GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11715531	88731	None	13	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236013	88731	None	13	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	28400380	89951	None	1	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237945	89951	None	1	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11415838	136444	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	CHEMBL373484	136444	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	28400046	89844	None	2	Human	Functional	pEC50	=	6.0	6.0	32	2	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237737	89844	None	2	Human	Functional	pEC50	=	6.0	6.0	32	2	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10198518	73562	None	25	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	CHEMBL201724	73562	None	25	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	24955646	58051	None	0	Human	Functional	pEC50	=	6.0	6.0	-186	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672639	58051	None	0	Human	Functional	pEC50	=	6.0	6.0	-186	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	1591	131	None	45	Human	Functional	pEC50	=	4.9	4.9	-33	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	6485181	131	None	45	Human	Functional	pEC50	=	4.9	4.9	-33	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	CHEMBL428730	131	None	45	Human	Functional	pEC50	=	4.9	4.9	-33	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	28400196	90286	None	10	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238376	90286	None	10	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	44433532	152498	None	0	Human	Functional	pEC50	=	4.9	4.9	-16	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL397055	152498	None	0	Human	Functional	pEC50	=	4.9	4.9	-16	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	11219885	83495	None	0	Human	Functional	pEC50	=	4.9	4.9	-3	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL220001	83495	None	0	Human	Functional	pEC50	=	4.9	4.9	-3	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	15604642	75280	None	0	Human	Functional	pEC50	=	5.9	5.9	-323	3	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036948	75280	None	0	Human	Functional	pEC50	=	5.9	5.9	-323	3	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	43131474	151730	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396382	151730	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11961288	199166	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL564914	199166	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	15604637	75286	None	0	Human	Functional	pEC50	=	6.9	6.9	-70	3	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036955	75286	None	0	Human	Functional	pEC50	=	6.9	6.9	-70	3	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11380943	83492	None	0	Human	Functional	pEC50	=	4.9	4.9	-20	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83492	None	0	Human	Functional	pEC50	=	4.9	4.9	-20	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	45269912	198366	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL559204	198366	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11687485	90083	None	1	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238164	90083	None	1	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	126	None	0	Human	Functional	pEC50	=	5.8	5.8	-14	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	1589	126	None	0	Human	Functional	pEC50	=	5.8	5.8	-14	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	CHEMBL375493	126	None	0	Human	Functional	pEC50	=	5.8	5.8	-14	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	11483496	126	None	0	Human	Functional	pEC50	=	5.8	5.8	-14	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	None	0	Human	Functional	pEC50	=	5.8	5.8	-14	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	None	0	Human	Functional	pEC50	=	5.8	5.8	-14	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	28400406	89952	None	1	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237946	89952	None	1	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11528819	145594	None	15	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391473	145594	None	15	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	2829816	88781	None	35	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236219	88781	None	35	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	17965902	89848	None	3	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237739	89848	None	3	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	11379903	84305	None	0	Human	Functional	pEC50	=	4.8	4.8	-6	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84305	None	0	Human	Functional	pEC50	=	4.8	4.8	-6	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271548	90290	None	7	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238387	90290	None	7	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11379903	84305	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84305	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11379903	84305	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	CHEMBL221282	84305	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	11436345	143	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11218626	84926	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL223623	84926	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	13153555	93916	None	26	Human	Functional	pEC50	=	4.7	4.7	-42	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	CHEMBL247921	93916	None	26	Human	Functional	pEC50	=	4.7	4.7	-42	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	15605571	75261	None	0	Human	Functional	pEC50	=	6.7	6.7	-23	5	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036813	75261	None	0	Human	Functional	pEC50	=	6.7	6.7	-23	5	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	11470798	138054	None	0	Human	Functional	pEC50	=	4.7	4.7	-2	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL376419	138054	None	0	Human	Functional	pEC50	=	4.7	4.7	-2	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	283475	89839	None	66	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237731	89839	None	66	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11528793	88736	None	1	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL236028	88736	None	1	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10263467	140981	None	1	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382096	140981	None	1	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	2776549	73416	None	49	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201513	73416	None	49	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	3684804	90284	None	37	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238374	90284	None	37	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11322738	136853	None	0	Human	Functional	pEC50	=	4.7	4.7	-13	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL374111	136853	None	0	Human	Functional	pEC50	=	4.7	4.7	-13	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3729086	145685	None	40	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391547	145685	None	40	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10465474	140544	None	24	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	CHEMBL380939	140544	None	24	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	11322761	141693	None	0	Human	Functional	pEC50	=	4.6	4.6	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL385103	