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Ligand source activities (1 row/activity)

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3635	2694	37	None	1698	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant full length human GPR18 expressed in CHO cells assessed as forskolin-stimulated cAMP accumulation after 10 mins by enzyme immunoassayAgonist activity at recombinant full length human GPR18 expressed in CHO cells assessed as forskolin-stimulated cAMP accumulation after 10 mins by enzyme immunoassay	ChEMBL	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	10.1016/j.ejmech.2018.05.050
	5283389	2694	37	None	1698	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant full length human GPR18 expressed in CHO cells assessed as forskolin-stimulated cAMP accumulation after 10 mins by enzyme immunoassayAgonist activity at recombinant full length human GPR18 expressed in CHO cells assessed as forskolin-stimulated cAMP accumulation after 10 mins by enzyme immunoassay	ChEMBL	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	10.1016/j.ejmech.2018.05.050
	CHEMBL161343	2694	37	None	1698	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant full length human GPR18 expressed in CHO cells assessed as forskolin-stimulated cAMP accumulation after 10 mins by enzyme immunoassayAgonist activity at recombinant full length human GPR18 expressed in CHO cells assessed as forskolin-stimulated cAMP accumulation after 10 mins by enzyme immunoassay	ChEMBL	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	10.1016/j.ejmech.2018.05.050
	3635	2694	37	None	1698	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR18 expressed in HEK293 cells assessed as induction of p44/42 MAPK phosphorylation after 5 mins by Western blot analysisAgonist activity at recombinant human GPR18 expressed in HEK293 cells assessed as induction of p44/42 MAPK phosphorylation after 5 mins by Western blot analysis	ChEMBL	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	10.1016/j.ejmech.2018.05.050
	5283389	2694	37	None	1698	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR18 expressed in HEK293 cells assessed as induction of p44/42 MAPK phosphorylation after 5 mins by Western blot analysisAgonist activity at recombinant human GPR18 expressed in HEK293 cells assessed as induction of p44/42 MAPK phosphorylation after 5 mins by Western blot analysis	ChEMBL	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	10.1016/j.ejmech.2018.05.050
	CHEMBL161343	2694	37	None	1698	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR18 expressed in HEK293 cells assessed as induction of p44/42 MAPK phosphorylation after 5 mins by Western blot analysisAgonist activity at recombinant human GPR18 expressed in HEK293 cells assessed as induction of p44/42 MAPK phosphorylation after 5 mins by Western blot analysis	ChEMBL	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	10.1016/j.ejmech.2018.05.050
	145958405	161530	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	464	10	0	5	6.0	Cc1cccc(C)c1OCCCCCCOc1cccc(/C=C2\N=C3SCCCN3C2=O)c1	10.1016/j.ejmech.2018.05.050
	CHEMBL4160778	161530	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	464	10	0	5	6.0	Cc1cccc(C)c1OCCCCCCOc1cccc(/C=C2\N=C3SCCCN3C2=O)c1	10.1016/j.ejmech.2018.05.050
	145974549	162508	0	None	3	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	456	9	0	5	5.6	O=C1/C(=C/c2cccc(OCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4176317	162508	0	None	3	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	456	9	0	5	5.6	O=C1/C(=C/c2cccc(OCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	145954189	162110	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	498	12	0	5	6.8	O=C1/C(=C/c2cccc(OCCCCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4169939	162110	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	498	12	0	5	6.8	O=C1/C(=C/c2cccc(OCCCCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	145958034	161692	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	358	4	1	4	4.1	CSC1=NC(=O)/C(=C/c2cccc(OCc3ccc(Cl)cc3)c2)N1	10.1016/j.ejmech.2018.05.050
	CHEMBL4163505	161692	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	358	4	1	4	4.1	CSC1=NC(=O)/C(=C/c2cccc(OCc3ccc(Cl)cc3)c2)N1	10.1016/j.ejmech.2018.05.050
