Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 59314313 | 133752 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 390 | 5 | 2 | 4 | 3.2 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C#N)cc3C2)c1OC1CCC1 | nan | ||
| CHEMBL3714964 | 133752 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 390 | 5 | 2 | 4 | 3.2 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C#N)cc3C2)c1OC1CCC1 | nan | ||
| 25160407 | 134087 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 353 | 5 | 2 | 3 | 3.1 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OC(C)C | nan | ||
| CHEMBL3716140 | 134087 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 353 | 5 | 2 | 3 | 3.1 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1OC(C)C | nan | ||
| 25159487 | 134020 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 375 | 4 | 2 | 2 | 4.3 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1=CCCCC1 | nan | ||
| CHEMBL3715904 | 134020 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 375 | 4 | 2 | 2 | 4.3 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1C1=CCCCC1 | nan | ||
| 25160281 | 134440 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 367 | 6 | 2 | 3 | 3.5 | CCC(C)Oc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| CHEMBL3717337 | 134440 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 367 | 6 | 2 | 3 | 3.5 | CCC(C)Oc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| 25160799 | 134924 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 367 | 4 | 2 | 2 | 3.9 | CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 | nan | ||
| CHEMBL3718924 | 134924 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 367 | 4 | 2 | 2 | 3.9 | CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccc(F)cc2C1 | nan | ||
| 2905078 | 27165 | None | 7 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 386 | 3 | 3 | 4 | 4.7 | Cc1ccc(O)c(NC(=S)NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)c1 | nan | ||
| CHEMBL1366012 | 27165 | None | 7 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 386 | 3 | 3 | 4 | 4.7 | Cc1ccc(O)c(NC(=S)NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)c1 | nan | ||
| 1472329 | 34856 | None | 22 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 278 | 3 | 0 | 5 | 2.1 | Cc1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])cn2)cc1 | nan | ||
| CHEMBL1431608 | 34856 | None | 22 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 278 | 3 | 0 | 5 | 2.1 | Cc1ccc(S(=O)(=O)c2ccc([N+](=O)[O-])cn2)cc1 | nan | ||
| 4883406 | 20819 | None | 2 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 382 | 4 | 2 | 4 | 3.6 | O=C(NNC(=O)c1cc(-c2ccccc2)nn1-c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL1309871 | 20819 | None | 2 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 382 | 4 | 2 | 4 | 3.6 | O=C(NNC(=O)c1cc(-c2ccccc2)nn1-c1ccccc1)c1ccccc1 | nan | ||
| 2884240 | 31862 | None | 4 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 436 | 3 | 1 | 5 | 3.3 | COC(=O)C1=NN(C(=O)c2cccc(Br)c2)C(O)(c2ccc(Cl)cc2)C1 | nan | ||
| CHEMBL1406895 | 31862 | None | 4 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 436 | 3 | 1 | 5 | 3.3 | COC(=O)C1=NN(C(=O)c2cccc(Br)c2)C(O)(c2ccc(Cl)cc2)C1 | nan | ||
| 25159484 | 134777 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 379 | 4 | 2 | 2 | 4.1 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1C1=CCCC1 | nan | ||
| CHEMBL3718468 | 134777 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 379 | 4 | 2 | 2 | 4.1 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1C1=CCCC1 | nan | ||
| 25160411 | 133888 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 441 | 7 | 2 | 4 | 3.5 | C=CCOc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| CHEMBL3715464 | 133888 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 441 | 7 | 2 | 4 | 3.5 | C=CCOc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| 59314112 | 134225 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 349 | 3 | 2 | 2 | 3.3 | O=C(NC1(C(=O)O)Cc2ccccc2C1)c1ccc(F)c2ccccc12 | nan | ||
| CHEMBL3716580 | 134225 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 349 | 3 | 2 | 2 | 3.3 | O=C(NC1(C(=O)O)Cc2ccccc2C1)c1ccc(F)c2ccccc12 | nan | ||
| 25160671 | 134351 | None | 4 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 351 | 5 | 2 | 2 | 3.5 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1CC(C)C | nan | ||
| CHEMBL3717006 | 134351 | None | 4 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 351 | 5 | 2 | 2 | 3.5 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccccc3C2)c1CC(C)C | nan | ||
| 16452954 | 39899 | None | 8 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 419 | 5 | 1 | 5 | 3.8 | Cc1ccccc1CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(F)cc2)n1 | nan | ||
| CHEMBL1477528 | 39899 | None | 8 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 1 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 419 | 5 | 1 | 5 | 3.8 | Cc1ccccc1CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(F)cc2)n1 | nan | ||
| 135443554 | 67492 | None | 6 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -3 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 277 | 3 | 2 | 4 | 3.8 | C/C(=N\Nc1ccc2ccccc2n1)c1ccccc1O | nan | ||
| CHEMBL1892026 | 67492 | None | 6 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -3 | 3 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 277 | 3 | 2 | 4 | 3.8 | C/C(=N\Nc1ccc2ccccc2n1)c1ccccc1O | nan | ||
