 nan
10369638 134504 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 527 7 1 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3717556 134504 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 527 7 1 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2ccncc2)cc1 nan
20827657 134661 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 414 6 1 5 4.0 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718096 134661 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 414 6 1 5 4.0 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
20827654 134690 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 485 7 1 5 4.1 CN(C)C(=O)C(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718191 134690 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 485 7 1 5 4.1 CN(C)C(=O)C(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
57834432 134782 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 484 8 1 4 4.7 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(CCC(=O)N(C)C)cc2)cc1 nan
CHEMBL3718491 134782 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 484 8 1 4 4.7 Cc1ccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(CCC(=O)N(C)C)cc2)cc1 nan
20827656 134808 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 471 8 1 5 3.8 CN(C)C(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3718571 134808 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 471 8 1 5 3.8 CN(C)C(=O)CCc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccncc2)cc1 nan
10098884 134865 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 543 7 1 6 3.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
CHEMBL3718738 134865 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 543 7 1 6 3.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2C(=O)c2cc[n+]([O-])cc2)cc1 nan
10432752 134878 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccnc(C)c2)cc1 nan
CHEMBL3718779 134878 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 428 6 1 5 4.3 CC(=O)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C(=O)c2ccnc(C)c2)cc1 nan
10049261 135029 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 446 6 1 5 3.9 COc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
CHEMBL3719297 135029 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 446 6 1 5 3.9 COc1ccc(S(=O)(=O)Nc2ccc(Br)cc2C(=O)c2ccncc2)cc1 nan
20827699 135030 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 467 6 1 6 5.0 Cc1cccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(-c3cnc(C)o3)cc2)n1 nan
CHEMBL3719300 135030 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assayAntagonist activity against CCR9 in human MOLT4 cells assessed as inhibition of human recombinant TECK-induced cell migration pre-treated for 15 mins before TECK stimulation for 150 mins by fluorescence based assay
ChEMBL 467 6 1 6 5.0 Cc1cccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(-c3cnc(C)o3)cc2)n1 nan
122185768 122815 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 489 8 4 7 4.3 CNc1cnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(NCCO)n1 10.1016/j.bmcl.2015.06.046
CHEMBL3604504 122815 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 489 8 4 7 4.3 CNc1cnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(NCCO)n1 10.1016/j.bmcl.2015.06.046
122185752 122798 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 417 4 2 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncncc2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604488 122798 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 417 4 2 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncncc2O)cc1 10.1016/j.bmcl.2015.06.046
122185759 122806 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 447 5 3 6 4.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604495 122806 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 447 5 3 6 4.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
127053023 140728 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 343 4 2 3 4.3 CC(C)(O)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814546 140728 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 343 4 2 3 4.3 CC(C)(O)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
127053026 140712 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 354 3 1 3 4.5 O=C(O)c1cc2ncc(Cl)cc2n1Cc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814251 140712 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 354 3 1 3 4.5 O=C(O)c1cc2ncc(Cl)cc2n1Cc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.05.043
122185756 122803 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(N)c2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604492 122803 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(N)c2O)cc1 10.1016/j.bmcl.2015.06.046
10343454 3983 None 29 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assayAntagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
9046 3983 None 29 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assayAntagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
CHEMBL2178578 3983 None 29 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assayAntagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
DB15250 3983 None 29 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assayAntagonist activity at CCR9 assessed as inhibition of CCL25-induced chemotaxis by cell based assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
127049675 140740 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814736 140740 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
127053024 140730 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 394 5 1 4 5.4 CC(C)(c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1)c1ncco1 10.1016/j.bmcl.2016.05.043
CHEMBL3814577 140730 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 394 5 1 4 5.4 CC(C)(c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1)c1ncco1 10.1016/j.bmcl.2016.05.043
122185755 122802 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 476 7 4 7 4.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(NCCO)ncc2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604491 122802 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 476 7 4 7 4.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(NCCO)ncc2O)cc1 10.1016/j.bmcl.2015.06.046
1448028 140707 None 1 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 313 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3sccc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814185 140707 None 1 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 313 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3sccc32)cc1 10.1016/j.bmcl.2016.05.043
127050864 140709 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 341 3 1 2 5.3 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814202 140709 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 341 3 1 2 5.3 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
122185761 122808 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 2 5 4.9 CNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604497 122808 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 2 5 4.9 CNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
