Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
25174150 15889 0 None 64 2 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099326 15889 0 None 64 2 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
25191879 15898 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 599 18 2 5 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099335 15898 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 599 18 2 5 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O 10.1021/jm1001919
25191880 15895 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 587 18 2 6 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099332 15895 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 587 18 2 6 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192021 15886 0 None 223 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099323 15886 0 None 223 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192023 15303 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 625 18 2 7 7.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094346 15303 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 625 18 2 7 7.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192174 15894 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 586 18 2 5 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099331 15894 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 586 18 2 5 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
132379 118509 19 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 118509 19 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
25192176 15304 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 626 18 2 8 7.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094347 15304 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 626 18 2 8 7.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192175 15897 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 588 18 2 7 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099334 15897 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 588 18 2 7 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192022 10128 7 None 21 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6158 10128 7 None 21 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
CHEMBL1098560 10128 7 None 21 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
23501721 15893 0 None 316 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099330 15893 0 None 316 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
25192325 15896 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 621 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099333 15896 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 621 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O 10.1021/jm1001919
25192326 15802 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 592 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1098550 15802 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 592 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192327 15900 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 624 18 2 6 8.2 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099337 15900 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 624 18 2 6 8.2 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192468 15306 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094349 15306 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O 10.1021/jm1001919
132379 118509 19 None - 1 Human 9.1 pIC50 = 9.1 Functional
Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 118509 19 None - 1 Human 9.1 pIC50 = 9.1 Functional
Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
25192471 15305 0 None 15 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094348 15305 0 None 15 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
10319829 32890 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 32890 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10341135 36161 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 36161 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10047140 34380 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 34380 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
14946858 35934 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 35934 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
6444688 194099 35 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 194099 35 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
10071290 34873 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 34873 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
25192022 10128 7 None 21 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6158 10128 7 None 21 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
CHEMBL1098560 10128 7 None 21 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6444688 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00100a034
CHEMBL49302 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00100a034
10343923 34556 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 34556 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10477988 34916 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 34916 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10364772 34933 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 34933 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
25192471 15305 0 None 15 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094348 15305 0 None 15 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
6444688 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm960088k
CHEMBL49302 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm960088k
46888200 15899 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 637 18 3 4 9.1 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099336 15899 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 637 18 3 4 9.1 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O 10.1021/jm1001919
10341242 34926 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 34926 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
6450158 193953 20 None - 1 Human 6.9 pIC50 = 6.9 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 193953 20 None - 1 Human 6.9 pIC50 = 6.9 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
46888199 15892 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 696 18 2 8 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099329 15892 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 696 18 2 8 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
114999 10311 21 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
6156 10311 21 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
CHEMBL14823 10311 21 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
44382384 66316 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL171666 66316 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10092630 34594 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 34594 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10475503 34781 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 34781 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10023244 32934 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 32934 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357534 33513 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 33513 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10406292 35169 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 35169 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9865985 35446 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 35446 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
10427789 34713 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 34713 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
23501721 15893 0 None 316 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099330 15893 0 None 316 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
9976757 35274 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 35274 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44382378 65643 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL168854 65643 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10474602 32751 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 32751 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
46888201 15901 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 654 19 2 7 8.2 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1 10.1021/jm1001919
CHEMBL1099338 15901 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 654 19 2 7 8.2 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1 10.1021/jm1001919
3368 7956 26 None -3 2 Mouse 7.5 pIC50 = 7.5 Functional
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 7956 26 None -3 2 Mouse 7.5 pIC50 = 7.5 Functional
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 7956 26 None -3 2 Mouse 7.5 pIC50 = 7.5 Functional
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
10001576 35154 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 35154 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10046878 35206 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 35206 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
46888196 15888 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 640 20 2 6 8.5 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1 10.1021/jm1001919
CHEMBL1099325 15888 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 640 20 2 6 8.5 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1 10.1021/jm1001919
44382275 66511 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL172457 66511 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
25192021 15886 0 None 223 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099323 15886 0 None 223 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
44382276 127094 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL352814 127094 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
9978895 125754 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL342416 125754 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10021742 16228 6 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 16228 6 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
44356239 34615 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 361 8 0 2 4.9 CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1 10.1021/jm00100a034
CHEMBL137121 34615 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 361 8 0 2 4.9 CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1 10.1021/jm00100a034
46888197 15890 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099327 15890 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O 10.1021/jm1001919
46888198 15891 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 668 18 2 8 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099328 15891 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 668 18 2 8 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
9934323 107029 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL288758 107029 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
10091738 34576 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 34576 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
46888202 15307 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 656 18 2 6 8.4 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094350 15307 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 656 18 2 6 8.4 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
44382468 65862 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL169639 65862 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10430674 126116 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 126116 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
25174150 15889 0 None 64 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099326 15889 0 None 64 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
44357546 123531 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 123531 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
46888195 15887 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 616 18 2 4 8.7 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099324 15887 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 616 18 2 4 8.7 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O 10.1021/jm1001919
122023 57569 60 None 1 3 Human 7.1 pIC50 = 7.1 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
CHEMBL15766 57569 60 None 1 3 Human 7.1 pIC50 = 7.1 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
CHEMBL45460 57569 60 None 1 3 Human 7.1 pIC50 = 7.1 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
132379 118509 19 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 118509 19 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
3368 7956 26 None 3 2 Human 8.0 pIC50 = 8.0 Functional
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 7956 26 None 3 2 Human 8.0 pIC50 = 8.0 Functional
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 7956 26 None 3 2 Human 8.0 pIC50 = 8.0 Functional
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
10022413 34431 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 34431 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10692884 194944 0 None - 0 Human 8.0 pKi = 8.0 Functional
Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs
ChEMBL 409 10 1 3 5.1 CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1 10.1021/jm980540v
CHEMBL49866 194944 0 None - 0 Human 8.0 pKi = 8.0 Functional
Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs
ChEMBL 409 10 1 3 5.1 CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1 10.1021/jm980540v
60490 214040 106 None -8 2 Human 8.2 pIC50 = 8.2 Functional
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
Drug Central 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O None
CHEMBL93 214040 106 None -8 2 Human 8.2 pIC50 = 8.2 Functional
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
Drug Central 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O None
71398 113216 44 None 3 14 Human 8.2 pIC50 = 8.2 Functional
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
Drug Central 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 None
CHEMBL313972 113216 44 None 3 14 Human 8.2 pIC50 = 8.2 Functional
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
Drug Central 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 None