	145952824	162083	0	None	4	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	378	6	0	4	4.4	O=C1/C(=C/c2cccc(OCCCc3ccccc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4169536	162083	0	None	4	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	378	6	0	4	4.4	O=C1/C(=C/c2cccc(OCCCc3ccccc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	145956612	161443	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	484	11	0	5	6.4	O=C1/C(=C/c2cccc(OCCCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4159298	161443	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	484	11	0	5	6.4	O=C1/C(=C/c2cccc(OCCCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	145954816	162007	0	None	26	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	428	4	0	4	4.7	O=C1/C(=C/c2cccc(OCc3ccc(Br)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4168388	162007	0	None	26	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	428	4	0	4	4.7	O=C1/C(=C/c2cccc(OCc3ccc(Br)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	145958480	161626	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	512	6	1	4	6.4	O=C1NC(SCc2ccc(Br)cc2)=N/C1=C\c1cccc(OCc2ccc(Cl)cc2)c1	10.1016/j.ejmech.2018.05.050
	CHEMBL4162436	161626	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	512	6	1	4	6.4	O=C1NC(SCc2ccc(Br)cc2)=N/C1=C\c1cccc(OCc2ccc(Cl)cc2)c1	10.1016/j.ejmech.2018.05.050
	145951064	162411	0	None	12	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	450	10	0	5	5.7	Cc1ccc(OCCCCCCOc2cccc(/C=C3\N=C4SCCCN4C3=O)c2)cc1	10.1016/j.ejmech.2018.05.050
	CHEMBL4174825	162411	0	None	12	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	450	10	0	5	5.7	Cc1ccc(OCCCCCCOc2cccc(/C=C3\N=C4SCCCN4C3=O)c2)cc1	10.1016/j.ejmech.2018.05.050
	145950071	162217	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	442	8	0	5	5.3	O=C1/C(=C/c2cccc(OCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4171815	162217	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	442	8	0	5	5.3	O=C1/C(=C/c2cccc(OCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	145958551	161742	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	464	11	0	5	5.9	CCc1ccc(OCCCCCCOc2cccc(/C=C3\N=C4SCCCN4C3=O)c2)cc1	10.1016/j.ejmech.2018.05.050
	CHEMBL4164171	161742	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	464	11	0	5	5.9	CCc1ccc(OCCCCCCOc2cccc(/C=C3\N=C4SCCCN4C3=O)c2)cc1	10.1016/j.ejmech.2018.05.050
	145958428	161557	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	428	7	0	5	4.9	O=C1/C(=C/c2cccc(OCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4161205	161557	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	428	7	0	5	4.9	O=C1/C(=C/c2cccc(OCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	10871668	161472	2	None	-1	2	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	344	4	2	3	3.3	O=C1NC(=S)N/C1=C\c1cccc(OCc2ccc(Cl)cc2)c1	10.1016/j.ejmech.2018.05.050
	CHEMBL4159707	161472	2	None	-1	2	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	344	4	2	3	3.3	O=C1NC(=S)N/C1=C\c1cccc(OCc2ccc(Cl)cc2)c1	10.1016/j.ejmech.2018.05.050
	145951404	162299	0	None	2	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	364	4	0	4	4.3	Cc1ccc(COc2cccc(/C=C3\N=C4SCCCN4C3=O)c2)cc1	10.1016/j.ejmech.2018.05.050
	CHEMBL4172931	162299	0	None	2	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	364	4	0	4	4.3	Cc1ccc(COc2cccc(/C=C3\N=C4SCCCN4C3=O)c2)cc1	10.1016/j.ejmech.2018.05.050
	145971274	162559	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	448	7	1	4	5.7	O=C1NC(SCCc2ccccc2)=N/C1=C\c1cccc(OCc2ccc(Cl)cc2)c1	10.1016/j.ejmech.2018.05.050
	CHEMBL4177155	162559	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	448	7	1	4	5.7	O=C1NC(SCCc2ccccc2)=N/C1=C\c1cccc(OCc2ccc(Cl)cc2)c1	10.1016/j.ejmech.2018.05.050
	145960178	161587	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	414	6	0	5	4.5	O=C1/C(=C/c2cccc(OCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4161619	161587	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	414	6	0	5	4.5	O=C1/C(=C/c2cccc(OCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	145953879	162013	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	470	10	0	5	6.0	O=C1/C(=C/c2cccc(OCCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	CHEMBL4168457	162013	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assayAntagonist activity at recombinant human GPR18 expressed in CHO cells assessed as inhibition of delta9-THC-induced beta-arrestin recruitment preincubated for 60 mins followed by delta9-THC addition for 90 mins measured for 1 sec by luminescence assay	ChEMBL	470	10	0	5	6.0	O=C1/C(=C/c2cccc(OCCCCCCOc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1016/j.ejmech.2018.05.050
	4150	776	36	None	-7	4	Human	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	None
	5288	776	36	None	-7	4	Human	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	None
	644019	776	36	None	-7	4	Human	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	None
	CHEMBL190461	776	36	None	-7	4	Human	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	None
	DB09061	776	36	None	-7	4	Human	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	None