122185738 122783 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 1 4 5.5 COc1ccnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 10.1016/j.bmcl.2015.06.046
CHEMBL3604474 122783 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 1 4 5.5 COc1ccnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 10.1016/j.bmcl.2015.06.046
122185758 122805 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 501 5 2 7 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nncc(N3CCOCC3)c2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604494 122805 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 501 5 2 7 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nncc(N3CCOCC3)c2N)cc1 10.1016/j.bmcl.2015.06.046
122185767 122814 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 474 7 3 6 4.6 Cc1cnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(NCCO)n1 10.1016/j.bmcl.2015.06.046
CHEMBL3604503 122814 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 474 7 3 6 4.6 Cc1cnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(NCCO)n1 10.1016/j.bmcl.2015.06.046
122185754 122801 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 446 5 3 6 4.6 CNc1ncc(O)c(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)n1 10.1016/j.bmcl.2015.06.046
CHEMBL3604490 122801 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 446 5 3 6 4.6 CNc1ncc(O)c(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)n1 10.1016/j.bmcl.2015.06.046
127049672 140723 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cn1 10.1016/j.bmcl.2016.05.043
CHEMBL3814511 140723 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cn1 10.1016/j.bmcl.2016.05.043
122185740 122785 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 4 5.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604476 122785 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 4 5.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2O)cc1 10.1016/j.bmcl.2015.06.046
122185749 122795 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncncc2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604485 122795 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncncc2N)cc1 10.1016/j.bmcl.2015.06.046
122185750 122796 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604486 122796 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2N)cc1 10.1016/j.bmcl.2015.06.046
122185751 122797 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nnccc2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604487 122797 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nnccc2N)cc1 10.1016/j.bmcl.2015.06.046
122185743 122788 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 429 5 2 4 5.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2CN)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604479 122788 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 429 5 2 4 5.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2CN)cc1 10.1016/j.bmcl.2015.06.046
122185763 122810 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 460 7 3 6 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604499 122810 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 460 7 3 6 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
122185744 122790 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 6 1 4 5.6 COCc1cccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604480 122790 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 6 1 4 5.6 COCc1cccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
127053025 140746 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 372 6 1 4 4.4 COCC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814811 140746 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 372 6 1 4 4.4 COCC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
127048631 140695 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 385 3 1 2 5.4 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Br)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3813888 140695 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 385 3 1 2 5.4 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Br)cc32)cc1 10.1016/j.bmcl.2016.05.043
122185765 122812 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 487 8 2 6 4.9 CN(C)CCNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604501 122812 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 487 8 2 6 4.9 CN(C)CCNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
127053022 140700 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cc(Cl)ncc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814037 140700 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cc(Cl)ncc32)cc1 10.1016/j.bmcl.2016.05.043
122185753 122799 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(N)ncc2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604489 122799 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(N)ncc2O)cc1 10.1016/j.bmcl.2015.06.046
122185762 122809 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 6 2 5 5.3 CCNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604498 122809 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 444 6 2 5 5.3 CCNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
127049674 140732 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cccc(Cl)c32)cn1 10.1016/j.bmcl.2016.05.043
CHEMBL3814598 140732 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cccc(Cl)c32)cn1 10.1016/j.bmcl.2016.05.043
122185745 122791 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 432 4 2 4 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2c(O)ccc[n+]2[O-])cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604481 122791 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 432 4 2 4 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2c(O)ccc[n+]2[O-])cc1 10.1016/j.bmcl.2015.06.046
10343454 3983 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2016.05.043
9046 3983 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2016.05.043
CHEMBL2178578 3983 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2016.05.043
DB15250 3983 None 29 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2016.05.043
127049978 140739 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)nc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814735 140739 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)nc32)cc1 10.1016/j.bmcl.2016.05.043
122185746 122792 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 459 5 3 5 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(C(N)=O)c2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604482 122792 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 459 5 3 5 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(C(N)=O)c2O)cc1 10.1016/j.bmcl.2015.06.046
122185760 122807 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 445 5 2 5 5.2 CCc1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
CHEMBL3604496 122807 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 445 5 2 5 5.2 CCc1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
122185764 122811 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 474 8 3 6 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCCO)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604500 122811 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 474 8 3 6 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCCO)cc1 10.1016/j.bmcl.2015.06.046