6157 9708 20 None - 1 Human 5.8 pIC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6438358 9708 20 None - 1 Human 5.8 pIC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
CHEMBL422420 9708 20 None - 1 Human 5.8 pIC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
114999 10311 21 None - 1 Human 6.1 pIC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
6156 10311 21 None - 1 Human 6.1 pIC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
CHEMBL14823 10311 21 None - 1 Human 6.1 pIC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
3368 7956 26 None 3 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
9867257 7956 26 None 3 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
CHEMBL51770 7956 26 None 3 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
25192022 10128 7 None 21 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
6158 10128 7 None 21 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
CHEMBL1098560 10128 7 None 21 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
177941 8369 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
2948 8369 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
CHEMBL329123 8369 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
DB12850 8369 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
6154 7421 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
6154 7421 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
9956189 7421 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
9956189 7421 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
6155 7959 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
9823886 7959 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
CHEMBL301829 7959 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
DB13053 7959 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
44379678 171701 0 None - 0 Human 10.0 pIC50 = 10 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 527 14 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL422388 171701 0 None - 0 Human 10.0 pIC50 = 10 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 527 14 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
44379453 64859 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 513 13 1 6 4.9 CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167350 64859 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 513 13 1 6 4.9 CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
15817161 64909 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 499 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167804 64909 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 499 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
9865985 35446 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 35446 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
114999 10311 21 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
6156 10311 21 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
CHEMBL14823 10311 21 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
204058 170238 8 None - 1 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm960088k
CHEMBL419948 170238 8 None - 1 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm960088k
196905 118408 8 None - 0 Human 8.8 pIC50 = 8.8 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm960088k
CHEMBL328492 118408 8 None - 0 Human 8.8 pIC50 = 8.8 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm960088k
2487 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
5280492 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
CHEMBL65061 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
DB12961 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
6444688 194099 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49302 194099 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
2487 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
5280492 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
CHEMBL65061 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
DB12961 9147 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
11799000 23940 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
CHEMBL125611 23940 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
10385899 34180 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL136805 34180 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
9999755 33345 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136094 33345 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
44357534 33513 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 33513 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10071290 34873 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 34873 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
196905 118408 8 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL328492 118408 8 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
11756030 65534 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL168658 65534 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
14946858 35934 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 35934 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10407251 125859 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL342688 125859 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
15666577 15973 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL110402 15973 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 10.1021/jm00095a011
15666579 12399 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 10.1021/jm00095a011
CHEMBL107760 12399 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 10.1021/jm00095a011
15666578 14676 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 10.1021/jm00095a011
CHEMBL109015 14676 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 10.1021/jm00095a011
15666603 14910 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109176 14910 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
15666621 16014 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 406 12 1 2 7.2 O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL110707 16014 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 406 12 1 2 7.2 O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1 10.1021/jm00095a011
44315785 21423 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205307 21423 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL80541 21423 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
11741184 34935 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
CHEMBL137342 34935 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
15666575 11960 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCCc1csc(CCc2ccccc2)c1 10.1021/jm00095a011
CHEMBL106055 11960 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCCc1csc(CCc2ccccc2)c1 10.1021/jm00095a011
15666597 116415 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.9 O=C(O)CCCCCCc1csc(Cc2ccccc2)c1 10.1021/jm00095a011
CHEMBL322290 116415 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.9 O=C(O)CCCCCCc1csc(Cc2ccccc2)c1 10.1021/jm00095a011
135531245 212043 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL78966 212043 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
10046878 35206 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 35206 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
135503765 211992 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1 10.1021/jm00041a021
CHEMBL78605 211992 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1 10.1021/jm00041a021
15666618 16026 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.7 CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL110767 16026 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.7 CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
10024190 32745 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL135431 32745 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10052488 65825 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.2 CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169446 65825 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.2 CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10069417 171687 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL422282 171687 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
18373405 38471 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL140539 38471 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
9985159 65900 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 555 14 1 8 6.4 CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169835 65900 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 555 14 1 8 6.4 CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44385218 66445 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/S0960-894X(97)00134-0
CHEMBL172201 66445 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/S0960-894X(97)00134-0
44385131 136277 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL367291 136277 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
6444688 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL49302 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00046a017
18963028 21394 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205053 21394 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47716 21394 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
10343923 34556 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 34556 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
135401173 111556 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O 10.1021/jm00041a021
CHEMBL310870 111556 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O 10.1021/jm00041a021
6444688 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00070a015
CHEMBL49302 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00070a015
10053662 66434 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 565 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
CHEMBL172168 66434 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 565 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
44337707 116519 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL322985 116519 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
9980059 35132 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1 10.1021/jm00101a008
CHEMBL137480 35132 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1 10.1021/jm00101a008
44385159 68125 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1 10.1016/S0960-894X(97)00134-0
CHEMBL176747 68125 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1 10.1016/S0960-894X(97)00134-0
6444688 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49302 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
10091738 34576 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 34576 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
6444688 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49302 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
6444688 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00172a020
CHEMBL49302 194099 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00172a020
6435820 171795 6 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
CHEMBL422598 171795 6 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
204058 170238 8 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL419948 170238 8 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
9805394 64357 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL166699 64357 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10385899 34180 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL136805 34180 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
10474602 32751 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 32751 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10069416 35158 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137497 35158 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10341135 36161 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 36161 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44381856 175335 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 1 7 6.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O 10.1021/jm00006a002
CHEMBL435665 175335 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 1 7 6.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O 10.1021/jm00006a002
9930128 67192 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.1 COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL175073 67192 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.1 COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
11726048 34371 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136953 34371 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10071290 34873 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 34873 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10318241 35121 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137472 35121 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10250881 31842 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 408 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134698 31842 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 408 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10390056 123327 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 472 10 2 4 5.9 O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL336303 123327 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 472 10 2 4 5.9 O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10451768 34669 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137168 34669 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
15666613 16015 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1 10.1021/jm00095a011
CHEMBL110708 16015 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1 10.1021/jm00095a011
44385199 66417 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 375 7 2 3 4.6 COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL172091 66417 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 375 7 2 3 4.6 COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
20704716 191504 0 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
CHEMBL485054 191504 0 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
11549986 162986 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1542 48 11 26 1.8 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1 10.1021/jm050383h
CHEMBL406432 162986 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1542 48 11 26 1.8 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1 10.1021/jm050383h