141693	None	0	Human	Functional	pEC50	=	4.6	4.6	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3824366	89542	None	35	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	3953363	89542	None	35	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL237296	89542	None	35	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	45269046	198843	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL562675	198843	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11708383	88553	None	22	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235144	88553	None	22	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10421571	74251	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202351	74251	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10398515	135360	None	26	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL372727	135360	None	26	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400056	152312	None	1	Human	Functional	pEC50	=	6.6	6.6	74	2	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396879	152312	None	1	Human	Functional	pEC50	=	6.6	6.6	74	2	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11276453	84910	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	CHEMBL223566	84910	None	0	Human	Functional	pEC50	=	6.6	6.6	1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	11492560	88552	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235141	88552	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10014206	73065	None	2	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201048	73065	None	2	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	11715556	120	None	29	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	5801	120	None	29	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	CHEMBL236011	120	None	29	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	44250176	1131	None	0	Human	Functional	pEC50	=	8.5	8.5	2951	2	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	5800	1131	None	0	Human	Functional	pEC50	=	8.5	8.5	2951	2	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	CHEMBL564300	1131	None	0	Human	Functional	pEC50	=	8.5	8.5	2951	2	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	51346919	57860	None	5	Human	Functional	pEC50	=	6.5	6.5	-100	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1671877	57860	None	5	Human	Functional	pEC50	=	6.5	6.5	-100	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	1595	259	None	36	Human	Functional	pEC50	=	5.5	5.5	-4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	259	None	36	Human	Functional	pEC50	=	5.5	5.5	-4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	259	None	36	Human	Functional	pEC50	=	5.5	5.5	-4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	10353934	133229	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL370386	133229	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10422270	73397	None	1	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201409	73397	None	1	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4992776	90274	None	30	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL238358	90274	None	30	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	11565047	147306	None	13	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL392830	147306	None	13	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	2942936	149952	None	13	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL394906	149952	None	13	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	44434363	169074	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL439028	169074	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10330955	169208	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	CHEMBL440041	169208	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	10398583	73995	None	11	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202157	73995	None	11	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400038	88643	None	29	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL235615	88643	None	29	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	44433529	88570	None	0	Human	Functional	pEC50	=	5.5	5.5	5	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	88570	None	0	Human	Functional	pEC50	=	5.5	5.5	5	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	2771812	89845	None	39	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237738	89845	None	39	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	43187344	90288	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238385	90288	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11817645	84940	None	0	Human	Functional	pEC50	=	4.5	4.5	-12	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223700	84940	None	0	Human	Functional	pEC50	=	4.5	4.5	-12	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10013684	74055	None	1	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202206	74055	None	1	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4712703	141309	None	32	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382863	141309	None	32	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433529	88570	None	0	Human	Functional	pEC50	=	5.4	5.4	5	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	88570	None	0	Human	Functional	pEC50	=	5.4	5.4	5	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	11322762	137689	None	0	Human	Functional	pEC50	=	4.4	4.4	-5	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375625	137689	None	0	Human	Functional	pEC50	=	4.4	4.4	-5	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43085192	89465	None	1	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237077	89465	None	1	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	126	None	0	Human	Functional	pEC50	=	6.4	6.4	-14	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	126	None	0	Human	Functional	pEC50	=	6.4	6.4	-14	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	126	None	0	Human	Functional	pEC50	=	6.4	6.4	-14	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11311474	165877	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL424750	165877	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43187332	152309	None	1	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396878	152309	None	1	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1447952	89843	None	1	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237735	89843	None	1	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	11744994	89840	None	23	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237732	89840	None	23	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1597	1965	None	47	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	2736690	1965	None	47	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	CHEMBL381638	1965	None	47	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	45268162	198695	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561720	198695	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	28399894	149375	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	CHEMBL394468	149375	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	11324121	84700	None	0	Human	Functional	pEC50	=	5.4	5.4	-5	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL222472	84700	None	0	Human	Functional	pEC50	=	5.4	5.4	-5	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	776421	89962	None	65	Human	Functional	pEC50	=	4.4	4.4	-30	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL238002	89962	None	65	Human	Functional	pEC50	