127053027 140735 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 384 4 1 4 4.5 CC1(c2ccc(Cn3c(C(=O)O)cc4ncc(Cl)cc43)cc2)CCOCC1 10.1016/j.bmcl.2016.05.043
CHEMBL3814683 140735 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 384 4 1 4 4.5 CC1(c2ccc(Cn3c(C(=O)O)cc4ncc(Cl)cc43)cc2)CCOCC1 10.1016/j.bmcl.2016.05.043
122185769 122816 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 494 7 3 6 5.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(Cl)cnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604505 122816 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 494 7 3 6 5.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(Cl)cnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
127051189 140757 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 337 4 1 3 4.7 COc1ccc2cc(C(=O)O)n(Cc3ccc(C(C)(C)C)cc3)c2c1 10.1016/j.bmcl.2016.05.043
CHEMBL3815051 140757 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 337 4 1 3 4.7 COc1ccc2cc(C(=O)O)n(Cc3ccc(C(C)(C)C)cc3)c2c1 10.1016/j.bmcl.2016.05.043
127049670 140703 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 332 3 1 3 4.6 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(C#N)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814136 140703 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 332 3 1 3 4.6 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(C#N)cc32)cc1 10.1016/j.bmcl.2016.05.043
122185747 122793 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 446 5 3 5 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604483 122793 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 446 5 3 5 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
122185766 122813 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 474 7 3 6 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCC(=O)O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604502 122813 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 474 7 3 6 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCC(=O)O)cc1 10.1016/j.bmcl.2015.06.046
127049671 140719 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 341 3 1 2 5.3 CC(C)(C)c1cccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)c1 10.1016/j.bmcl.2016.05.043
CHEMBL3814368 140719 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 341 3 1 2 5.3 CC(C)(C)c1cccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)c1 10.1016/j.bmcl.2016.05.043
127051188 140706 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 321 3 1 2 5.0 Cc1ccc2cc(C(=O)O)n(Cc3ccc(C(C)(C)C)cc3)c2c1 10.1016/j.bmcl.2016.05.043
CHEMBL3814176 140706 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 321 3 1 2 5.0 Cc1ccc2cc(C(=O)O)n(Cc3ccc(C(C)(C)C)cc3)c2c1 10.1016/j.bmcl.2016.05.043
122185742 122787 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 2 4 5.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2CO)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604478 122787 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 2 4 5.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2CO)cc1 10.1016/j.bmcl.2015.06.046
122185757 122804 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 460 5 2 6 4.7 CN(C)c1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
CHEMBL3604493 122804 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 460 5 2 6 4.7 CN(C)c1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
127049673 140754 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 333 3 1 4 4.0 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(C#N)cc32)cn1 10.1016/j.bmcl.2016.05.043
CHEMBL3815007 140754 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assayAntagonist activity at CCR9 (unknown origin) assessed as inhibition of TECK-stimulated calcium mobilization preincubated for 10 mins followed by agonist addition measured for 90 sec by fluo-8 dye-based FLIPR assay
ChEMBL 333 3 1 4 4.0 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(C#N)cc32)cn1 10.1016/j.bmcl.2016.05.043
122185741 122786 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 415 4 2 4 5.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604477 122786 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 415 4 2 4 5.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2N)cc1 10.1016/j.bmcl.2015.06.046
122185739 122784 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 1 4 5.5 COc1cccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604475 122784 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK inductionAntagonist activity at CCR9 receptor (unknown origin) assessed as inhibition of TECK-induced calcium mobilization incubated for 10 mins prior to TECK induction
ChEMBL 430 5 1 4 5.5 COc1cccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
10343454 3983 None 29 Human Functional pKi = 9.0 9.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
9046 3983 None 29 Human Functional pKi = 9.0 9.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
CHEMBL2178578 3983 None 29 Human Functional pKi = 9.0 9.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
DB15250 3983 None 29 Human Functional pKi = 9.0 9.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
118204799 139753 None 0 Human Functional pKi = 8 8.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccc(F)cn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797882 139753 None 0 Human Functional pKi = 8 8.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccc(F)cn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
124167959 139798 None 0 Human Functional pKi = 8 8.0 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccc[n+]2[O-])C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798178 139798 None 0 Human Functional pKi = 8 8.0 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccc[n+]2[O-])C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197543 140140 None 0 Human Functional pKi = 7 7.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 6 1 5 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(CCc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3800351 140140 None 0 Human Functional pKi = 7 7.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 6 1 5 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(CCc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204773 140184 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1cc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccn1 10.1021/acs.jmedchem.5b01840
CHEMBL3800612 140184 None 0 Human Functional pKi = 7.0 7.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1cc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccn1 10.1021/acs.jmedchem.5b01840
118204881 139711 None 0 Human Functional pKi = 8.0 8.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccncc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797572 139711 None 0 Human Functional pKi = 8.0 8.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccncc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204818 139744 None 0 Human Functional pKi = 8.0 8.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 4 1 5 5.3 Cc1cnc(C)c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3797825 139744 None 0 Human Functional pKi = 8.0 8.0 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 4 1 5 5.3 Cc1cnc(C)c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