| 25160543 | 133827 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 421 | 5 | 2 | 3 | 4.2 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C(F)(F)F)cc3C2)c1OC(C)C | nan | ||
| CHEMBL3715190 | 133827 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 421 | 5 | 2 | 3 | 4.2 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(C(F)(F)F)cc3C2)c1OC(C)C | nan | ||
| 25160921 | 134181 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 385 | 4 | 2 | 2 | 4.0 | CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2cc(F)c(F)cc2C1 | nan | ||
| CHEMBL3716436 | 134181 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 385 | 4 | 2 | 2 | 4.0 | CC(C)=Cc1c(C)cccc1C(=O)NC1(C(=O)O)Cc2cc(F)c(F)cc2C1 | nan | ||
| 25160669 | 134599 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 369 | 5 | 2 | 2 | 3.7 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C | nan | ||
| CHEMBL3717871 | 134599 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 369 | 5 | 2 | 2 | 3.7 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3ccc(F)cc3C2)c1CC(C)C | nan | ||
| 59314242 | 134645 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 377 | 6 | 2 | 2 | 4.6 | CC/C=C(/CC)c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| CHEMBL3718051 | 134645 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 377 | 6 | 2 | 2 | 4.6 | CC/C=C(/CC)c1c(C)cccc1C(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| 25160278 | 134410 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 443 | 6 | 2 | 4 | 3.7 | CC(C)Oc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| CHEMBL3717217 | 134410 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 443 | 6 | 2 | 4 | 3.7 | CC(C)Oc1c(Cl)cc(Cl)cc1S(=O)(=O)NC1(C(=O)O)Cc2ccccc2C1 | nan | ||
| 4889526 | 45125 | None | 6 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 4 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 386 | 5 | 1 | 7 | 3.8 | COCCCn1c(N)c(-c2nc3ccccc3n2C)c2nc3ccccc3nc21 | nan | ||
| CHEMBL1524932 | 45125 | None | 6 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -1 | 4 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 386 | 5 | 1 | 7 | 3.8 | COCCCn1c(N)c(-c2nc3ccccc3n2C)c2nc3ccccc3nc21 | nan | ||
| 25160920 | 134959 | None | 4 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 387 | 5 | 2 | 2 | 3.8 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3cc(F)c(F)cc3C2)c1CC(C)C | nan | ||
| CHEMBL3719066 | 134959 | None | 4 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 387 | 5 | 2 | 2 | 3.8 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3cc(F)c(F)cc3C2)c1CC(C)C | nan | ||
| 805087 | 48676 | None | 4 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -2 | 4 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 299 | 3 | 1 | 4 | 3.6 | O=C(Nc1nnc(-c2ccccc2)o1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1557648 | 48676 | None | 4 | Human | Functional | pIC50 | = | 4.8 | 4.8 | -2 | 4 | PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334]PUBCHEM_BIOASSAY: SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using a CXCR5 receptor luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540334] |
ChEMBL | 299 | 3 | 1 | 4 | 3.6 | O=C(Nc1nnc(-c2ccccc2)o1)c1ccc(Cl)cc1 | nan | ||
| 59314413 | 134783 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 387 | 5 | 2 | 4 | 3.8 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3c(C)sc(C)c3C2)c1OC(C)C | nan | ||
| CHEMBL3718493 | 134783 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 387 | 5 | 2 | 4 | 3.8 | Cc1cccc(C(=O)NC2(C(=O)O)Cc3c(C)sc(C)c3C2)c1OC(C)C | nan | ||
| 25160542 | 134386 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 383 | 6 | 2 | 4 | 3.1 | COc1ccc2c(c1)CC(NC(=O)c1cccc(C)c1OC(C)C)(C(=O)O)C2 | nan | ||
| CHEMBL3717124 | 134386 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | Antagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assayAntagonist activity against human CXCR5 expressed in RBL cells assessed as inhibition of human CXCL13-induced intracellular Ca2+ level by fluo-4/AM dye based FLIPR assay |
ChEMBL | 383 | 6 | 2 | 4 | 3.1 | COc1ccc2c(c1)CC(NC(=O)c1cccc(C)c1OC(C)C)(C(=O)O)C2 | nan | ||
Showing 1 to 50 of 152 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 171348748 | 194743 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at CXCR5 (unknown origin)Antagonist activity at CXCR5 (unknown origin) |
ChEMBL | 481 | 6 | 1 | 2 | 6.5 | C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccccc4)ccc3CCC2)cc1)C1CCOCC1 | 10.1021/acs.jmedchem.5b01337 | ||
| CHEMBL5288861 | 194743 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at CXCR5 (unknown origin)Antagonist activity at CXCR5 (unknown origin) |
ChEMBL | 481 | 6 | 1 | 2 | 6.5 | C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccccc4)ccc3CCC2)cc1)C1CCOCC1 | 10.1021/acs.jmedchem.5b01337 | ||
| CHEMBL5315516 | 194743 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at CXCR5 (unknown origin)Antagonist activity at CXCR5 (unknown origin) |
ChEMBL | 481 | 6 | 1 | 2 | 6.5 | C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccccc4)ccc3CCC2)cc1)C1CCOCC1 | 10.1021/acs.jmedchem.5b01337 | ||
| 3645 | 1249 | None | 0 | Human | Binding | pKd | = | 7.3 | 7.3 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 22913878 | ||||
Showing 1 to 4 of 4 entries