Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 10069786 | 169204 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -147 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL439968 | 169204 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -147 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 2541 | 786 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -8128 | 10 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acsmedchemlett.1c00240 | ||
| 2541.0 | 786 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -8128 | 10 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acsmedchemlett.1c00240 | ||
| 587 | 786 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -8128 | 10 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acsmedchemlett.1c00240 | ||
| 6907 | 786 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -8128 | 10 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL1016 | 786 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -8128 | 10 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acsmedchemlett.1c00240 | ||
| DB00796 | 786 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -8128 | 10 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acsmedchemlett.1c00240 | ||
| DB13919 | 786 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -8128 | 10 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acsmedchemlett.1c00240 | ||
| 2806 | 3969 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -5623 | 4 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acsmedchemlett.1c00240 | ||
| 3937 | 3969 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -5623 | 4 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acsmedchemlett.1c00240 | ||
| 593 | 3969 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -5623 | 4 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acsmedchemlett.1c00240 | ||
| 60846 | 3969 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -5623 | 4 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acsmedchemlett.1c00240 | ||
| 60846.0 | 3969 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -5623 | 4 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL1069 | 3969 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -5623 | 4 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acsmedchemlett.1c00240 | ||
| DB00177 | 3969 | None | 65 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -5623 | 4 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acsmedchemlett.1c00240 | ||
| 44341650 | 169990 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | -7 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL444060 | 169990 | None | 0 | Human | Functional | pEC50 | = | 4.6 | 4.6 | -7 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 1481 | 2066 | None | 66 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -457 | 6 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 3749 | 2066 | None | 66 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -457 | 6 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 3749.0 | 2066 | None | 66 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -457 | 6 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 589 | 2066 | None | 66 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -457 | 6 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 6908 | 2066 | None | 66 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -457 | 6 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL1513 | 2066 | None | 66 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -457 | 6 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| DB01029 | 2066 | None | 66 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -457 | 6 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 164613537 | 185232 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -21 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4856425 | 185232 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -21 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 164616479 | 185422 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -16 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4859498 | 185422 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -16 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 44341785 | 10149 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -2 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL115771 | 10149 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -2 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 67903280 | 186308 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -4 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4872989 | 186308 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -4 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 164611301 | 185124 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | 1 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4854916 | 185124 | None | 0 | Human | Functional | pEC50 | = | 5.1 | 5.1 | 1 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| 67903275 | 186629 | None | 4 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -257 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4877651 | 186629 | None | 4 | Human | Functional | pEC50 | = | 5.1 | 5.1 | -257 | 2 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 44342039 | 10295 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -117 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL116170 | 10295 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -117 | 3 | Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay |
ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 25174150 | 9119 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -64 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 582 | 18 | 2 | 6 | 7.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099326 | 9119 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -64 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 582 | 18 | 2 | 6 | 7.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192022 | 3355 | None | 7 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -21 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| 6158 | 3355 | None | 7 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -21 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1098560 | 3355 | None | 7 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -21 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| 25192471 | 8535 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -15 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 642 | 18 | 2 | 6 | 8.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1094348 | 8535 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -15 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 642 | 18 | 2 | 6 | 8.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 23501721 | 9123 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -316 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 581 | 18 | 2 | 5 | 7.9 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099330 | 9123 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -316 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 581 | 18 | 2 | 5 | 7.9 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192021 | 9116 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -223 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 580 | 18 | 2 | 4 | 8.5 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099323 | 9116 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -223 | 2 | Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 580 | 18 | 2 | 4 | 8.5 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