	16078	1335	19	None	-58	7	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	2424	1335	19	None	-58	7	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	4109	1335	19	None	-58	7	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	CHEMBL465	1335	19	None	-58	7	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	DB00470	1335	19	None	-58	7	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	2125	376	79	None	-4466	4	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	554	4	1	4	5.9	Ic1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	21595653
	3317	376	79	None	-4466	4	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	554	4	1	4	5.9	Ic1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	21595653
	CHEMBL285932	376	79	None	-4466	4	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	554	4	1	4	5.9	Ic1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	21595653
	4150	776	36	None	-7	4	Human	4.3	pEC50	=	4.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	21595653
	5288	776	36	None	-7	4	Human	4.3	pEC50	=	4.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	21595653
	644019	776	36	None	-7	4	Human	4.3	pEC50	=	4.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	21595653
	CHEMBL190461	776	36	None	-7	4	Human	4.3	pEC50	=	4.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	21595653
	DB09061	776	36	None	-7	4	Human	4.3	pEC50	=	4.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	21595653
	5311007	455	25	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	343	15	1	1	6.4	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC1CC1	21595653
	739	455	25	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	343	15	1	1	6.4	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC1CC1	21595653
	CHEMBL418353	455	25	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	343	15	1	1	6.4	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC1CC1	21595653
	2364	409	33	None	-208	4	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	16	2	2	5.2	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO	21595653
	5281969	409	33	None	-208	4	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	16	2	2	5.2	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO	21595653
	CHEMBL15848	409	33	None	-208	4	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	16	2	2	5.2	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO	21595653
	16078	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	21595653
	16078	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	22014123
	2424	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	21595653
	2424	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	22014123
	4109	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	21595653
	4109	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	22014123
	CHEMBL465	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	21595653
	CHEMBL465	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	22014123
	DB00470	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	21595653
	DB00470	1335	19	None	-58	7	Human	6.0	pEC50	=	6.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	22014123
	5526	222	26	None	-36	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)cc(c1[C@@H]1C=C(C)CC[C@H]1C(=C)C)O	21595653
	89949	222	26	None	-36	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)cc(c1[C@@H]1C=C(C)CC[C@H]1C(=C)C)O	21595653
	CHEMBL499876	222	26	None	-36	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	314	6	2	2	5.8	CCCCCc1cc(O)cc(c1[C@@H]1C=C(C)CC[C@H]1C(=C)C)O	21595653
	11081	3168	1	None	-	1	Human	6.3	pEC50	=	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	None
	44437220	3168	1	None	-	1	Human	6.3	pEC50	=	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	None
	CHEMBL239232	3168	1	None	-	1	Human	6.3	pEC50	=	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	None
	45073499	2856	34	None	-22	2	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	258	2	2	2	4.4	CC1=C[C@H]([C@@H](CC1)C(=C)C)c1c(C)cc(cc1O)O	21595653
	5525	2856	34	None	-22	2	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	258	2	2	2	4.4	CC1=C[C@H]([C@@H](CC1)C(=C)C)c1c(C)cc(cc1O)O	21595653
	CHEMBL3402654	2856	34	None	-22	2	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	258	2	2	2	4.4	CC1=C[C@H]([C@@H](CC1)C(=C)C)c1c(C)cc(cc1O)O	21595653
	3635	2694	37	None	1698	2	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	21595653
	5283389	2694	37	None	1698	2	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	21595653
	CHEMBL161343	2694	37	None	1698	2	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	361	16	2	2	5.3	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O	21595653
	104850	3278	93	None	-79	6	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	Drug Central	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	None
	4150	3278	93	None	-79	6	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	Drug Central	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	None
