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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	CHEMBL5498461	197343	None	0	Wild turkey	Functional	pEC50	=	10	10.0	-	1	Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesEvaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes	ChEMBL		None	None	None		None	10.1021/jm020046y
	CHEMBL2021421	212950	None	0	Rat	Functional	pEC50	=	9	9.0	-	1	Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)	ChEMBL		None	None	None		BP(=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)OP(=O)(O)O	10.1021/jm020251d
	CHEMBL2448329	212950	None	0	Rat	Functional	pEC50	=	9	9.0	-	1	Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)	ChEMBL		None	None	None		BP(=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)OP(=O)(O)O	10.1021/jm020251d
	1711	77	None	13	Rat	Functional	pEC50	=	9	9.0	-1	7	Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsConcentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells	ChEMBL	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10.1021/jm049771u
	5310983	77	None	13	Rat	Functional	pEC50	=	9	9.0	-1	7	Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsConcentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells	ChEMBL	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10.1021/jm049771u
	CHEMBL336208	77	None	13	Rat	Functional	pEC50	=	9	9.0	-1	7	Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsConcentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells	ChEMBL	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10.1021/jm049771u
	70693397	77891	None	0	Rat	Functional	pEC50	=	9	9.0	-	1	Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsConcentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells	ChEMBL	569	9	7	15	-0.8	CSc1nc(N)c2ncn(C3O[C@H](CO[P@](O)(=S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/jm049771u
	CHEMBL2093075	77891	None	0	Rat	Functional	pEC50	=	9	9.0	-	1	Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsConcentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells	ChEMBL	569	9	7	15	-0.8	CSc1nc(N)c2ncn(C3O[C@H](CO[P@](O)(=S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/jm049771u
	5310950	116727	None	0	Wild turkey	Functional	pEC50	=	8.8	8.8	-	1	Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesEvaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes	ChEMBL	658	12	8	16	0.3	Nc1ccc(CCSc2nc(N)c3ncn([C@@H]4O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]4O)c3n2)cc1	10.1021/jm020046y
	CHEMBL337062	116727	None	0	Wild turkey	Functional	pEC50	=	8.8	8.8	-	1	Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesEvaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes	ChEMBL	658	12	8	16	0.3	Nc1ccc(CCSc2nc(N)c3ncn([C@@H]4O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]4O)c3n2)cc1	10.1021/jm020046y
	121990	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1710	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1763	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	CHEMBL435402	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	46229259	203585	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human P2Y1 receptor expressed in human 1321N1 cells by PLC assayAgonist activity at human P2Y1 receptor expressed in human 1321N1 cells by PLC assay	ChEMBL	391	4	5	9	-0.5	Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@@]2(COP(=O)(O)O)C[C@H]12	10.1021/jm9018542
	CHEMBL603128	203585	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human P2Y1 receptor expressed in human 1321N1 cells by PLC assayAgonist activity at human P2Y1 receptor expressed in human 1321N1 cells by PLC assay	ChEMBL	391	4	5	9	-0.5	Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@@]2(COP(=O)(O)O)C[C@H]12	10.1021/jm9018542
	121990	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1710	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1763	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	CHEMBL435402	75	None	11	Human	Functional	pEC50	=	8.7	8.7	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	46876123	204937	None	0	Wild turkey	Functional	pEC50	=	8	8.0	-	1	Agonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranesAgonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranes	ChEMBL	623	14	7	15	1.0	CCCCCCSc1nc(N)c2ncn(C3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/jm990158y
	CHEMBL611285	204937	None	0	Wild turkey	Functional	pEC50	=	8	8.0	-	1	Agonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranesAgonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranes	ChEMBL	623	14	7	15	1.0	CCCCCCSc1nc(N)c2ncn(C3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/jm990158y
	121990	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Activation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assayActivation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assay	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm9018542
	1710	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Activation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assayActivation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assay	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm9018542
	1763	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Activation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assayActivation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assay	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm9018542
	CHEMBL435402	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Activation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assayActivation of human P2Y1 receptor expressed in human 1321N1 cells assessed as induction of calcium flux by FLIPR assay	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm9018542