123416489 139731 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 5 4.2 Cc1cc[n+]([O-])cc1CN1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3797753 139731 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 5 4.2 Cc1cc[n+]([O-])cc1CN1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204621 139864 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798612 139864 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197452 140097 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3800062 140097 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204904 139752 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
CHEMBL3797880 139752 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
118204585 140015 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 463 5 1 6 3.6 O=C1c2cccc(NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799583 140015 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 463 5 1 6 3.6 O=C1c2cccc(NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
118204645 140116 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 5.0 CCOc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3800183 140116 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 5.0 CCOc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
118204555 139713 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 501 5 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ncccc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797603 139713 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 501 5 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ncccc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197423 139947 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799220 139947 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
123866952 140130 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 5 4.2 Cc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)[n+]([O-])c1 10.1021/acs.jmedchem.5b01840
CHEMBL3800291 140130 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 5 4.2 Cc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)[n+]([O-])c1 10.1021/acs.jmedchem.5b01840
118197428 1046 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
9252 1046 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
CHEMBL3797271 1046 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
118204586 139860 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 465 4 1 5 3.8 O=C1c2cccc(NS(=O)(=O)c3ccc(F)c(C(F)(F)F)c3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798585 139860 None 0 Human Functional pKi = 5.9 5.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 465 4 1 5 3.8 O=C1c2cccc(NS(=O)(=O)c3ccc(F)c(C(F)(F)F)c3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
118204557 139771 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(C)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3797989 139771 None 0 Human Functional pKi = 7.9 7.9 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(C)n1 10.1021/acs.jmedchem.5b01840
118204648 139728 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1ncc(C)cc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3797722 139728 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1ncc(C)cc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204670 139826 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)nc1C 10.1021/acs.jmedchem.5b01840
CHEMBL3798346 139826 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)nc1C 10.1021/acs.jmedchem.5b01840
118197481 140095 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 485 4 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3800052 140095 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 485 4 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204599 140108 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccncc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3800135 140108 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccncc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118205008 139660 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 508 4 1 6 4.8 Cc1cnc(C#N)c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3797290 139660 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 508 4 1 6 4.8 Cc1cnc(C#N)c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
123776529 140186 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1C 10.1021/acs.jmedchem.5b01840
CHEMBL3800627 140186 None 0 Human Functional pKi = 7.8 7.8 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1C 10.1021/acs.jmedchem.5b01840
118197424 140081 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 449 4 1 5 4.3 Cc1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2c1C(=O)N(c1cccnc1)C2=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799957 140081 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 449 4 1 5 4.3 Cc1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2c1C(=O)N(c1cccnc1)C2=O 10.1021/acs.jmedchem.5b01840
118197515 139924 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 474 5 1 6 3.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(C#N)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799062 139924 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 474 5 1 6 3.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(C#N)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204768 140042 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
CHEMBL3799770 140042 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
118204853 140098 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccc(F)nc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3800073 140098 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccc(F)nc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204630 139999 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799487 139999 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204692 140038 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799726 140038 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204755 139723 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 481 4 1 5 4.4 O=C1c2cccc(NS(=O)(=O)c3ccc(Cl)c(C(F)(F)F)c3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797668 139723 None 0 Human Functional pKi = 6.7 6.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 481 4 1 5 4.4 O=C1c2cccc(NS(=O)(=O)c3ccc(Cl)c(C(F)(F)F)c3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
118204758 139833 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)nc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798400 139833 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)nc1 10.1021/acs.jmedchem.5b01840
118204879 139684 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1cccnc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3797425 139684 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1cccnc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118197480 139750 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797858 139750 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197542 140136 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3800331 140136 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