44386172 172569 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 397 6 2 5 4.2 COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL424779 172569 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 397 6 2 5 4.2 COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
11726048 34371 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136953 34371 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
44359651 125961 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL343124 125961 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
6441619 213561 18 None - 1 Human 4.8 pIC50 = 4.8 Binding
Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 213561 18 None - 1 Human 4.8 pIC50 = 4.8 Binding
Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
15718079 108214 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL297501 108214 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
10430674 126116 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 126116 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
10315808 33722 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 9 1 3 5.3 O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL136433 33722 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 9 1 3 5.3 O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10248148 122773 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335525 122773 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
15839736 21412 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL1205143 21412 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL58534 21412 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
44385258 67142 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 7 2 3 5.1 CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL174638 67142 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 7 2 3 5.1 CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
6444688 194099 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
CHEMBL49302 194099 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
10022413 34431 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 34431 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10343923 34556 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 34556 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10341242 34926 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 34926 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
6444688 194099 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 194099 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
9805394 64357 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL166699 64357 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
18963032 107869 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL294987 107869 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
114999 10311 21 None - 1 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
6156 10311 21 None - 1 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
CHEMBL14823 10311 21 None - 1 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
10477988 34916 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 34916 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357546 123531 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 123531 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
178581 147032 2 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C
ChEMBL 413 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1 10.1021/jm050383h
CHEMBL380555 147032 2 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C
ChEMBL 413 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1 10.1021/jm050383h
15666615 15949 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 372 11 1 2 6.4 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1 10.1021/jm00095a011
CHEMBL110243 15949 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 372 11 1 2 6.4 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1 10.1021/jm00095a011
10386030 126049 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 395 9 1 3 6.1 O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL343710 126049 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 395 9 1 3 6.1 O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1 10.1021/jm00101a008
44379592 63932 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 387 10 3 4 4.7 [N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1 10.1016/s0960-894x(00)00103-7
CHEMBL164721 63932 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 387 10 3 4 4.7 [N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1 10.1016/s0960-894x(00)00103-7
44379573 64874 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL167465 64874 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
10021622 35373 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 10 1 3 5.7 O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137676 35373 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 10 1 3 5.7 O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10430946 122270 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335142 122270 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O 10.1021/jm00101a007
15718082 193952 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL49209 193952 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O 10.1021/jm00064a006
195214 190618 19 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 454 16 2 4 6.2 CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL48068 190618 19 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 454 16 2 4 6.2 CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1021/jm00064a006
443292 11797 17 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 299 3 2 5 3.6 CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1 10.1021/jm00045a011
CHEMBL105139 11797 17 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 299 3 2 5 3.6 CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1 10.1021/jm00045a011
9934500 172380 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL424290 172380 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
10319829 32890 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 32890 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10387303 34373 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136955 34373 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
15839732 52461 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15299 52461 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
44404447 175537 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 2973 97 22 50 0.7 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL437275 175537 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 2973 97 22 50 0.7 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
10007005 127571 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.1 C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC 10.1021/jm00006a002
CHEMBL355503 127571 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.1 C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC 10.1021/jm00006a002
10474602 32751 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 32751 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9999718 31838 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134697 31838 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10046386 35348 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137654 35348 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O 10.1021/jm00101a007
10482767 175391 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 553 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
CHEMBL436047 175391 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 553 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
44384958 66653 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL172974 66653 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1 10.1016/S0960-894X(97)00134-0
135507252 212376 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 438 13 3 5 5.0 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
CHEMBL81503 212376 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 438 13 3 5 5.0 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
10483151 66345 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 571 14 1 8 7.1 CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL171780 66345 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 571 14 1 8 7.1 CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
18373300 126103 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
CHEMBL344176 126103 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
10406292 35169 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 35169 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
204055 215090 8 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 215090 8 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
6444688 194099 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 194099 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
6444688 194099 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
CHEMBL49302 194099 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
10023244 32934 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 32934 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
9999755 33345 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136094 33345 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
10091738 34576 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 34576 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10475503 34781 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 34781 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10406292 35169 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 35169 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9976757 35274 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 35274 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10362331 35498 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
CHEMBL137801 35498 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
10451768 34669 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137168 34669 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
10387480 34785 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137248 34785 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
10407251 125859 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL342688 125859 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
10024190 32745 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL135431 32745 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10362331 35498 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
CHEMBL137801 35498 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
44403823 168724 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL415548 168724 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
129065 114322 29 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 377 4 3 6 3.2 Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C 10.1021/jm00045a011
CHEMBL318809 114322 29 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 377 4 3 6 3.2 Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C 10.1021/jm00045a011
18963030 21395 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205054 21395 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47725 21395 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
15666588 103651 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
CHEMBL265563 103651 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
15666614 118080 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1 10.1021/jm00095a011
CHEMBL326650 118080 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1 10.1021/jm00095a011
9841175 21421 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 21421 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 21421 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
114999 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
6156 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
CHEMBL14823 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
44213761 127511 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 346 9 3 3 3.7 O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL354872 127511 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 346 9 3 3 3.7 O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
114999 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
6156 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
CHEMBL14823 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
10387303 34373 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136955 34373 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10427789 34713 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 34713 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10455429 35735 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 431 8 1 3 6.6 CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL138018 35735 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 431 8 1 3 6.6 CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10430678 175188 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1 10.1021/jm00101a007
CHEMBL434810 175188 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1 10.1021/jm00101a007
10314767 35315 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 333 7 1 3 4.7 O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137633 35315 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 333 7 1 3 4.7 O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10407131 168735 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
CHEMBL415687 168735 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
114999 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
6156 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
CHEMBL14823 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
15666630 14861 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 362 11 1 3 6.0 Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1 10.1021/jm00095a011
CHEMBL109129 14861 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 362 11 1 3 6.0 Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1 10.1021/jm00095a011
15666582 117463 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 360 12 1 3 5.5 COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1 10.1021/jm00095a011
CHEMBL326000 117463 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 360 12 1 3 5.5 COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1 10.1021/jm00095a011
