Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
59314313 133160 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 390 5 2 4 3.2 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C#N)cc3C2)c1OC1CCC1 nan
CHEMBL3714964 133160 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 390 5 2 4 3.2 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C#N)cc3C2)c1OC1CCC1 nan
25160407 133495 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 353 5 2 3 3.1 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OC(C)C nan
CHEMBL3716140 133495 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 353 5 2 3 3.1 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OC(C)C nan
25159487 133428 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 375 4 2 2 4.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1=CCCCC1 nan
CHEMBL3715904 133428 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 375 4 2 2 4.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1=CCCCC1 nan
25160281 133848 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 367 6 2 3 3.5 CCC(C)Oc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3717337 133848 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 367 6 2 3 3.5 CCC(C)Oc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
25160799 134332 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 367 4 2 2 3.9 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 nan
CHEMBL3718924 134332 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 367 4 2 2 3.9 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 nan
2905078 26950 10 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 386 3 3 4 4.7 Cc1ccc(O)c(NC(=S)NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)c1 nan
CHEMBL1366012 26950 10 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 386 3 3 4 4.7 Cc1ccc(O)c(NC(=S)NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)c1 nan
1472329 34623 19 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 278 3 0 5 2.1 Cc1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])cn2)cc1 nan
CHEMBL1431608 34623 19 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 278 3 0 5 2.1 Cc1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])cn2)cc1 nan
4883406 20612 6 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 382 4 2 4 3.6 O=C(NNC(=O)c1cc(-c2ccccc2)nn1-c1ccccc1)c1ccccc1 nan
CHEMBL1309871 20612 6 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 382 4 2 4 3.6 O=C(NNC(=O)c1cc(-c2ccccc2)nn1-c1ccccc1)c1ccccc1 nan
2884240 31638 4 None -1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 436 3 1 5 3.3 COC(=O)C1=NN(C(=O)c2cccc(Br)c2)C(O)(c2ccc(Cl)cc2)C1 nan
CHEMBL1406895 31638 4 None -1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 436 3 1 5 3.3 COC(=O)C1=NN(C(=O)c2cccc(Br)c2)C(O)(c2ccc(Cl)cc2)C1 nan
25159484 134185 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 379 4 2 2 4.1 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1C1=CCCC1 nan
CHEMBL3718468 134185 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 379 4 2 2 4.1 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1C1=CCCC1 nan
25160411 133296 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 441 7 2 4 3.5 C=CCOc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3715464 133296 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 441 7 2 4 3.5 C=CCOc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
59314112 133633 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 349 3 2 2 3.3 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1ccc(F)c2ccccc12 nan
CHEMBL3716580 133633 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 349 3 2 2 3.3 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1ccc(F)c2ccccc12 nan
25160671 133759 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 351 5 2 2 3.5 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1CC(C)C nan
CHEMBL3717006 133759 2 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 351 5 2 2 3.5 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1CC(C)C nan
16452954 39646 10 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 419 5 1 5 3.8 Cc1ccccc1CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(F)cc2)n1 nan
CHEMBL1477528 39646 10 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 419 5 1 5 3.8 Cc1ccccc1CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(F)cc2)n1 nan
135443554 67131 9 None -3 3 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 277 3 2 4 3.8 C/C(=N\Nc1ccc2ccccc2n1)c1ccccc1O nan
CHEMBL1892026 67131 9 None -3 3 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 277 3 2 4 3.8 C/C(=N\Nc1ccc2ccccc2n1)c1ccccc1O nan
