Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 137642920 | 158207 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4086893 | 158207 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134157586 | 154252 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -3 | 3 | Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay |
ChEMBL | 366 | 8 | 1 | 3 | 5.5 | O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3985509 | 154252 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -3 | 3 | Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay |
ChEMBL | 366 | 8 | 1 | 3 | 5.5 | O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90407037 | 157380 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 377 | 8 | 1 | 3 | 5.3 | CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4076902 | 157380 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 377 | 8 | 1 | 3 | 5.3 | CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90405670 | 164789 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay |
ChEMBL | 425 | 7 | 1 | 3 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4217143 | 164789 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay |
ChEMBL | 425 | 7 | 1 | 3 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 118707082 | 113071 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR |
ChEMBL | 309 | 4 | 1 | 3 | 3.3 | COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311196 | 113071 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR |
ChEMBL | 309 | 4 | 1 | 3 | 3.3 | COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 925016 | 113093 | None | 13 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR |
ChEMBL | 289 | 3 | 1 | 2 | 3.7 | Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311314 | 113093 | None | 13 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR |
ChEMBL | 289 | 3 | 1 | 2 | 3.7 | Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137649416 | 157611 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4079893 | 157611 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 82051616 | 159551 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | 12 | 2 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4101323 | 159551 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | 12 | 2 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2017.01.034 | ||
| 975397 | 113099 | None | 6 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR |
ChEMBL | 335 | 5 | 1 | 4 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311324 | 113099 | None | 6 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR |
ChEMBL | 335 | 5 | 1 | 4 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC | 10.1016/j.bmcl.2014.05.012 | ||
| 137634844 | 156207 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 412 | 9 | 1 | 3 | 6.1 | CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4063239 | 156207 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 412 | 9 | 1 | 3 | 6.1 | CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 137640323 | 157070 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 358 | 7 | 1 | 4 | 4.3 | O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4073013 | 157070 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 358 | 7 | 1 | 4 | 4.3 | O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137653973 | 158776 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 354 | 6 | 2 | 3 | 4.3 | Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4093067 | 158776 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 354 | 6 | 2 | 3 | 4.3 | Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O | 10.1016/j.bmcl.2017.01.034 | ||
| 134133275 | 143730 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -8 | 2 | Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay |
ChEMBL | 384 | 5 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3899885 | 143730 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -8 | 2 | Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay |
ChEMBL | 384 | 5 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 85472225 | 162856 | None | 0 | Mouse | Functional | pEC50 | = | 7.0 | 7.0 | -2 | 3 | Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay |
ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4171724 | 162856 | None | 0 | Mouse | Functional | pEC50 | = | 7.0 | 7.0 | -2 | 3 | Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay |
ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 134133797 | 143655 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay |
ChEMBL | 338 | 3 | 0 | 4 | 3.6 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3899190 | 143655 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay |
ChEMBL | 338 | 3 | 0 | 4 | 3.6 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 85472621 | 162898 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4172392 | 162898 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| 145955668 | 162520 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 415 | 7 | 1 | 4 | 6.0 | Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4166208 | 162520 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 415 | 7 | 1 | 4 | 6.0 | Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| 134149615 | 148664 | None | 0 | Mouse | Functional | pEC50 | = | 7.0 | 7.0 | 1 | 3 | Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay |
ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3939004 | 148664 | None | 0 | Mouse | Functional | pEC50 | = | 7.0 | 7.0 | 1 | 3 | Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay |
ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137640701 | 157181 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 427 | 9 | 1 | 4 | 6.2 | CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4074388 | 157181 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 427 | 9 | 1 | 4 | 6.2 | CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 137636217 | 156184 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4063013 | 156184 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 137642920 | 158207 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4086893 | 158207 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay |
ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 90418476 | 162881 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 511 | 7 | 1 | 4 | 6.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4172136 | 162881 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay |
ChEMBL | 511 | 7 | 1 | 4 | 6.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 57521919 | 76304 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 23 | 2 | Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay |
ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058532 | 76304 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 23 | 2 | Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay |
ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL4207911 | 76304 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 23 | 2 | Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay |
ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| 137636217 | 156184 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay |
ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4063013 | 156184 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay |
ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134138099 | 147910 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | 4 | 2 | Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay |
ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | ||
Showing 1 to 50 of 1,053 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 134154473 | 152463 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay |
ChEMBL | 370 | 6 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3970238 | 152463 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay |
ChEMBL | 370 | 6 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 73776979 | 143446 | None | 0 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay |
ChEMBL | 419 | 5 | 1 | 3 | 5.9 | O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3897637 | 143446 | None | 0 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay |
ChEMBL | 419 | 5 | 1 | 3 | 5.9 | O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 137638318 | 156826 | None | 0 | Mouse | Binding | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay |
ChEMBL | 402 | 4 | 1 | 5 | 4.4 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 | 10.1021/acs.jmedchem.7b00210 | ||
| CHEMBL4070359 | 156826 | None | 0 | Mouse | Binding | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay |
ChEMBL | 402 | 4 | 1 | 5 | 4.4 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 | 10.1021/acs.jmedchem.7b00210 | ||
| 171351623 | 193594 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 484 | 10 | 2 | 8 | 3.7 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5266523 | 193594 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 484 | 10 | 2 | 8 | 3.7 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| 171342834 | 193713 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 486 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5269688 | 193713 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 486 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| 171354496 | 194105 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 486 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5278791 | 194105 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 486 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| 171348900 | 194335 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 466 | 8 | 2 | 7 | 4.3 | Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5283726 | 194335 | None | 0 | Human | Binding | pEC50 | = | 5 | 5.0 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 466 | 8 | 2 | 7 | 4.3 | Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| 127031569 | 139271 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay |
ChEMBL | 264 | 4 | 1 | 1 | 3.3 | O=C(O)CCc1ccc(C#CCc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | ||
| CHEMBL3787580 | 139271 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay |
ChEMBL | 264 | 4 | 1 | 1 | 3.3 | O=C(O)CCc1ccc(C#CCc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | ||
| 145971522 | 163211 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay |
ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4177287 | 163211 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay |
ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| 134129938 | 142527 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 0 | Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay |
ChEMBL | 414 | 6 | 1 | 4 | 5.0 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3890089 | 142527 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 0 | Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay |
ChEMBL | 414 | 6 | 1 | 4 | 5.0 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 156011529 | 177502 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin) |
ChEMBL | 420 | 7 | 1 | 3 | 6.2 | CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1 | 10.1016/j.bmc.2019.115263 | ||
| CHEMBL4638249 | 177502 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin) |
ChEMBL | 420 | 7 | 1 | 3 | 6.2 | CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1 | 10.1016/j.bmc.2019.115263 | ||
| 134132142 | 144957 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment |
ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3909872 | 144957 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment |
ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | ||
| 73777175 | 143996 | None | 0 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay |
ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3901994 | 143996 | None | 0 | Mouse | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay |
ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 85472621 | 162898 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay |
ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4172392 | 162898 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay |
ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| 66562488 | 90405 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay |
ChEMBL | 336 | 4 | 1 | 1 | 4.3 | O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F | 10.1021/ml4000673 | ||
| CHEMBL2386364 | 90405 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay |
ChEMBL | 336 | 4 | 1 | 1 | 4.3 | O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F | 10.1021/ml4000673 | ||
| 171352188 | 193918 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 492 | 6 | 2 | 7 | 4.9 | Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5274344 | 193918 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 492 | 6 | 2 | 7 | 4.9 | Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | ||
| 164888199 | 194467 | None | 2 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulation |
ChEMBL | 362 | 3 | 0 | 4 | 3.6 | C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.0c01002 | ||
| CHEMBL5286838 | 194467 | None | 2 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulation |
ChEMBL | 362 | 3 | 0 | 4 | 3.6 | C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.0c01002 | ||
| 73777153 | 142910 | None | 0 | Mouse | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay |
ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3893026 | 142910 | None | 0 | Mouse | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay |
ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 171353999 | 194022 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 417 | 6 | 2 | 8 | 4.3 | Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12 | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5276740 | 194022 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 417 | 6 | 2 | 8 | 4.3 | Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12 | 10.1021/acsmedchemlett.2c00160 | ||
| 171355332 | 194219 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 442 | 6 | 2 | 7 | 4.0 | Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5281423 | 194219 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 442 | 6 | 2 | 7 | 4.0 | Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | ||
| 171349936 | 194525 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 482 | 9 | 2 | 8 | 3.9 | COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5288340 | 194525 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 482 | 9 | 2 | 8 | 3.9 | COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.2c00160 | ||
| 137640163 | 156940 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay |
ChEMBL | 372 | 5 | 1 | 5 | 4.4 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12 | 10.1021/acs.jmedchem.7b00210 | ||
| CHEMBL4071523 | 156940 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay |
ChEMBL | 372 | 5 | 1 | 5 | 4.4 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12 | 10.1021/acs.jmedchem.7b00210 | ||
| 7614387 | 194382 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 389 | 5 | 2 | 8 | 3.5 | Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1 | 10.1021/acsmedchemlett.2c00160 | ||
| CHEMBL5284985 | 194382 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis |
ChEMBL | 389 | 5 | 2 | 8 | 3.5 | Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1 | 10.1021/acsmedchemlett.2c00160 | ||
| 11195 | 3882 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay |
ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| 86280676 | 3882 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay |
ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3941880 | 3882 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay |
ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| 171354782 | 193990 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assay |
ChEMBL | 462 | 7 | 1 | 3 | 6.9 | OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F | 10.1021/acs.jmedchem.0c01002 | ||
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