44317392 212026 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 511 13 2 7 4.8 CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
CHEMBL78859 212026 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 511 13 2 7 4.8 CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
2487 9147 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
5280492 9147 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
CHEMBL65061 9147 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
DB12961 9147 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
114999 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
6156 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
CHEMBL14823 10311 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
10053028 65780 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 540 13 2 8 5.9 CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169120 65780 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 540 13 2 8 5.9 CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
6441619 213561 18 None - 1 Human 5.5 pIC50 = 5.5 Binding
Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 213561 18 None - 1 Human 5.5 pIC50 = 5.5 Binding
Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
18963062 21554 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1206683 21554 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL295799 21554 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
15666601 12918 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.7 O=C(O)CCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL108094 12918 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.7 O=C(O)CCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
15839733 52410 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15295 52410 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
44296838 201619 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself
ChEMBL 334 14 2 2 5.4 CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O 10.1016/S0960-894X(01)80795-2
CHEMBL53967 201619 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself
ChEMBL 334 14 2 2 5.4 CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O 10.1016/S0960-894X(01)80795-2
15839729 213667 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
CHEMBL15559 213667 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
CHEMBL90788 213667 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
15839729 213667 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15559 213667 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL90788 213667 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
9955657 213434 15 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 455 13 2 5 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1 10.1021/jm960088k
CHEMBL89326 213434 15 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 455 13 2 5 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1 10.1021/jm960088k
9893718 213280 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL292768 213280 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL88337 213280 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
9893718 213280 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL292768 213280 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL88337 213280 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10046878 35206 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 35206 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
9976757 35274 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 35274 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10430674 126116 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 126116 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
9912012 168983 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL416277 168983 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
10364772 34933 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 34933 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
204055 215090 8 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 215090 8 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135543808 212363 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 480 11 3 6 4.9 CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
CHEMBL81401 212363 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 480 11 3 6 4.9 CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
132379 118509 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm9506985
CHEMBL328712 118509 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm9506985
132379 118509 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 118509 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
10292143 123375 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL336665 123375 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL48667 123375 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10292143 123375 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL336665 123375 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL48667 123375 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
10090758 65774 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 373 9 2 3 3.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL169055 65774 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 373 9 2 3 3.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
10047140 34380 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 34380 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10001576 35154 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 35154 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
9999718 31838 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134697 31838 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
14946858 35934 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 35934 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10068808 34483 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 387 8 1 5 4.9 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137030 34483 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 387 8 1 5 4.9 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
18373405 38471 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL140539 38471 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
18373357 123571 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL337790 123571 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
44359651 125961 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL343124 125961 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
10021742 16228 6 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 16228 6 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
10248148 122773 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335525 122773 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
44270188 58160 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15817 58160 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
18963059 21396 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205055 21396 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47726 21396 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
204055 215090 8 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 215090 8 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
60490 214040 106 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
ChEMBL 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O 10.1021/jm950725r
CHEMBL93 214040 106 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
ChEMBL 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O 10.1021/jm950725r
114999 10311 21 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
6156 10311 21 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
CHEMBL14823 10311 21 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
9934323 107029 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL288758 107029 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
10170399 21594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL1207275 21594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL384950 21594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
10415107 21670 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
CHEMBL1207951 21670 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
CHEMBL462734 21670 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
10022413 34431 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 34431 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10170399 21594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL1207275 21594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL384950 21594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
15666610 14677 1 None - 0 Human 5.4 pIC50 = 5.4 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109016 14677 1 None - 0 Human 5.4 pIC50 = 5.4 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
44385160 68126 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL176748 68126 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1 10.1016/S0960-894X(97)00134-0
19427041 21415 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL1205171 21415 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL60881 21415 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10023244 32934 1 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 32934 1 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10047140 34380 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 34380 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10475503 34781 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 34781 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10318241 35121 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137472 35121 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10001576 35154 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 35154 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10436331 127322 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 2 7 5.0 CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL354553 127322 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 2 7 5.0 CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
15237280 64875 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 511 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167474 64875 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 511 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
3368 7956 26 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 7956 26 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 7956 26 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
135543742 212167 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1 10.1021/jm00041a021
CHEMBL79991 212167 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1 10.1021/jm00041a021
44348541 23592 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 323 7 1 2 3.0 CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1 10.1021/jm9506985
CHEMBL124717 23592 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 323 7 1 2 3.0 CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1 10.1021/jm9506985
44357534 33513 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 33513 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10341135 36161 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 36161 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10427789 34713 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 34713 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10363959 35286 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137594 35286 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10387480 34785 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137248 34785 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
11725988 34759 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 359 8 1 5 4.2 c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL137234 34759 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 359 8 1 5 4.2 c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1 10.1021/jm00101a007
10340408 125343 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1 10.1021/jm00101a008
CHEMBL341565 125343 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1 10.1021/jm00101a008
18373300 126103 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
CHEMBL344176 126103 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
15666581 12420 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.2 O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1 10.1021/jm00095a011
CHEMBL107781 12420 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.2 O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1 10.1021/jm00095a011
10391552 127100 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL352863 127100 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135507183 212421 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
CHEMBL81817 212421 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
44403823 168724 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL415548 168724 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
135507225 110998 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 424 12 3 5 4.6 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
CHEMBL309883 110998 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 424 12 3 5 4.6 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
10247237 35260 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 8 1 3 5.2 CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137570 35260 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 8 1 3 5.2 CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10032156 65791 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 647 16 1 8 8.6 CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169246 65791 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 647 16 1 8 8.6 CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
9906324 21391 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205046 21391 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL46820 21391 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
9906324 21391 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL1205046 21391 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL46820 21391 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
9865985 35446 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 35446 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