	743	3278	93	None	-79	6	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	Drug Central	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	None
	CHEMBL111	3278	93	None	-79	6	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	Drug Central	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	None
	DB06155	3278	93	None	-79	6	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	Drug Central	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	None

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	104850	3278	93	None	-	6	Human	5.0	pEC50	=	5	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1039/C3MD00394A
	4150	3278	93	None	-	6	Human	5.0	pEC50	=	5	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1039/C3MD00394A
	743	3278	93	None	-	6	Human	5.0	pEC50	=	5	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1039/C3MD00394A
	CHEMBL111	3278	93	None	-	6	Human	5.0	pEC50	=	5	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1039/C3MD00394A
	DB06155	3278	93	None	-	6	Human	5.0	pEC50	=	5	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1039/C3MD00394A
	162656142	180358	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	392	3	1	7	1.8	Cn1c(=O)c2c(nc3n2CCCCN3CCc2c[nH]c3ccccc23)n(C)c1=O	10.1021/acsmedchemlett.0c00208
	CHEMBL4758188	180358	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	392	3	1	7	1.8	Cn1c(=O)c2c(nc3n2CCCCN3CCc2c[nH]c3ccccc23)n(C)c1=O	10.1021/acsmedchemlett.0c00208
	16078	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	2424	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	4109	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	CHEMBL465	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	DB00470	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	16078	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assayAgonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/jm4005175
	2424	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assayAgonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/jm4005175
	4109	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assayAgonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/jm4005175
	CHEMBL465	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assayAgonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/jm4005175
	DB00470	1335	19	None	-	6	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assayAgonist activity at human GPR18 transfected in CHO cells after 90 mins by beta-arrestin translocation assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/jm4005175
	11081	3168	1	None	-	6	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1021/acsmedchemlett.0c00208
	44437220	3168	1	None	-	6	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1021/acsmedchemlett.0c00208
	CHEMBL239232	3168	1	None	-	6	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1021/acsmedchemlett.0c00208
	162663623	181450	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	364	3	1	7	1.0	Cn1c(=O)c2c(nc3n2CCN3CCc2c[nH]c3ccccc23)n(C)c1=O	10.1021/acsmedchemlett.0c00208
	CHEMBL4780863	181450	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	364	3	1	7	1.0	Cn1c(=O)c2c(nc3n2CCN3CCc2c[nH]c3ccccc23)n(C)c1=O	10.1021/acsmedchemlett.0c00208
	104895	1161	23	None	-	4	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	730	1161	23	None	-	4	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	734	1161	23	None	-	4	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	CHEMBL559612	1161	23	None	-	4	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR18 expressed in CHO cells assessed as induction of beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	16078	1335	19	None	-	6	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	2424	1335	19	None	-	6	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	4109	1335	19	None	-	6	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	CHEMBL465	1335	19	None	-	6	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	DB00470	1335	19	None	-	6	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assayAgonist activity at human GPR18 expressed in HEK203 cells by MAP kinase assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	1281706	109016	1	None	-	1	Human	5.0	pIC50	=	5	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	336	3	0	4	4.2	O=C1/C(=C/c2cccc(Oc3ccccc3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	CHEMBL3221186	109016	1	None	-	1	Human	5.0	pIC50	=	5	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	336	3	0	4	4.2	O=C1/C(=C/c2cccc(Oc3ccccc3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	90667660	109025	0	None	-	3	Human	5.0	pIC50	=	5	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	364	4	0	4	4.3	O=C1/C(=C/c2cccc(OCc3ccccc3)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	CHEMBL3221197	109025	0	None	-	3	Human	5.0	pIC50	=	5	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	364	4	0	4	4.3	O=C1/C(=C/c2cccc(OCc3ccccc3)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	71682799	90140	0	None	-	2	Human	5.0	pIC50	=	5	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	370	7	0	3	5.8	CCCCCc1cc(OC)c2cc(Cc3ccc(Cl)cc3)c(=O)oc2c1	10.1021/jm4005175
