Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 172461075 | 196528 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -2 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 561 | 17 | 5 | 8 | 3.7 | CC(C)(C)OC(=O)NCCNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5425930 | 196528 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -2 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 561 | 17 | 5 | 8 | 3.7 | CC(C)(C)OC(=O)NCCNCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172457202 | 196457 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | 1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 501 | 12 | 4 | 7 | 3.1 | CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5424361 | 196457 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | 1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 501 | 12 | 4 | 7 | 3.1 | CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172444590 | 195530 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 390 | 11 | 4 | 6 | 1.7 | NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5405388 | 195530 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 390 | 11 | 4 | 6 | 1.7 | NCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172470467 | 197125 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -9 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5439297 | 197125 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -9 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172461948 | 196818 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 517 | 13 | 4 | 8 | 2.3 | CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5432813 | 196818 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 517 | 13 | 4 | 8 | 2.3 | CC(C)(C)OC(=O)NCCOCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172447016 | 195443 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 404 | 12 | 4 | 6 | 2.1 | NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5403958 | 195443 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | 1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 404 | 12 | 4 | 6 | 2.1 | NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172471932 | 197160 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | 1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 487 | 11 | 4 | 7 | 2.7 | CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5440093 | 197160 | None | 0 | Mouse | Functional | pEC50 | = | 5.9 | 5.9 | 1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 487 | 11 | 4 | 7 | 2.7 | CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172457202 | 196457 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 501 | 12 | 4 | 7 | 3.1 | CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5424361 | 196457 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 501 | 12 | 4 | 7 | 3.1 | CC(C)(C)OC(=O)NCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172471932 | 197160 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 487 | 11 | 4 | 7 | 2.7 | CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5440093 | 197160 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 487 | 11 | 4 | 7 | 2.7 | CC(C)(C)OC(=O)NCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 171378461 | 197076 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -2 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5438140 | 197076 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -2 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172470467 | 197125 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -9 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5439297 | 197125 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -9 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172447016 | 195443 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 404 | 12 | 4 | 6 | 2.1 | NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5403958 | 195443 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 404 | 12 | 4 | 6 | 2.1 | NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172461697 | 196647 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | 1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 529 | 14 | 4 | 7 | 3.9 | CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5428882 | 196647 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | 1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 529 | 14 | 4 | 7 | 3.9 | CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 1110 | 3698 | None | 67 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -1 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 21952380 | 3698 | None | 67 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -1 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 2487 | 3698 | None | 67 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -1 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 3637 | 3698 | None | 67 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -1 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL576 | 3698 | None | 67 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -1 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| DB00139 | 3698 | None | 67 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -1 | 2 | Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172462290 | 196722 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | 1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 515 | 13 | 4 | 7 | 3.5 | CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5430763 | 196722 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | 1 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 515 | 13 | 4 | 7 | 3.5 | CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172461697 | 196647 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 529 | 14 | 4 | 7 | 3.9 | CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5428882 | 196647 | None | 0 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 529 | 14 | 4 | 7 | 3.9 | CC(C)(C)OC(=O)NCCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172470467 | 197125 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | 9 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5439297 | 197125 | None | 0 | Mouse | Functional | pEC50 | = | 6.7 | 6.7 | 9 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 1110 | 3698 | None | 67 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | 1 | 2 | Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 21952380 | 3698 | None | 67 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | 1 | 2 | Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 2487 | 3698 | None | 67 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | 1 | 2 | Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 3637 | 3698 | None | 67 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | 1 | 2 | Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL576 | 3698 | None | 67 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | 1 | 2 | Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| DB00139 | 3698 | None | 67 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | 1 | 2 | Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assayAgonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production by cAMP assay |