9978895 125754 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL342416 125754 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
6450158 193953 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49210 193953 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
6450158 193953 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 193953 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
135516891 164295 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 384 10 3 6 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL407983 164295 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 384 10 3 6 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
18963040 21640 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL1207571 21640 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL416259 21640 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10364772 34933 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 34933 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10092630 34594 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 34594 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
132425 13637 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL108415 13637 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
11799000 23940 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
CHEMBL125611 23940 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
10319829 32890 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 32890 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10363959 35286 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137594 35286 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
15666631 14859 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.0 O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109128 14859 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.0 O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1 10.1021/jm00095a011
44379572 127078 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 540 10 2 4 5.3 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL352717 127078 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 540 10 2 4 5.3 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1 10.1016/s0960-894x(00)00103-7
9849151 65870 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169683 65870 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
15839731 56225 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15648 56225 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
10339300 137003 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL367943 137003 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
10341242 34926 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 34926 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
10477988 34916 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 34916 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357546 123531 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 123531 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
9911868 24806 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined
ChEMBL 455 11 1 7 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1 10.1016/S0960-894X(97)00025-5
CHEMBL126463 24806 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined
ChEMBL 455 11 1 7 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1 10.1016/S0960-894X(97)00025-5
15666586 115344 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
CHEMBL320258 115344 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
44379573 64874 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL167465 64874 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
10019853 35309 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 335 8 1 3 4.9 O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137625 35309 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 335 8 1 3 4.9 O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10337448 34880 1 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 342 8 0 3 5.9 N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137307 34880 1 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 342 8 0 3 5.9 N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9841175 21421 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 21421 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 21421 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
44315539 21569 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1206776 21569 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL305933 21569 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
135430350 174833 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
CHEMBL432363 174833 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
10021742 16228 6 None - 1 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 16228 6 None - 1 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
10349070 137666 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 630 16 2 7 7.9 CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL368540 137666 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 630 16 2 7 7.9 CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10481412 66559 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL172628 66559 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44384957 173017 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 389 7 2 4 4.3 COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL426773 173017 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 389 7 2 4 4.3 COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
44403368 168106 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 2750 92 21 47 -1.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL412510 168106 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 2750 92 21 47 -1.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
3368 7956 26 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
9867257 7956 26 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
CHEMBL51770 7956 26 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
9958915 64897 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167669 64897 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
10741106 124580 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 426 9 0 4 4.7 CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21 10.1021/jm950699x
CHEMBL340180 124580 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 426 9 0 4 4.7 CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21 10.1021/jm950699x
15666623 174575 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL430520 174575 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
9841175 21421 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 21421 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 21421 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
11740566 126225 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 381 8 1 3 5.7 CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL345047 126225 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 381 8 1 3 5.7 CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
9934500 172380 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL424290 172380 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
44315583 21420 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205289 21420 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL76530 21420 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
9976891 34940 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1 10.1021/jm00101a007
CHEMBL137346 34940 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1 10.1021/jm00101a007
135543741 212375 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.7 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1 10.1021/jm00041a021
CHEMBL81489 212375 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.7 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1 10.1021/jm00041a021
44385920 68156 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O 10.1016/S0960-894X(97)00134-0
CHEMBL176974 68156 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O 10.1016/S0960-894X(97)00134-0
15718085 108122 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL296869 108122 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
135507273 212074 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
CHEMBL79233 212074 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
122023 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL15766 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL45460 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
4534 198681 94 None - 0 Human 7.1 pIC50 = 7.1 Binding
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
ChEMBL 302 5 4 4 3.6 CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 10.1021/jm00085a019
CHEMBL52 198681 94 None - 0 Human 7.1 pIC50 = 7.1 Binding
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
ChEMBL 302 5 4 4 3.6 CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 10.1021/jm00085a019
122023 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL15766 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL45460 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
122023 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL15766 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL45460 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
122023 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
CHEMBL15766 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
CHEMBL45460 57569 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
135500104 170552 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
CHEMBL420576 170552 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
10347709 65876 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 557 13 2 8 6.6 CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169722 65876 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 557 13 2 8 6.6 CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135457469 112417 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL312483 112417 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
10092630 34594 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 34594 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10737187 22291 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 359 8 0 2 4.5 CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 10.1021/jm9506985
CHEMBL121748 22291 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 359 8 0 2 4.5 CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 10.1021/jm9506985
18373357 123571 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL337790 123571 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
44386171 68148 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 377 5 2 2 5.4 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl 10.1016/S0960-894X(97)00134-0
CHEMBL176903 68148 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 377 5 2 2 5.4 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl 10.1016/S0960-894X(97)00134-0
10052575 65728 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 525 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL168944 65728 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 525 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44385966 67200 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 4.8 COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL175128 67200 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 4.8 COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
25114442 9835 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
5817 9835 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
CHEMBL3286797 9835 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
DB12024 9835 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
192617 107528 22 None - 1 Human 10.4 pKi = 10.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292782 107528 22 None - 1 Human 10.4 pKi = 10.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 107528 22 None - 1 Human 10.4 pKi = 10.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292782 107528 22 None - 1 Human 10.4 pKi = 10.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
19600933 209579 0 None - 1 Human 10.1 pKi = 10.1 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL62265 209579 0 None - 1 Human 10.1 pKi = 10.1 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
10745838 124840 0 None - 1 Human 10.0 pKi = 10.0 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL340460 124840 0 None - 1 Human 10.0 pKi = 10.0 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
2487 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
5280492 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
CHEMBL65061 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
DB12961 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
2487 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
5280492 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
CHEMBL65061 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
DB12961 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
2487 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
5280492 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
CHEMBL65061 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
DB12961 9147 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
132379 118509 19 None - 1 Human 9.9 pKi = 9.9 Binding
Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 118509 19 None - 1 Human 9.9 pKi = 9.9 Binding
Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
10120811 103227 0 None - 1 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL262231 103227 0 None - 1 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00046a017
CHEMBL292782 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00046a017
192617 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL292782 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
192617 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292782 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292782 107528 22 None - 1 Human 9.3 pKi = 9.3 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
10745838 124840 0 None - 1 Human 9.2 pKi = 9.2 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL340460 124840 0 None - 1 Human 9.2 pKi = 9.2 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
6441619 213561 18 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 213561 18 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