	CHEMBL2387530	90140	0	None	-	2	Human	5.0	pIC50	=	5	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	370	7	0	3	5.8	CCCCCc1cc(OC)c2cc(Cc3ccc(Cl)cc3)c(=O)oc2c1	10.1021/jm4005175
	104850	3278	93	None	-	6	Human	5.0	pIC50	=	5	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1021/jm4005175
	4150	3278	93	None	-	6	Human	5.0	pIC50	=	5	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1021/jm4005175
	743	3278	93	None	-	6	Human	5.0	pIC50	=	5	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1021/jm4005175
	CHEMBL111	3278	93	None	-	6	Human	5.0	pIC50	=	5	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1021/jm4005175
	DB06155	3278	93	None	-	6	Human	5.0	pIC50	=	5	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1021/jm4005175
	71682637	90189	0	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	322	4	0	3	4.8	COc1ccccc1Cc1cc2c(C)ccc(C(C)C)c2oc1=O	10.1021/jm4005175
	CHEMBL2387744	90189	0	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	322	4	0	3	4.8	COc1ccccc1Cc1cc2c(C)ccc(C(C)C)c2oc1=O	10.1021/jm4005175
	70678101	82624	13	None	-	2	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	408	9	2	4	6.4	CCCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3O)c(=O)oc2c1	10.1021/jm4005175
	CHEMBL2181542	82624	13	None	-	2	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	408	9	2	4	6.4	CCCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3O)c(=O)oc2c1	10.1021/jm4005175
	76325292	104978	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayInverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay	ChEMBL	435	4	2	2	6.5	COC(C)(C)/C=C/C[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@@]12C	10.1021/np400850g
	CHEMBL3120632	104978	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayInverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay	ChEMBL	435	4	2	2	6.5	COC(C)(C)/C=C/C[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@@]12C	10.1021/np400850g
	11152300	109024	0	None	-	2	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	350	3	0	4	4.5	O=C1/C(=C/c2cccc(Oc3ccccc3)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	CHEMBL3221196	109024	0	None	-	2	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	350	3	0	4	4.5	O=C1/C(=C/c2cccc(Oc3ccccc3)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	90667659	108745	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	398	3	0	5	4.2	O=C(Oc1cccc(/C=C2\N=C3SCCCN3C2=O)c1)c1ccc(Cl)cc1	10.1039/C3MD00394A
	CHEMBL3217791	108745	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	398	3	0	5	4.2	O=C(Oc1cccc(/C=C2\N=C3SCCCN3C2=O)c1)c1ccc(Cl)cc1	10.1039/C3MD00394A
	70678099	82622	0	None	-	2	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	394	8	2	4	6.0	CCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3O)c(=O)oc2c1	10.1021/jm4005175
	CHEMBL2181540	82622	0	None	-	2	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	394	8	2	4	6.0	CCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3O)c(=O)oc2c1	10.1021/jm4005175
	90667655	109019	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	384	4	0	4	4.6	O=C1/C(=C/c2cccc(OCc3ccccc3Cl)c2)N=C2SCCCN12	10.1039/C3MD00394A
	CHEMBL3221189	109019	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	384	4	0	4	4.6	O=C1/C(=C/c2cccc(OCc3ccccc3Cl)c2)N=C2SCCCN12	10.1039/C3MD00394A
	90667656	109020	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	418	4	0	4	5.2	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3Cl)c2)N=C2SCCCN12	10.1039/C3MD00394A
	CHEMBL3221190	109020	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	418	4	0	4	5.2	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3Cl)c2)N=C2SCCCN12	10.1039/C3MD00394A
	85469571	109018	16	None	-	2	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	384	4	0	4	4.6	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	CHEMBL3221188	109018	16	None	-	2	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	384	4	0	4	4.6	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	11475997	109029	0	None	-	3	Human	5.3	pIC50	=	5.3	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	432	4	0	4	5.6	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3Cl)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	CHEMBL3221201	109029	0	None	-	3	Human	5.3	pIC50	=	5.3	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	432	4	0	4	5.6	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3Cl)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	104895	1161	23	None	-	4	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1021/jm4005175