ChEMBL | 118 | 3 | 2 | 2 | -0.1 | OC(=O)CCC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172462290 | 196722 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 515 | 13 | 4 | 7 | 3.5 | CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5430763 | 196722 | None | 0 | Mouse | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 2 | Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 515 | 13 | 4 | 7 | 3.5 | CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)n2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172471391 | 197165 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -8 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 504 | 13 | 4 | 7 | 3.7 | CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5440168 | 197165 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -8 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 504 | 13 | 4 | 7 | 3.7 | CC(C)(C)OC(=O)NCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172449130 | 195582 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -3 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 446 | 14 | 3 | 6 | 3.1 | CN(C)CCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5406481 | 195582 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -3 | 2 | Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysisAgonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as inhibition of forskolin-induced cAMP production incubated for 30 mins by TR-FRET analysis |
ChEMBL | 446 | 14 | 3 | 6 | 3.1 | CN(C)CCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
Showing 1 to 50 of 356 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 172470467 | 197125 | None | 0 | Mouse | Binding | pKd | = | 5.9 | 5.9 | 1 | 2 | Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5439297 | 197125 | None | 0 | Mouse | Binding | pKd | = | 5.9 | 5.9 | 1 | 2 | Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 171378461 | 197076 | None | 0 | Mouse | Binding | pKd | = | 5.9 | 5.9 | -1 | 2 | Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5438140 | 197076 | None | 0 | Mouse | Binding | pKd | = | 5.9 | 5.9 | -1 | 2 | Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 171378461 | 197076 | None | 0 | Mouse | Binding | pKd | = | 5.8 | 5.8 | -1 | 2 | Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5438140 | 197076 | None | 0 | Mouse | Binding | pKd | = | 5.8 | 5.8 | -1 | 2 | Binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assayBinding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 10 mins by BRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172470467 | 197125 | None | 0 | Human | Binding | pKd | = | 5.8 | 5.8 | -1 | 2 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5439297 | 197125 | None | 0 | Human | Binding | pKd | = | 5.8 | 5.8 | -1 | 2 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 567 | 15 | 4 | 11 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172446384 | 195262 | None | 0 | Human | Binding | pKd | = | 6.5 | 6.5 | - | 1 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assay |
ChEMBL | 651 | 12 | 3 | 10 | 4.3 | Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5399663 | 195262 | None | 0 | Human | Binding | pKd | = | 6.5 | 6.5 | - | 1 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 5 mins by NanoBRET assay |
ChEMBL | 651 | 12 | 3 | 10 | 4.3 | Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172446384 | 195262 | None | 0 | Human | Binding | pKd | = | 6.3 | 6.3 | - | 1 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay |
ChEMBL | 651 | 12 | 3 | 10 | 4.3 | Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5399663 | 195262 | None | 0 | Human | Binding | pKd | = | 6.3 | 6.3 | - | 1 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay |
ChEMBL | 651 | 12 | 3 | 10 | 4.3 | Cc1cc(CN2CCN(CCNC3C=CC([N+](=O)[O-])c4nonc43)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 171378461 | 197076 | None | 0 | Human | Binding | pKd | = | 6.2 | 6.2 | 1 | 2 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5438140 | 197076 | None | 0 | Human | Binding | pKd | = | 6.2 | 6.2 | 1 | 2 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells assessed as dissociation constant incubated for 15 mins by BRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 171378461 | 197076 | None | 0 | Human | Binding | pKd | = | 6 | 6.0 | 1 | 2 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5438140 | 197076 | None | 0 | Human | Binding | pKd | = | 6 | 6.0 | 1 | 2 | Binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assayBinding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in human Flp-In-T-REx-293 cells using assessed as dissociation constant incubated with for 30 mins by NanoBRET assay |