25160543 133235 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 421 5 2 3 4.2 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C(F)(F)F)cc3C2)c1OC(C)C nan
CHEMBL3715190 133235 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 421 5 2 3 4.2 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C(F)(F)F)cc3C2)c1OC(C)C nan
25160921 133589 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 385 4 2 2 4.0 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2cc(F)c(F)cc2C1 nan
CHEMBL3716436 133589 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 385 4 2 2 4.0 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2cc(F)c(F)cc2C1 nan
25160669 134007 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 5 2 2 3.7 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C nan
CHEMBL3717871 134007 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 5 2 2 3.7 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C nan
59314242 134053 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 377 6 2 2 4.6 CC/C=C(/CC)c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3718051 134053 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 377 6 2 2 4.6 CC/C=C(/CC)c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
25160278 133818 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 443 6 2 4 3.7 CC(C)Oc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3717217 133818 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 443 6 2 4 3.7 CC(C)Oc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
4889526 44857 10 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 386 5 1 7 3.8 COCCCn1c(N)c(-c2nc3ccccc3n2C)c2nc3ccccc3nc21 nan
CHEMBL1524932 44857 10 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 386 5 1 7 3.8 COCCCn1c(N)c(-c2nc3ccccc3n2C)c2nc3ccccc3nc21 nan
25160920 134367 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 387 5 2 2 3.8 Cc1cccc(C(=O)NC2(C(=O)O)Cc3cc(F)c(F)cc3C2)c1CC(C)C nan
CHEMBL3719066 134367 2 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 387 5 2 2 3.8 Cc1cccc(C(=O)NC2(C(=O)O)Cc3cc(F)c(F)cc3C2)c1CC(C)C nan
805087 48398 8 None -2 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 299 3 1 4 3.6 O=C(Nc1nnc(-c2ccccc2)o1)c1ccc(Cl)cc1 nan
CHEMBL1557648 48398 8 None -2 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 299 3 1 4 3.6 O=C(Nc1nnc(-c2ccccc2)o1)c1ccc(Cl)cc1 nan
59314413 134191 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 387 5 2 4 3.8 Cc1cccc(C(=O)NC2(C(=O)O)Cc3c(C)sc(C)c3C2)c1OC(C)C nan
CHEMBL3718493 134191 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 387 5 2 4 3.8 Cc1cccc(C(=O)NC2(C(=O)O)Cc3c(C)sc(C)c3C2)c1OC(C)C nan
25160542 133794 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 383 6 2 4 3.1 COc1ccc2c(c1)CC(NC(=O)c1cccc(C)c1OC(C)C)(C(=O)O)C2 nan
CHEMBL3717124 133794 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 383 6 2 4 3.1 COc1ccc2c(c1)CC(NC(=O)c1cccc(C)c1OC(C)C)(C(=O)O)C2 nan
59314410 133379 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 361 4 2 2 3.5 CCCC#Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3715725 133379 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 361 4 2 2 3.5 CCCC#Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
59314091 133140 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 375 5 2 3 3.6 CCOc1ccc2ccccc2c1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3714900 133140 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 375 5 2 3 3.6 CCOc1ccc2ccccc2c1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
25160800 133255 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 353 4 2 2 3.5 C/C=C/c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 nan
CHEMBL3715285 133255 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 353 4 2 2 3.5 C/C=C/c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 nan
59314103 133585 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 378 5 2 4 3.0 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C#N)cc3C2)c1OC(C)C nan
CHEMBL3716430 133585 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 378 5 2 4 3.0 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C#N)cc3C2)c1OC(C)C nan
2460453 28976 6 None -1 3 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 439 6 0 6 5.2 Cc1sc2nc(SCCN(C)C)n(-c3ccccc3)c(=O)c2c1-c1ccc(F)cc1 nan
CHEMBL1382003 28976 6 None -1 3 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 439 6 0 6 5.2 Cc1sc2nc(SCCN(C)C)n(-c3ccccc3)c(=O)c2c1-c1ccc(F)cc1 nan
59314294 134444 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 337 5 2 2 3.3 CCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3719322 134444 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 337 5 2 2 3.3 CCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