6441619 213561 18 None - 1 Human 9.1 pKi = 9.1 Binding
Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960088k
CHEMBL90214 213561 18 None - 1 Human 9.1 pKi = 9.1 Binding
Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960088k
9850643 214465 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 554 19 2 6 6.4 CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm00046a017
CHEMBL95453 214465 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 554 19 2 6 6.4 CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm00046a017
15658147 16356 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
CHEMBL112487 16356 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
CHEMBL112520 16356 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
9850974 213046 0 None - 1 Human 9.0 pKi = 9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 568 20 2 6 6.8 CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm960088k
CHEMBL86900 213046 0 None - 1 Human 9.0 pKi = 9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 568 20 2 6 6.8 CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm960088k
15658147 16356 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL112487 16356 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL112520 16356 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
10120811 103227 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL262231 103227 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
19600933 209579 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL62265 209579 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
9893718 213280 0 None - 1 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL292768 213280 0 None - 1 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL88337 213280 0 None - 1 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10529082 25590 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 489 10 1 5 6.4 COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL127913 25590 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 489 10 1 5 6.4 COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
9893718 213280 0 None - 1 Human 8.9 pKi = 8.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292768 213280 0 None - 1 Human 8.9 pKi = 8.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL88337 213280 0 None - 1 Human 8.9 pKi = 8.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
204058 170238 8 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm00046a017
CHEMBL419948 170238 8 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm00046a017
10529241 25284 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 493 9 1 4 7.1 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1 10.1021/jm960248s
CHEMBL127376 25284 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 493 9 1 4 7.1 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1 10.1021/jm960248s
10648186 24939 1 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 473 10 1 4 6.8 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1 10.1021/jm960248s
CHEMBL126976 24939 1 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 473 10 1 4 6.8 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1 10.1021/jm960248s
11798848 23304 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 477 9 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1 10.1021/jm960248s
CHEMBL123722 23304 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 477 9 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1 10.1021/jm960248s
9958441 123612 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 517 12 1 5 7.2 COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL337995 123612 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 517 12 1 5 7.2 COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
2487 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
5280492 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
CHEMBL65061 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
DB12961 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
2487 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
5280492 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
CHEMBL65061 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
DB12961 9147 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
18963032 107869 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL294987 107869 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
44340787 21353 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1204561 21353 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL326397 21353 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15839729 213667 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15559 213667 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL90788 213667 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
10046307 21568 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1206771 21568 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL305560 21568 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15658110 21346 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113528 21346 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1204495 21346 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658157 21347 0 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL114454 21347 0 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL1204496 21347 0 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
10037501 191503 4 None - 1 Human 4.0 pKi = 4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 245 1 1 5 0.5 CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N 10.1021/np50100a005
CHEMBL485053 191503 4 None - 1 Human 4.0 pKi = 4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 245 1 1 5 0.5 CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N 10.1021/np50100a005
18963059 21396 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205055 21396 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47726 21396 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
14977959 16259 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 506 15 2 5 6.0 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112018 16259 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 506 15 2 5 6.0 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
18963030 21395 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205054 21395 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47725 21395 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
21765776 170470 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL420488 170470 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
14977907 16322 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 483 18 2 5 6.8 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL112310 16322 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 483 18 2 5 6.8 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
14977965 118126 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 524 15 2 5 6.2 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL326909 118126 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 524 15 2 5 6.2 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
11798329 25277 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 463 8 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1 10.1021/jm960248s
CHEMBL127341 25277 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 463 8 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1 10.1021/jm960248s
11800543 26163 0 None - 1 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129272 26163 0 None - 1 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
122023 57569 60 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL15766 57569 60 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL45460 57569 60 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
23257866 16238 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL111908 16238 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
10021742 16228 6 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 16228 6 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
14977963 16415 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 574 15 2 5 7.1 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112737 16415 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 574 15 2 5 7.1 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
9829619 107529 0 None - 1 Human 7.9 pKi = 7.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292783 107529 0 None - 1 Human 7.9 pKi = 7.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
9977200 36149 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL138370 36149 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL60617 36149 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10292143 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL336665 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL48667 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10292143 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL336665 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL48667 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10292143 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL336665 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL48667 123375 1 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
18963040 21640 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1207571 21640 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL416259 21640 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15658122 16536 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 453 12 2 4 6.0 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113514 16536 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 453 12 2 4 6.0 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658098 176095 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 383 13 2 3 6.3 CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL441647 176095 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 383 13 2 3 6.3 CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1 10.1021/jm00074a012
14977952 115814 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 676 19 2 7 7.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL321261 115814 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 676 19 2 7 7.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977946 117357 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 531 18 2 6 6.2 CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL325423 117357 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 531 18 2 6 6.2 CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
44270188 58160 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15817 58160 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
9984593 16409 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 533 17 2 5 7.3 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1 10.1021/jm00046a017
CHEMBL112707 16409 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 533 17 2 5 7.3 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1 10.1021/jm00046a017
15839733 52410 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15295 52410 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
14977913 16033 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 5.7 COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL110797 16033 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 5.7 COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977924 117724 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL326192 117724 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10812265 64921 0 None - 1 Human 7.8 pKi = 7.8 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167923 64921 0 None - 1 Human 7.8 pKi = 7.8 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10475982 168603 0 None -15 2 Human 4.8 pKi = 4.8 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL414462 168603 0 None -15 2 Human 4.8 pKi = 4.8 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
21765774 16473 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL113146 16473 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
14977898 16862 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 519 15 3 6 5.3 COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL115437 16862 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 519 15 3 6 5.3 COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977924 117724 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL326192 117724 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
10405361 21417 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205188 21417 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL62051 21417 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15839732 52461 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15299 52461 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
44382468 65862 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL169639 65862 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44341107 16232 0 None - 1 Human 4.7 pKi = 4.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 277 4 1 3 3.2 Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1 10.1021/jm00074a014
CHEMBL111872 16232 0 None - 1 Human 4.7 pKi = 4.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 277 4 1 3 3.2 Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1 10.1021/jm00074a014
23257889 16274 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 535 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112088 16274 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 535 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
132379 118509 19 None - 1 Human 8.7 pKi = 8.7 Binding
Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 118509 19 None - 1 Human 8.7 pKi = 8.7 Binding
Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
132379 118509 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00070a015
CHEMBL328712 118509 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00070a015
132379 118509 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00046a017
CHEMBL328712 118509 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00046a017
10694814 23342 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 449 12 1 5 5.9 COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL123862 23342 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 449 12 1 5 5.9 COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
