Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 44252324 | 142475 | None | 1 | Human | Functional | pIC50 | = | 9.4 | 9.4 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Human | Functional | pIC50 | = | 9.4 | 9.4 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252324 | 142475 | None | 1 | Human | Functional | pIC50 | = | 9 | 9.0 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Human | Functional | pIC50 | = | 9 | 9.0 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252324 | 142475 | None | 1 | Human | Functional | pIC50 | = | 9 | 9.0 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Human | Functional | pIC50 | = | 9 | 9.0 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252324 | 142475 | None | 1 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252324 | 142475 | None | 1 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 42 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509355 | 142730 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 507 | 7 | 2 | 5 | 3.4 | N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(C(F)(F)F)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3891692 | 142730 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 507 | 7 | 2 | 5 | 3.4 | N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(C(F)(F)F)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509356 | 152664 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 439 | 7 | 2 | 5 | 2.6 | N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCCCC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3971826 | 152664 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 439 | 7 | 2 | 5 | 2.6 | N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCCCC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509165 | 147963 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 457 | 7 | 2 | 6 | 2.6 | Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3933303 | 147963 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 457 | 7 | 2 | 6 | 2.6 | Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N | 10.1016/j.bmcl.2016.09.047 | ||
| 44252464 | 146755 | None | 0 | Mouse | Functional | pIC50 | = | 6 | 6.0 | -89 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3923733 | 146755 | None | 0 | Mouse | Functional | pIC50 | = | 6 | 6.0 | -89 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58504873 | 147048 | None | 0 | Mouse | Functional | pIC50 | = | 5 | 5.0 | -17 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 483 | 7 | 2 | 4 | 4.1 | CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3926111 | 147048 | None | 0 | Mouse | Functional | pIC50 | = | 5 | 5.0 | -17 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 483 | 7 | 2 | 4 | 4.1 | CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58504900 | 142677 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 517 | 7 | 2 | 4 | 4.8 | CC1CCN(C(=O)C(CCc2ccccc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3891289 | 142677 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 517 | 7 | 2 | 4 | 4.8 | CC1CCN(C(=O)C(CCc2ccccc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58508974 | 149504 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 50 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 467 | 7 | 1 | 6 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3c2ccn3C)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3945769 | 149504 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 50 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 467 | 7 | 1 | 6 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3c2ccn3C)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509106 | 151393 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 455 | 7 | 3 | 6 | 1.6 | N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(O)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3960700 | 151393 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 455 | 7 | 3 | 6 | 1.6 | N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(O)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509273 | 143356 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 414 | 7 | 1 | 5 | 2.4 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3896799 | 143356 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 414 | 7 | 1 | 5 | 2.4 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509102 | 152371 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 483 | 7 | 2 | 6 | 3.0 | N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCCCC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3969321 | 152371 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 483 | 7 | 2 | 6 | 3.0 | N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCCCC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 151 | 2 | Antagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP productionAntagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP production |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 151 | 2 | Antagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP productionAntagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP production |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509238 | 149917 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 473 | 7 | 2 | 6 | 2.8 | CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3948828 | 149917 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 473 | 7 | 2 | 6 | 2.8 | CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Mouse | Functional | pIC50 | = | 5.8 | 5.8 | -151 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Mouse | Functional | pIC50 | = | 5.8 | 5.8 | -151 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 134155728 | 151120 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)[C@H](CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3958582 | 151120 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)[C@H](CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252324 | 142475 | None | 1 | Mouse | Functional | pIC50 | = | 4.8 | 4.8 | -42 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Mouse | Functional | pIC50 | = | 4.8 | 4.8 | -42 | 2 | Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509160 | 146110 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 3.0 | CC1CCCCN1C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3918664 | 146110 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 453 | 7 | 2 | 5 | 3.0 | CC1CCCCN1C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 151 | 2 | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
Showing 1 to 50 of 128 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 44252324 | 142475 | None | 1 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252324 | 142475 | None | 1 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3889627 | 142475 | None | 1 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252468 | 152678 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3[nH]ccc3c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3971886 | 152678 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3[nH]ccc3c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509125 | 149293 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 474 | 7 | 2 | 7 | 2.2 | CC1CCN(C(=O)C(CCn2nccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3943972 | 149293 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 474 | 7 | 2 | 7 | 2.2 | CC1CCN(C(=O)C(CCn2nccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509238 | 149917 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 473 | 7 | 2 | 6 | 2.8 | CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3948828 | 149917 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 473 | 7 | 2 | 6 | 2.8 | CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 44252464 | 146755 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3923733 | 146755 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 453 | 7 | 2 | 5 | 2.8 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509147 | 151822 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 507 | 7 | 2 | 6 | 3.4 | CC1CCN(C(=O)C(CCn2ccnc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3964547 | 151822 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 507 | 7 | 2 | 6 | 3.4 | CC1CCN(C(=O)C(CCn2ccnc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509213 | 150192 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Reversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assayReversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3951018 | 150192 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | Reversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assayReversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assay |
ChEMBL | 497 | 7 | 2 | 6 | 3.2 | CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509350 | 144746 | None | 2 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 518 | 8 | 2 | 8 | 2.7 | CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3908230 | 144746 | None | 2 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 518 | 8 | 2 | 8 | 2.7 | CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58504873 | 147048 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 483 | 7 | 2 | 4 | 4.1 | CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3926111 | 147048 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 483 | 7 | 2 | 4 | 4.1 | CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509350 | 144746 | None | 2 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 518 | 8 | 2 | 8 | 2.7 | CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3908230 | 144746 | None | 2 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 518 | 8 | 2 | 8 | 2.7 | CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 | 10.1016/j.bmcl.2016.09.047 | ||
| 58509165 | 147963 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 457 | 7 | 2 | 6 | 2.6 | Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N | 10.1016/j.bmcl.2016.09.047 | ||
| CHEMBL3933303 | 147963 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis |
ChEMBL | 457 | 7 | 2 | 6 | 2.6 | Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N | 10.1016/j.bmcl.2016.09.047 | ||
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