59314237 133647 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 7 2 2 4.1 CCCCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3716634 133647 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 7 2 2 4.1 CCCCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
25160798 133458 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 335 4 2 2 3.4 C/C=C/c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3716008 133458 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 335 4 2 2 3.4 C/C=C/c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
59314148 133797 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 337 5 2 4 2.9 Cc1cccc(C(=O)NC2(C(=O)O)CCSCC2)c1OC(C)C nan
CHEMBL3717131 133797 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 337 5 2 4 2.9 Cc1cccc(C(=O)NC2(C(=O)O)CCSCC2)c1OC(C)C nan
3372218 44611 16 None - 1 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 351 5 0 3 4.3 Cc1cccc2c1N(CCCOc1ccc(C(C)(C)C)cc1)C(=O)C2=O nan
CHEMBL1522544 44611 16 None - 1 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 351 5 0 3 4.3 Cc1cccc2c1N(CCCOc1ccc(C(C)(C)C)cc1)C(=O)C2=O nan
5928021 67292 5 None -1 3 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 339 3 1 5 2.7 CC(C)(C)c1ccc2c(c1)OC(C(=O)N/N=C\c1ccccn1)CO2 nan
CHEMBL1904956 67292 5 None -1 3 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 339 3 1 5 2.7 CC(C)(C)c1ccc2c(c1)OC(C(=O)N/N=C\c1ccccn1)CO2 nan
68588620 134015 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 403 4 2 2 4.5 CC(C)=Cc1c(C(=O)NC2(C(=O)O)Cc3ccccc3C2)cccc1C(F)(F)F nan
CHEMBL3717912 134015 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 403 4 2 2 4.5 CC(C)=Cc1c(C(=O)NC2(C(=O)O)Cc3ccccc3C2)cccc1C(F)(F)F nan
1201889 26188 13 None - 1 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 411 4 0 5 5.6 CN1CCc2nc(SCc3ccc(Cl)cc3)c(C#N)c(-c3cccs3)c2C1 nan
CHEMBL1359342 26188 13 None - 1 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 411 4 0 5 5.6 CN1CCc2nc(SCc3ccc(Cl)cc3)c(C#N)c(-c3cccs3)c2C1 nan
25160280 133569 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 437 5 2 3 4.4 O=C(NC1(C(=O)O)Cc2ccc(F)cc2C1)c1cc(Cl)cc(Cl)c1OC1CCC1 nan
CHEMBL3716354 133569 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 437 5 2 3 4.4 O=C(NC1(C(=O)O)Cc2ccc(F)cc2C1)c1cc(Cl)cc(Cl)c1OC1CCC1 nan
59314337 133292 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 381 5 2 3 3.8 Cc1cc2c(cc1C)CC(NC(=O)c1cccc(C)c1OC(C)C)(C(=O)O)C2 nan
CHEMBL3715458 133292 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 381 5 2 3 3.8 Cc1cc2c(cc1C)CC(NC(=O)c1cccc(C)c1OC(C)C)(C(=O)O)C2 nan
59314405 134387 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 3 2 3 3.6 Cc1sc(C)c2c1CC(NC(=O)c1cccc3c1CCCC3)(C(=O)O)C2 nan
CHEMBL3719127 134387 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 3 2 3 3.6 Cc1sc(C)c2c1CC(NC(=O)c1cccc3c1CCCC3)(C(=O)O)C2 nan
59314401 133282 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 6 2 3 3.1 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OCC1CC1 nan
CHEMBL3715405 133282 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 6 2 3 3.1 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OCC1CC1 nan
25159363 133933 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 353 3 2 2 3.1 O=C(NC1(C(=O)O)Cc2ccc(F)cc2C1)c1cccc2c1CCCC2 nan
CHEMBL3717606 133933 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 353 3 2 2 3.1 O=C(NC1(C(=O)O)Cc2ccc(F)cc2C1)c1cccc2c1CCCC2 nan
59314187 133930 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 5 2 2 3.7 Cc1cccc(C(=O)N[C@]2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C nan
CHEMBL3717598 133930 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 5 2 2 3.7 Cc1cccc(C(=O)N[C@]2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C nan
59314380 133331 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 357 3 2 4 2.0 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cc(F)cc2c1OCOC2 nan
CHEMBL3715579 133331 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 357 3 2 4 2.0 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cc(F)cc2c1OCOC2 nan
59314263 134283 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 360 3 2 3 2.8 N#Cc1ccc2c(c1)CC(NC(=O)c1cccc3c1CCCC3)(C(=O)O)C2 nan
CHEMBL3718773 134283 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 360 3 2 3 2.8 N#Cc1ccc2c(c1)CC(NC(=O)c1cccc3c1CCCC3)(C(=O)O)C2 nan
5280335 201938 64 None -1 2 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 299 15 3 3 3.9 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO nan
CHEMBL67166 201938 64 None -1 2 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 299 15 3 3 3.9 CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO nan