	730	1161	23	None	-	4	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1021/jm4005175
	734	1161	23	None	-	4	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1021/jm4005175
	CHEMBL559612	1161	23	None	-	4	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1021/jm4005175
	90667657	109021	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	418	4	0	4	5.2	O=C1/C(=C/c2cccc(OCc3ccc(Cl)c(Cl)c3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	CHEMBL3221191	109021	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	418	4	0	4	5.2	O=C1/C(=C/c2cccc(OCc3ccc(Cl)c(Cl)c3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	90667658	109022	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	364	3	0	5	3.6	O=C(Oc1cccc(/C=C2\N=C3SCCCN3C2=O)c1)c1ccccc1	10.1039/C3MD00394A
	CHEMBL3221192	109022	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	364	3	0	5	3.6	O=C(Oc1cccc(/C=C2\N=C3SCCCN3C2=O)c1)c1ccccc1	10.1039/C3MD00394A
	90667465	109003	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	392	3	0	5	4.3	Cc1ccc(C(=O)Oc2cccc(/C=C3\N=C4SCCCCN4C3=O)c2)cc1	10.1039/C3MD00394A
	CHEMBL3220943	109003	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	392	3	0	5	4.3	Cc1ccc(C(=O)Oc2cccc(/C=C3\N=C4SCCCCN4C3=O)c2)cc1	10.1039/C3MD00394A
	90667662	109028	0	None	-	2	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	398	4	0	4	5.0	O=C1/C(=C/c2cccc(OCc3ccccc3Cl)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	CHEMBL3221200	109028	0	None	-	2	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	398	4	0	4	5.0	O=C1/C(=C/c2cccc(OCc3ccccc3Cl)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	90667654	109017	0	None	-	2	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	350	4	0	4	3.9	O=C1/C(=C/c2cccc(OCc3ccccc3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	CHEMBL3221187	109017	0	None	-	2	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAntagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	350	4	0	4	3.9	O=C1/C(=C/c2cccc(OCc3ccccc3)c2)N=C2SCCCN12	10.1039/C3MD00394A
	70678097	82097	0	None	-	2	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	378	8	1	3	6.3	CCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3)c(=O)oc2c1	10.1021/jm4005175
	CHEMBL2177264	82097	0	None	-	2	Human	5.1	pIC50	=	5.1	Binding	Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assayAntagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay	ChEMBL	378	8	1	3	6.3	CCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3)c(=O)oc2c1	10.1021/jm4005175
	11081	3168	1	None	-	6	Human	6.0	pIC50	=	6.0	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment by measuring 2-(3-(6-(4-chlorophenoxy)hexyloxy)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one IC50 at 1 uM after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment by measuring 2-(3-(6-(4-chlorophenoxy)hexyloxy)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one IC50 at 1 uM after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1021/acsmedchemlett.0c00208
	44437220	3168	1	None	-	6	Human	6.0	pIC50	=	6.0	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment by measuring 2-(3-(6-(4-chlorophenoxy)hexyloxy)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one IC50 at 1 uM after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment by measuring 2-(3-(6-(4-chlorophenoxy)hexyloxy)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one IC50 at 1 uM after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1021/acsmedchemlett.0c00208
	CHEMBL239232	3168	1	None	-	6	Human	6.0	pIC50	=	6.0	Binding	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment by measuring 2-(3-(6-(4-chlorophenoxy)hexyloxy)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one IC50 at 1 uM after 90 mins by beta-galactosidase based topcount luminescence analysisAgonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment by measuring 2-(3-(6-(4-chlorophenoxy)hexyloxy)benzylidene)-6,7-dihydro-2H-imidazo[2,1-b][1,3]thiazin-3(5H)-one IC50 at 1 uM after 90 mins by beta-galactosidase based topcount luminescence analysis	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1021/acsmedchemlett.0c00208
	23643046	17660	0	None	-	2	Human	5.0	pIC50	=	5	Binding	Inverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayInverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay	ChEMBL	403	1	1	1	6.9	CC(C)=C[C@H]1C[C@]2(C)[C@H](CC[C@@]3(C)[C@H]2CC[C@H]2Cc4c([nH]c5ccccc45)[C@@]23C)O1	10.1021/np400850g
	CHEMBL1258979	17660	0	None	-	2	Human	5.0	pIC50	=	5	Binding	Inverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assayInverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay	ChEMBL	403	1	1	1	6.9	CC(C)=C[C@H]1C[C@]2(C)[C@H](CC[C@@]3(C)[C@H]2CC[C@H]2Cc4c([nH]c5ccccc45)[C@@]23C)O1	10.1021/np400850g

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Ligand source activities (1 row/activity)