=	4.4	4.4	-30	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	1595	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	1595	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	11183678	84806	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223140	84806	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	51576	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	CHEMBL278488	259	None	36	Human	Functional	pEC50	=	5.4	5.4	-4	2	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	11992587	197954	None	1	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL553415	197954	None	1	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11148966	1122	None	2	Human	Functional	pEC50	=	5.3	5.3	4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	1598	1122	None	2	Human	Functional	pEC50	=	5.3	5.3	4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	CHEMBL436301	1122	None	2	Human	Functional	pEC50	=	5.3	5.3	4	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	11380943	83492	None	0	Human	Functional	pEC50	=	5.3	5.3	-20	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	83492	None	0	Human	Functional	pEC50	=	5.3	5.3	-20	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11436345	143	None	0	Human	Functional	pEC50	=	5.3	5.3	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	143	None	0	Human	Functional	pEC50	=	5.3	5.3	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	143	None	0	Human	Functional	pEC50	=	5.3	5.3	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	9971057	74329	None	2	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	CHEMBL202427	74329	None	2	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	28399946	89841	None	7	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237733	89841	None	7	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11739420	84791	None	0	Human	Functional	pEC50	=	5.3	5.3	-12	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223013	84791	None	0	Human	Functional	pEC50	=	5.3	5.3	-12	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11413114	137706	None	0	Human	Functional	pEC50	=	5.3	5.3	-2	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375754	137706	None	0	Human	Functional	pEC50	=	5.3	5.3	-2	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271417	90285	None	1	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238375	90285	None	1	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11992688	198195	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL557298	198195	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11514348	153178	None	2	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL397616	153178	None	2	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	4738197	151394	None	26	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL396073	151394	None	26	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	653819	141348	None	38	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	CHEMBL383099	141348	None	38	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	59343664	75282	None	0	Human	Functional	pEC50	=	7.2	7.2	-29	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036951	75282	None	0	Human	Functional	pEC50	=	7.2	7.2	-29	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	43187366	90289	None	8	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL238386	90289	None	8	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	28400003	149377	None	28	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394469	149377	None	28	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11184165	83487	None	0	Human	Functional	pEC50	=	5.2	5.2	-5	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL219950	83487	None	0	Human	Functional	pEC50	=	5.2	5.2	-5	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	2833647	149955	None	15	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL394907	149955	None	15	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	16775596	89645	None	1	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237525	89645	None	1	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	59304608	75285	None	0	Human	Functional	pEC50	=	7.2	7.2	-67	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036954	75285	None	0	Human	Functional	pEC50	=	7.2	7.2	-67	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11992588	197905	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL552399	197905	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11379903	84305	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	84305	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10331019	74439	None	25	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202586	74439	None	25	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28399894	149375	None	1	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394468	149375	None	1	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	44434380	89644	None	16	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237524	89644	None	16	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	44433528	147610	None	0	Human	Functional	pEC50	=	6.1	6.1	10	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393064	147610	None	0	Human	Functional	pEC50	=	6.1	6.1	10	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	22271415	88558	None	41	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235168	88558	None	41	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10058774	74443	None	24	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202614	74443	None	24	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433530	147612	None	0	Human	Functional	pEC50	=	5.1	5.1	2	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393065	147612	None	0	Human	Functional	pEC50	=	5.1	5.1	2	2	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	117629482	2823	None	82	Human	Functional	pEC50	=	4.1	4.1	-26	4	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1588	2823	None	82	Human	Functional	pEC50	=	4.1	4.1	-26	4	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1594	2823	None	82	Human	Functional	pEC50	=	4.1	4.1	-26	4	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	2835	2823	None	82	Human	Functional	pEC50	=	4.1	4.1	-26	4	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	938	2823	None	82	Human	Functional	pEC50	=	4.1	4.1	-26	4	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	CHEMBL573	2823	None	82	Human	Functional	pEC50	=	4.1	4.1	-26	4	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	DB00627	2823	None	82	Human	Functional	pEC50	=	4.1	4.1	-26	4	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	11992592	198487	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL560254	198487	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11992591	198726	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561920	198726	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11992790	197648	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL550563	197648	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	2103992	169229	None	36	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL440217	169229	None	36	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	45269904	199188	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL565055	199188	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11608532	73319	None	27	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	CHEMBL201278	73319	None	27	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	28400019	88600	None	9	