118204744 140177 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cc(F)ccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3800584 140177 None 0 Human Functional pKi = 7.7 7.7 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cc(F)ccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204628 139975 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1cncc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3799348 139975 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1cncc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
118204615 139655 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1ccncc1CN1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3797235 139655 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1ccncc1CN1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204870 139942 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 527 6 1 6 5.2 CCc1c(OC)cncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799199 139942 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 527 6 1 6 5.2 CCc1c(OC)cncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118197490 140083 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799968 140083 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204633 140058 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799853 140058 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197480 139750 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797858 139750 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204583 139667 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 447 4 1 5 3.7 O=C1c2cccc(NS(=O)(=O)c3cccc(C(F)(F)F)c3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797343 139667 None 0 Human Functional pKi = 5.6 5.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 447 4 1 5 3.7 O=C1c2cccc(NS(=O)(=O)c3cccc(C(F)(F)F)c3)c2C(=O)N1c1cccnc1 10.1021/acs.jmedchem.5b01840
118204706 139876 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1nccc(C)c1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3798723 139876 None 0 Human Functional pKi = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 5 1 6 5.0 COc1nccc(C)c1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
91810833 139951 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799229 139951 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118197452 140097 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3800062 140097 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
91810833 139951 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799229 139951 None 0 Human Functional pKi = 8.5 8.5 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
10343454 3983 None 29 Human Functional pKi = 8.4 8.4 - 1
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
9046 3983 None 29 Human Functional pKi = 8.4 8.4 - 1
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
CHEMBL2178578 3983 None 29 Human Functional pKi = 8.4 8.4 - 1
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
DB15250 3983 None 29 Human Functional pKi = 8.4 8.4 - 1
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
123327510 139716 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cc[n+]([O-])cc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797624 139716 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cc[n+]([O-])cc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204600 140053 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 494 4 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccc(C#N)n2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799828 140053 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 494 4 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccc(C#N)n2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197510 140112 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3800161 140112 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cncc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
118204597 139962 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 508 5 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cncc(C#N)c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799280 139962 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 508 5 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cncc(C#N)c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204630 139999 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799487 139999 None 0 Human Functional pKi = 7.5 7.5 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
124167985 139829 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 515 5 1 6 3.9 COc1c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccc[n+]1[O-] 10.1021/acs.jmedchem.5b01840
CHEMBL3798368 139829 None 0 Human Functional pKi = 8.4 8.4 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 515 5 1 6 3.9 COc1c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccc[n+]1[O-] 10.1021/acs.jmedchem.5b01840
118204598 139870 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 494 4 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cc(C#N)ccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798681 139870 None 0 Human Functional pKi = 7.4 7.4 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 494 4 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cc(C#N)ccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204847 140134 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 463 5 1 5 4.3 Cc1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2c1C(=O)N(Cc1cccnc1)C2=O 10.1021/acs.jmedchem.5b01840
CHEMBL3800309 140134 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 463 5 1 5 4.3 Cc1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2c1C(=O)N(Cc1cccnc1)C2=O 10.1021/acs.jmedchem.5b01840
118197598 139978 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 435 4 1 5 4.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2cccc3c2C(=O)N(c2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799381 139978 None 0 Human Functional pKi = 6.3 6.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 435 4 1 5 4.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2cccc3c2C(=O)N(c2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204622 139802 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 4 1 5 5.3 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(C)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3798186 139802 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 4 1 5 5.3 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(C)n1 10.1021/acs.jmedchem.5b01840
118204829 139928 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3799111 139928 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
118204681 139807 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)nc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798206 139807 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)nc1 10.1021/acs.jmedchem.5b01840
118204596 139869 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccnc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3798670 139869 None 0 Human Functional pKi = 7.3 7.3 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccnc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