25160672 133885 4 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 349 4 2 2 3.8 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3717460 133885 4 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 349 4 2 2 3.8 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
59314391 134173 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 371 6 2 3 3.3 C=CCOc1c(Cl)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3718418 134173 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 371 6 2 3 3.3 C=CCOc1c(Cl)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
25161298 134078 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 385 4 2 2 4.0 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2c(F)ccc(F)c2C1 nan
CHEMBL3718117 134078 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 385 4 2 2 4.0 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2c(F)ccc(F)c2C1 nan
25160667 133950 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 383 5 2 3 3.4 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1OC1CCC1 nan
CHEMBL3717675 133950 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 383 5 2 3 3.4 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1OC1CCC1 nan
25160412 133542 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 379 7 2 2 4.6 CCCC(CC)c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3716277 133542 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 379 7 2 2 4.6 CCCC(CC)c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
25159485 133674 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 6 2 2 4.2 CCC/C=C/c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3716747 133674 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 6 2 2 4.2 CCC/C=C/c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
59314127 134120 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 373 5 2 2 3.6 CCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2cc(F)c(F)cc2C1 nan
CHEMBL3718266 134120 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 373 5 2 2 3.6 CCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2cc(F)c(F)cc2C1 nan
59314129 133470 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 355 5 2 2 3.4 CCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 nan
CHEMBL3716043 133470 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 355 5 2 2 3.4 CCCc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 nan
25160282 134311 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 5 2 3 3.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OC1CCC1 nan
CHEMBL3718851 134311 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 5 2 3 3.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OC1CCC1 nan
59314284 133376 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 351 6 2 3 2.9 C=CCOc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3715720 133376 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 351 6 2 3 2.9 C=CCOc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
25102804 134389 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 385 4 2 2 4.0 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)c(F)c2C1 nan
CHEMBL3719134 134389 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 385 4 2 2 4.0 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)c(F)c2C1 nan
2911166 39027 8 None -8 2 Human 4.3 pIC50 = 4.3 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 347 3 1 4 2.2 O=C1C2C3C=CC(CO)(O3)C2C(=O)N1c1ccccc1-c1ccccc1 nan
CHEMBL1470485 39027 8 None -8 2 Human 4.3 pIC50 = 4.3 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 347 3 1 4 2.2 O=C1C2C3C=CC(CO)(O3)C2C(=O)N1c1ccccc1-c1ccccc1 nan
25160673 133570 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 4 2 2 4.0 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1CCCC1 nan
CHEMBL3716359 133570 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 4 2 2 4.0 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1CCCC1 nan
25160540 133796 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 371 5 2 3 3.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1OC(C)C nan
CHEMBL3717130 133796 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 371 5 2 3 3.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1OC(C)C nan
59314348 133370 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 331 3 2 2 3.2 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cccc2ccccc12 nan
CHEMBL3715707 133370 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 331 3 2 2 3.2 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cccc2ccccc12 nan