	121990	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1710	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1763	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	CHEMBL435402	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	121990	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1710	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1763	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	CHEMBL435402	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	121990	75	None	11	Rat	Functional	pEC50	=	7	7.0	-100	5	Activity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increaseActivity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increase	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm050955y
	1710	75	None	11	Rat	Functional	pEC50	=	7	7.0	-100	5	Activity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increaseActivity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increase	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm050955y
	1763	75	None	11	Rat	Functional	pEC50	=	7	7.0	-100	5	Activity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increaseActivity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increase	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm050955y
	CHEMBL435402	75	None	11	Rat	Functional	pEC50	=	7	7.0	-100	5	Activity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increaseActivity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increase	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm050955y
	1712	288	None	48	Wild turkey	Functional	pEC50	=	7	7.0	-21	6	Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysisAgonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1016/j.ejmech.2008.07.015
	6022	288	None	48	Wild turkey	Functional	pEC50	=	7	7.0	-21	6	Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysisAgonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1016/j.ejmech.2008.07.015
	CHEMBL14830	288	None	48	Wild turkey	Functional	pEC50	=	7	7.0	-21	6	Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysisAgonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1016/j.ejmech.2008.07.015
	1725	3153	None	14	Human	Functional	pEC50	=	6	6.0	-1	6	Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytesEvaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytes	ChEMBL	511	8	5	11	1.4	O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C	10.1021/jm020046y
	4881	3153	None	14	Human	Functional	pEC50	=	6	6.0	-1	6	Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytesEvaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytes	ChEMBL	511	8	5	11	1.4	O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C	10.1021/jm020046y
	CHEMBL1437958	3153	None	14	Human	Functional	pEC50	=	6	6.0	-1	6	Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytesEvaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytes	ChEMBL	511	8	5	11	1.4	O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C	10.1021/jm020046y
	CHEMBL69234	3153	None	14	Human	Functional	pEC50	=	6	6.0	-1	6	Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytesEvaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytes	ChEMBL	511	8	5	11	1.4	O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C	10.1021/jm020046y
	121990	75	None	11	Human	Functional	pEC50	=	7.0	7.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1710	75	None	11	Human	Functional	pEC50	=	7.0	7.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	1763	75	None	11	Human	Functional	pEC50	=	7.0	7.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	CHEMBL435402	75	None	11	Human	Functional	pEC50	=	7.0	7.0	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm970684u
	121990	75	None	11	Human	Functional	pEC50	=	8.0	8.0	-39	5	Activity against human P2Y1-GFP expressed in 1321N1 cells by intracellular calcium increaseActivity against human P2Y1-GFP expressed in 1321N1 cells by intracellular calcium increase	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm050955y

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	73348774	89580	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptorAccumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor	ChEMBL	483	7	6	12	-0.4	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)OP(=O)(O)O)C[C@@H]34)c2n1	10.1021/jm010538v
	CHEMBL2373948	89580	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptorAccumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor	ChEMBL	483	7	6	12	-0.4	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)OP(=O)(O)O)C[C@@H]34)c2n1	10.1021/jm010538v
	71459897	78577	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human P2Y1R in human 1321N1 cellsAgonist activity at human P2Y1R in human 1321N1 cells	ChEMBL	483	7	6	12	-0.4	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)OP(=O)(O)O)C[C@H]34)c2n1	10.1039/D1MD00167A
	CHEMBL2112093	78577	None	0	Human	Binding	pEC50	=	9.4	9.4	-	0	Agonist activity at human P2Y1R in human 1321N1 cellsAgonist activity at human P2Y1R in human 1321N1 cells	ChEMBL	483	7	6	12	-0.4	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)OP(=O)(O)O)C[C@H]34)c2n1	10.1039/D1MD00167A
	73348774	89580	None	0	Wild turkey	Binding	pEC50	=	9.1	9.1	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	483	7	6	12	-0.4	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)OP(=O)(O)O)C[C@@H]34)c2n1	10.1021/jm010538v
	CHEMBL2373948	89580	None	0	Wild turkey	Binding	pEC50	=	9.1	9.1	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	483	7	6	12	-0.4	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)OP(=O)(O)O)C[C@@H]34)c2n1	10.1021/jm010538v