2487 9147 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
5280492 9147 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
CHEMBL65061 9147 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
DB12961 9147 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
10182429 64913 0 None - 1 Human 7.7 pKi = 7.7 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 428 10 2 5 5.7 CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167850 64913 0 None - 1 Human 7.7 pKi = 7.7 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 428 10 2 5 5.7 CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
11800543 26163 0 None - 1 Human 7.7 pKi = 7.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129272 26163 0 None - 1 Human 7.7 pKi = 7.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
18963040 21640 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1207571 21640 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL416259 21640 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
18963040 21640 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL1207571 21640 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL416259 21640 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
114999 10311 21 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
6156 10311 21 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
CHEMBL14823 10311 21 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
44341141 16206 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 667 18 1 7 6.9 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL111723 16206 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 667 18 1 7 6.9 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
23257891 16477 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 551 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL113167 16477 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 551 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10325873 16291 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL112169 16291 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
44382378 65643 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL168854 65643 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44341318 16321 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 349 8 2 4 3.5 Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1 10.1021/jm00074a014
CHEMBL112309 16321 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 349 8 2 4 3.5 Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1 10.1021/jm00074a014
23257882 117192 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 564 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL324478 117192 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 564 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10745069 36869 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 542 13 2 4 7.9 CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC 10.1021/jm00022a006
CHEMBL138954 36869 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 542 13 2 4 7.9 CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC 10.1021/jm00022a006
177941 8369 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
2948 8369 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
CHEMBL329123 8369 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
DB12850 8369 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
9906324 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL1205046 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL46820 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
9906324 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205046 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL46820 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
9906324 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL1205046 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL46820 21391 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
14977920 16251 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL111969 16251 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O 10.1021/jm00074a013
44341073 16900 0 None - 1 Human 4.6 pKi = 4.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 307 5 1 4 3.2 COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1 10.1021/jm00074a014
CHEMBL115679 16900 0 None - 1 Human 4.6 pKi = 4.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 307 5 1 4 3.2 COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1 10.1021/jm00074a014
10324028 16800 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 509 15 2 6 5.6 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL115040 16800 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 509 15 2 6 5.6 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
44302963 21413 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205145 21413 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL58794 21413 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9826485 113141 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00070a015
CHEMBL313923 113141 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00070a015
114999 10311 21 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
6156 10311 21 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
CHEMBL14823 10311 21 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
15658099 170112 0 None - 1 Human 5.6 pKi = 5.6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 385 14 2 3 6.2 CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL419036 170112 0 None - 1 Human 5.6 pKi = 5.6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 385 14 2 3 6.2 CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1 10.1021/jm00074a012
9826485 113141 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL313923 113141 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
14977927 17028 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 652 18 2 7 7.7 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL116101 17028 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 652 18 2 7 7.7 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
15658155 21344 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL113288 21344 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL1204493 21344 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
10179915 64881 0 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167520 64881 0 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
44302965 205733 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 551 14 1 7 6.5 CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2 10.1021/jm990504b
CHEMBL58495 205733 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 551 14 1 7 6.5 CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2 10.1021/jm990504b
192624 175270 2 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 394 10 2 5 5.1 CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL435273 175270 2 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 394 10 2 5 5.1 CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
9912012 168983 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL416277 168983 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
9906324 21391 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL1205046 21391 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL46820 21391 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
6157 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
6438358 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
CHEMBL422420 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
44302966 103274 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 484 13 2 6 4.9 CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO 10.1021/jm990504b
CHEMBL262530 103274 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 484 13 2 6 4.9 CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO 10.1021/jm990504b
10554820 37052 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 556 13 2 5 7.5 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139115 37052 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 556 13 2 5 7.5 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
44302963 21413 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205145 21413 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL58794 21413 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9845585 64930 0 None - 1 Human 7.5 pKi = 7.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL168011 64930 0 None - 1 Human 7.5 pKi = 7.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
44382275 66511 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL172457 66511 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44382384 66316 0 None - 1 Human 5.5 pKi = 5.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL171666 66316 0 None - 1 Human 5.5 pKi = 5.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
14977911 16371 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 499 18 2 5 6.0 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL112544 16371 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 499 18 2 5 6.0 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O 10.1021/jm00074a013
14977931 16428 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 520 16 2 6 7.0 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112808 16428 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 520 16 2 6 7.0 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10021742 16228 6 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/jm00074a014
CHEMBL111825 16228 6 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/jm00074a014
14977957 16292 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 490 15 2 5 7.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112176 16292 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 490 15 2 5 7.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
14977933 16662 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 552 16 2 7 5.7 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL114290 16662 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 552 16 2 7 5.7 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10507666 37691 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 592 13 2 6 7.1 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139799 37691 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 592 13 2 6 7.1 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
9807782 26200 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129463 26200 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
6444688 194099 35 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00074a014
CHEMBL49302 194099 35 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00074a014
23257894 16427 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 521 16 1 5 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112804 16427 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 521 16 1 5 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10342316 64925 0 None - 1 Human 7.4 pKi = 7.4 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167972 64925 0 None - 1 Human 7.4 pKi = 7.4 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10363485 65877 0 None -29 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL169743 65877 0 None -29 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
9800998 106144 2 None -32 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL282524 106144 2 None -32 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
9829619 107529 0 None - 1 Human 7.4 pKi = 7.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292783 107529 0 None - 1 Human 7.4 pKi = 7.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
44382463 65998 0 None -9 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL170226 65998 0 None -9 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
6157 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
6438358 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
CHEMBL422420 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
6157 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
6438358 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
CHEMBL422420 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
9807782 26200 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129463 26200 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
9893718 213280 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292768 213280 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL88337 213280 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
3083459 127166 1 None - 1 Human 8.3 pKi = 8.3 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL353378 127166 1 None - 1 Human 8.3 pKi = 8.3 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
6439436 16326 2 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112338 16326 2 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
6439436 16326 2 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL112338 16326 2 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
10292143 123375 1 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL336665 123375 1 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL48667 123375 1 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10050724 16896 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 477 13 2 5 5.7 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1 10.1021/jm00046a017
CHEMBL115658 16896 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 477 13 2 5 5.7 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1 10.1021/jm00046a017
15839731 56225 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15648 56225 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
9872540 37214 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 560 13 2 5 8.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139254 37214 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 560 13 2 5 8.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O 10.1021/jm00022a006
14977894 117384 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 471 17 3 5 5.6 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O 10.1021/jm00074a013
CHEMBL325615 117384 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 471 17 3 5 5.6 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O 10.1021/jm00074a013
14977961 16282 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 558 15 2 5 8.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112135 16282 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 558 15 2 5 8.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