25159486 133206 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 361 4 2 2 3.9 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1=CCCC1 nan
CHEMBL3715092 133206 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 361 4 2 2 3.9 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1=CCCC1 nan
25159483 134453 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 403 3 2 2 3.9 O=C(NC1(C(=O)O)Cc2ccc(C(F)(F)F)cc2C1)c1cccc2c1CCCC2 nan
CHEMBL3719362 134453 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 403 3 2 2 3.9 O=C(NC1(C(=O)O)Cc2ccc(C(F)(F)F)cc2C1)c1cccc2c1CCCC2 nan
25159359 133829 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 335 3 2 2 2.9 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cccc2c1CCCC2 nan
CHEMBL3717266 133829 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 335 3 2 2 2.9 O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cccc2c1CCCC2 nan
71044102 133389 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 5 2 2 3.7 Cc1cccc(C(=O)N[C@@]2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C nan
CHEMBL3715759 133389 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 369 5 2 2 3.7 Cc1cccc(C(=O)N[C@@]2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C nan
4261263 29012 14 None 1 4 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 443 6 1 6 3.0 O=C(CSc1cccc2cccnc12)Nc1ccc(S(=O)(=O)N2CCOCC2)cc1 nan
CHEMBL1382320 29012 14 None 1 4 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 443 6 1 6 3.0 O=C(CSc1cccc2cccnc12)Nc1ccc(S(=O)(=O)N2CCOCC2)cc1 nan
59314381 133165 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 433 5 2 3 4.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C(F)(F)F)cc3C2)c1OC1CCC1 nan
CHEMBL3714985 133165 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 433 5 2 3 4.3 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C(F)(F)F)cc3C2)c1OC1CCC1 nan
25160796 134308 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 361 5 2 2 3.8 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1/C=C/C1CC1 nan
CHEMBL3718838 134308 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 361 5 2 2 3.8 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1/C=C/C1CC1 nan
25161302 133804 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 383 4 2 2 4.4 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(Cl)cc2C1 nan
CHEMBL3717162 133804 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 383 4 2 2 4.4 CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(Cl)cc2C1 nan
4887113 35837 10 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 334 1 2 5 1.2 CN1C(=O)C(=C2CC(c3ccc(Cl)cc3)NN2)C(=O)N(C)C1=O nan
CHEMBL1443778 35837 10 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 334 1 2 5 1.2 CN1C(=O)C(=C2CC(c3ccc(Cl)cc3)NN2)C(=O)N(C)C1=O nan
901998 35160 10 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 332 3 0 5 2.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)nc1 nan
CHEMBL1437683 35160 10 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 332 3 0 5 2.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2cccc(C(F)(F)F)c2)nc1 nan
16211024 66818 31 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 1131 14 13 23 -1.3 C/C=C(\C)C(=O)OC1[C@H](OC(C)=O)C2(CO)C(CC1(C)C)C1=CCC3C4(C)CCC(O[C@@H]5O[C@H](C(=O)O)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@](C)(CO)C4CCC3(C)[C@]1(C)C[C@H]2O nan
CHEMBL1875956 66818 31 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]
ChEMBL 1131 14 13 23 -1.3 C/C=C(\C)C(=O)OC1[C@H](OC(C)=O)C2(CO)C(CC1(C)C)C1=CCC3C4(C)CCC(O[C@@H]5O[C@H](C(=O)O)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@](C)(CO)C4CCC3(C)[C@]1(C)C[C@H]2O nan
25159361 133827 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 4 2 3 2.9 COc1ccc2c(c1)CC(NC(=O)c1cccc3c1CCCC3)(C(=O)O)C2 nan
CHEMBL3717257 133827 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 365 4 2 3 2.9 COc1ccc2c(c1)CC(NC(=O)c1cccc3c1CCCC3)(C(=O)O)C2 nan
25160797 134240 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 6 2 2 3.7 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1CCC1CC1 nan
CHEMBL3718638 134240 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 6 2 2 3.7 Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1CCC1CC1 nan
25159482 134275 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 6 2 2 4.2 CCC/C=C\c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan
CHEMBL3718742 134275 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay
ChEMBL 363 6 2 2 4.2 CCC/C=C\c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 nan


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
3645 1223 0 None - 1 Human 7.3 pKd = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 22913878