118204826 139788 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1cccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3798104 139788 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1cccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
118204898 139969 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1cncc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
CHEMBL3799328 139969 None 0 Human Functional pKi = 7.2 7.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1cncc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c1 10.1021/acs.jmedchem.5b01840
118197428 1046 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
9252 1046 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
CHEMBL3797271 1046 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
124167959 139798 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccc[n+]2[O-])C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798178 139798 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccc[n+]2[O-])C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204900 139840 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cnccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3798484 139840 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cnccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204621 139864 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798612 139864 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204622 139802 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 4 1 5 5.3 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(C)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3798186 139802 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 4 1 5 5.3 Cc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(C)n1 10.1021/acs.jmedchem.5b01840
124167985 139829 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 515 5 1 6 3.9 COc1c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccc[n+]1[O-] 10.1021/acs.jmedchem.5b01840
CHEMBL3798368 139829 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 515 5 1 6 3.9 COc1c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccc[n+]1[O-] 10.1021/acs.jmedchem.5b01840
118204829 139928 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3799111 139928 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1cccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
118197518 139678 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 449 5 1 5 4.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2cccc3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797407 139678 None 0 Human Functional pKi = 6.2 6.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 449 5 1 5 4.0 CC(C)(C)c1ccc(S(=O)(=O)Nc2cccc3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204611 140054 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799829 140054 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 4 1 5 4.9 Cc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204633 140058 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799853 140058 None 0 Human Functional pKi = 8.2 8.2 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204918 140141 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 494 4 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cncc(C#N)c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3800355 140141 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 494 4 1 6 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cncc(C#N)c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197423 139947 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799220 139947 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197461 139765 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
CHEMBL3797948 139765 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 499 5 1 6 4.6 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
118204739 139857 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1ncccc1CN1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3798577 139857 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 4.6 COc1ncccc1CN1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204759 139803 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 529 6 1 7 4.7 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(OC)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3798193 139803 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 529 6 1 7 4.7 COc1ccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)c(OC)n1 10.1021/acs.jmedchem.5b01840
118204599 140108 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccncc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3800135 140108 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccncc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204712 139980 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
CHEMBL3799395 139980 None 0 Human Functional pKi = 7.1 7.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 497 5 1 5 4.9 Cc1ccc(CN2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)cn1 10.1021/acs.jmedchem.5b01840
118204671 140129 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 5.0 CCOc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3800270 140129 None 0 Human Functional pKi = 8.1 8.1 - 0
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assayAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
ChEMBL 513 6 1 6 5.0 CCOc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840


Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
10586 2139 None 4 Human Binding pIC50 = 8 8.0 - 0
Inhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cellsInhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cells
ChEMBL 379 5 1 6 4.3 CC[C@@H](n1c(=S)[nH]c(c1C(=O)OC)c1ccno1)c1ccc(c(c1)F)F 10.1021/acs.jmedchem.6b01309
11617815 2139 None 4 Human Binding pIC50 = 8 8.0 - 0
Inhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cellsInhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cells
ChEMBL 379 5 1 6 4.3 CC[C@@H](n1c(=S)[nH]c(c1C(=O)OC)c1ccno1)c1ccc(c(c1)F)F 10.1021/acs.jmedchem.6b01309
CHEMBL5290248 2139 None 4 Human Binding pIC50 = 8 8.0 - 0
Inhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cellsInhibition of human CCR9 in recombinant MCP-1-induced calcium mobilization in THP-1 cells
ChEMBL 379 5 1 6 4.3 CC[C@@H](n1c(=S)[nH]c(c1C(=O)OC)c1ccno1)c1ccc(c(c1)F)F 10.1021/acs.jmedchem.6b01309
122185757 122804 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 460 5 2 6 4.7 CN(C)c1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
CHEMBL3604493 122804 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 460 5 2 6 4.7 CN(C)c1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
127053027 140735 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 384 4 1 4 4.5 CC1(c2ccc(Cn3c(C(=O)O)cc4ncc(Cl)cc43)cc2)CCOCC1 10.1016/j.bmcl.2016.05.043
CHEMBL3814683 140735 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 384 4 1 4 4.5 CC1(c2ccc(Cn3c(C(=O)O)cc4ncc(Cl)cc43)cc2)CCOCC1 10.1016/j.bmcl.2016.05.043
10343454 3983 None 29 Human Binding pIC50 = 8.0 8.0 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
9046 3983 None 29 Human Binding pIC50 = 8.0 8.0 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