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235394	88600	None	9	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	56950369	3559	None	16	Human	Functional	pEC50	=	7.0	7.0	-47	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	8469	3559	None	16	Human	Functional	pEC50	=	7.0	7.0	-47	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	CHEMBL2036958	3559	None	16	Human	Functional	pEC50	=	7.0	7.0	-47	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	DB12433	3559	None	16	Human	Functional	pEC50	=	7.0	7.0	-47	4	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	11264843	137707	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375762	137707	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	259	None	36	Human	Functional	pIC50	=	5.5	5.5	-4	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	259	None	36	Human	Functional	pIC50	=	5.5	5.5	-4	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	259	None	36	Human	Functional	pIC50	=	5.5	5.5	-4	2	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	117629482	2823	None	82	Human	Functional	pEC50	=	8.2	8.2	-26	4	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1588	2823	None	82	Human	Functional	pEC50	=	8.2	8.2	-26	4	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1594	2823	None	82	Human	Functional	pEC50	=	8.2	8.2	-26	4	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	2835	2823	None	82	Human	Functional	pEC50	=	8.2	8.2	-26	4	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	938	2823	None	82	Human	Functional	pEC50	=	8.2	8.2	-26	4	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	CHEMBL573	2823	None	82	Human	Functional	pEC50	=	8.2	8.2	-26	4	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	DB00627	2823	None	82	Human	Functional	pEC50	=	8.2	8.2	-26	4	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	5798	1502	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	6923517	1502	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	9060	1502	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	CHEMBL292303	1502	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	DB03225	1502	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	5797	1475	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	6919011	1475	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	71567	1475	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	CHEMBL379630	1475	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	DB02556	1475	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	11367166	101	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	2933	101	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	117629482	2823	None	82	Human	Functional	pEC50	=	5.3	5.3	-26	4	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1588	2823	None	82	Human	Functional	pEC50	=	5.3	5.3	-26	4	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1594	2823	None	82	Human	Functional	pEC50	=	5.3	5.3	-26	4	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	2835	2823	None	82	Human	Functional	pEC50	=	5.3	5.3	-26	4	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	938	2823	None	82	Human	Functional	pEC50	=	5.3	5.3	-26	4	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	CHEMBL573	2823	None	82	Human	Functional	pEC50	=	5.3	5.3	-26	4	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	DB00627	2823	None	82	Human	Functional	pEC50	=	5.3	5.3	-26	4	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	5796	67	None	51	Human	Functional	pEC50	=	5.4	5.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	94180	67	None	51	Human	Functional	pEC50	=	5.4	5.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	CHEMBL4447980	67	None	51	Human	Functional	pEC50	=	5.4	5.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	1152206	1440	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	5799	1440	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	6971244	1440	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	CHEMBL1233899	1440	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	1597	1965	None	47	Human	Functional	pEC50	=	6.4	6.4	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	2736690	1965	None	47	Human	Functional	pEC50	=	6.4	6.4	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	CHEMBL381638	1965	None	47	Human	Functional	pEC50	=	6.4	6.4	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	12418	1476	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	444718	1476	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	DB02494	1476	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	11715556	120	None	29	Human	Functional	pEC50	=	7.5	7.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	5801	120	None	29	Human	Functional	pEC50	=	7.5	7.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	CHEMBL236011	120	None	29	Human	Functional	pEC50	=	7.5	7.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	44250176	1131	None	0	Human	Functional	pEC50	=	8.5	8.5	2951	2	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	5800	1131	None	0	Human	Functional	pEC50	=	8.5	8.5	2951	2	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	CHEMBL564300	1131	None	0	Human	Functional	pEC50	=	8.5	8.5	2951	2	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	1595	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	1595	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	1595	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	1595	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	51576	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	51576	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	51576	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	51576	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	CHEMBL278488	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	CHEMBL278488	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	CHEMBL278488	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	CHEMBL278488	259	None	36	Human	Functional	pEC50	None	5.0	5.0	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	11148966	1122	None	2	Human	Functional	pEC50	None	5.3	5.3	4	2	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	1598	1122	None	2	Human	Functional	pEC50	None	5.3	5.3	4	2	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	CHEMBL436301	1122	None	2	Human	Functional	pEC50	None	5.3	5.3	4	2	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	11436345	143	None	0	Human	Functional	pEC50	None	6.7	6.7	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	1599	143	None	0	Human	Functional	pEC50	None	6.7	6.7	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	CHEMBL424938	143	None	0	Human	Functional	pEC50	None	6.7	6.7	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	53232	188732	None	57	Human	Functional	pIC50	=	8.2	8.2	1	10	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
	CHEMBL503	188732	None	57	Human	Functional	pIC50	=	8.2	8.2	1	10	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1595	259	None	36	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	51576	259	None	36	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	CHEMBL278488	259	None	36	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	135899171	16177	None	0	Human	Binding	pIC50	=	4.5	4.5	-	0	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224070	16177	None	0	Human	Binding	pIC50	=	4.5	4.5	-	0	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108

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Main reference

Ligand source activities (1 row/activity)