Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
259210 141411 20 None - 0 Bovine 4.4 pEC50 = 4.4 Binding
Binding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopyBinding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopy
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q
CHEMBL387152 141411 20 None - 0 Bovine 4.4 pEC50 = 4.4 Binding
Binding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopyBinding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopy
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q
259210 141411 20 None - 0 Bovine 4.8 pIC50 = 4.8 Binding
Inhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assayInhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assay
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q
CHEMBL387152 141411 20 None - 0 Bovine 4.8 pIC50 = 4.8 Binding
Inhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assayInhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assay
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q