CHEMBL2178578 3983 None 29 Human Binding pIC50 = 8.0 8.0 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
DB15250 3983 None 29 Human Binding pIC50 = 8.0 8.0 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
122185740 122785 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 416 4 2 4 5.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604476 122785 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 416 4 2 4 5.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncccc2O)cc1 10.1016/j.bmcl.2015.06.046
127050864 140709 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 341 3 1 2 5.3 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814202 140709 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 341 3 1 2 5.3 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ccc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
122185763 122810 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay
ChEMBL 460 7 3 6 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604499 122810 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay
ChEMBL 460 7 3 6 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
122185745 122791 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 432 4 2 4 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2c(O)ccc[n+]2[O-])cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604481 122791 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 432 4 2 4 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2c(O)ccc[n+]2[O-])cc1 10.1016/j.bmcl.2015.06.046
122185758 122805 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 501 5 2 7 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nncc(N3CCOCC3)c2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604494 122805 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 501 5 2 7 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nncc(N3CCOCC3)c2N)cc1 10.1016/j.bmcl.2015.06.046
10343454 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
9046 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
CHEMBL2178578 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
DB15250 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9B expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
10343454 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
9046 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
CHEMBL2178578 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
DB15250 3983 None 29 Human Binding pIC50 = 8.6 8.6 -34 2
Antagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assayAntagonist activity at recombinant human CCR9A expressed in BAF3 cells assessed as reduction in CCL25-induced chemotaxis preincubated for 10 mins followed by addition of CCL25 and measured after 120 min by QUANT dye based fluorescence assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.ejmech.2019.111805
127053025 140746 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 372 6 1 4 4.4 COCC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814811 140746 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 372 6 1 4 4.4 COCC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
122185750 122796 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604486 122796 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2N)cc1 10.1016/j.bmcl.2015.06.046
122185751 122797 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nnccc2N)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604487 122797 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 416 4 2 5 4.5 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nnccc2N)cc1 10.1016/j.bmcl.2015.06.046
122185761 122808 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 430 5 2 5 4.9 CNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604497 122808 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 430 5 2 5 4.9 CNc1nccnc1-c1cc(Cl)ccc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2015.06.046
127053022 140700 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cc(Cl)ncc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814037 140700 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cc(Cl)ncc32)cc1 10.1016/j.bmcl.2016.05.043
127049675 140740 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814736 140740 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3ncc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
122185753 122799 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(N)ncc2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604489 122799 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nc(N)ncc2O)cc1 10.1016/j.bmcl.2015.06.046
122185759 122806 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 447 5 3 6 4.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604495 122806 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 447 5 3 6 4.1 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
122185747 122793 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 446 5 3 5 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604483 122793 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 446 5 3 5 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccc(CO)c2O)cc1 10.1016/j.bmcl.2015.06.046
122185763 122810 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 460 7 3 6 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604499 122810 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 460 7 3 6 4.3 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2nccnc2NCCO)cc1 10.1016/j.bmcl.2015.06.046
122185756 122803 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(N)c2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604492 122803 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 432 4 3 6 4.2 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncnc(N)c2O)cc1 10.1016/j.bmcl.2015.06.046
10343454 3983 None 29 Human Binding pIC50 = 6.3 6.3 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
9046 3983 None 29 Human Binding pIC50 = 6.3 6.3 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
CHEMBL2178578 3983 None 29 Human Binding pIC50 = 6.3 6.3 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
DB15250 3983 None 29 Human Binding pIC50 = 6.3 6.3 -34 2
Antagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by serum chemotaxis assay
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1016/j.bmcl.2015.06.046
127049676 140745 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cnc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814804 140745 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 342 3 1 3 4.7 CC(C)(C)c1ccc(Cn2c(C(=O)O)cc3cnc(Cl)cc32)cc1 10.1016/j.bmcl.2016.05.043
127053026 140712 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 354 3 1 3 4.5 O=C(O)c1cc2ncc(Cl)cc2n1Cc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.05.043
CHEMBL3814251 140712 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrsInhibition of CCR9-mediated chemotaxis in human MOLT4 cells preincubated for 10 mins followed by TECK addition in presence of 0.1% BSA measured after 2 hrs
ChEMBL 354 3 1 3 4.5 O=C(O)c1cc2ncc(Cl)cc2n1Cc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.05.043
10343454 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Binding affinity to CCR9Binding affinity to CCR9