	121990	75	None	11	Human	Binding	pEC50	=	8.9	8.9	-10	2	Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	8.9	8.9	-10	2	Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	8.9	8.9	-10	2	Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	8.9	8.9	-10	2	Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	121990	75	None	11	Human	Binding	pEC50	=	7	7.0	-10	2	Effective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	7	7.0	-10	2	Effective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	7	7.0	-10	2	Effective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	7	7.0	-10	2	Effective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	9830068	89078	None	0	Wild turkey	Binding	pEC50	=	5	5.0	-	0	Compounds was tested for its ability to stimulate phospholipase C activity at the P2Y purinoceptor 1 in turkey erythrocyte membranes.Compounds was tested for its ability to stimulate phospholipase C activity at the P2Y purinoceptor 1 in turkey erythrocyte membranes.	ChEMBL	595	12	7	15	0.3	CCCCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm990156d
	CHEMBL2364564	89078	None	0	Wild turkey	Binding	pEC50	=	5	5.0	-	0	Compounds was tested for its ability to stimulate phospholipase C activity at the P2Y purinoceptor 1 in turkey erythrocyte membranes.Compounds was tested for its ability to stimulate phospholipase C activity at the P2Y purinoceptor 1 in turkey erythrocyte membranes.	ChEMBL	595	12	7	15	0.3	CCCCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm990156d
	CHEMBL2364580	89078	None	0	Wild turkey	Binding	pEC50	=	5	5.0	-	0	Compounds was tested for its ability to stimulate phospholipase C activity at the P2Y purinoceptor 1 in turkey erythrocyte membranes.Compounds was tested for its ability to stimulate phospholipase C activity at the P2Y purinoceptor 1 in turkey erythrocyte membranes.	ChEMBL	595	12	7	15	0.3	CCCCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm990156d
	121990	75	None	11	Human	Binding	pEC50	=	8.0	8.0	-10	2	Effective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	8.0	8.0	-10	2	Effective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	8.0	8.0	-10	2	Effective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	8.0	8.0	-10	2	Effective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	121990	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human S314T mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	73351851	89559	None	0	Wild turkey	Binding	pEC50	=	5.0	5.0	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	515	8	7	12	-0.9	Nc1ncnc2c1ncn2C1C(O)C(O)[C@@]2(COP(=O)(O)OP(=O)(O)CP(=O)(O)O)C[C@H]12	10.1021/jm010538v
	CHEMBL2373325	89559	None	0	Wild turkey	Binding	pEC50	=	5.0	5.0	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	515	8	7	12	-0.9	Nc1ncnc2c1ncn2C1C(O)C(O)[C@@]2(COP(=O)(O)OP(=O)(O)CP(=O)(O)O)C[C@H]12	10.1021/jm010538v
	73345772	89579	None	0	Wild turkey	Binding	pEC50	=	5.9	5.9	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	403	5	5	10	-0.5	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)O)C[C@@H]34)c2n1	10.1021/jm010538v
	CHEMBL2373947	89579	None	0	Wild turkey	Binding	pEC50	=	5.9	5.9	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	403	5	5	10	-0.5	CSc1nc(N)c2ncn([C@H]3[C@H](O)[C@H](O)[C@@]4(COP(=O)(O)O)C[C@@H]34)c2n1	10.1021/jm010538v
	121990	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	7.9	7.9	-10	2	Effective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	14252049	16411	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human P2Y1R in human 1321N1 cellsAgonist activity at human P2Y1R in human 1321N1 cells	ChEMBL	411	6	5	10	-0.7	Nc1ncnc2c1ncn2[C@H]1C[C@H](OP(=O)(O)O)[C@@H](COP(=O)(O)O)O1	10.1039/D1MD00167A
	CHEMBL1230817	16411	None	0	Human	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at human P2Y1R in human 1321N1 cellsAgonist activity at human P2Y1R in human 1321N1 cells	ChEMBL	411	6	5	10	-0.7	Nc1ncnc2c1ncn2[C@H]1C[C@H](OP(=O)(O)O)[C@@H](COP(=O)(O)O)O1	10.1039/D1MD00167A
	44306835	102125	None	0	Wild turkey	Binding	pEC50	=	7.9	7.9	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	517	8	7	13	-1.0	Nc1ncnc2c1ncn2C1C(O)C(O)C2(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)CC12	10.1021/jm010538v
	CHEMBL302077	102125	None	0	Wild turkey	Binding	pEC50	=	7.9	7.9	-	0	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesActivation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	517	8	7	13	-1.0	Nc1ncnc2c1ncn2C1C(O)C(O)C2(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)CC12	10.1021/jm010538v
	121990	75	None	11	Human	Binding	pEC50	=	6.8	6.8	-10	2	Effective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	6.8	6.8	-10	2	Effective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	6.8	6.8	-10	2	Effective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	6.8	6.8	-10	2	Effective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human D204E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	121990	75	None	11	Human	Binding	pEC50	=	4.8	4.8	-10	2	Effective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	4.8	4.8	-10	2	Effective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	4.8	4.8	-10	2	Effective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	4.8	4.8	-10	2	Effective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	121990	75	None	11	Human	Binding	pEC50	=	7.8	7.8	-10	2	Effective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1710	75	None	11	Human	Binding	pEC50	=	7.8	7.8	-10	2	Effective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	1763	75	None	11	Human	Binding	pEC50	=	7.8	7.8	-10	2	Effective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	CHEMBL435402	75	None	11	Human	Binding	pEC50	=	7.8	7.8	-10	2	Effective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c
	121990	75	None	11	Human	Binding	pEC50	=	7.8	7.8	-10	2	Effective concentration required for the activation of human H132A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateEffective concentration required for the activation of human H132A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473	7	6	13	-1.0	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O	10.1021/jm049914c

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Ligand source activities (1 row/activity)