6450158 193953 20 None - 1 Human 7.4 pKi = 7.4 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49210 193953 20 None - 1 Human 7.4 pKi = 7.4 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
14977916 118102 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL326779 118102 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O 10.1021/jm00074a013
10405361 21417 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205188 21417 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL62051 21417 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9977200 36149 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL138370 36149 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL60617 36149 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
21765772 117387 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL325637 117387 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
10793277 37858 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 576 13 2 5 7.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139969 37858 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 576 13 2 5 7.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O 10.1021/jm00022a006
6450158 193953 20 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 193953 20 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
15658112 69948 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1788228 69948 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1789864 69948 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658139 21348 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL115826 21348 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL1204497 21348 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
18963028 21394 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205053 21394 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47716 21394 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
44382276 127094 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL352814 127094 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10371282 117390 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 595 18 2 7 6.0 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL325643 117390 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 595 18 2 7 6.0 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
20704716 191504 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
CHEMBL485054 191504 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
10159791 64782 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167261 64782 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10046307 21568 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1206771 21568 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL305560 21568 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
19427041 21415 0 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL1205171 21415 0 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL60881 21415 0 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
15658149 21343 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL111811 21343 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL1204492 21343 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
15658119 16583 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 437 12 2 4 7.0 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113792 16583 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 437 12 2 4 7.0 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
14977948 16364 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 660 19 2 7 8.2 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112510 16364 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 660 19 2 7 8.2 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
9845587 172408 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL424361 172408 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10670634 64450 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 437 11 2 6 5.1 CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL166862 64450 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 437 11 2 6 5.1 CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
122023 57569 60 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL15766 57569 60 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL45460 57569 60 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
10600128 64884 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 462 10 2 5 6.1 CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167580 64884 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 462 10 2 5 6.1 CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
6435820 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
CHEMBL422598 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
6435820 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL422598 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
6435820 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960088k
CHEMBL422598 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960088k
6435820 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL422598 171795 6 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
6444688 194099 35 None - 1 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49302 194099 35 None - 1 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
6852392 24042 4 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 361 14 3 4 4.0 CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1 10.1021/jm00074a012
CHEMBL1256923 24042 4 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 361 14 3 4 4.0 CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1 10.1021/jm00074a012
14977943 121740 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 592 17 3 7 6.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL334267 121740 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 592 17 3 7 6.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977939 103492 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 505 16 1 5 7.4 COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL264197 103492 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 505 16 1 5 7.4 COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
15839736 21412 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL1205143 21412 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL58534 21412 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
122023 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL15766 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL45460 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
122023 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL15766 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL45460 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
122023 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL15766 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL45460 57569 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
14977955 16348 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 548 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112455 16348 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 548 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10257351 117419 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 19 2 6 7.2 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL325773 117419 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 19 2 6 7.2 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
9959228 16847 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL115362 16847 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
9959228 16847 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL115362 16847 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
18963062 21554 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1206683 21554 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL295799 21554 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
10346127 16450 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 507 14 2 6 5.7 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL112972 16450 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 507 14 2 6 5.7 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
15658097 16507 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 401 14 3 4 5.2 CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL113351 16507 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 401 14 3 4 5.2 CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1 10.1021/jm00074a012
44341265 17177 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 263 4 2 2 3.2 Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1 10.1021/jm00074a014
CHEMBL116278 17177 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 263 4 2 2 3.2 Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1 10.1021/jm00074a014
15658135 21345 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL113401 21345 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL1204494 21345 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
None 222976 0 3H-LTB4 3 2 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 336 14 3 3 4.2 CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 222979 0 3H-LTB4 -6 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC(=O)C=CC=CCC=CCCCC(=O)O None
None 222981 0 3H-LTB4 1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC=CCC=CC=CC(=O)CCCC(=O)O None
None 222982 0 3H-LTB4 -1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 222985 0 3H-LTB4 1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 302 12 1 1 5.7 CCCCCC=CCC=CCC=CCC#CCCCC(=O)O None
None 222978 0 3H-LTB4 -57 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O None
None 222982 0 3H-LTB4 -1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 222983 0 3H-LTB4 -10 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 15 2 2 5.2 C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO None
None 222984 0 3H-LTB4 -10 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CC=CC(CC=CCCCC(=O)O)O None
None 222987 0 3H-LTB4 -4365 4 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 473 7 2 3 7.9 CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O None
None 222992 0 3H-LTB4 1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 332 13 0 3 5.3 CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)OC None
132191096 222986 0 3H-LTB4 -1 2 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 352 14 4 4 3.1 CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O None
None 222988 0 3H-LTB4 4 2 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 625 25 7 8 2.8 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N None
None 222990 0 3H-LTB4 2 2 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 439 18 4 5 4.3 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N None
None 222980 0 3H-LTB4 218 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 361 14 3 4 4.0 CCCCCC=CCC(C=CC1=NC(=CC=C1)CC(CCCCO)O)O None
None 222977 0 3H-LTB4 2 2 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 334 13 3 3 3.9 CCC=CCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 222989 0 3H-LTB4 2 2 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 496 20 5 6 3.4 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N None
None 222991 0 3H-LTB4 1 2 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 568 23 6 7 3.7 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)NC(=O)CCC(C(=O)O)N None
2855 10904 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3322 10904 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717 10904 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
CHEMBL603 10904 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
DB00549 10904 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3325 10676 0 None - 1 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 14 3 4 4.0 CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O 10513580
6449854 10676 0 None - 1 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 14 3 4 4.0 CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O 10513580
3351 9181 0 None - 1 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1659282
35025716 9181 0 None - 1 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1659282
3405 6800 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
5283156 6800 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
CHEMBL1435825 6800 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
177941 8369 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
2948 8369 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
CHEMBL329123 8369 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
DB12850 8369 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
114999 10311 21 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
6156 10311 21 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
CHEMBL14823 10311 21 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
3399 6830 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
5280745 6830 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
CHEMBL1593789 6830 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
6155 7959 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
9823886 7959 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
CHEMBL301829 7959 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
DB13053 7959 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
6157 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6438358 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
CHEMBL422420 9708 20 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6154 7421 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
6154 7421 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
9956189 7421 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
9956189 7421 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
2487 9147 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
5280492 9147 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
CHEMBL65061 9147 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
DB12961 9147 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
2855 10904 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3322 10904 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717 10904 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
CHEMBL603 10904 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
DB00549 10904 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None