Showing 1 to 50 of 89 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 162655235 | 180814 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 385 | 7 | 1 | 2 | 5.4 | O=C(O)c1ccccc1-c1ccc(CN(C(=O)CC2CC2)c2ccccc2)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4755611 | 180814 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 385 | 7 | 1 | 2 | 5.4 | O=C(O)c1ccccc1-c1ccc(CN(C(=O)CC2CC2)c2ccccc2)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162656403 | 180941 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 412 | 8 | 1 | 3 | 5.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C#N)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4757022 | 180941 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 412 | 8 | 1 | 3 | 5.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C#N)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162668994 | 182713 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 388 | 8 | 1 | 3 | 5.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccncc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4788291 | 182713 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 388 | 8 | 1 | 3 | 5.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccncc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162673156 | 183153 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 386 | 8 | 1 | 2 | 5.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(N)=O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4794074 | 183153 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 386 | 8 | 1 | 2 | 5.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(N)=O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162666244 | 182466 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 464 | 9 | 1 | 4 | 4.8 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)NS(C)(=O)=O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4784810 | 182466 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 464 | 9 | 1 | 4 | 4.8 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)NS(C)(=O)=O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162648208 | 180023 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 387 | 8 | 1 | 2 | 5.5 | CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4746093 | 180023 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 387 | 8 | 1 | 2 | 5.5 | CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162660119 | 181369 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 405 | 8 | 1 | 2 | 5.9 | CCCCC(=O)N(Cc1ccc(-c2cc(F)ccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4761937 | 181369 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 405 | 8 | 1 | 2 | 5.9 | CCCCC(=O)N(Cc1ccc(-c2cc(F)ccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162650943 | 180386 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 417 | 9 | 1 | 3 | 5.8 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(OC)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4750707 | 180386 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 417 | 9 | 1 | 3 | 5.8 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(OC)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 126508826 | 182832 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 411 | 8 | 1 | 4 | 5.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4789730 | 182832 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 411 | 8 | 1 | 4 | 5.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162649472 | 180183 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 345 | 5 | 1 | 2 | 4.6 | CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4748013 | 180183 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 345 | 5 | 1 | 2 | 4.6 | CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162644087 | 181876 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 447 | 7 | 1 | 4 | 5.4 | CC(C)CC(=O)N(Cc1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4777675 | 181876 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 447 | 7 | 1 | 4 | 5.4 | CC(C)CC(=O)N(Cc1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162654469 | 180688 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 401 | 8 | 1 | 2 | 6.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4754213 | 180688 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 401 | 8 | 1 | 2 | 6.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 59738470 | 180052 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 401 | 9 | 1 | 2 | 5.8 | CCCCC(=O)N(Cc1ccccc1)Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4746397 | 180052 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 401 | 9 | 1 | 2 | 5.8 | CCCCC(=O)N(Cc1ccccc1)Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162670341 | 183083 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 405 | 8 | 1 | 2 | 5.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4793225 | 183083 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 405 | 8 | 1 | 2 | 5.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 51529932 | 812 | None | 25 | Human | Binding | pEC50 | = | 7.5 | 7.5 | -4 | 2 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.0c00588 | ||
| 6161 | 812 | None | 25 | Human | Binding | pEC50 | = | 7.5 | 7.5 | -4 | 2 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4637519 | 812 | None | 25 | Human | Binding | pEC50 | = | 7.5 | 7.5 | -4 | 2 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.0c00588 | ||
| 162672880 | 183212 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 393 | 8 | 1 | 2 | 5.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)C1CCCCC1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4794649 | 183212 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 393 | 8 | 1 | 2 | 5.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)C1CCCCC1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162669252 | 182716 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 389 | 8 | 1 | 3 | 4.6 | COCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4788324 | 182716 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 389 | 8 | 1 | 3 | 4.6 | COCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162648232 | 179862 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 388 | 8 | 1 | 3 | 5.2 | CCCCC(=O)N(Cc1ccc(-c2cnccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4744319 | 179862 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 388 | 8 | 1 | 3 | 5.2 | CCCCC(=O)N(Cc1ccc(-c2cnccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162657757 | 181134 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 387 | 7 | 1 | 2 | 5.6 | CC(C)CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4759277 | 181134 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 387 | 7 | 1 | 2 | 5.6 | CC(C)CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162646830 | 179717 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 421 | 7 | 1 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CN(C(=O)Cc2ccccc2)c2ccccc2)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4742371 | 179717 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 421 | 7 | 1 | 2 | 5.8 | O=C(O)c1ccccc1-c1ccc(CN(C(=O)Cc2ccccc2)c2ccccc2)cc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162665828 | 182494 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 359 | 6 | 1 | 2 | 5.0 | CCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4785290 | 182494 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 359 | 6 | 1 | 2 | 5.0 | CCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162647867 | 179995 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 373 | 6 | 1 | 2 | 5.2 | CC(C)C(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4745803 | 179995 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 373 | 6 | 1 | 2 | 5.2 | CC(C)C(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162646206 | 179579 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 415 | 10 | 1 | 2 | 5.8 | CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)CCc1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4740860 | 179579 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 415 | 10 | 1 | 2 | 5.8 | CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)CCc1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162653821 | 180592 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 373 | 7 | 1 | 2 | 5.4 | CCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| CHEMBL4753057 | 180592 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 373 | 7 | 1 | 2 | 5.4 | CCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
| 162670478 | 183026 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay |
ChEMBL | 373 | 8 | 1 | 2 | 5.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2CO)cc1)c1ccccc1 | 10.1021/acs.jmedchem.0c00588 | ||
Showing 1 to 50 of 118 entries