ChEMBL | 624 | 19 | 5 | 12 | 3.7 | O=C(O)C[C@H](NC(=O)c1ccc(-c2ccc(OCCCCCCNCCNc3ccc([N+](=O)[O-])c4nonc34)cc2)o1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 142429204 | 194991 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 453 | 7 | 1 | 4 | 6.9 | O=C(O)CCc1cccc(Oc2ccc(Oc3cccc4cnccc34)cc2C(F)(F)F)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5394500 | 194991 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 453 | 7 | 1 | 4 | 6.9 | O=C(O)CCc1cccc(Oc2ccc(Oc3cccc4cnccc34)cc2C(F)(F)F)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 162664232 | 182185 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 365 | 5 | 2 | 2 | 4.9 | O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL4781545 | 182185 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 365 | 5 | 2 | 2 | 4.9 | O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 137553168 | 196727 | None | 3 | Mouse | Binding | pKi | = | 5.8 | 5.8 | -5 | 2 | Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 398 | 7 | 3 | 5 | 2.3 | O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5430997 | 196727 | None | 3 | Mouse | Binding | pKi | = | 5.8 | 5.8 | -5 | 2 | Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 398 | 7 | 3 | 5 | 2.3 | O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 162664232 | 182185 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 365 | 5 | 2 | 2 | 4.9 | O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL4781545 | 182185 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 365 | 5 | 2 | 2 | 4.9 | O=C(O)Cc1ccccc1NC(=O)c1cccc(-c2ccc(Cl)cc2)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 137553168 | 196727 | None | 3 | Human | Binding | pKi | = | 6.6 | 6.6 | 5 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 398 | 7 | 3 | 5 | 2.3 | O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5430997 | 196727 | None | 3 | Human | Binding | pKi | = | 6.6 | 6.6 | 5 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 398 | 7 | 3 | 5 | 2.3 | O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172463317 | 196804 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 379 | 5 | 2 | 2 | 5.2 | Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5432512 | 196804 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 379 | 5 | 2 | 2 | 5.2 | Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 137553168 | 196727 | None | 3 | Human | Binding | pKi | = | 6.5 | 6.5 | 5 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 398 | 7 | 3 | 5 | 2.3 | O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5430997 | 196727 | None | 3 | Human | Binding | pKi | = | 6.5 | 6.5 | 5 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 398 | 7 | 3 | 5 | 2.3 | O=C(O)C[C@H](NC(=O)c1cccc(-c2ccc(OC(F)(F)F)cc2)n1)C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 10519 | 2813 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | 218 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 443 | 7 | 2 | 4 | 4.0 | CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 138811017 | 2813 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | 218 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 443 | 7 | 2 | 4 | 4.0 | CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL4790324 | 2813 | None | 27 | Human | Binding | pKi | = | 7.4 | 7.4 | 218 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 443 | 7 | 2 | 4 | 4.0 | CN1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)C(=O)Nc1ccccc1CC(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172468500 | 196567 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 457 | 7 | 2 | 4 | 4.3 | Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5426854 | 196567 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 457 | 7 | 2 | 4 | 4.3 | Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172463317 | 196804 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 379 | 5 | 2 | 2 | 5.2 | Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5432512 | 196804 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 379 | 5 | 2 | 2 | 5.2 | Cc1cc(Cl)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 2734802 | 1984 | None | 42 | Mouse | Binding | pKi | = | 4.4 | 4.4 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 132 | 2 | 2 | 3 | -1.1 | OC(=O)[C@@H]1O[C@@H]1C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 9631 | 1984 | None | 42 | Mouse | Binding | pKi | = | 4.4 | 4.4 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 132 | 2 | 2 | 3 | -1.1 | OC(=O)[C@@H]1O[C@@H]1C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL1741775 | 1984 | None | 42 | Mouse | Binding | pKi | = | 4.4 | 4.4 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 132 | 2 | 2 | 3 | -1.1 | OC(=O)[C@@H]1O[C@@H]1C(=O)O | 10.1021/acs.jmedchem.3c00552 | ||
| 172468500 | 196567 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 457 | 7 | 2 | 4 | 4.3 | Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5426854 | 196567 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | - | 1 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 457 | 7 | 2 | 4 | 4.3 | Cc1cc(CN2CCN(C)CC2)ccc1-c1cccc(C(=O)Nc2ccccc2CC(=O)O)c1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172447933 | 195873 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 418 | 13 | 4 | 6 | 2.5 | NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5412414 | 195873 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 418 | 13 | 4 | 6 | 2.5 | NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172447933 | 195873 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 418 | 13 | 4 | 6 | 2.5 | NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5412414 | 195873 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 418 | 13 | 4 | 6 | 2.5 | NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 169205458 | 196510 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 347 | 8 | 3 | 5 | 2.0 | CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5425639 | 196510 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged human succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2465 by BRET assay |
ChEMBL | 347 | 8 | 3 | 5 | 2.0 | CCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| 172447933 | 195873 | None | 0 | Mouse | Binding | pKi | = | 6.2 | 6.2 | -1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 418 | 13 | 4 | 6 | 2.5 | NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
| CHEMBL5412414 | 195873 | None | 0 | Mouse | Binding | pKi | = | 6.2 | 6.2 | -1 | 2 | Competitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assayCompetitive binding affinity to N-terminal Nluc-tagged mouse succinate receptor 1 expressed in Flp-In-T-REx-293 cells assessed as inhibition constant incubated for 5 mins in the presence of TUG-2384 by BRET assay |
ChEMBL | 418 | 13 | 4 | 6 | 2.5 | NCCCCCCOc1ccc(-c2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)o2)cc1 | 10.1021/acs.jmedchem.3c00552 | ||
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