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
9046 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Binding affinity to CCR9Binding affinity to CCR9
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
CHEMBL2178578 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Binding affinity to CCR9Binding affinity to CCR9
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
DB15250 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Binding affinity to CCR9Binding affinity to CCR9
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/jm300682j
122185760 122807 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 445 5 2 5 5.2 CCc1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
CHEMBL3604496 122807 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 445 5 2 5 5.2 CCc1ncnc(-c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1O 10.1016/j.bmcl.2015.06.046
122185752 122798 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 417 4 2 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncncc2O)cc1 10.1016/j.bmcl.2015.06.046
CHEMBL3604488 122798 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assayAntagonist activity at CCR9 receptor (unknown origin) by buffer chemotaxis assay
ChEMBL 417 4 2 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)cc2-c2ncncc2O)cc1 10.1016/j.bmcl.2015.06.046
10343454 3983 None 29 Human Binding pKi = 8 8.0 -34 2
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
9046 3983 None 29 Human Binding pKi = 8 8.0 -34 2
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
CHEMBL2178578 3983 None 29 Human Binding pKi = 8 8.0 -34 2
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
DB15250 3983 None 29 Human Binding pKi = 8 8.0 -34 2
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
124167985 139829 None 0 Human Binding pKi = 7.0 7.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 515 5 1 6 3.9 COc1c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccc[n+]1[O-] 10.1021/acs.jmedchem.5b01840
CHEMBL3798368 139829 None 0 Human Binding pKi = 7.0 7.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 515 5 1 6 3.9 COc1c(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)ccc[n+]1[O-] 10.1021/acs.jmedchem.5b01840
118197452 140097 None 0 Human Binding pKi = 7.9 7.9 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 483 4 1 5 4.9 Cc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3800062 140097 None 0 Human Binding pKi = 7.9 7.9 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 483 4 1 5 4.9 Cc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118204829 139928 None 0 Human Binding pKi = 7.7 7.7 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 483 4 1 5 4.9 Cc1cccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
CHEMBL3799111 139928 None 0 Human Binding pKi = 7.7 7.7 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 483 4 1 5 4.9 Cc1cccc(N2C(=O)c3c(Cl)ccc(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3C2=O)n1 10.1021/acs.jmedchem.5b01840
118197428 1046 None 0 Human Binding pKi = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
9252 1046 None 0 Human Binding pKi = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
CHEMBL3797271 1046 None 0 Human Binding pKi = 7.6 7.6 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 10.1021/acs.jmedchem.5b01840
118204630 139999 None 0 Human Binding pKi = 8.5 8.5 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 6 4.6 COc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799487 139999 None 0 Human Binding pKi = 8.5 8.5 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 6 4.6 COc1ccncc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
91810833 139951 None 0 Human Binding pKi = 7.5 7.5 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 6 4.6 COc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
CHEMBL3799229 139951 None 0 Human Binding pKi = 7.5 7.5 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 6 4.6 COc1ncccc1N1C(=O)c2c(Cl)ccc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2C1=O 10.1021/acs.jmedchem.5b01840
118197480 139750 None 0 Human Binding pKi = 6.5 6.5 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3797858 139750 None 0 Human Binding pKi = 6.5 6.5 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 483 5 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccnc2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118197423 139947 None 0 Human Binding pKi = 7.4 7.4 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799220 139947 None 0 Human Binding pKi = 7.4 7.4 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2ccc[n+]([O-])c2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
124167959 139798 None 0 Human Binding pKi = 7.4 7.4 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccc[n+]2[O-])C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798178 139798 None 0 Human Binding pKi = 7.4 7.4 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 499 5 1 5 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(Cc2cccc[n+]2[O-])C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204621 139864 None 0 Human Binding pKi = 8.1 8.1 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3798612 139864 None 0 Human Binding pKi = 8.1 8.1 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 469 4 1 5 4.6 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2ccccn2)C3=O)cc1 10.1021/acs.jmedchem.5b01840
118204633 140058 None 0 Human Binding pKi = 7.0 7.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
CHEMBL3799853 140058 None 0 Human Binding pKi = 7.0 7.0 - 1
Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate systemAntagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
ChEMBL 487 4 1 5 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cl)c3c2C(=O)N(c2cccnc2F)C3=O)cc1 10.1021/acs.jmedchem.5b01840
10343454 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.
Guide to Pharmacology 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 20660125
9046 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.
Guide to Pharmacology 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 20660125
CHEMBL2178578 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.
Guide to Pharmacology 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 20660125
DB15250 3983 None 29 Human Binding pIC50 = 8.2 8.2 -34 2
Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.Measuring inhibition of antagonist tracer [<sup>3</sup>H]CCX807 binding to human Molt-4 cells.
Guide to Pharmacology 444 5 1 4 4.3 Clc1ccc(c(c1)C(=O)c1cc[n+](cc1)[O-])NS(=O)(=O)c1ccc(cc1)C(C)(C)C 20660125
118197428 1046 None 0 Human Binding pKi = 8.2 8.2 - 1
FLIPR calcium assay using MOLT4 cellsFLIPR calcium assay using MOLT4 cells
Guide to Pharmacology 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 26987013
9252 1046 None 0 Human Binding pKi = 8.2 8.2 - 1
FLIPR calcium assay using MOLT4 cellsFLIPR calcium assay using MOLT4 cells
Guide to Pharmacology 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 26987013
CHEMBL3797271 1046 None 0 Human Binding pKi = 8.2 8.2 - 1
FLIPR calcium assay using MOLT4 cellsFLIPR calcium assay using MOLT4 cells
Guide to Pharmacology 499 4 1 5 4.2 O=C1c2c(ccc(c2C(=O)N1c1ccc[n+](c1C)[O-])Cl)NS(=O)(=O)c1ccc(cc1)C(C)(C)C 26987013